Journal of Medicinal and Chemical Sciences

Original Article

Formulation and Development of Doxycycline Hyclate Loaded Chitosan Nanoparticles Crosslinked Topical Hydrogel Patches for Healing Diabetic Foot Ulcer

Sidhavatam Harshavardhan Reddy; Manimaran V

Articles in Press, Accepted Manuscript, Available Online from 21 April 2024

https://doi.org/10.26655/JMCHEMSCI.2024.6.1

Abstract

Diabetic foot ulcer pose a significant challenge in healthcare, often leading to prolonged healing processes and complications requiring sophisticated and advanced therapeutic interventions. ... Read More Diabetic foot ulcer pose a significant challenge in healthcare, often leading to prolonged healing processes and complications requiring sophisticated and advanced therapeutic interventions. This study focuses on the formulation and development of Doxycycline hyclate loaded chitosan nanoparticles in cross-linked topical hydrogel patches for targeted management of DFU healing. Various characterization techniques, such as FT-IR, Zeta potential, DSC, XRD, and SEM, were employed to confirm and gain insights into the structural and morphological features of the cross-linked topical hydrogel patches. The evaluation parameters encompassed analyzing sol-gel behavior, swelling dynamics, and in vitro drug release studies at pH values of 5.5, 6.5, and 7.4. Drug permeation and deposition was performed utilizing the Franz diffusion cell method. The topical hydrogel patches showed pH-sensitive behavior, with enhanced drug release, swelling, and permeation observed at pH 7.4. The synthesized nanoparticles exhibited a spherical morphology, varying particle sizes ranging from 92.83 nm to 206.2 nm, and a zeta potential measuring -22.4 mV. The patches were produced by incorporating CNPs as carriers for DCH into a polymeric matrix, which required the optimization of free radical polymerization. The ion gelation method was utilized to prepare the CNPs. The solvent evaporation technique was used for grafting the topical hydrogel patches. Among the seven formulations, topical hydrogel patch F6 exhibited the most favorable characteristics, as evidenced by a substantial drug content of 97.21 ± 0.524%. The F6 formulation excelled over other formulations over 72 hours at pH 7.4. Stability testing of the selected F6 formulation over 6 months under accelerated conditions confirmed its viability. Therefore, this polymeric network represents an innovative technology for accelerating the healing process of diabetic foot ulcers through the use of doxycycline hyclate loaded chitosan nanoparticles cross-linked in topical hydrogel patches.

Review Article

Real-World Effectiveness of Remdesivir in Patients with Coronavirus Disease 2019 (COVID-19): A Systematic Review

Heni Retnowulan; Jarir at Thobari; Yanri Wijayanti Subronto; Dhite Bayu Nugroho

Articles in Press, Accepted Manuscript, Available Online from 21 April 2024

https://doi.org/10.26655/JMCHEMSCI.2024.6.2

Abstract

Background: COVID-19, caused by the SARS-CoV-2 virus, has been a global health crisis, affecting individuals of all ages and leading to complications like ARDS, sepsis, and multi-organ ... Read More Background: COVID-19, caused by the SARS-CoV-2 virus, has been a global health crisis, affecting individuals of all ages and leading to complications like ARDS, sepsis, and multi-organ failure. The pandemic has notably impacted healthcare systems in countries like India and Indonesia. Remdesivir has emerged as a popular treatment option, but its real-world effectiveness remains a subject of debate due to varying patient demographics, disease severities, and healthcare settings.Aim: This review aims to systematically analyse observational study data to evaluate the real-world efficacy of Remdesivir in treating COVID-19 patients across various global healthcare settings. It focuses on patients with moderate to severe COVID-19, synthesizing data to understand the role and benefits as well as potential limitations of Remdesivir in clinical practice.Methods: The review protocol was registered with PROSPERO and involved comprehensive literature searches in databases like PubMed, the Cochrane Library, and Google Scholar. The search, spanning from the beginning of the pandemic until April 2022, focused on studies involving adult patients with severe or serious COVID-19 treated with Remdesivir. Data extraction followed a standardized form, and the quality of non-randomized studies was assessed using the ROBINS-I method. The review included a narrative synthesis due to the heterogeneity of the studies.Results: The review analysed data from nine studies, revealing varied outcomes in terms of The World Health Organization (WHO) ordinal scale clinical improvement, mortality rates, need for oxygen support and hospital stay length. The results indicated that Remdesivir, particularly in combination with other treatments like corticosteroids, could have a positive impact on reducing symptom severity, mortality rates, and hospitalization duration in COVID-19 patients.Conclusion: Remdesivir, as part of COVID-19 treatment Regimens, shows promise in real-world clinical settings, particularly in reducing the severity and mortality of the disease. However, Remdesivir effectiveness varies based on patient demographics, disease severity, and the healthcare environment. Future research should focus on long-term outcomes and the identification of patient subgroups that could benefit the most from Remdesivir.

Review Article

Impact of Excipients Blending on Sugar-Stabilized Therapeutic Proteins

Cynthia Marisca Muntu; Christina Avanti; Hayun Hayun; Silvia Surini

Articles in Press, Accepted Manuscript, Available Online from 22 April 2024

https://doi.org/10.26655/JMCHEMSCI.2024.6.3

Abstract

Sugars have long been used as stabilizing excipients for protein-based therapeutics during the development and production process. Incorporating stabilizing agents, such as sucrose ... Read More

Journal of Medicinal and Chemical Sciences

Articles in Press

Current Issue

Volume 7 (2024)

Volume 6 (2023)

Volume 5 (2022)

Volume 4 (2021)

Volume 3 (2020)

Volume 2 (2019)

Volume 1 (2018)

Volume & Issue: Articles in Press / Accepted Manuscript

Formulation and Development of Doxycycline Hyclate Loaded Chitosan Nanoparticles Crosslinked Topical Hydrogel Patches for Healing Diabetic Foot Ulcer

Abstract

Real-World Effectiveness of Remdesivir in Patients with Coronavirus Disease 2019 (COVID-19): A Systematic Review

Abstract

Impact of Excipients Blending on Sugar-Stabilized Therapeutic Proteins

Abstract