Journal of Medicinal and Chemical Sciences

Original Article

Tactics of Treatment of Catastrophic Anti-Phospholipid Syndrome in Pregnant Woman: Based on a Clinical Case

Nataliya Tytarenko; Inna Kukuruza; Olga Zasadnіuk; Andriy Kostyuchenko; Andrii Vozniuk

Volume 6, Issue 11 , November 2023, Pages 2569-2579

https://doi.org/10.26655/JMCHEMSCI.2023.11.1

Abstract

Objective: The objective of this study is to investigate the occurrence and management of acute thrombotic microangiopathy, a severe complication associated with antiphospholipid syndrome ... Read More Objective: The objective of this study is to investigate the occurrence and management of acute thrombotic microangiopathy, a severe complication associated with antiphospholipid syndrome (APS), particularly in the context of catastrophic APS (CAPS) during pregnancy. The study aims to enhance the understanding of CAPS in pregnancy, improve early diagnosis, and evaluate the effectiveness of different treatment modalities.Materials and methods: The study employed a case report methodology, focusing on a pregnant patient diagnosed with CAPS and experiencing acute thrombotic microangiopathy. The clinical presentation, laboratory findings, diagnostic procedures, and treatment interventions were documented and analysed. The treatment approach included the use of anticoagulants, glucocorticoids, and plasma exchange. The response to treatment, complications, and patient outcomes were assessed.Results: The study observed a rapid development of liver, central nervous system, and renal lesions within a week, indicating the severity of CAPS in the pregnant patient. Despite the pregnancy termination, the patient's clinical condition did not show improvement, suggesting a lack of response similar to observations in other cases. The patient received standard CAPS treatment, except for intravenous administration of immunoglobulins. Further details were reported regarding the treatment outcomes, laboratory parameters, and imaging findings.Conclusion: This study highlights the challenges associated with diagnosing and managing CAPS during pregnancy, specifically focusing on acute thrombotic microangiopathy. Early diagnosis, aggressive treatment with anticoagulants and glucocorticoids, and the use of plasma exchange or intravenous immunoglobulin are crucial in achieving positive outcomes. The study suggests the consideration of alternative interventions, such as immunosuppressive therapy or targeted biologic agents, in refractory cases of CAPS. Further research is needed to elucidate the optimal treatment strategies and long-term outcomes in pregnant patients with CAPS.

Original Article

Symptoms of Acute and Chronic Viral Hepatitis: Effects on Human Body

Marko Kozyk; Kateryna Strubchevska; Vitalina Yuzkiv; Ulyna Bezkorovayna; Roksolana Nedilko

Volume 6, Issue 11 , November 2023, Pages 2580-2587

https://doi.org/10.26655/JMCHEMSCI.2023.11.2

Abstract

Objective: The objective of this article is to study the theoretical and applied principles of the symptoms of acute and chronic viral hepatitis and the consequences of their impact ... Read More

Original Article

Emergency Medical Care Functioning During COVID-19 Pandemic in Eastern Europe

Oleksandr Knigavko; Nadiia Baranova; Ievgen Bausov; Maryna Dolzhenko; Nataliia Lantukhova

Volume 6, Issue 11 , November 2023, Pages 2588-2599

https://doi.org/10.26655/JMCHEMSCI.2023.11.3

Abstract

Objective: The objective of this study is to examine the challenges faced by treatment organizations and assess the current state of emergency medical care facilities in Poland and ... Read More

Original Article

Exploring Factors Influencing the Efficacy of Dual Therapy in Gonorrhea Treatment: A Retrospective Study

Hamidah Luthfidyaningrum; Afif Nurul Hidayati; Damayanti Damayanti; Muhammad Yulianto Listiawan; Cita Rosita Sigit Prakoeswa; Linda Astari; Budi Utomo

Volume 6, Issue 11 , November 2023, Pages 2600-2607

https://doi.org/10.26655/JMCHEMSCI.2023.11.4

Abstract

Background: Gonorrhea infection (GO) has a high prevalence in Indonesia, making it a significant public health concern. Effective treatment is crucial in controlling GO. However, the ... Read More

Original Article

Antimicrobial Effectiveness of Methicillin, Amoxicillin and Ampicillin against Methicillin-Resistant Staphylococcus Aureus (MRSA) Strains Isolated from Bovine Mastitis

Riveliño Ramon-Curay; Darwin Robalino Salas; Nelly Tacle García; Jenny Martínez Moreira; Favian Bayas-Morejón

Volume 6, Issue 11 , November 2023, Pages 2608-2619

https://doi.org/10.26655/JMCHEMSCI.2023.11.5

Abstract

Staphylococcus aureus is a Gram-positive pathogen that is commonly associated with bovine mastitis, which is an infectious condition affecting the udder of cows. The objective of the ... Read More

Original Article

Investigating the Effect of E-Learning with a Blended Approach on the Rate of Learning in Nursing Students during COVID-19 Pandemic

Saba Karimi; Mehrdad Derakhshan; Fatemeh Jabinian; Amirhossein Tondro

Volume 6, Issue 11 , November 2023, Pages 2620-2627

https://doi.org/10.26655/JMCHEMSCI.2023.11.6

Abstract

Introduction: Coronavirus 2019 (COVID-19) is a highly infectious disease. It has spread throughout the world in a short period and this widespread outbreak has caused many problems ... Read More

Original Article

The Prevalence of Left Ventricular Hypertrophy in Patients with Atrial Fibrillation and Hypertension

Serwan Mohammed Ismail Abdulrahman; Damat Mahmood Izzat Mahmood; Raz Nawzad Mohemmad Karim

Volume 6, Issue 11 , November 2023, Pages 2628-2640

https://doi.org/10.26655/JMCHEMSCI.2023.11.7

Abstract

Background and objective: Left ventricular hypertrophy (LVH) is a common cardiac condition characterized by the thickening and enlargement of the left ventricle as the main pumping ... Read More

Original Article

Heart Rate Variability and QT Changes in Children with Hemophilia

Asmaa A. El Sehmawy; Nadia Ahmed Agiba; Heba Tawfik Okda; Rasha Mahmoud Gouda; Nglaa Fathi Agba; Mona Gamal El Din Al Anany; Azza A. Katta

Volume 6, Issue 11 , November 2023, Pages 2641-2649

https://doi.org/10.26655/JMCHEMSCI.2023.11.8

Abstract

Background: Hemophilia-A is a sex-related hereditary bleeding disorder, like the general populations, mortality from cardiovascular diseases is currently responsible for one-third of ... Read More

Original Article

The Role of several Biomarkers and Scoring Systems Assessed During Emergency Department Admission Day in Predicting Septic Shock

Nur Farhanah; Hendro Wahjono; Banundari - Rachmawati; Suharyo Hadisaputro; Muhammad Hussein Gasem

Volume 6, Issue 11 , November 2023, Pages 2650-2664

https://doi.org/10.26655/JMCHEMSCI.2023.11.9

Abstract

Sepsis results in a life-threatening organ dysfunction due to the dysregulation of organ dysfunction detection, risk stratification, prognosis, and treatment is crucial for sepsis and ... Read More

Original Article

An Anti-Inflammatory Dental Pulp of Eugenol Extracted from Clove (Eugenia Caryophyllata)

Nendika Dyah Ayu Murika Sari; Ikmal Hafizi; Nida Faradisa Fauziyah; Ratih Hartinawati; Zakia Sholiha

Volume 6, Issue 11 , November 2023, Pages 2665-2671

https://doi.org/10.26655/JMCHEMSCI.2023.11.10

Abstract

Objective: To determine the effective volume of eugenol on day 3 in the inflamed pulp.Methods: Experimental research with a posttest-only control group design The experimental animals ... Read More

Original Article

Radiographic Findings of Lung CT Scans of COVID-19 Patients: Delta and Omicron Variants

Somayeh Mehrpour; Reihane Tabaraii; Hassan Safdari; Mohammad Aghaali; Mansoureh Shakeri; Alireza Shahhamzeh; Mahnaz Rahimi Jafari

Volume 6, Issue 11 , November 2023, Pages 2672-2678

https://doi.org/10.26655/JMCHEMSCI.2023.11.11

Abstract

Objective: The present study was designed with the aim of comparing the radiological findings of the CT scan of the lungs of patients with Delta and Omicron variants of COVID-19 hospitalized ... Read More Objective: The present study was designed with the aim of comparing the radiological findings of the CT scan of the lungs of patients with Delta and Omicron variants of COVID-19 hospitalized in the intensive care unit.Methods: This was a retrospective comparative study conducted during the fifth peak of COVID-19 in Iran, August to November 2021 (the predominance of Delta variant) and March to April 2022 (the predominance of Omicron variant) in Qom, Iran. Radiologic findings of lung CT scans reported by a single radiologist were compared between these two cohorts. To analyze the collected data, SPSS version 22 statistical software is used through chi-square or fisher exact test, independent t-test, and Mann-Whitney test. A p-value of lower than 0.05 was considered as statistically significant.Results: The total number of 50 patients in Delta (mean age of 58.68±14.77 years, 56% male) and 46 patients in Omicron (mean age of 70.45±18.02 years, 47% male) periods were included in study. Lesions of Right middle lobe (RML), left upper lobe (LUL), and Lingual lobes were more common in Delta period than Omicron (P<0.05). GGOs were more common in Delta period than in the Omicron ‎ (P=0.013). There were no Unilateral GGOs during the Delta period, while 9 of 32 (28.1%) patients having GGO lesions in Omicron era had unilateral ones (P<0.001). Peripheral lesion was not differentiating Omicron from Delta. Crazy Pavings, Parenchymal bands, Halo signs, and Pleural effusions were more common in omicron period than in the Delta (P<0.05). Total Chest CT severity score was statistically higher in Delta period (22.75±5.24 units) than Omicron period (13.97±9 units).Conclusion: There were the significant differences in the radiologic characteristics between the two variants. This study suggests that with evolving the virus variants, while severity of lung involvement has decreased, GGOs of COVID-19 might have tended to manifest as unilateral lesions with more specific radiographic features.

Case Report

Hemolytic Anemia in Pregnancy: A Rare and Challenging Case in Indonesia

Miftah Hasanah; Yetti Hernaningsih

Volume 6, Issue 11 , November 2023, Pages 2679-2685

https://doi.org/10.26655/JMCHEMSCI.2023.11.12

Abstract

Autoimmune hemolytic anemia (AIHA) is an infrequent etiology of anemia during pregnancy, and its occurrence in the postpartum period is even more uncommon. This study presents the case ... Read More

Original Article

Comparative Study Between Cuff Leak Test and Laryngeal U/S for Detection of Post Extubation Oedema in Prone Position Patient with General Anesthesia

Abdel Wahab Abdelsattar Saleh Mohammad; Maher A sheriff; Yara Ayman Iskandarani; Wael Mohammed Mossa; Mohamrd Hamdi Alqassas

Volume 6, Issue 11 , November 2023, Pages 2686-2698

https://doi.org/10.26655/JMCHEMSCI.2023.11.13

Abstract

Background: Endotracheal intubation is a routine procedure in the ICU that may save a patient's life. The stridor probability after extubation increases with a smaller cuff-leak volume. ... Read More

Original Article

Effects of Different Filtration and Clarification Techniques on Palestinian Virgin Olive Oil Chemical and Microbial Quality

Ziad Ayyad; Wafaa Alsioury; Zaher Barghouthi; Diab Qadah; Mohannad Qurie

Volume 6, Issue 11 , November 2023, Pages 2699-2706

https://doi.org/10.26655/JMCHEMSCI.2023.11.14

Abstract

Virgin olive oil filtration is a pre-treatment usually used before bottling to facilitate suspended particle removal and reduce the moisture content so that the quality and organoleptic ... Read More Virgin olive oil filtration is a pre-treatment usually used before bottling to facilitate suspended particle removal and reduce the moisture content so that the quality and organoleptic properties are preserved during storage. In the current study, samples of virgin olive oils were subjected to different clarification and filtration techniques such as (1) commercial filtration (CF) using diatomaceous earth as a filter aid, (2) clarification by insufflating of carbon dioxide, and (3) argon gas. All treated samples as well as control unfiltered (UF) virgin olive oil (VOO) were bottled under dark conditions in diffused daylight glass bottles and kept at room temperature for six months. Basic quality indices (free acidity (FA), peroxide value (PV), and extension coefficient) and total polar phenol were determined within respected time of analysis during the storage period of six months. In addition, microbial quality was evaluated by determination of yeasts and molds, total plate count, Bacillus cereus, and clostridium perfringens. The main results showed that at the end of the storage, acidity increased in all samples with time in both storage conditions, whereas samples stored in dark more stable compared to those stored under diffused daylight. On the other hand, clarified samples with CO2 showed significant stability compared to the rest of the samples stored under diffused day light. Peroxide values (PV) and K232 increased in all stored samples. Moreover, K270 increased with time, and showed more stability in samples stored in dark. Total polar phenols decrease in all samples, but showed no significant difference among all samples after 180 days of storage. Microbial results revealed the presence of yeasts and molds in all samples at the beginning of storage, and then disappeared after 135 days for all samples except UF. Total plate count, Bacillus cereus, and clostridium perfringens were not found in any stored VOO.

Original Article

Characteristics of Intercalated Discs Responsible for Histological Changes of the Left Ventricle in the Experiment Involving Mechanical Loading on 30-Day-Old White Rats

Anzor Gogiberidze; Ramaz Khetsuriani; Marina Pailodze; Manana Arabuli; Sopiko Kandelaki; Magda Tortladze; Lizi Khitiri; Irma Jikia

Volume 6, Issue 11 , November 2023, Pages 2707-2715

https://doi.org/10.26655/JMCHEMSCI.2023.11.15

Abstract

In our own experiment, we studied microscopic changes in the anterior wall of the left ventricle of young, middle-aged, and old rats on the 30th day after exercising. Plasmorrhagia, ... Read More

Original Article

The Prevalence of Anti-DFS70 Antibodies in SLE and Non-SLE Patients

Kusworini Handono; Hani Susianti; Syahrul Chilmi; Andrea Aprilia; Rahmatul Yasiro; Natalia Sukarta

Volume 6, Issue 11 , November 2023, Pages 2716-2726

https://doi.org/10.26655/JMCHEMSCI.2023.11.16

Abstract

Background: The presence of anti-DFS70 antibodies was considered by some rheumatologists as a tool to help exclude the diagnosis of systemic autoimmune rheumatic diseases (SARDs) such ... Read More

Original Article

Alterations in Left Ventricular End-Systolic and End-Diastolic Volumes in 12-13-Week-Old Laboratory Rats Subjected to Dosed Swimming Exercise

Nikoloz Vachadze; Anzor Gogiberidze; Ramaz Khetsuriani; Marina Pailodze; Elene Shvangiradze; Nino Pruidze

Volume 6, Issue 11 , November 2023, Pages 2727-2734

https://doi.org/10.26655/JMCHEMSCI.2023.11.17

Abstract

The objective of this study was to explore the alterations in end-systolic and end-diastolic volumes of the left ventricle in 12-13-week-old rats subjected to a six-week regimen of ... Read More

Review Article

Pharmacological Potential of Some Indonesian Medicinal Plants as Promising Options for COVID-19 During the Pandemic Era: A Literature Review

Neny Purwitasari; Siswandono Siswodihardjo; Mohammed Abdelfatah Alhoot; Mangestuti Agil

Volume 6, Issue 11 , November 2023, Pages 2735-2749

https://doi.org/10.26655/JMCHEMSCI.2023.11.18

Abstract

The utilization of traditional medicine in Indonesia is highly prevalent and favoured by the Indonesian people for maintaining health and treating ailments, drawing upon the experience, ... Read More

Original Article

The Effect of Moringa Oleifera Extract on CPK and Quality of Life of Breast Cancer Hpatinnts Reseiving Aromatase Inhibitor Therapy

Yan Wisnu Prajoko; Sugeng Pramono; Agung Hartanto; Mada Aji Prakoso

Volume 6, Issue 11 , November 2023, Pages 2750-2755

https://doi.org/10.26655/JMCHEMSCI.2023.11.19

Abstract

Aromatase inhibitors (AI) are commonly used adjuvant therapy drugs for women with hormone receptor-positive postmenopausal breast cancer. Frequently AI associated side effects include ... Read More

Original Article

The Use of the Ilizarov Method in the Correction of Neglected Clubfoot

Zainab Abdulwahab Muhammed

Volume 6, Issue 11 , November 2023, Pages 2756-2766

https://doi.org/10.26655/JMCHEMSCI.2023.11.20

Abstract

Objectives: A clubfoot, or the Congenital Talipes Equinovarus, is one of the most common congenital orthopedic deformities, occurs in different severity. The Ilizarov method's external ... Read More Objectives: A clubfoot, or the Congenital Talipes Equinovarus, is one of the most common congenital orthopedic deformities, occurs in different severity. The Ilizarov method's external fixation and gradual distraction are considered the best choice of treatment for correction of severe. The aim of this study was to evaluate the effectiveness of the Ilizarov technique in the correction of neglected clubfoot deformities.Methods: In this retrospective cross-sectional study, individuals were included in the study by census; the author treated sixteen feet in 14 children and adults with resistant club foot, the patients were treated with Ilizarov method. All patients were assessed pre operatively according to Pirani score and radiological technique and postoperatively through clinical follow up and according to the American Orthopaedic Foot and Ankle Society scores. SPSS software was used for analysis and a significance level of less than 0.05 was considered.Results: The preoperative assessment of the patients showed that 12 (75.0%) of them were classified as having grade III Pirani scores, with a mean score of 5.063 ± 0.6551, among them 11 (68.7%) were subjected to elongation of tendo-Achilles, plantar fasciatomy, and mid tarsal osteotomy. The radiological findings, pre- and post-operatively showed a high statistical difference in relation to Talo calcaneal angle- antero-posterior, Talo calcaneal angle- lateral, and Talo first metatarsal angle. Patients’ scores showed that the outcome of 9 (56.25%) of them was satisfactory. The postoperative clinical assessment of the patients revealed that 12 (75.0%) of the patients had achieved more than 90° ankle dorsiflexion, and 13 (81.25%) had a normal foot appearance. Also, the position of the foot when standing showed that 10 (62.5%) had 5° valgus and the majority 12 (75.0%) had achieved normal gait.Conclusion: The application of Ilizarov technique could be considered as a convenient, efficient, and successful method for neglected clubfeet deformities.

Original Article

LC-ESI-QTOF-HRMS-Based Myxobacterial Metabolite Profiling for Potential Anti-Breast Cancer Extracts

Yen Thi Ngoc Nguyen; Chung Duong-Dinh; Hieu Vu-Quang; Linh Thi Lan Dinh; Thai Nguyen-Minh; Nga Dinh Nguyen; Anh Tu Nguyen

Volume 6, Issue 11 , November 2023, Pages 2767-2777

https://doi.org/10.26655/JMCHEMSCI.2023.11.21

Abstract

Members of Myxococcales have been known as slime bacteria, a unique microbiome in natural habitats with complex multicellular behaviour, sliding movement, and unusual fruiting body ... Read More

Case Report

Osteogenesis Imperfecta Type IV in Siblings

Savitri Kuntari; Nur Rochmah; Muhammad Faizi; Yuni Hisbiyah; Rayi Kurnia Perwitasari

Volume 6, Issue 11 , November 2023, Pages 2778-2784

https://doi.org/10.26655/JMCHEMSCI.2023.11.22

Abstract

A rare bone condition known as osteogenesis imperfecta (OI) is brought on by an inherited connective tissue abnormality. Even within families who share a common mutation, symptoms might ... Read More

Original Article

Curcuma Longa May Prevent Endothelial Dysfunction in Rattus Norvegicus Exposed by Soot Particulate through Changes of OxLDL and eNOS Levels

Muhammad Aminuddin; Djanggan Sargowo; Teguh Wahju Sardjono; Widjiati Widjiati

Volume 6, Issue 11 , November 2023, Pages 2785-2792

https://doi.org/10.26655/JMCHEMSCI.2023.11.23

Abstract

The purpose of this study is to prove the efficacy of Curcuma longa (turmeric) extracts against soot (carbon black)-exposed rats with Ox-LDL and eNOS levels. A total of 30 rats were ... Read More

Review Article

Comparison of Complication between Autograft and Xenograft Duraplasty: A Systematic Review and Meta-Analysis

Muhammad Irfan Rahmatullah; Asra Al Fauzi; Nur Setiawan Suroto; Muhammad Arifin Parenrengi; Wihasto Suryaningtyas; Dyah Fauziah; Budi Utomo; Billy Dema Justia Wahid; I Wisnawa

Volume 6, Issue 11 , November 2023, Pages 2793-2803

https://doi.org/10.26655/JMCHEMSCI.2023.11.24

Abstract

Background: Cerebrospinal fluid (CSF) leakage is a well-documented and significant complication that can occur following neurosurgical procedures. The association between CSF leakage ... Read More Background: Cerebrospinal fluid (CSF) leakage is a well-documented and significant complication that can occur following neurosurgical procedures. The association between CSF leakage and various morbidities has been extensively studied. Research on different materials as potential dura mater grafts has been conducted since 1890. The search for the optimal material for dura mater grafts remains ongoing in current research. This investigation aims to assess the incidence of CSF leakage and infection subsequent to duraplasty using xenografts in comparison to autografts.Methods: This study aims to systematically analyze the CSF leakage and infection rates following duraplasty procedures utilizing xenografts and autografts. The research methodology includes a comprehensive search of the PubMed electronic database and a manual search of Google Scholar, adhering to the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines.Results: Among the patients in the xenograft group, a total of 90 individuals out of 452 experienced complications in the form of CSF leaks and complicated pseudo-meningoceles. This study was conducted to investigate the incidence of CSF leaks and complicated pseudo-meningoceles in autografts, with a sample size of 540 patients. The results showed that 79 patients experienced these complications, with a statistically significant p-value of 0.05 and an odds ratio of 1.45 (95% confidence interval 1.00-2.10). Another aspect of the study examined the incidence of meningitis complications in xenografts, with a sample size of 400 patients. The results showed that 25 patients experienced meningitis. Among the 446 patients who underwent autografts, 11 patients (p=0.05; OR 2.10, 95% CI 1.01-4.36) experienced meningitis complications.Conclusion: The analysis of duraplasty techniques shows that the use of xenografts increases the incidence of CSF leaks and pseudo-meningocele complications while raising the risk of meningitis.

Original Article

Risk of Increased Post-Transfusion IL-8 Levels in Adult Patients with Malignancy Receiving Non-Leukodepleted Packed Red Cell Transfusions

Teguh Triyono; Ida Adhayanti; Usi Sukorini

Volume 6, Issue 11 , November 2023, Pages 2804-2811

https://doi.org/10.26655/JMCHEMSCI.2023.11.25

Abstract

Background: Cancer is one of the primary causes of death, and almost > 40% of cancer patients experience anemia. Transfusion serves as one of the therapies given to anemic patients. ... Read More

Original Article

Levels of Zinc and Iron Serum in Children with Febrile Seizures: Systematic Review and Meta-Analysis

Savitri Kuntari; Rifah Zafarani Soumena; Melinda Masturina; Ratih Kumala Sari; Sunny Mariana Samosir; Riza Noviandi; Citrawati Dyah Kencono Wungu; Prastiya Indra Gunawan

Volume 6, Issue 11 , November 2023, Pages 2812-2823

https://doi.org/10.26655/JMCHEMSCI.2023.11.26

Abstract

Background: Febrile seizures are common in the paediatric population; the frequency of febrile seizures is significantly influenced by hereditary variables. Other variables, such as ... Read More

Case Report

Erythema Nodosum: A Manifestation of Trichomoniasis and Vulvovaginal Candidiasis

Alvian Arifin Saiboo; Dwi Murtiastutik; Sawitri Sawitri; Rahmadewi Rahmadewi; Damayanti Damayanti; Linda Astari; Willy Sandhika; Putri Halla Shavira

Volume 6, Issue 11 , November 2023, Pages 2824-2831

https://doi.org/10.26655/JMCHEMSCI.2023.11.27

Abstract

Background: Erythema nodosum (EN) is the most common form of septal panniculitis resulting from a hypersensitivity reaction in response to numerous antigens or triggers.Case: A 43-year-old ... Read More

Original Article

Prevalence of Iron Overload in Patients with Multiple Sclerosis

Asma Alanazi; Ayah Ogailan; Jenan Alnamassi; Haya Alrakban; Taif Almutairi; Nouf Almousa; Yaser Almalik; Asma Eltaweel

Volume 6, Issue 11 , November 2023, Pages 2832-2840

https://doi.org/10.26655/JMCHEMSCI.2023.11.28

Abstract

Background: Multiple sclerosis (MS) is a chronic autoimmune inflammatory condition results in dysfunction of the central nervous system. There are multiple causes linked to the development ... Read More

Original Article

Haemoglobin Variant Study by HPLC Method at a Tertiary Care Centre

Pradnya Phalak; Abhijit Pratap

Volume 6, Issue 11 , November 2023, Pages 2841-2848

https://doi.org/10.26655/JMCHEMSCI.2023.11.29

Abstract

Haemoglobinopathies are genetic disorders arising due to defect in the globin chain of haemoglobin. It is relatively common amongst genetic disorders. Beta thalassemia and Sickle cell ... Read More

Review Article

Lung Disease Detection and Classification Using Single Shot Multi-Box Detector Network: A Comprehensive Study

Mansour Alhlalat; Ahmad Sharieh; Mohammed Alzoubi

Volume 6, Issue 11 , November 2023, Pages 2849-2866

https://doi.org/10.26655/JMCHEMSCI.2023.11.30

Abstract

Lung diseases significantly impact the world regarding health, economic cost, and social and psychological well-being. X-ray images are a primary method for diagnosing lung diseases, ... Read More Lung diseases significantly impact the world regarding health, economic cost, and social and psychological well-being. X-ray images are a primary method for diagnosing lung diseases, but the manual analysis of these images can be time-consuming, subjective, and prone to inaccuracies. However, it is essential to diagnose lung diseases in a timely manner and with high accuracy to ensure effective treatment and management. This study introduces an innovative deep-learning version termed the "ESSDN-LN model" to overcome these challenges. It is a variant of the single shot detector (SSD) network. This model aims to rapidly and accurately detect and classify six types of lung disease: aortic enlargement, cardiomegaly, pleural thickening, pulmonary fibrosis, COVID-19, and pneumonia. The ESSDN-LD model was introduced in three versions: ESSDN-LDV1, ESSDN-LDV2, and ESSDN-LDV3. ESSDN-LDV1 incorporates the SSD with batch normalization, dropout regularization, and data augmentation techniques. ESSDN-LDV2 builds upon the advancements of ESSDN-LDV1 by incorporating the random search algorithm for adjusting model hyper-parameters and introducing the skip connections technique to enhance the detection performance. Furthermore, ESSDN-LDV3 further enhances the capabilities of ESSDN-LDV1 using the genetic algorithm for hyper-parameter tuning and incorporating feature fusion and skip connections techniques, thereby significantly improving the detection performance. The ESSDN-LDV3 model demonstrated exceptional performance compared to other versions, achieving a remarkable accuracy of 96.5% and a prediction time of 0.018 seconds in the seven-class classification. Furthermore, it achieved a total accuracy of 98.4% and a prediction time of 0.013 seconds in the three-class classification, encompassing Covid-19, pneumonia, and no-finding cases. These impressive results highlight the effectiveness and efficiency of the proposed method in accurately classifying lung diseases and can contribute to improved patient outcomes and treatment decisions.

Volume 7 (2024)

Volume 6 (2023)

Volume 5 (2022)

Volume 4 (2021)

Volume 3 (2020)

Volume 2 (2019)

Volume 1 (2018)

Volume & Issue: Volume 6, Issue 11, November 2023, Pages 2569-2866

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