Journal of Medicinal and Chemical Sciences

Original Article

Intensity Modulated Radiation and Volumetric Modulated Arc Therapies in Breast Cancer

May Z. Saddik; Fatiheea F. Hassan

Volume 6, Issue 9 , September 2023, Pages 1925-1934

https://doi.org/10.26655/JMCHEMSCI.2023.9.1

Abstract

Background: Breast cancer is the most common malignant neoplasm in women, accounting for 25% of all cancers. Radiotherapy is one of the safest methods compared with other treatments.Methods: ... Read More

Original Article

Clinical and Laboratory Characteristics of COVID-19 Patients with Fecal SARS-CoV-2 Detection at a Tertiary Hospital in Indonesia

Andrew Adhytia Lieputra; Rebriarina Hapsari; Cecilia Oktaria Permatadewi; Irfan Kesumayadi; Iva Puspitasari; Purnomo Hadi; Nur Farhanah; Hendro Wahyono; Hery Djagat Purnomo

Volume 6, Issue 9 , September 2023, Pages 1935-1942

https://doi.org/10.26655/JMCHEMSCI.2023.9.2

Abstract

Transmission prevention is important to prevent the spread of COVID-19. Although most cases are transmitted through droplets and aerosols, several studies have shown the possibility ... Read More

Original Article

Density Functional Theory, ADME, and Molecular Docking of Some Anthranilic Acid Derivatives as Cyclooxygenase Inhibitors

Karam S. Atrushi; Dana M. Ameen; Shaymaa H. Abdulrahman; Faris T. Abachi

Volume 6, Issue 9 , September 2023, Pages 1943-1952

https://doi.org/10.26655/JMCHEMSCI.2023.9.3

Abstract

Nonsteroidal anti-inflammatories (NSAIDs), are very effective agents in relieving mild to moderate pain and inflammation by inhibiting two isoforms of prostaglandin G-H synthetase (I ... Read More

Review Article

Perception of Patient Safety Incident Reporting System among Healthcare Workers in Palestinian Government Hospital

Salam Al Ratrout

Volume 6, Issue 9 , September 2023, Pages 1953-1969

https://doi.org/10.26655/JMCHEMSCI.2023.9.4

Abstract

The aim of the current study was to determine the system perception for reporting patient safety incidents among workers in the field of health care, evaluating the factors affecting ... Read More

Original Article

Communicable Diseases (CDs) Among Paramedics in Private Healthcare in India

Soumya Ranjan Ray Choudhury; B. Chandra Mohan Patnaik; Ipseeta Satpathy

Volume 6, Issue 9 , September 2023, Pages 1967-1974

https://doi.org/10.26655/JMCHEMSCI.2023.9.5

Abstract

Humanitarian emergencies including disasters associated with natural hazards, conflict, complex emergencies, and famines can pose significant risks to public health, especially when ... Read More

Original Article

Synthesis of Benzimidazole and Phthaloylamino Acid derivatives and Antibacterial Activity

Hussniya A. AlDifar; Basma S. Baaiu; Khalid M. A. Darwish; Mohamad F. Ali; Othman O. Dakhil; Mansour Abd-Alsalam; Haneen Al Difar

Volume 6, Issue 9 , September 2023, Pages 1975-1984

https://doi.org/10.26655/JMCHEMSCI.2023.9.6

Abstract

Seven novel benzimidazole and phthaloylamino acid derivatives were synthesized. In the presence of acetic acid, the phthalic anhydride reacted with benzidine in a cyclization reaction ... Read More

Original Article

Competitive Adsorption of Li+, Na+, and K+ Ions on Phillip Site/Chabazite Zeolitic Tuff from Jordan

Reem Naser Dabaibeh; Hiba Hamed Amayrah

Volume 6, Issue 9 , September 2023, Pages 1985-1997

https://doi.org/10.26655/JMCHEMSCI.2023.9.7

Abstract

The adsorption of alkali metal ions on zeolite has no such possibility of precipitation. In the current work, we have studied the adsorption isotherms, and the effect of pH and temperature ... Read More

Original Article

Critical Role of Monocyte Chemotactic Protein -1 and Macrophage Migration Inhibitory Factor in Children who Have Pneumonia

Gehad Nabil Abd El-Aal; Shimaa Moustafa Kamel; Mona Sayed Mohammad Attaya; Dalia Mahmoud Eldewi; Fatma Elzahraa AE. Diab; Marwa Mohsen Ramadan Hassan; Suzan Mohamed Abdel Kareem Mohamed

Volume 6, Issue 9 , September 2023, Pages 1998-2009

https://doi.org/10.26655/JMCHEMSCI.2023.9.8

Abstract

Background: The leading cause of death for children under the age of five years old worldwide is pneumonia. The assessment of illness progression and clinical stage is necessary for ... Read More

Original Article

Assessment of Salivary Alpha-Amylase, Cortisol, and Prevalence of Temporomandibular Disorder in Patients with Major Depressive Disorder

Ameer Ali Althabhawee; Taghreed Fadhil Zaidan Zaidan

Volume 6, Issue 9 , September 2023, Pages 2010-2017

https://doi.org/10.26655/JMCHEMSCI.2023.9.9

Abstract

There has been a general uptick in the number of people diagnosed with major depressive disorder (MDD) worldwide, which has led to a commensurate rise in the need for oral medicine ... Read More

Original Article

Predictors of Mortality in Sepsis Patients Resulting from Severe and Critical COVID-19

Nur Farhanah; Supriadi Supriadi; Hendro Wahjono; Suharyo Hadisaputro; Muhammad Hussein Gasem

Volume 6, Issue 9 , September 2023, Pages 2018-2027

https://doi.org/10.26655/JMCHEMSCI.2023.9.10

Abstract

Patients with severe and critical COVID-19 may exhibit sepsis and mortality resulting from multi-organ failure. Neutrophil-lymphocyte-ratio (NLR) values, C-reactive protein (CRP) levels, ... Read More

Original Article

Impact of Pharmacological and Non-Pharmacological Intervention among Pregnant Women Complaining of Nausea and Vomiting

Shaymaa S. Maqsood; Ibrahim H. Mustafa

Volume 6, Issue 9 , September 2023, Pages 2028-2037

https://doi.org/10.26655/JMCHEMSCI.2023.9.11

Abstract

This study was conducted with the aim of investigating the effect of pharmaceutical and non-pharmacological interventions in pregnant women complaining of nausea and vomiting because ... Read More

Original Article

Survival Analysis of Delta versus Omicron Variants in COVID-19 Intensive Care Unit (ICU)

Somayeh Mehrpour; Mojdeh Bahadorzadeh; Hassan Safdari; Mansoureh Shakeri; Reihane Tabaraii

Volume 6, Issue 9 , September 2023, Pages 2038-2045

https://doi.org/10.26655/JMCHEMSCI.2023.9.12

Abstract

Objective: COVID-19 has presented numerous epidemiological and clinical pictures from its beginning and much effort has been paid to detect the behavior of disease and its new types. ... Read More Objective: COVID-19 has presented numerous epidemiological and clinical pictures from its beginning and much effort has been paid to detect the behavior of disease and its new types. Therefore, in this study, we aimed to compare the in-hospital survival time of Delta and Omicron variant patients admitted to the intensive care unit. Methods: This was a secondary data analysis of the QCOVICU data registry of 200 COVID-19 patients admitted to the ICU of Shahid Beheshti-Amir Al-Momenin Hospital of Qom City, in 2021. Likewise, time to event data, demographics, and baseline laboratory data was collected. Time of transfer to ICU, survivals, and possible predictors of hazards of death was compared within the variants of Omicron and delta.Results: Two hundred patients (62.98±19.94 years old, 94 females/106 males; 100 Delta and 100 Omicron variant) participated in this study. Fifty percent of the population had died. Cross-tabulation showed comparable death rates among variants of delta and omicron (50.5% vs. 51%; p=0.999). There was a statistically significant higher time to ICU admission in Delta variant victims than in Omicron variant victims. The mean survival time of delta variant patients was 21.52 days (95% CI: 17.96 – 25.09) which was statistically higher than the mean survival of omicron patients (17.15 days, 95% CI: 13.65-20.64, p=0.018). The mean survival time of delta variant patients was ‎statistically higher than omicron patients (21.52 vs. 17.15 days, ‎p=0.018). Gender, age (years), and lymphocyte count were significant predictors of mortality based on the Cox regression analysis (P>0.05). There was a 5.9 times higher risk of mortality in females compared with males’ gender after adjusting for other variables and a 5.6% increase in death risk with a 1-year increase in age, and a 31.8% decrease in death risk with a 1% lymphocyte percentage increase.Conclusion: Critically patients with Delta variant are getting ICU admitted later and withstand more days at ICU than Omicron patients. It seems that Omicron variant causes sudden deterioration of the patient's condition.

Original Article

Ghrelin and Serotonin Expression on Restricted Feed with Curcuma xanthorrhixa Roxb. and Iron Supplementation

Amallia Nuggetsiana Setyawati; Diky Syahrul Ramadhan; Kusmiyati Tjahjono; Ryan Halleyantoro; Puspita Kusuma Dewi

Volume 6, Issue 9 , September 2023, Pages 2046-2055

https://doi.org/10.26655/JMCHEMSCI.2023.9.13

Abstract

Background: Nutritional shortages and acute malnutrition are caused by insufficient protein and calorie consumption. With severe short- and long-term morbidity and death, malnutrition ... Read More

Original Article

Rigidity and Flexibility of Pyrazole, s-Triazole, and v-Triazole Derivative of Chloroquine as Potential Therapeutic against COVID-19

Adel M. Najar; Asma Eswayah; Moayed Ben Moftah; Ruwida Omar M.K.; Eman Bobtaina; Mohamed Najwa; Tawfeg A. Elhisadi; Aeyad Tahani; Salha M.Tawati; Aliaa M. M.Khalifa; Aly Abdou; Ahmed Emhamed DowAltome

Volume 6, Issue 9 , September 2023, Pages 2056-2084

https://doi.org/10.26655/JMCHEMSCI.2023.9.14

Abstract

Based on the core unit of chloroquine, new types of N-heterocyclic compounds that are fused together have been made. The compounds were put into two groups. In series A, the five-member ... Read More

Original Article

Comparing Black Trepang and Curryfish Extract's Antimalarial Activity Using In Vitro Screening

Prawesty Diah Utami; M. Fathi Ilmawan; Herin Setianingsih

Volume 6, Issue 9 , September 2023, Pages 2085-2095

https://doi.org/10.26655/JMCHEMSCI.2023.9.15

Abstract

Background: Malaria resistance to artemisinin combination therapy has prompted researchers to explore anti-plasmodium materials. One of the marine biotas thought to have the potential ... Read More

Original Article

Effectiveness Comparison of Decontamination Sputum Specimen between Kudoh and Petroff Modification Technique in Mycobacterium Culture

Andritta Febriana; Ni Made Mertaniasih; Pepy Dwi Endraswari; Lindawati Alimsardjono; Eko Budi Koendhori

Volume 6, Issue 9 , September 2023, Pages 2096-2103

https://doi.org/10.26655/JMCHEMSCI.2023.9.16

Abstract

Objectives: Tuberculosis (TB) is the common cause of death due to a single infectious agent. MTB culture is still the gold standard for TB diagnosis. For optimal care of pulmonary TB, ... Read More

Original Article

Modified Lung Ultrasound Score to Determine the Degree of Perioperative Atelectasis in Adults Undergoing Elective Laparoscopic Surgery Under General Anaesthesia- A Prospective Observational Study

Dhivya R; Arun Prasath D; Yachendra V.S.G; Surya R; Lakshmi Ramakrishnan

Volume 6, Issue 9 , September 2023, Pages 2104-2110

https://doi.org/10.26655/JMCHEMSCI.2023.9.17

Abstract

Background: Lung ultrasound score (LUS) is a semiquantitative assessment tool that has been proposed to assess lung aeration changes in mechanically ventilated patients after therapeutic ... Read More

Original Article

Correlation Between the Bacterial and Fungal Profiles from the Clinical Specimens with the CD4 Counts and the NLR Values of HIV/AIDS Patients at Tertiary Referral Hospital in Indonesia

Nafdzu Makhmudatul Muna; Agung Dwi Wahyu Widodo; Pepy Dwi Endraswari; M. Vitanata Arfijanto

Volume 6, Issue 9 , September 2023, Pages 2111-2127

https://doi.org/10.26655/JMCHEMSCI.2023.9.18

Abstract

Human immunodeficiency virus (HIV) poses a significant problem for the global public health with high morbidity and mortality rates. HIV/AIDS cases in Indonesia, the country with the ... Read More

Original Article

Synthesis, Antibacterial Evaluation, and Docking Studies of Some Azo Compounds and Schiff Bases Derived from Sulfonamide

Munther Abduljaleel Muhammad-Ali; Ekhlas Qanber Jasim; Abdullah H. Al-Saadoon

Volume 6, Issue 9 , September 2023, Pages 2128-2139

https://doi.org/10.26655/JMCHEMSCI.2023.9.19

Abstract

Objective: The aim of study was to synthesize new products of sulfonamide compounds containing azo and Schiff base fragments and confirm the structures by 1H-NMR and FT-IR spectroscopy, ... Read More

Original Article

Removal of Nickel(II) by Silica Aerogel-Activated Carbon Nanocomposite from Wastewater

Lubna Salah Muhammed

Volume 6, Issue 9 , September 2023, Pages 2140-2153

https://doi.org/10.26655/JMCHEMSCI.2023.9.20

Abstract

HMs (HMs) are important pollutants in the environment. The main purpose of this study was to evaluate the efficiency of nickel(II) adsorption process by Silica Airgel-Activated Carbon ... Read More

Original Article

Comparative Effect of Nigella Sativa+ Black Pepper and Letrozole + Tamoxifen on Female Infertility in Women with Polycystic Ovarian Syndrome: A Randomized Clinical Trial

Athar Rasekh Jahromi; Asra Ansari; Zahra Zareibabaarabi; Vahid Rahmanian; Nader Sharifi

Volume 6, Issue 9 , September 2023, Pages 2154-2163

https://doi.org/10.26655/JMCHEMSCI.2023.9.21

Abstract

Background: Polycystic ovary syndrome (PCOS), one of the most common reasons for infertility in terms of anovulation, influences 4–7% of reproductive women.Objectives: This study ... Read More

Original Article

Prevalence of Respiratory Disorders among Petrol Pump Workers: A Cross-Sectional Descriptive Study

Mustafa Mohammad Ameen; Salih Ahmed Abdulla

Volume 6, Issue 9 , September 2023, Pages 2164-2176

https://doi.org/10.26655/JMCHEMSCI.2023.9.22

Abstract

Objectives: Gas station workers who are continuously exposed to gasoline/diesel smoke, are at high risk of causing respiratory problems. This study was conducted to determine the prevalence ... Read More

Original Article

The Role of Dynamic (99m) Tc Pertechnetate Scintigraphy in Early Detection and Differentiation of Hyperthyroidism

Ramë Miftari; Hana Maloku; Afërdita Bajqinca; Bujar Rexhaj; Sanije Miftari; Ylli Kaqiu

Volume 6, Issue 9 , September 2023, Pages 2177-2185

https://doi.org/10.26655/JMCHEMSCI.2023.9.23

Abstract

Thyrotoxicosis is hypermetabolic states that is not always associated with hyperfunction of thyroid gland and can present a problem in diagnostic differentiation. We have tried to prove ... Read More

Original Article

Survey on Enhancement of Nuclear Cardiology Images Based on Image Processing Techniques for Diagnosis of Ischemic Patients

Loai Abudaqa; Nabil Al-Swari; Shady Hegazi; Osama Alyasseen; Maro Gharbi; Farah Alaila; Hadeel Lozon; Arif Al Nooryani

Volume 6, Issue 9 , September 2023, Pages 2186-2197

https://doi.org/10.26655/JMCHEMSCI.2023.9.24

Abstract

A blockage of the blood vessels feeding the area causes ischemia, which is defined as a localized absence of blood flow. If an organ is not getting enough oxygen and blood flow, such ... Read More

Original Article

Upregulation of INSR Gene Expression and Restoration of Melatonin Levels by Tinospora Cordifolia Stem Extract and Alkaloid Rich Fraction against Continuous Light Induced Polycystic Ovary Syndrome in Rodents

Murali Krishna Moka; Sumithra M

Volume 6, Issue 9 , September 2023, Pages 2198-2217

https://doi.org/10.26655/JMCHEMSCI.20239.25

Abstract

Females of childbearing age often suffer from polycystic ovary syndrome (PCOS), a hormonal condition. Symptoms including insulin resistance, high androgen levels, irregular menstrual ... Read More Females of childbearing age often suffer from polycystic ovary syndrome (PCOS), a hormonal condition. Symptoms including insulin resistance, high androgen levels, irregular menstrual (estrous) cycles, and polycystic ovaries are linked to this condition. The study's objective is to determine the therapeutic effect of Tinospora cordifolia stemextract and Alkaloid Rich Fraction against continuously Light Induced Polycystic Ovary Syndrome in Sprague Dawley (SD) female rats. Animals were grouped into six groups where the control group received only distilled water and the standard group received Clomiphene citrate 20 mg/Kg. The test groups received Tinospora cordifolia Stem Extract (200 mg/kg b.w and 400 mg/kg b.w) and Alkaloid Rich Fraction (10 mg/kg b.w and 20 mg/kg b.w) for the period of 4 weeks after PCOS induction. The results showed a significant reduction in elevated testosterone levels compared to that of the PCOS group (Light Induced Group (L/L 24 hrs Continuous), but follicle-stimulating hormone (FSH), insulin levels reported significant increase compared to that of the L/L PCOS group (Light Induced Group (L/L 24 hrs Continuous) and increased expression of INSR gene and restoration of melatonin levels. From the results, it was concluded that High doses of Tinospora cordifolia Stem Extract (400 mg/kg b.w) and Alkaloid Rich Fraction (20 mg/kg b.w) could be effective against Continuously Light Induced Polycystic Ovary Syndrome in Rodents it has due to decreased testosterone levels and increase insulin sensitivity by up-regulating INSR gene expression followed by restoration of melatonin levels. After treatment period a significant decrease in elevated LH levels, testosterone levels, and a significant increase in insulin and follicle-stimulating hormone (FSH) levels when compared to the L/L PCOS group (Light Induced Group (L/L 24 hrs Continuous), as well as increased INSR gene expression and restored melatonin levels.

Original Article

Tofacitinib in Pharmaceutical Solid Dosage from Dissolution Study: Development and Validation of RP-HPLC Method

Krishna Prasad Narapereddy; Devi Sravanthi Alladi

Volume 6, Issue 9 , September 2023, Pages 2218-2227

https://doi.org/10.26655/JMCHEMSCI.2023.9.26

Abstract

A simple, sensitive, precise, and accurate reversed phase high performance liquid chromatographic (RP-HPLC) method has been developed for the dissolution study of Tofacitinib in Tofacitinib ... Read More

Original Article

Microcapsules of Protein-Polysaccharide Complexes Produced on a Variety of Matrices

Ali L Alfalluji; Fadhel Omran Essa

Volume 6, Issue 9 , September 2023, Pages 2228-2233

https://doi.org/10.26655/JMCHEMSCI.2023.9.27

Abstract

In this work, the chance of the microcapsules development by layer-by-layer adsorption of biopolyelectrolytes was investigated on the cores of inorganic (particles CaCO3) and polymer ... Read More

Original Article

Evaluation of Relationship between Serum Hemoglobin A1C Level and Severity of Diabetic Foot Ulcers Based on Wagner Criteria

Alireza Ghanbari; Majid Nouri; Mohammad Darvishi

Volume 6, Issue 9 , September 2023, Pages 2234-2241

https://doi.org/10.26655/JMCHEMSCI.2023.9.28

Abstract

Introduction: One of the important risk factors for diabetic patients, including foot ulcers, is lack of blood sugar control, the standard criterion for which in the long run is the ... Read More

Original Article

Effects of Dietary Supplements and Anabolic Hormones on Hematological and Biochemical Parameters among Young Bodybuilders in Kurdistan Region of Iraq

Saman Sulaiman; Safin Hussein; Karzan Qurbani; Kale Husen; Shara Rasul; Avesta Mustafa

Volume 6, Issue 9 , September 2023, Pages 2242-2248

https://doi.org/10.26655/JMCHEMSCI.2023.9.29

Abstract

Athletes and bodybuilders frequently utilize vitamins and anabolic hormones. Utilizing these substances, gymgoers can achieve their goals faster by consuming a combination of supplements ... Read More

Original Article

Type-2 Diabetes Among Investors Community in India

Srutiva Mishra; B. Chandra Mohan Mohan Patnaik; Ipseeta Satpathy

Volume 6, Issue 9 , September 2023, Pages 2249-2258

https://doi.org/10.26655/JMCHEMSCI.2023.9.30

Abstract

Comorbidity and mortality are high among people with type-2 diabetes. Globally, diabetes is a major health issue, with a growing number of patients at risk of complications. A change ... Read More

Scope of Nanotechnology in Cosmetics: Dermatology and Skin Care Products

Awais Hameed; Gull Rida Fatima; Kainat Malik; Ayesha Muqadas; M. Fazal-ur-Rehman

Volume 2, Issue 1 , January 2019, , Pages 9-16

https://doi.org/10.26655/jmchemsci.2019.6.2

Abstract

Women and men have been wearing cosmetics for centuries, although the styles have certainly undergone some dramatic changes over time. Cosmetics is a very vast field which has served ... Read More

Effect of Temperature of Water Used For Reconstitution On Stability Of Antibiotic Dry Suspension

Ebtihal Almadani Alforjany; Ruwida Mohamed Kamour

Volume 2, Issue 4 , July and August 2019, , Pages 177-183

https://doi.org/10.26655/jmchemsci.2019.8.8

Abstract

This study is carried out to test the stability of antibiotic dry suspensions reconstituted with various water temperatures. The testing included physical, microbial and chemical changes ... Read More

Primary Treatment of Landfill Leachate Effects on Heavy Metal and Soil Chemical Properties in Kwashe Industrial Area in Duhok Province, Kurdistan Region of Iraq

Najmaldin Ezaldin Hassan; Mustafa Ismail Umer

Volume 5, Issue 1 , January and February 2022, , Pages 1-9

https://doi.org/10.26655/JMCHEMSCI.2022.1.1

Abstract

Leachate is a major problem created from municipal solid waste (MSW) landfills and is considered the worst source of surface water and groundwater pollution. Kwashe industrial area ... Read More

A new flavonoid glycoside from Trichilia emetica

Abdullahi Usman; Vera Thoss; Mohammad Nur-e-Alam

Volume 2, Issue 4 , July and August 2019, , Pages 144-150

https://doi.org/10.26655/jmchemsci.2019.8.4

Abstract

A new compound, catechin-3-O-α-L-rhamnopyranosyl (1→4) β-D-glucopyranoside was isolated from the ethylacetate soluble fraction of the aqueous extract of the whole seeds ... Read More

Work Life Balance of Health Care Workers in the New Normal: A Review of Literature

Tapaswini Pattnaik; Sasmita Rani Samanta; Jitendra Mohanty

Volume 5, Issue 1 , January and February 2022, , Pages 42-54

https://doi.org/10.26655/JMCHEMSCI.2022.1.6

Abstract

Life of a health care worker is very different compared with any other professional. This is distinct not from the perspective of an overwhelming level of personal and professional ... Read More

Original Article

Quality of Life of Blood Cancer Investors in India

Stutee Mohanty; B. Chandra Mohan Patnaik; Ipseeta Satpathy

Articles in Press, Accepted Manuscript, Available Online from 30 April 2023

https://doi.org/10.26655/JMCHEMSCI.2023.10.1

Abstract

The meaning of “Quality of Life” (QoL) varies from person to person. A person’s perception of the term depends on the situation. This research study makes an attempt ... Read More

Original Article

The Effectiveness of Massaging, Swaddling, and Reflexology Intervention in Mothers’ Practices Regarding Infantile Colic

Gulala K. Azeez; Abass Al-Rabati; Shukir S. Hasan

Articles in Press, Accepted Manuscript, Available Online from 30 April 2023

https://doi.org/10.26655/JMCHEMSCI.2023.10.2

Abstract

Background and objectives: During the first few months of a baby's life, the parents should deal with terrible condition of infantile colic, in which the infantile cries, groans, or ... Read More

Original Article

Evaluation of Pain Between Double Slot Orthodontic Brackets Versus Single Slot by Visual Analogue Scale and Saliva Biomarkers

Muhammed Hussein Saleh; Bayan Abdulla Hasan

Articles in Press, Accepted Manuscript, Available Online from 03 May 2023

https://doi.org/10.26655/JMCHEMSCI.2023.10.3

Abstract

Brackets and various arch-wires are used in fixed orthodontic appliances to apply forces to the teeth. The amino-acid glutamate is one neurotransmitter that has been discussed in the ... Read More

Original Article

Prevalence of Entamoeba Histolytica and Giardia Lamblia in Children Visiting to Heevi Pediatric Hospital in Dohuk City, Kurdistan Region, Iraq

Haveen Khalid Hasan; Souzan Hussain Eassa; Haval Mohammed Khalid

Articles in Press, Accepted Manuscript, Available Online from 04 May 2023

https://doi.org/10.26655/JMCHEMSCI.2023.10.4

Abstract

Entamoeba histolytica and Giardia lamblia are considered as two of the most widely distributed gastrointestinal protozoan parasites in the world, especially in underdeveloped nations, ... Read More

Original Article

Prophylactic Low Dose Intravenous Ketamine Infusion in Prevention of Intraoperative and Postoperative Shivering after Spinal Anesthesia in Adults Scheduled for Abdominal and Lower Limb Surgeries- A Prospective Randomized Controlled Trial

Surya R; Vaishali A.S; Tasneem Fathima Ahmed; Prem Chandar L.K; Yachendra V.S.G; Lakshmi R

Articles in Press, Accepted Manuscript, Available Online from 08 May 2023

https://doi.org/10.26655/JMCHEMSCI.2023.10.5

Abstract

Background: Incidence of perioperative shivering following spinal anesthesia (SA) is 40% to 60% based on current literature. Ketamine in doses between 0.2 to 0.75 mg/kg has been used ... Read More

Review Article

Flavonoids as Antioxidants: A Review on Tempuyung Plant (Sonchus Arvensis)

Nita Parisa; Muhammad Totong Kamaluddin; Masagus Irsan Saleh; Ernawati Sinaga Sinaga; Radiyati Umi Partan; Irfannuddin Irfannuddin

Articles in Press, Accepted Manuscript, Available Online from 10 May 2023

https://doi.org/10.26655/JMCHEMSCI.2021.10.6

Abstract

Flavonoids are prevalent in plants, fruits, and seeds; they are responsible for the colour, aroma, and flavour of things. Changes in the environment dramatically boost the antioxidant ... Read More

Original Article

Effects of a Home-Based Nursing Intervention Program on Caregivers Care Adherence of Children Affected with Type I Diabetes Mellitus

Shevan Y. Othman; Shukir S. Hasan; Nadir A. Garjees

Articles in Press, Accepted Manuscript, Available Online from 22 May 2023

https://doi.org/10.26655/JMCHEMSCI.2023.10.7

Abstract

Type 1 diabetes mellitus (T1DM) is a chronic disease that affects many children worldwide. Caregivers of children with T1DM play a crucial role in managing the child's health, but often ... Read More

Original Article

Acute and Sub-Acute Oral Toxicity Evaluation of Avicularin

Girdhari Lal Gupta; Nikita Patil Samant

Articles in Press, Accepted Manuscript, Available Online from 15 May 2023

https://doi.org/10.26655/JMCHEMSCI.2023.10.8

Abstract

Avicularin is a bioactive flavonoid that mainly found in blueberries, American cranberries, apples, and tea. Avicularin isolated from various plants including, Polygonum aviculare, ... Read More

Original Article

Determining Levels Awareness of Vitamin D as a Silent Epidemic among the Population in Southern Saudi Arabia

Amal A. Abdulbaqi; Rym Hassani; Omaymah Radwan

Articles in Press, Accepted Manuscript, Available Online from 16 May 2023

https://doi.org/10.26655/JMCHEMSCI.2023.10.9

Abstract

Vitamin D (VD) is an important nutrient for the human body because it is associated with many diseases. There were many health problems in which vitamin D deficiency had a role, the ... Read More

Original Article

Effect of Forest Bee Honey (Apis dorsata) Supplementation on Expression of HIF-1α, SOD, and TNF-α in Rats (Rattus norvegicus) Liver Exposed to Physical Stress

Hani Plumeriastuti; Widjiati Widjiati; Mey Vanda Pusparina Sajida; Annise Proboningrat

Articles in Press, Accepted Manuscript, Available Online from 19 May 2023

https://doi.org/10.26655/JMCHEMSCI.2023.10.10

Abstract

Physical activity in general improves metabolic processes by stimulating muscles to contract actively, improving blood circulation, and supplying oxygen. On the other hand, it will ... Read More

Original Article

Urinary Tract Infection Caused by the Extended-Spectrum β-lactamase (ESBL)-Producing Enterobacteriaceae in Hospitalized Pediatric Patients before and after Ceftriaxone Restriction Policy in a Tertiary Referral Hospital

Helmia Farida; Loraine Harinda; Hanna Fraleya Pattipeiluhu; Bazilah Dayana; Mujahidah Mujahidah

Articles in Press, Accepted Manuscript, Available Online from 19 May 2023

https://doi.org/10.26655/JMCHEMSCI.2023.10.11

Abstract

Objectives: The third-generation cephalosporins have been very widely used in Indonesia, raising concerns about the increase of infections caused by multidrug resistance organisms, ... Read More

Original Article

Predictive Value of Prognostic Nutritional Index in Children with COVID-19

Radhitio Adi Nugroho; Nur Aisiyah Widjaja; Retno Asih Setyoningrum

Articles in Press, Accepted Manuscript, Available Online from 19 May 2023

https://doi.org/10.26655/JMCHEMSCI.2023.10.12

Abstract

Background and aim: Severe malnutrition might contribute the poor outcomes in COVID-19. This study aims to investigate the relationship between prognostic nutritional index (PNI) and ... Read More

Original Article

The Effect of Nanochitosane of Red Snapper Fish Scales (Lutjanus Sp.) on Pain and Pulp Inflammation

Noor Hafida Widyastuti; Nur Ariska Nugrahani; Mellania Awwaliannisa; Amara Syifa Tifani

Articles in Press, Accepted Manuscript, Available Online from 14 May 2023

https://doi.org/10.26655/JMCHEMSCI.2023.10.13

Abstract

Pulpitis, or pulp inflammation, is a type of dental disease that is commonly associated with tooth pain symptoms. The immune reaction, characterized by TNF- α biomarkers and leukocyte ... Read More

Original Article

The Context of Nursing Intervention of Sand Bed Culture in Reducing Osteoarthritis Pain Scale

Syaifurrahman Hidayat; Yuni Sufyanti Arief; Ferry Effendi; Mujib Hannan; Nailiy Huzaimah

Articles in Press, Accepted Manuscript, Available Online from 22 May 2023

https://doi.org/10.26655/JMCHEMSCI.2023.10.14

Abstract

Aging causes physiological function to decrease as a result of the aging process. Osteoarthritis is common in the elderly causing chronic pain conditions. The purpose of this study ... Read More

Original Article

Triphenyltin (IV) Dithiocarbamate Compounds Induce Cytotoxicity in Acute Lymphoblastic Leukemia (Jurkat E6.1) Primarily via DNA Fragmentation and Cell Cycle Arrest

Normah Awang; Noor Hanim Mohd Nor; Nurul Farahana Kamaludin; Sharifah Nadhira Syed Annuar

Articles in Press, Accepted Manuscript, Available Online from 21 May 2023

https://doi.org/10.26655/JMCHEMSCI.2023.10.15

Abstract

Introduction: A chemotherapeutic agent known as the etoposide is used to treat acute lymphoblastic leukaemia (ALL). Over the years, the etoposide usage in treating ALL has yielded positive ... Read More Introduction: A chemotherapeutic agent known as the etoposide is used to treat acute lymphoblastic leukaemia (ALL). Over the years, the etoposide usage in treating ALL has yielded positive outcomes. Nevertheless, it has been discovered that a number of ALL patients experience side-effects and are susceptible to cancer cells. Accordingly, drug research for improved chemotherapy becomes necessary. The results of numerous investigations using compounds containing organotin (IV) dithiocarbamate were encouraging.Aim: The objective of this study is to examine the genotoxicity effects on Jurkat E6.1 cells, derivatives of the aforementioned substances were chosen for this investigation.Materials and Methods: The assessment of cell cycle arrest and genotoxic effects on Jurkat E6.1 cell lines was accomplished using the substances triphenyltin (IV) diisopropyldithiocarbamate (C1) and triphenyltin (IV) dialkyldithiocarbamate (C2). The cell cycle arrest was established using cell cycle analysis. The average DNA tail moment score was used to calculate the genotoxic effects of DNA damage. Inhibitory concentration (IC50) was used to conduct both analyses. C1 has an IC50 of 0.1 M, while C2 has an IC50 of 0.2 M. On the other hand, the etoposide, which served as a positive control, has an IC50 of 0.87 M.Results: The research findings demonstrated that after four hours of treatment, both triphenyltin (IV) dithiocarbamate and etoposide compounds prompted cell cycle arrest, with a significant difference (p < 0.05) in the S phase. Following a four-hour etoposide treatment, the findings of genotoxicity assessment revealed substantial DNA damage (p < 0.05). Furthermore, the C1 and C2 treatments revealed a similar level of DNA damage. However, when a statistical analysis of the comet assay results was accomplished, no discernible change (p > 0.05) was observed.Conclusion: In summary, DNA damage and cell cycle trapping were caused by etoposide, C1, and C2 in Jurkat E6.1 cells.

Review Article

Effects of Stevia on Hypertension of Metabolic Syndrome: A Systematic Review

Mohamed J. Saadh; Sivapriya Thiyagarajan; Juan Carlos Cotrina-Aliaga; Mohammed I. Suleiman; Ali A. Fahdil; Salam Ahjel; Abtin Soleimanian; Mahmoud Mirzaei; Kun Harismah

Articles in Press, Accepted Manuscript, Available Online from 28 May 2023

https://doi.org/10.26655/JMCHEMSCI.2023.10.16

Abstract

By the importance of dealing with metabolic syndrome (MetS), this work was performed to systematically review available articles on effects of stevia on hypertension as a leading risk ... Read More

Original Article

Exploring Impacts of Oil and Water Environments on Structural and Electronic Features of Vitamin B3 along with DFT Calculations

Mohamed J. Saadh; Faris Anad Muhammad; Romina Mahdavi; Yasaman Nazariyan Parizi; Ebrahim Balali; Juan Carlos Cotrina-Aliaga; Mohaned Adil; Salam Ahjel; Meryelem Tania Churampi Arellano; Yenina Gallardo-Lolandes; Renato R. Maaliw III; Mahmoud Mirzaei; Kun Harismah

Articles in Press, Accepted Manuscript, Available Online from 29 May 2023

Abstract

Density functional theory (DFT) calculations were performed to investigate the features of vitamin B3 (Vit-B3) in oil and water environments. Two up and down structural conformations ... Read More

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Original Article

Design, Synthesis, Characterization, and Study of in vitro Antioxidant Activity of Some Substituted Biginelli Derivatives

Abdul Lathiff M.K.M; Suresh Ramalingam; Senthamarai Rajagopalan

Articles in Press, Accepted Manuscript, Available Online from 31 May 2023

Abstract

The Biginelli class of 3,4-dihydropyrimidinone (DHPM) or its thione (DHPMT) derivatives can act as an exciting pharmacophoric moiety, which in turn has attracted the extensive attention ... Read More The Biginelli class of 3,4-dihydropyrimidinone (DHPM) or its thione (DHPMT) derivatives can act as an exciting pharmacophoric moiety, which in turn has attracted the extensive attention of medicinal chemists in the last few decades. Similarly, imidazolidin-4-one also occupies an inevitable place in drug discovery chemistry. Despite numerous diverse pharmacologic effects ascribed to these two derivatives together being reported, there are few reports on the antioxidant evaluation of the Biginelli class of pyrimidinone derivatives annexed to imidazolidinone by an amide bond. In this study, the synthesis of 20 novel 3,4-dihydropyrimidinones with imidazolidin-4-one derivatives is described. The physical characteristics of the synthesized 3,4-DHPM and DHPMT derivatives were determined and analytically characterized by various spectral tools like FT-IR, Lc-Ms/Ms, and proton and carbon NMR. The scavenging radical potential for the synthesized 20 novel Biginelli derivatives was assessed using the DPPH assay. The results indicated that all the tested compounds had good to excellent antioxidant potency in comparison to the standard drug ascorbic acid. The synthesized compounds 1, 6, 8, 9, 14, 15, 16, 17, 18, and 19 showed a good degree of scavenging potency. Interestingly, remarkable activity was observed with compounds 16, 17, and 19. The present study reveals that not only the compounds with an OH group can exhibit a high degree of scavenging potency, but other groups like -OCH3, –CH3, and -Cl can also exhibit activity effectively. In addition, the radical scavenging potential for the studied compounds could be due to either the presence of more than one labile hydrogen atom attached to a nitrogen atom or the conjugated system, i.e. the 3,4-dihydropyrimidinone ring attached to an amide linkage, present in these compounds, which would have further sponsored the compound to get stabilized when these compounds become radicals by donating an electron to ROS.

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Original Article

Xpert MTB/RIF and Microscopic Cytology of FNAB in Tuberculosis

Ayu Lidya Paramita; Ni Made Mertaniasih; Etty Hary Kusumastuti; Eko Budi Koendhori; Pepy Dwi Endraswari

Articles in Press, Accepted Manuscript, Available Online from 31 May 2023

Abstract

Background: The symptom of lymphadenopathy can describe several disorders, including tuberculosis (TB) lymphadenitis. The suspicious gland will undergo supportive investigations to ... Read More

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Original Article

Phytochemicals and Biological Activities of Ethanolic Extract of Garcinia atroviridis Leaf Grown in Indonesia

Muhammad Fauzan Lubis; Vera Estefania Kaban; Kasta Gurning; Parhan Parhan; Hafid Syahputra; Nur Aira Juwita; Ririn Astyka; Ichpan Zulfansyah

Articles in Press, Accepted Manuscript, Available Online from 31 May 2023

Abstract

The current investigation examined the potential antibacterial and antihyperlipidemic properties of ethanolic extract derived from the leaves of Garcinia atroviridis (EGA). The phytochemical ... Read More

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Facts & Figures
Journal date created	2018
Google Scholar h-index	17
Google Scholar i10-index	36
Google Scholar Citation	1266
WOS Citation	596
CiteScore 2022	1.5
Scopus (H-index)	9
SJR 2021	0.203
SNIP 2021	0.272
Scopus Journal Rank (2022)	Q3
Impact Score	1.49
No. of volumes	6
No. of Issues	32
Number of articles	529
Review papers	16
No. of contributors	1,479
No. of submissions	1,090
Article view	279,312
View per article	528
PDF download	153,436
PDF Download Per Article	290.05
Rejected Submissions	457
Accepted Submissions	522
Acceptance Rate	48
Accept Date (Days)	44
No. of reviewers	8189
Contributing countries	36
No. of databases	10

Volume 6 (2023)

Volume 5 (2022)

Volume 4 (2021)

Volume 3 (2020)

Volume 2 (2019)

Volume 1 (2018)

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