Journal of Medicinal and Chemical Sciences

Synthesis, Anti-Cancer, and Molecular Docking Studies of Alkyne Derivatives Bearing Imidazo Pyridine Moiety

Amera H. Hamd; Naeemah Al-Lami; Jaafar Suhail Wadi

Volume 6, Issue 6 , June 2023, , Pages 1310-1322

https://doi.org/10.26655/JMCHEMSCI.2023.6.11

Abstract

A series of alkynes Mannich bases containing Imidazo [1,2-a] pyridine ring was synthesized from reacting Mannich bases with propargyl bromide in the presence of potassium carbonate ... Read More

Qsar and Docking Studies of New Triazolopiperazine Derivatives as Potent Hypoglycemic Candidates

Swarna Bharathi Kalli; Velmurugan Vadivel

Volume 6, Issue 7 , July 2023, , Pages 1598-1613

https://doi.org/10.26655/JMCHEMSCI.2023.7.11

Abstract

Dipeptidyl peptidase 4 (DPP-4) inhibition is a promising therapy for type 2 diabetes. Inhibition of DPP-4 limits the breakdown of glucagon-like peptide 1 (GLP-1), hence increasing functional ... Read More

Relationship of Azoospermia Factor (AZF) and Inhibin B Level in Patients with Non-Obstructive Azoospermia

Ahmed Gamal El-Metwaly Ghanem; Mohamed Ali Atwa Barakat; Reham Mohammed El-Farahaty; Youssef Elbayoumi Youssef Soliman; Sohier Yahia; Hosam Abdel Twab

Volume 6, Issue 8 , August 2023, , Pages 1830-1842

https://doi.org/10.26655/JMCHEMSCI.2023.8.11

Abstract

Background: Non-obstructive azoospermia (NOA) is a challenging subset in management of infertile males. Micro-deletion of the azoospermia factor (AZF) region located on long arm of ... Read More

Impact of Pharmacological and Non-Pharmacological Intervention among Pregnant Women Complaining of Nausea and Vomiting

Shaymaa S. Maqsood; Ibrahim H. Mustafa

Volume 6, Issue 9 , September 2023, , Pages 2028-2037

https://doi.org/10.26655/JMCHEMSCI.2023.9.11

Abstract

This study was conducted with the aim of investigating the effect of pharmaceutical and non-pharmacological interventions in pregnant women complaining of nausea and vomiting because ... Read More

Urinary Tract Infection Caused by the Extended-Spectrum β-lactamase (ESBL)-Producing Enterobacteriaceae in Hospitalized Pediatric Patients before and after Ceftriaxone Restriction Policy in a Tertiary Referral Hospital

Helmia Farida; Loraine Harinda; Hanna Fraleya Pattipeiluhu; Bazilah Dayana; Mujahidah Mujahidah

Volume 6, Issue 10 , October 2023, , Pages 2357-2366

https://doi.org/10.26655/JMCHEMSCI.2023.10.11

Abstract

Objectives: The third-generation cephalosporins have been very widely used in Indonesia, raising concerns about the increase of infections caused by multidrug resistance organisms, ... Read More

Multi-Detector in Vivo Dosimetry of Volumetric Arcs of Total Body Irradiation: An Institutional Comparative Study

Reena Kumari; Budhi Singh Yadav; Pankaj Kumar

Volume 6, Issue 12 , December 2023, , Pages 2964-2973

https://doi.org/10.26655/JMCHEMSCI.2023.12.11

Abstract

Background: The purpose of this study was to evaluate the dosimetric difference in calculated and measured doses for volumetric modulated arc therapy enabled total body irradiation ... Read More

Effect of Pangasius Hypophthalmus Fish Extract on Blood Sugar and Uric Acid Levels in Alloxan-Induced Rattus Norvegicus

Fitri Handajani; Nabil Nabil

Volume 7, Issue 1 , January 2024, , Pages 124-131

https://doi.org/10.26655/JMCHEMSCI.2024.1.12

Abstract

Pangasius hypophthalmus fish, as a dietary source, contains vitamins and minerals that serve as antioxidants, effectively preventing oxidative stress. Diabetes mellitus is rooted in ... Read More

Medical Comparison of Two Different Doses of Intravenous Ketorolac for Treating of Acute Renal Colic: A Randomized Clinical Trial

Hojat Rastegari Najafabadi; Sheida Mehrdad; Mehdi Galavi; Hoseinali Danesh; Ali Abdolrazaghnejad

Volume 5, Issue 3 , May and June 2022, , Pages 376-384

https://doi.org/10.26655/JMCHEMSCI.2022.3.12

Abstract

Renal colic is a symptom of urinary tract obstruction, and stones are the most common cause of this pain. His study was performed to compare two single-dose intravenous ketorolac ... Read More

Steroid Compounds from Endophytic (Penicillium sp.) of Mangrove Avicennia marina

Syaiful Bahri; Annisa Elcentia Fajarwati; Andi Setiawan; John Hendri; Suripto Dwi Yuwono; Yuli Ambarwati; Rahadian Zainul

Volume 7, Issue 2 , February 2024, , Pages 402-425

https://doi.org/10.26655/JMCHEMSCI.2024.2.12

Abstract

In this study, we explore a steroid compound from the endophytic of the mangrove (Avicennia marina). Penicillium sp. is one of the microbes endophytic isolated from the mangrove and ... Read More

Performance Analysis of Selected Decision Tree Algorithms for Predicting Drug Adverse Reaction among COVID-19 Hospitalized Patients

Raoof Nopour; Mehrnaz Mashoufi; Morteza Amraei; Nahid Mehrabi; Alireza Mohammadnia; Abdollah Mahdavi; Nader Mirani; Mojgan Saki; Mostafa Shanbehzadeh

Volume 5, Issue 4 , July and August 2022, , Pages 505-517

https://doi.org/10.26655/JMCHEMSCI.2022.4.7

Abstract

Increase in drug allergies and unpleasant adverse effects caused by COVID-19 medication therapies has doubled the need for computing technologies and intelligent systems for predicting ... Read More

Synthesis, Characterization of Azetidine Derivative and Studying the Antioxidant Activity

Osama S.Hashim

Volume 6, Issue 3 , March 2023, , Pages 553-558

https://doi.org/10.26655/JMCHEMSCI.2023.3.12

Abstract

In this study, a derivative of azetidine was obtained by refluxing Schiff-base with an aromatic aldehyde. Schiff-base was prepared by reaction of hydrazine hydrate with chloroacetylchloride ... Read More

Disturbances of Lipid Profile, Hemoglobin and Serum Ferritin Levels in Thalassemia Patients in Misan City, Amara, Iraq

Eman Khammas AlSaadi

Volume 5, Issue 5 , September and October 2022, , Pages 779-786

https://doi.org/10.26655/JMCHEMSCI.2022.5.12

Abstract

Background: One of the most common hereditary hematological disorders is beta thalassemia major manifested by severe hemolysis and profound anemia for which the regular blood transfusions ... Read More Background: One of the most common hereditary hematological disorders is beta thalassemia major manifested by severe hemolysis and profound anemia for which the regular blood transfusions are required that leading to the iron accumulation in blood and body organs as well as increased serum ferritin. Thalassemic patient’s lipid profile levels are significantly variable in many studies.Aims: The study aimed to detect any alteration of serum lipid profiles in thalassemic major patients and to find out if they are correlated with serum ferritin and Hb concentration.Method sand patients: Sixty-two Beta thalassemia major patients were enrolled in the study, aged (6months-15 years) randomly selected (65) matched control children. Obtaining serum samples for lipid profile, and ferritin estimation, as well as blood test of hemoglobin concentration was done. Statistical data analysis was performed using standard methods.Results: The most presented age was (>5-10 years.) followed by (6mo-5years) then (>11-15 years.) (27, 21, 14) patients, respectively. Female were slightly predominant than male (54.8%), (45.2%), respectively mainly in group 2 (55.9%), while male slightly predominates in the younger and older groups (26.5%), (17.7%), respectively. Serum ferritin levels were very high in (98.4%) of cases, mainly in group 2 (43%), then in group 1 (34%), followed by group 3 (23%). The majority of patients had normal cholesterol level (95.16%). Lipoprotein were Low in (35.5%) of patients mainly in group 2 (54.5%) and normal in (64.5%) mainly equally distributed in groups, although not statistically significant, (p.value=0.7). Low Density Lipoprotein was normal in most patients (95.16%), and not significant statistically (P value=0.8). Triglyceride was high in most patients (83.9%), while normal in (16.1%), it was with no statistically significant (p. value=0.4).Conclusion: The present study concluded a positive correlation between (high Triglyceride, low, and high density Lipoprotein) and (low Hb and high ferritin levels) which may attribute to the future fatal cardiac complication.

Estimation of Irisin and Some Biochemical Parameters in Diabetes Mellitus Iraqi Patients

Najlaa Abed Jassim

Volume 6, Issue 4 , April 2023, , Pages 809-815

https://doi.org/10.26655/JMCHEMSCI.2023.4.12

Abstract

There is a great interest on the role of irisin level in the pathogenesis of many diseases, in particular diabetes mellitus. This research attempted to focus on assessing of irisin ... Read More

Cloud Point and Solvent Extraction of Copper (II) by Bis(3-chloro acetylacetone) Ethylenediamine

Israa A. Jassem; Wathiq. S. Abdul-Hassan; Ibrahim A. Flafel; Sahir A. A. Ali; Zahraa M. Mahdi

Volume 5, Issue 6 , November and December 2022, , Pages 988-1000

https://doi.org/10.26655/JMCHEMSCI.2022.6.12

Abstract

In this work, the extraction of copper (II) by bis(3-chloro acetylacetone) ethylenediamine as a chelating reagent was studied by CPE using Triton X-100 as non-ionic surfactant and by ... Read More

Organic Synthesis of Some New Compounds Derived from Furfural and Their Evaluation as Antioxidants

Andy N. S. Shamaya; Oday H. R. Al-Jeilawi

Volume 6, Issue 5 , May 2023, , Pages 1065-1076

https://doi.org/10.26655/JMCHEMSCI.2023.5.12

Abstract

Heterogeneous organic compounds play an important role in our daily life as they contribute in many medical and industrial fields and are in continuous development as a result of the ... Read More

Synthesis, Spectral Analysis, Stability, Antibacterial, and Antioxidant of Fe(II) Mixed Ligands Complex of Imidazole and 1,10-Phenanthroline

Salwa Neama Abdoon; Saba S. M. Al-Obaidy; Yahya Fahim Al-Khafaji

Volume 5, Issue 7 , November and December 2022, , Pages 1231-1241

https://doi.org/10.26655/JMCHEMSCI.2022.7.12

Abstract

In this study, a new complex consisting of iron metal coordination in a binary oxidation state, synthesized with mixed ligands, which are imidazole and 1,10-phenanthroline. The absorbance ... Read More

An Evaluation of Activity of Prepared Zinc Nanoparticles with Extract Green Plant in Treatments of Diclofenac, Levofloxacin, and Tetracycline in Water

Suzan Muslim Abdullah; Abbas Ali Salih AL-Hamdani; Suha Mohamed Ibrahim; Labeeb Ahmed Al-Zubaidi; Farqad Abdullah Rashid

Volume 6, Issue 6 , June 2023, , Pages 1323-1335

https://doi.org/10.26655/JMCHEMSCI.2023.6.12

Abstract

Myrtle plant was washed, dried, and powdered after harvesting to produce a fine powder used in water treatment. An alcoholic extract was created from the myrtle plant using ethanol, ... Read More

The Effect of Addition Radish Oil on Some Mechanical Properties

Sadeq Aadi Rahi Al-Husseini; Wasmaa Sadik Mahmood

Volume 6, Issue 7 , July 2023, , Pages 1614-1620

https://doi.org/10.26655/JMCHEMSCI.2023.7.12

Abstract

The objective of this study is to investigate the effects of radish oil on the transverse strength and surface roughness of polymethyl methacrylate. In this study, a total of sixty ... Read More

Mechanism of Immune System for Evading and Escaping Cancer Cells: A Brief Review

Ali Mohammed Abd AL-Ameer; Lubna Abdulazeem; Mazin H. Kzar; Essam Shawky Khattab; Ahmed Samir Naje

Volume 6, Issue 8 , August 2023, , Pages 1843-1850

https://doi.org/10.26655/JMCHEMSCI.2023.8.12

Abstract

For everyone, at all ages, to live healthy lives and to promote well-being, there should be good health and welfare at every stage of one's life, beginning at birth, whereas health ... Read More

Survival Analysis of Delta versus Omicron Variants in COVID-19 Intensive Care Unit (ICU)

Somayeh Mehrpour; Mojdeh Bahadorzadeh; Hassan Safdari; Mansoureh Shakeri; Reihane Tabaraii

Volume 6, Issue 9 , September 2023, , Pages 2038-2045

https://doi.org/10.26655/JMCHEMSCI.2023.9.12

Abstract

Objective: COVID-19 has presented numerous epidemiological and clinical pictures from its beginning and much effort has been paid to detect the behavior of disease and its new types. ... Read More Objective: COVID-19 has presented numerous epidemiological and clinical pictures from its beginning and much effort has been paid to detect the behavior of disease and its new types. Therefore, in this study, we aimed to compare the in-hospital survival time of Delta and Omicron variant patients admitted to the intensive care unit. Methods: This was a secondary data analysis of the QCOVICU data registry of 200 COVID-19 patients admitted to the ICU of Shahid Beheshti-Amir Al-Momenin Hospital of Qom City, in 2021. Likewise, time to event data, demographics, and baseline laboratory data was collected. Time of transfer to ICU, survivals, and possible predictors of hazards of death was compared within the variants of Omicron and delta.Results: Two hundred patients (62.98±19.94 years old, 94 females/106 males; 100 Delta and 100 Omicron variant) participated in this study. Fifty percent of the population had died. Cross-tabulation showed comparable death rates among variants of delta and omicron (50.5% vs. 51%; p=0.999). There was a statistically significant higher time to ICU admission in Delta variant victims than in Omicron variant victims. The mean survival time of delta variant patients was 21.52 days (95% CI: 17.96 – 25.09) which was statistically higher than the mean survival of omicron patients (17.15 days, 95% CI: 13.65-20.64, p=0.018). The mean survival time of delta variant patients was ‎statistically higher than omicron patients (21.52 vs. 17.15 days, ‎p=0.018). Gender, age (years), and lymphocyte count were significant predictors of mortality based on the Cox regression analysis (P>0.05). There was a 5.9 times higher risk of mortality in females compared with males’ gender after adjusting for other variables and a 5.6% increase in death risk with a 1-year increase in age, and a 31.8% decrease in death risk with a 1% lymphocyte percentage increase.Conclusion: Critically patients with Delta variant are getting ICU admitted later and withstand more days at ICU than Omicron patients. It seems that Omicron variant causes sudden deterioration of the patient's condition.

Predictive Value of Prognostic Nutritional Index in Children with COVID-19

Radhitio Adi Nugroho; Nur Aisiyah Widjaja; Retno Asih Setyoningrum

Volume 6, Issue 10 , October 2023, , Pages 2367-2378

https://doi.org/10.26655/JMCHEMSCI.2023.10.12

Abstract

Background and aim: Severe malnutrition might contribute the poor outcomes in COVID-19. This study aims to investigate the relationship between prognostic nutritional index (PNI) and ... Read More

The Effects of Transcutaneous Auricular Vagus Nerve Stimulation and Exercise on Functional Capacity of Chronic Low Back Pain

Retno Kusumastuti; I Putu Alit Pawana; Yudith Dian Prawitri; Soenarnatalina Melaniani

Volume 6, Issue 12 , December 2023, , Pages 2974-2984

https://doi.org/10.26655/JMCHEMSCI.2023.12.12

Abstract

Background: Mechanical chronic low back pain (CLBP) known as a complex problem with low resolution rate and increased disabilities. Several studies showed vagus nerve stimulation benefit ... Read More

Identification of Residual Traces of Antibiotics in Food

Daria Dmitrievna Belova; Elena Nikolaevna Kharchenko; Olga Sergeevna Chaplygina

Volume 5, Issue 3 , May and June 2022, , Pages 385-392

https://doi.org/10.26655/JMCHEMSCI.2022.3.13

Abstract

Due to the widespread use of veterinary drugs and antibiotics in animal husbandry, one of the most critical problems in ensuring food safety is the presence of residual antibiotic traces ... Read More

Comparative Analysis of the Effect of Intravenous, Topical, and Oral Tranexamic Acid on Reducing Bleeding After Coronary Artery Bypass Surgery

Behnam Mahmodiyeh; Alireza Rostami; Ava Akhavan; Amir Almasi; Alireza Kamali

Volume 7, Issue 2 , February 2024, , Pages 426-435

https://doi.org/10.26655/JMCHEMSCI.2024.2.13

Abstract

Background: Bleeding is a significant complication of cardiac surgeries, leading to increased blood product utilization, higher rates of reoperation, and mortality. Tranexamic acid ... Read More Background: Bleeding is a significant complication of cardiac surgeries, leading to increased blood product utilization, higher rates of reoperation, and mortality. Tranexamic acid is one of the main medications used to control postoperative bleeding in these patients. Therefore, the aim of this study was to compare the effects of intravenous, topical, and oral tranexamic acid in reducing postoperative bleeding after coronary artery bypass grafting (CABG) surgery.Materials and methods: This clinical trial was conducted on 96 patients scheduled for CABG surgery. The patients were divided into three groups of 32, receiving oral, intravenous, and topical tranexamic acid. After the surgery and administration of the respective medication, the amount of bleeding within 72 hours postoperatively, as well as the amount of packed red blood cells, platelets, and fresh frozen plasma received within 24 hours postoperatively were assessed.Results: The mean age of the participating patients was 64±5.4 years, and the three groups did not significantly differ in terms of age, gender distribution, number of grafts (P=0.421), and duration of surgery (P=0.624). There was no significant difference in the bleeding score among the three groups, with scores of 3.9±0.88 in the intravenous group, 4.1±1.1 in the oral group, and 4.4±0.98 in the topical group (P=0.221). The average amount of packed red blood cells, platelets, and fresh frozen plasma received during and after surgery was similar in all three groups, with values of 2 (P=0.422), 3.5 (P=0.402), and 2.4 (P=0.412), respectively.Conclusion: In general, the results of this study indicate that the use of tranexamic acid in all three available forms (oral, intravenous, and topical) leads to a reduction in postoperative bleeding with similar outcomes. Therefore, concerning the fewer side effects of the topical and oral forms and their sufficient effectiveness, physicians can utilize these methods for prescribing tranexamic acid.

Influence of albocarbon-cyclic hybridization on biomedical activities: A review

Yasser Fakri Mustafa; Moath Kahtan Bashir; Mahmood Khudhayer Oglah

Volume 5, Issue 4 , July and August 2022, , Pages 518-536

https://doi.org/10.26655/JMCHEMSCI.2022.4.8

Abstract

There is an excellent demand in biomedical sciences for novel drug-like compounds with the best therapeutic benefits and minor adverse effects. The albocarbon moiety is seen to be abundantly ... Read More

Volume 7 (2024)

Volume 6 (2023)

Volume 5 (2022)

Volume 4 (2021)

Volume 3 (2020)

Volume 2 (2019)

Volume 1 (2018)

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract