Journal of Medicinal and Chemical Sciences

Heart Rate Variability and QT Changes in Children with Hemophilia

Asmaa A. El Sehmawy; Nadia Ahmed Agiba; Heba Tawfik Okda; Rasha Mahmoud Gouda; Nglaa Fathi Agba; Mona Gamal El Din Al Anany; Azza A. Katta

Volume 6, Issue 11 , November 2023, , Pages 2641-2649

https://doi.org/10.26655/JMCHEMSCI.2023.11.8

Abstract

Background: Hemophilia-A is a sex-related hereditary bleeding disorder, like the general populations, mortality from cardiovascular diseases is currently responsible for one-third of ... Read More

Evaluating the Effectiveness of Ketamine in reducing Postoperative Nausea and Vomiting in Adults after General Anaesthesia: A Prospective Randomized Controlled Trial

Yachendra V.S.G; Girimurugan .N; Ameerunnisha Begum; Anand. S; Surya. R; Lakshmi. R

Volume 6, Issue 12 , December 2023, , Pages 2934-2940

https://doi.org/10.26655/JMCHEMSCI.2023.12.8

Abstract

Background: Postoperative Nausea and Vomiting (PONV) is defined as any nausea, retching or vomiting occurring during the first 24-48 hours after surgery with a reported incidence of ... Read More Background: Postoperative Nausea and Vomiting (PONV) is defined as any nausea, retching or vomiting occurring during the first 24-48 hours after surgery with a reported incidence of 30% in all post-surgical patients and up to 80% in high risk groups especially in laparoscopic surgeries under general anaesthesia. Many drugs have been tried and tested for abolishing PONV. We evaluated the efficacy of low dose ketamine in decreasing the incidence and severity of PONV following elective laparoscopic surgeries under general anaesthesia.Method: 40 patients belonging to American Society of Anaesthesiologists Physical status I who were scheduled for elective laparoscopic surgeries under general anaesthesia were recruited and randomized into two groups Group A and Group B. Standard protocol for general anaesthesia were followed for all patients. Patients in Group A received Intravenous ketamine of 0.2mg/kg and Patients in Group B received the saline control half an hour before extubation. The incidence and severity of PONV, number of rescue drug administration, and side effects were recorded for first 24 postoperative hours in different time periods.Results: Demographic profile were comparable among the groups. The incidence and severity of postoperative nausea were significantly higher in Group B when compared to Group A for the first 6 postoperative hours (p<0.05) and thereafter, it was comparable between the groups. The incidence of postoperative vomiting was significantly higher in Group B when compared to Group A for the first 2 postoperative hours (p<0.04), and then it was comparable between the groups. The number of rescue medications were significantly higher in Group B when compared with Group A. No complications were noted.Conclusion: Low dose intravenous ketamine (0.2 mg/kg) administered as a single bolus reduced the incidence and severity of postoperative nausea and vomiting in adults undergoing laparoscopic surgeries under general anaesthesia without any complications.

A mini review: recent developments of heterocyclic chemistry in some drug discovery scaffolds synthesis

Ritu Sapra; Dhara Patel; Dhananjay Meshram

Volume 3, Issue 1 , January 2020, , Pages 71-78

https://doi.org/10.26655/JMCHEMSCI.2020.1.9

Abstract

Novel developments in the synthetic techniques that facilitate rapid access to various functionalized heterocyclic compounds are essential in medicinal chemistry. They enable an expansion ... Read More

Clinical Changes in Patterns of Moral Courage and Moral Distress Among Operating Room Nurses During COVID-19

Mahboobeh Khosravani; Ashkan Karimi; Sahar Khaki; Hamed Parnikh; Azam Moslemi; Zahra Mostafapour; Azadeh Amiri

Volume 7, Issue 1 , January 2024, , Pages 91-103

https://doi.org/10.26655/JMCHEMSCI.2024.1.9

Abstract

Healthcare personnel involved in COVID-19 care have been negatively affected by the associated excess stress. This study aimed to investigate the relationship between moral distress ... Read More Healthcare personnel involved in COVID-19 care have been negatively affected by the associated excess stress. This study aimed to investigate the relationship between moral distress and moral courage among operating room nurses due the hidden conditions of the effects of COVID during the outbreak of the coronavirus disease (COVID-19) crisis. This descriptive-correlation study was conducted on all operating room nurses working in educational and medical centers in Shiraz, Iran, 2022. The samples (n=141) were selected using a convenience sampling method. The required data were collected by questionnaires of demographic form, the Professional Sekerka Moral Courage and the Moral Distress Scale. The gathered data were analyzed in SPSS software through descriptive and analytical statistics. The mean scores of moral courage and moral distress only nurses who as Circuler Nurse were obtained at 61.67±7.79 was 47.4±18.9, respectively. It was revealed that there was a statistically significant relationship between the dimensions of moral courage and the dimensions of errors and inappropriate competencies and responsibilities of moral distress (P>0.05). The moral courage and moral distress of the nurses showed significant differences in terms of the type of employment, length of working experience, specialized field of surgery, and working ward, age, specialized field of surgery during the COVID-19 crisis. Moral agency and multiple values showed a statistically significant and direct relationship with total moral distress (R=0.20, P=0.01). Concerning the results of study, there can be stated that nurses were inclined to perform moral behaviors and an increase in their sense of responsibility during the COVID-19 crisis would lead to courageous behaviors and ultimately, a reduction in moral distress. Therefore, it is necessary that managers pay serious attention to the employment of training programs and improving the psychological knowledge of involved nurses and sharing nurses’ experiences of moral distress.

Preparation and crystal structures of new schiff bases derived from 3, 3ʹ-dihydroxy-4, 4ʹ-(propane-1, 2-dieloxy)-dibenzaldehyde

Aliakbar Dehno Khalaji

Volume 3, Issue 2 , April 2020, , Pages 176-182

https://doi.org/10.26655/jmchemsci.2020.2.9

Abstract

In this research study, two Schiff base compounds AP-DHPDB (1) synthesized from the reaction of 2-aminophenol (AP) with 3, 3ʹ-dihydroxy-4, 4ʹ-(propane-1, 2-dieloxy)-dibenzaldehyde ... Read More

Epidemiological and Pharmacal Study of Ankylosing Spondylitis in a Rheumatology Clinic in a Tertiary Health Care Center

Fatemeh Shirani; Suzan Maleki; Zeinab Shafinejad

Volume 5, Issue 3 , May and June 2022, , Pages 355-360

https://doi.org/10.26655/JMCHEMSCI.2022.3.9

Abstract

Determination of epidemiological characteristics in rheumatologic diseases is important to improve the diagnosis and treatment course in patients. This study was performed to determine ... Read More

Effect of Platelet Rich Fibrin Membrane (PRF) or Conjunctival Autograft on VEGF Expression and Microvascular Density Post Conjunctival Excision

Aulia Ramadhan; Lukisiari Agustini; Dicky Hermawan; Ismi Zuhria; Reni Prastyani; Hari Basuki Notobroto; Djoko Legowo

Volume 7, Issue 2 , February 2024, , Pages 374-382

https://doi.org/10.26655/JMCHEMSCI.2024.2.9

Abstract

The conjunctiva has a significant role in maintaining the health of the eye's surface, particularly the cornea. Preserving the integrity of the conjunctival tissue is essential, as ... Read More The conjunctiva has a significant role in maintaining the health of the eye's surface, particularly the cornea. Preserving the integrity of the conjunctival tissue is essential, as extensive damage, coupled with inadequate treatment, can lead to a spectrum of eye disorders, ranging from mild conditions to severe cases resulting in blindness. Various techniques are available for repairing such conjunctival damage, including conjunctival autograft, amniotic membrane transplantation (AMT), oral mucosal graft, and the latest innovation, the use of PRF (Platelet Rich Fibrin) membrane. Nevertheless, it has remained unclear whether there are distinct effects on VEGF expression and angiogenesis following conjunctival excision when comparing PRF membrane grafts to conjunctival autografts. This study employs a true experimental design, utilizing a randomized post-test only two-group design, to compare the impact of PRF membrane transplantation and conjunctival autografting on VEGF expression and angiogenesis subsequent to conjunctival excision in adult New Zealand white rabbits. Twenty adult male rabbits were randomly split into two categories: the autograft cohort and the PRF membrane cohort. Conjunctival excisions were performed on the temporal conjunctival aspect of the right eye in each rabbit. In the first group, the conjunctival defect was repaired through conjunctival autografting, while in the second group, the defect was closed using a PRF membrane. After a period of 14 days following treatment, all samples were collected, and the right eyes that had undergone treatment were enucleated. The conjunctival tissues from the treated areas were then processed for histopathological examination. Immunohistochemical and Hematoxylin and Eosin (HE) staining were conducted on each sample. The Independent T-Test used for statistical analysis demonstrated a notably elevated VEGF expression level in the PRF membrane group in comparison to the conjunctival autograft group (p<0.05). Additionally, a significant variance in angiogenesis was evident between the PRF membrane and the conjunctival autograft groups (p<0.05).

The Effect of Drug Information Provision on Level of Patient Compliance in Consuming Antibiotic for Patients in Dental Polyclinic

Morita Sari; Shafira Kurnia Rani Wibowo

Volume 5, Issue 4 , July and August 2022, , Pages 477-482

https://doi.org/10.26655/JMCHEMSCI.2022.4.4

Abstract

Antibiotics are substances produced by microorganisms that can be used as a solution to kill or inhibit the development of other microorganisms. Antibiotics are often misused, which ... Read More

Potential Role of NLRP3 Inflammasome Activation in the Pathogenesis of Periodontitis Patients with Type 2 Diabetes Mellitus

Mohammed Jasim Al-Obaidi; Batool Hassan Al-Ghurabi

Volume 6, Issue 3 , March 2023, , Pages 522-531

https://doi.org/10.26655/JMCHEMSCI.2023.3.9

Abstract

Background: In response to microbial infection and cellular injury, the NLRP3 inflammasome, an essential part of the innate immune system, causes caspase-1 activation and the release ... Read More Background: In response to microbial infection and cellular injury, the NLRP3 inflammasome, an essential part of the innate immune system, causes caspase-1 activation and the release of the proinflammatory cytokines IL-1 β and IL-18. However, various inflammatory diseases, including periodontal disease, have been linked to the abnormal activation of the NLRP3 inflammasome.Aim of study: This study was conducted to investigate the crucial role of NLRP3 inflammasome activation and IL-18 in the pathogenesis of periodontitis patients with type 2 diabetes mellitus.Materials and Methods: This case control study included eighty-five participants., their age range (23-55) years, they divided into three groups: two groups had periodontitis one of them with type two diabetic mellitus and the other one systemically healthy, the third group was the control group with clinically healthy periodontium and systemically healthy. Serum samples from both patients and controls were analyzed using an ELISA kit designed to detect NLRP3 inflammasome activity and interleukin-18.Results: Conclusions: Elevated NLRP3 and IL-18 levels in PD +T2DM patients, as well as their positive correlation with clinical parameters, suggest a critical role in the pathogenesis of PD with and without diabetes.. A significant positive correlation also noticed between NLRP3 and each of (GI, PPD, CAL and BOP) in PD+T2DM patients. Regarding the group of PD patients there was no significance correlation between NLRP3 and clinical parameters. Additionally, IL-18 was discovered to have a positive correlation with GI, PPD, CAL, and BOP in PD+T2DM patients, w. Meanwhile, there is a significant correlation between NLRP3 as well as interleukin-18 in patients with and without type 2 diabetic mellitus.Conclusions: Elevated NLRP3 and IL-18 levels in PD +T2DM patients, as well as their positive correlation with clinical parameters, suggest a critical role in the pathogenesis of PD with and without diabetes.

Formulation and Characterization of Eleutherine palmifolia Extraction in Carriers of Microspheres with Variations in Chitosan Polymer Concentration

Roihatul Mutiah; Edi Humaidi; Muhammad Yusral Fahmi Rahmatullah; Ermin Rachmawati; Avin Ainur Fitrianingsih; Rahmi Annisa

Volume 7, Issue 4 , April 2024, , Pages 649-659

https://doi.org/10.26655/JMCHEMSCI.2024.4.9

Abstract

This study aims to determine the effect of variations in chitosan concentration as a polymer on the physical characteristics, mucoadhesive properties, and dissolution profiles of mucoadhesive ... Read More

Surveillance of Multidrug-resistant Iraqibacter Isolated from Patients with Urinary Tract Infection at a Baghdad Urology Center

Sinan Bahjat Alrifai; Wakas Saadi Mahmood; Noor Hamdi Jasem

Volume 5, Issue 5 , September and October 2022, , Pages 753-759

https://doi.org/10.26655/JMCHEMSCI.2022.5.9

Abstract

Background: We dealt with Multidrug- resistant Acinetobacter baumanniiisa “red alert” pathogen that is included in the acronym “ESKAPE” along with other five ... Read More

The Correlation Between Type 2 Diabetes Mellitus and Hypertension in Iraqi Patients

Abdullah Abbas Hamzah Al-Rubaye

Volume 6, Issue 4 , April 2023, , Pages 778-788

https://doi.org/10.26655/JMCHEMSCI.2023.4.9

Abstract

Type 2 diabetes (T2DM) is a long-term situation. It is indicated by the elevated blood glucose levels. Hypertension is a common comorbidity in people with some chronic diseases that ... Read More

The in vitro Effects of New Albocarbon-based Coumarins on Blood Glucose-controlling Enzymes

Sarah Ahmed Waheed; Yasser Fakri Mustafa

Volume 5, Issue 6 , November and December 2022, , Pages 954-967

https://doi.org/10.26655/JMCHEMSCI.2022.6.9

Abstract

The majority of the world’s most hazardous pathologies are linked to the oxidative damaging effect of free moieties. One of the diseases associated with these damaging radicals ... Read More The majority of the world’s most hazardous pathologies are linked to the oxidative damaging effect of free moieties. One of the diseases associated with these damaging radicals is diabetes. This disease is widely distributed among people of all ages, with the elderly being the most affected. Therefore, it is essential to conduct comprehensive investigations in order to promote the creation of the novel free radical-housing and hypoglycemic compounds. This study involves the synthesis of eight novel albocarbon-based coumarins, which were confirmed by various spectrophotometers. Their hypoglycemic and free radical-housing effects were analyzed. The pharmacokinetic profile was checked in silico using pre-ADMET, known as a free online program. The hypoglycemic influence was tested against two types of the blood glucose-controlling enzymes. In addition, the new compounds’ potency index was measured. The free radical-housing potential was analyzed by testing these coumarins’ ability to scavenge DDPT and hydroxyl harmful radicals. Pharmacokinetic studies demonstrated that the synthesized albocarbon-based coumarins penetrate the gastrointestinal mucosa very well, and the majority of these compounds penetrate the blood-brain barrier only slightly. These findings suggest the good oral bioavailability along with low neurological toxicity profiles. The investigation of the hypoglycemic influence of these new compounds revealed that they had a less potent enzyme inhibition capacity compared to the standard, with LY5 being the most powerful one. Besides, the assessment of the free radical-housing potential of these synthesized albocarbon-based coumarins also indicated that all of them were less active than the reference. Among them, LY0 was the strongest free radical-housing compound from these recognitions, along with the safety and good pharmacokinetic parameters in accordance with the computer-based study. The researchers believed that these new albocarbon-based coumarins can be applied for the creation of new successful drugs with hypoglycemic and free radical-housing effects which can help in the modulation of much serious pathology.

Spectorphotometric Methods for Determination of Terbutaline Sulphate in Pure and Pharamaceutical Formulation

Intisar Adil Shihab Al-Hammoodi; Mohammed Salim Al-Enizz; Abdussamed M. A. Saeed

Volume 6, Issue 5 , May 2023, , Pages 1032-1043

https://doi.org/10.26655/JMCHEMSCI.2023.5.9

Abstract

Two simple, sensitive, and accurate spectrophotometric methods are described to determine terbutaline sulfate in pure and pharmaceutical formulations. They are primarily based totally ... Read More

Detection of the Mycotoxin T2 Produced by Fusarium spp. in Some local Cereal Products and Studying Its Phenotypic Characteristics in Baghdad City

Sudad Jasim Mohammed

Volume 5, Issue 7 , November and December 2022, , Pages 1208-1214

https://doi.org/10.26655/JMCHEMSCI.2022.7.9

Abstract

The greatest dangerous trichothecene generated through Fusarium spp., mainly F. sporotrichioides, is T-2 toxin. T-2 toxin is an environmental pollutant that really can cause a considerable ... Read More

Identification of Significant Instants of Voxels for Cognitive State Classification Using Interpretable Machine Learning Models

Siva Ramakrishna Jeevakala; Hariharan Ramasangu

Volume 6, Issue 6 , June 2023, , Pages 1291-1301

https://doi.org/10.26655/JMCHEMSCI.2023.6.9

Abstract

Despite decades of significant research, task-based functional MRI cannot reliably predict individual differences in cognition. Furthermore, searching for methods with greater predictability ... Read More

The Role of Neuregulin 4 Status in Female’s Primary Infertility Patients

Mustafa Saleam Khalaf; Zeena A. Alsaady

Volume 6, Issue 7 , July 2023, , Pages 1577-1581

https://doi.org/10.26655/JMCHEMSCI.2023.7.9

Abstract

Background: Female’s primary infertility (FPI) is females who have not pregnant after one year of sexual intercourse without using methods of birth control. Neuregulin 4 (NRG4) ... Read More

Synthesis of Dihydropyrimidinone (DHPM) Derivatives through a Multicomponent Reaction (MCR) and Their Biological Activity

Ahmad Fauzi; Azis Saifudin; Kamal Rullah

Volume 6, Issue 8 , August 2023, , Pages 1810-1817

https://doi.org/10.26655/JMCHEMSCI.2023.8.9

Abstract

The spread of incurable diseases, especially infectious diseases caused by antibiotic-resistant bacteria and certain cancers, has become a serious public health concern. Consequently, ... Read More

Assessment of Salivary Alpha-Amylase, Cortisol, and Prevalence of Temporomandibular Disorder in Patients with Major Depressive Disorder

Ameer Ali Althabhawee; Taghreed Fadhil Zaidan Zaidan

Volume 6, Issue 9 , September 2023, , Pages 2010-2017

https://doi.org/10.26655/JMCHEMSCI.2023.9.9

Abstract

There has been a general uptick in the number of people diagnosed with major depressive disorder (MDD) worldwide, which has led to a commensurate rise in the need for oral medicine ... Read More

Determining Levels Awareness of Vitamin D as a Silent Epidemic among the Population in Southern Saudi Arabia

Amal A. Abdulbaqi; Rym Hassani; Omaymah Radwan

Volume 6, Issue 10 , October 2023, , Pages 2338-2347

https://doi.org/10.26655/JMCHEMSCI.2023.10.9

Abstract

Vitamin D (VD) is an important nutrient for the human body because it is associated with many diseases. There were many health problems in which vitamin D deficiency had a role, the ... Read More

Impact of Ethanol Extract of Basil Leaves (Ocimum basilicum L.) on Mast Cell Reduction and Prostaglandin E2 Levels in Female Mice as a Model for Endometriosis Development

Khafidhiyah Nur Insaniyah; Ashon Sa’adi; Widjiati Widjiati

Volume 6, Issue 12 , December 2023, , Pages 2941-2951

https://doi.org/10.26655/JMCHEMSCI.2023.12.9

Abstract

Endometriosis, a painful inflammatory condition, arises from the growth of endometrial tissue beyond the uterus. The anti-inflammatory properties of basil (Ocimum basilicum L.) suggest ... Read More

Considering different kinds of gasoline unit catalysts

Amir Samimi; Soroush Zarinabadi; Amir Hossein Shahbazi Kootenaei; Alireza Azimi; Masoumeh Mirzaei

Volume 3, Issue 1 , January 2020, , Pages 79-94

https://doi.org/10.26655/JMCHEMSCI.2020.1.10

Abstract

The aim of this study is to investigate naphtha Gasoline unit catalysts. In two-factor catalysts, platinum or palladium was used as the active metal on the base alumina chloride, zirconia, ... Read More

The Impact of Obesity and Diabetes on COVID-19 Severity

Asma Alanazi; Raseel Alsubaie; Wed Alwabel; Aram Alzahrani; Wasan Alenezi; Bushra Almutawa; Nada Al Eisa

Volume 7, Issue 1 , January 2024, , Pages 104-115

https://doi.org/10.26655/JMCHEMSCI.2024.1.10

Abstract

The seven human coronavirus, sever acute respiratory syndrome coronavirus 2 (SARS-CoV-2) had started a worldwide health pandemic that raised concern regarding its severe outcomes in ... Read More

Detoxification of acetaminophen overdose using formulated carbo tablets

A.U. Itodo; S Ande; M.O. Audu

Volume 3, Issue 2 , April 2020, , Pages 183-198

https://doi.org/10.26655/jmchemsci.2020.2.10

Abstract

Acetaminophen overdose is one of severe global health challenges. In this study, adsorption technique was used to reduce acetaminophen overdose. Carbo tablets derived by wet granulation ... Read More

Medical Evaluation of Mortality and Complications of Thoracoscopic Surgery with the Help of Primary Video in Patients with Thoracic Trauma with Stable Hemodynamics, 2019-2020

Mehdi Khosravi; Fatemeh Jahanshahi; Amirhossein Tafreshian; Seyed Masoud Haghighi Kian

Volume 5, Issue 3 , May and June 2022, , Pages 361-368

https://doi.org/10.26655/JMCHEMSCI.2022.3.10

Abstract

In a retrospective multi-center study from August 2019 to Dec 2020, patients with chest trauma and stable hemodynamics who underwent VATS within their first week from traumawere enrolled ... Read More

Volume 7 (2024)

Volume 6 (2023)

Volume 5 (2022)

Volume 4 (2021)

Volume 3 (2020)

Volume 2 (2019)

Volume 1 (2018)

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