Journal of Medicinal and Chemical Sciences

Type-2 Diabetes Among Investors Community in India

Srutiva Mishra; B. Chandra Mohan Mohan Patnaik; Ipseeta Satpathy

Volume 6, Issue 9 , September 2023, , Pages 2249-2258

https://doi.org/10.26655/JMCHEMSCI.2023.9.30

Abstract

Comorbidity and mortality are high among people with type-2 diabetes. Globally, diabetes is a major health issue, with a growing number of patients at risk of complications. A change ... Read More

Effects of Stevia on Hypertension of Metabolic Syndrome: A Systematic Review

Mohamed J. Saadh; Sivapriya Thiyagarajan; Juan Carlos Cotrina-Aliaga; Mohammed I. Suleiman; Ali A. Fahdil; Salam Ahjel; Abtin Soleimanian; Mahmoud Mirzaei; Kun Harismah

Volume 6, Issue 10 , October 2023, , Pages 2407-2418

https://doi.org/10.26655/JMCHEMSCI.2023.10.16

Abstract

By the importance of dealing with metabolic syndrome (MetS), this work was performed to systematically review available articles on effects of stevia on hypertension as a leading risk ... Read More

Exploring Impacts of Oil and Water Environments on Structural and Electronic Features of Vitamin B3 along with DFT Calculations

Mohamed J. Saadh; Faris Anad Muhammad; Romina Mahdavi; Yasaman Nazariyan Parizi; Ebrahim Balali; Juan Carlos Cotrina-Aliaga; Mohaned Adil; Salam Ahjel; Meryelem Tania Churampi Arellano; Yanina Gallardo-Lolandes; Renato R. Maaliw III; Mahmoud Mirzaei; Kun Harismah

Volume 6, Issue 10 , October 2023, , Pages 2419-2431

https://doi.org/10.26655/JMCHEMSCI.2023.10.17

Abstract

Density functional theory (DFT) calculations were performed to investigate the features of vitamin B3 (Vit-B3) in oil and water environments. Two up and down structural conformations ... Read More

Design, Synthesis, Characterization, and Study of in vitro Antioxidant Activity of Some Substituted Biginelli Derivatives

Abdul Lathiff M.K.M; Suresh Ramalingam; Senthamarai Rajagopalan

Volume 6, Issue 10 , October 2023, , Pages 2432-2448

https://doi.org/10.26655/JMCHEMSCI.2023.10.18

Abstract

The Biginelli class of 3,4-dihydropyrimidinone (DHPM) or its thione (DHPMT) derivatives can act as an exciting pharmacophoric moiety, which in turn has attracted the extensive attention ... Read More The Biginelli class of 3,4-dihydropyrimidinone (DHPM) or its thione (DHPMT) derivatives can act as an exciting pharmacophoric moiety, which in turn has attracted the extensive attention of medicinal chemists in the last few decades. Similarly, imidazolidin-4-one also occupies an inevitable place in drug discovery chemistry. Despite numerous diverse pharmacologic effects ascribed to these two derivatives together being reported, there are few reports on the antioxidant evaluation of the Biginelli class of pyrimidinone derivatives annexed to imidazolidinone by an amide bond. In this study, the synthesis of 20 novel 3,4-dihydropyrimidinones with imidazolidin-4-one derivatives is described. The physical characteristics of the synthesized 3,4-DHPM and DHPMT derivatives were determined and analytically characterized by various spectral tools like FT-IR, Lc-Ms/Ms, and proton and carbon NMR. The scavenging radical potential for the synthesized 20 novel Biginelli derivatives was assessed using the DPPH assay. The results indicated that all the tested compounds had good to excellent antioxidant potency in comparison to the standard drug ascorbic acid. The synthesized compounds 1, 6, 8, 9, 14, 15, 16, 17, 18, and 19 showed a good degree of scavenging potency. Interestingly, remarkable activity was observed with compounds 16, 17, and 19. The present study reveals that not only the compounds with an OH group can exhibit a high degree of scavenging potency, but other groups like -OCH3, –CH3, and -Cl can also exhibit activity effectively. In addition, the radical scavenging potential for the studied compounds could be due to either the presence of more than one labile hydrogen atom attached to a nitrogen atom or the conjugated system, i.e. the 3,4-dihydropyrimidinone ring attached to an amide linkage, present in these compounds, which would have further sponsored the compound to get stabilized when these compounds become radicals by donating an electron to ROS.

Xpert MTB/RIF and Microscopic Cytology of FNAB in Tuberculosis

Ayu Lidya Paramita; Ni Made Mertaniasih; Etty Hary Kusumastuti; Eko Budi Koendhori; Pepy Dwi Endraswari

Volume 6, Issue 10 , October 2023, , Pages 2449-2455

https://doi.org/10.26655/JMCHEMSCI.2023.10.19

Abstract

Background: The symptom of lymphadenopathy can describe several disorders, including tuberculosis (TB) lymphadenitis. The suspicious gland will undergo supportive investigations to ... Read More

Phytochemicals and Biological Activities of Ethanolic Extract of Garcinia atroviridis Leaf Grown in Indonesia

Muhammad Fauzan Lubis; Vera Estefania Kaban; Kasta Gurning; Parhan Parhan; Hafid Syahputra; Nur Aira Juwita; Ririn Astyka; Ichpan Zulfansyah

Volume 6, Issue 10 , October 2023, , Pages 2456-2469

https://doi.org/10.26655/JMCHEMSCI.2023.10.20

Abstract

The current investigation examined the potential antibacterial and antihyperlipidemic properties of ethanolic extract derived from the leaves of Garcinia atroviridis (EGA). The phytochemical ... Read More

Sorbitol Dehydrogenase and Other Liver Enzymes Before and After Five Days Remdesivir Therapy in Covid-19 Patients

Puspa Wardhani; Kustiah Kustiah; M. Robiul Fuadi; Yulia Nadar Indrasari; Dwita Riadini; Bambang Pujo Semedi

Volume 6, Issue 10 , October 2023, , Pages 2470-2479

https://doi.org/10.26655/JMCHEMSCI.2023.10.21

Abstract

The antiviral remdesivir has the potential to cause drug-induced liver injury in Covid-19 patients as seen in increased alanine aminotransferase (ALT) and aspartate aminotransferase ... Read More

Evaluation of Thyroid Biomarkers in Patients with Alopecia Areata

Chiman Yousif Younis; Dindar Sharif Qurtas; Araz Hassan Muhammed

Volume 6, Issue 10 , October 2023, , Pages 2480-2493

https://doi.org/10.26655/JMCHEMSCI.2023.10.22

Abstract

Alopecia areata is an autoimmune hair loss condition influenced by factors like thyroid dysfunction. The objective of the study was to evaluate the thyroid biomarkers level in patients ... Read More

Clinical Features of Course of Different Types of Carpal Tunnel Syndrome

Oksana Haiko; Liudmyla Klymchuk; Roman Derkach; Valentyn Piontkovskyi

Volume 6, Issue 10 , October 2023, , Pages 2494-2501

https://doi.org/10.26655/JMCHEMSCI.2023.10.23

Abstract

Objective: This article aims to study clinical features of the courses of different types of CTS to improve diagnostics and substantiate tactics of treatment.Materials and methods: ... Read More

Effect of Formalin Exposure on Antral Follicle Development Disorders through Decreased Gonadotropin Hormone Regulation

Lutvia Krismayanti; Widjiati Widjiati; Bambang Purwanto

Volume 6, Issue 10 , October 2023, , Pages 2502-2509

https://doi.org/10.26655/JMCHEMSCI.2023.10.24

Abstract

An excessive amount of formalin exposure might result in reactive oxygen species (ROS) and oxidative stress in the body, which lowers the body's ability to regulate the gonadotropin ... Read More

Association Between Periodontal Disease and Obesity in a Sample of Libyan Adults

Logien Al Ghazal; Seham Ali; Salma Mahfoud

Volume 6, Issue 10 , October 2023, , Pages 2510-2517

https://doi.org/10.26655/JMCHEMSCI.2023.10.25

Abstract

Background: Obesity is a growing chronic health issue all around the globe. It has a serious number of complications. It has shown through several observational and clinical trials ... Read More

Detection of Active Chemical Compounds in Lycium Shawii Plant Using GC-MS Technique and Their Evaluation as Antioxidant

Ebtihaj Jassim Jabur; Ali Noory Fajer

Volume 6, Issue 10 , October 2023, , Pages 2518-2530

https://doi.org/10.26655/JMCHEMSCI.2023.10.26

Abstract

Lycium shawii is considered a thorny perennial and wild plant. Bramble usually grows in dry and hot lands because this plant lives on moisture. The height of the plant reaches one and ... Read More

Effect of Androgen Use among Children with Micropenis in Erbil City

Wesam Amjad Boya Kaka

Volume 6, Issue 10 , October 2023, , Pages 2531-2538

https://doi.org/10.26655/JMCHEMSCI.2023.10.27

Abstract

Background and objective: Micropenis is a condition where the penis is smaller than average, causing psychological distress and affecting sexual function. The aim of this study was ... Read More

Effect of Sacubitril/Valsartan on Hemodynamic Parameters, Biomarkers of Inflammation and Cardiac Remodeling in Rats with DOCA-Salt-Induced Hypertension

Goloshvili Davit; Okujava Maia; Liluashvili Konstantine; Mirziashvili Makrine; Manana Ghonghadze; Pachkoria Ketevan; Gongadze Nikoloz

Volume 6, Issue 10 , October 2023, , Pages 2539-2548

https://doi.org/10.26655/JMCHEMSCI.2023.10.28

Abstract

The aim of the study was to assess the influence of Sacubitril/Valsartan (S/V) on hemodynamic indices and heart remodeling events in rats with DOCA-salt arterial hypertension (AH). ... Read More The aim of the study was to assess the influence of Sacubitril/Valsartan (S/V) on hemodynamic indices and heart remodeling events in rats with DOCA-salt arterial hypertension (AH). Experiments were performed on Wistar rats. Animals were randomly divided into the four groups: (I) Control (C) group, (II) DOCA-salt group, (III) S/V + DOCA -salt as drinking water, and (IV) S/V after development of DOCA-salt hypertension. Heart beat (HB)/min and systolic and diastolic blood pressure (SBP, DBP, mmHg) were obtained by tail-cuff method in the morning hours. The level of ET-1, IL-1, TNF-alpha, and NF-kB transcription factor were measured in the blood plasma of rats by ELISA kits method. Morphometric and histomorphological changes in heart and aorta were analyzed in the tissue sections using electronical microscope. In the second group of animals, the mean values of SBP – 153,6 ± 5,4 mmHg, DBP – 67,9 ± 2,8 mmHg, and HB – 394 ± 12/min were significantly increased in comparison with C group of animals (123,0 ± 5,2 mmHg (p<0,001), 55,6 ± 3,0 mmHg (p<0,05), and 361 ± 24/min (p<0,001), respectively). Such alterations in cardiovascular parameters correlated with marked increase in DOCA-salt group blood plasma levels of ET-1, IL-1, TNF-alpha, and NF-kB vs. C animals. S/V treatment significantly reduced SBP, DBP, and HB (-30,2 ± 4 mmHg, (p<0,001), -11,4 ± 2,2 mmHg (p<0,05), and -33 ± 12/min, p<0,002, respectively) in hypertensive rats (HR) associated with marked decrease in blood levels of ET-1 (56,9%, p<0,01), IL-1 (67,3%, p<0,001), TNF-alpha (75,1%, p<0,001), and NF-kB (59,2%, p<0,001), with significant improvement of morphological changes of the heart in this group of animals. It is suggested that S/V in hypertensive state exerts a positive effect on hemodynamic parameters, providing reverse action on heart remodeling and can be considered as a valuable drug for the AH treatment and prevention of structural changes in target organs.

The Impact of High Intensity Intermittent Exercise (HIIE) on Serum Leptin Levels in Sedentary Overweight Adult Women

Siti Badriyah Zahrotul Ilmi; Niswatin Fahma Wibowo; Aldi Karimullah; Angelia Indra Devi; Yosnengsih Yosnengsih; Fajar Syamsudin; Purwo Sri Rejeki; Zulhabri Othman; Lilik Herawati

Volume 6, Issue 10 , October 2023, , Pages 2549-2557

https://doi.org/10.26655/JMCHEMSCI.2023.10.29

Abstract

The prevalence of a sedentary lifestyle is increasing, which can lead to overweight and subsequently obesity, potentially triggering metabolic diseases. The objective of this study ... Read More

Nurse Performance and Influence Factors in Discharge Planning Based on Knowledge Management SECI Model in Stroke Patients

Auliasari Siskaningrum; Ahmad Yusuf; Mahmudah Mahmudah; Abdulloh Machin

Volume 6, Issue 10 , October 2023, , Pages 2558-2568

https://doi.org/10.26655/JMCHEMSCI.2023.10.30

Abstract

Background: Implementation of discharge planning was found to be unsystematic and structured in stroke patients, resulting in gaps in knowledge transfer and knowledge between nurses, ... Read More

The Role of several Biomarkers and Scoring Systems Assessed During Emergency Department Admission Day in Predicting Septic Shock

Nur Farhanah; Hendro Wahjono; Banundari - Rachmawati; Suharyo Hadisaputro; Muhammad Hussein Gasem

Volume 6, Issue 11 , November 2023, , Pages 2650-2664

https://doi.org/10.26655/JMCHEMSCI.2023.11.9

Abstract

Sepsis results in a life-threatening organ dysfunction due to the dysregulation of organ dysfunction detection, risk stratification, prognosis, and treatment is crucial for sepsis and ... Read More

An Anti-Inflammatory Dental Pulp of Eugenol Extracted from Clove (Eugenia Caryophyllata)

Nendika Dyah Ayu Murika Sari; Ikmal Hafizi; Nida Faradisa Fauziyah; Ratih Hartinawati; Zakia Sholiha

Volume 6, Issue 11 , November 2023, , Pages 2665-2671

https://doi.org/10.26655/JMCHEMSCI.2023.11.10

Abstract

Objective: To determine the effective volume of eugenol on day 3 in the inflamed pulp.Methods: Experimental research with a posttest-only control group design The experimental animals ... Read More

Radiographic Findings of Lung CT Scans of COVID-19 Patients: Delta and Omicron Variants

Somayeh Mehrpour; Reihane Tabaraii; Hassan Safdari; Mohammad Aghaali; Mansoureh Shakeri; Alireza Shahhamzeh; Mahnaz Rahimi Jafari

Volume 6, Issue 11 , November 2023, , Pages 2672-2678

https://doi.org/10.26655/JMCHEMSCI.2023.11.11

Abstract

Objective: The present study was designed with the aim of comparing the radiological findings of the CT scan of the lungs of patients with Delta and Omicron variants of COVID-19 hospitalized ... Read More Objective: The present study was designed with the aim of comparing the radiological findings of the CT scan of the lungs of patients with Delta and Omicron variants of COVID-19 hospitalized in the intensive care unit.Methods: This was a retrospective comparative study conducted during the fifth peak of COVID-19 in Iran, August to November 2021 (the predominance of Delta variant) and March to April 2022 (the predominance of Omicron variant) in Qom, Iran. Radiologic findings of lung CT scans reported by a single radiologist were compared between these two cohorts. To analyze the collected data, SPSS version 22 statistical software is used through chi-square or fisher exact test, independent t-test, and Mann-Whitney test. A p-value of lower than 0.05 was considered as statistically significant.Results: The total number of 50 patients in Delta (mean age of 58.68±14.77 years, 56% male) and 46 patients in Omicron (mean age of 70.45±18.02 years, 47% male) periods were included in study. Lesions of Right middle lobe (RML), left upper lobe (LUL), and Lingual lobes were more common in Delta period than Omicron (P<0.05). GGOs were more common in Delta period than in the Omicron ‎ (P=0.013). There were no Unilateral GGOs during the Delta period, while 9 of 32 (28.1%) patients having GGO lesions in Omicron era had unilateral ones (P<0.001). Peripheral lesion was not differentiating Omicron from Delta. Crazy Pavings, Parenchymal bands, Halo signs, and Pleural effusions were more common in omicron period than in the Delta (P<0.05). Total Chest CT severity score was statistically higher in Delta period (22.75±5.24 units) than Omicron period (13.97±9 units).Conclusion: There were the significant differences in the radiologic characteristics between the two variants. This study suggests that with evolving the virus variants, while severity of lung involvement has decreased, GGOs of COVID-19 might have tended to manifest as unilateral lesions with more specific radiographic features.

Hemolytic Anemia in Pregnancy: A Rare and Challenging Case in Indonesia

Miftah Hasanah; Yetti Hernaningsih

Volume 6, Issue 11 , November 2023, , Pages 2679-2685

https://doi.org/10.26655/JMCHEMSCI.2023.11.12

Abstract

Autoimmune hemolytic anemia (AIHA) is an infrequent etiology of anemia during pregnancy, and its occurrence in the postpartum period is even more uncommon. This study presents the case ... Read More

Comparative Study Between Cuff Leak Test and Laryngeal U/S for Detection of Post Extubation Oedema in Prone Position Patient with General Anesthesia

Abdel Wahab Abdelsattar Saleh Mohammad; Maher A sheriff; Yara Ayman Iskandarani; Wael Mohammed Mossa; Mohamrd Hamdi Alqassas

Volume 6, Issue 11 , November 2023, , Pages 2686-2698

https://doi.org/10.26655/JMCHEMSCI.2023.11.13

Abstract

Background: Endotracheal intubation is a routine procedure in the ICU that may save a patient's life. The stridor probability after extubation increases with a smaller cuff-leak volume. ... Read More

Effects of Different Filtration and Clarification Techniques on Palestinian Virgin Olive Oil Chemical and Microbial Quality

Ziad Ayyad; Wafaa Alsioury; Zaher Barghouthi; Diab Qadah; Mohannad Qurie

Volume 6, Issue 11 , November 2023, , Pages 2699-2706

https://doi.org/10.26655/JMCHEMSCI.2023.11.14

Abstract

Virgin olive oil filtration is a pre-treatment usually used before bottling to facilitate suspended particle removal and reduce the moisture content so that the quality and organoleptic ... Read More Virgin olive oil filtration is a pre-treatment usually used before bottling to facilitate suspended particle removal and reduce the moisture content so that the quality and organoleptic properties are preserved during storage. In the current study, samples of virgin olive oils were subjected to different clarification and filtration techniques such as (1) commercial filtration (CF) using diatomaceous earth as a filter aid, (2) clarification by insufflating of carbon dioxide, and (3) argon gas. All treated samples as well as control unfiltered (UF) virgin olive oil (VOO) were bottled under dark conditions in diffused daylight glass bottles and kept at room temperature for six months. Basic quality indices (free acidity (FA), peroxide value (PV), and extension coefficient) and total polar phenol were determined within respected time of analysis during the storage period of six months. In addition, microbial quality was evaluated by determination of yeasts and molds, total plate count, Bacillus cereus, and clostridium perfringens. The main results showed that at the end of the storage, acidity increased in all samples with time in both storage conditions, whereas samples stored in dark more stable compared to those stored under diffused daylight. On the other hand, clarified samples with CO2 showed significant stability compared to the rest of the samples stored under diffused day light. Peroxide values (PV) and K232 increased in all stored samples. Moreover, K270 increased with time, and showed more stability in samples stored in dark. Total polar phenols decrease in all samples, but showed no significant difference among all samples after 180 days of storage. Microbial results revealed the presence of yeasts and molds in all samples at the beginning of storage, and then disappeared after 135 days for all samples except UF. Total plate count, Bacillus cereus, and clostridium perfringens were not found in any stored VOO.

Characteristics of Intercalated Discs Responsible for Histological Changes of the Left Ventricle in the Experiment Involving Mechanical Loading on 30-Day-Old White Rats

Anzor Gogiberidze; Ramaz Khetsuriani; Marina Pailodze; Manana Arabuli; Sopiko Kandelaki; Magda Tortladze; Lizi Khitiri; Irma Jikia

Volume 6, Issue 11 , November 2023, , Pages 2707-2715

https://doi.org/10.26655/JMCHEMSCI.2023.11.15

Abstract

In our own experiment, we studied microscopic changes in the anterior wall of the left ventricle of young, middle-aged, and old rats on the 30th day after exercising. Plasmorrhagia, ... Read More

The Prevalence of Anti-DFS70 Antibodies in SLE and Non-SLE Patients

Kusworini Handono; Hani Susianti; Syahrul Chilmi; Andrea Aprilia; Rahmatul Yasiro; Natalia Sukarta

Volume 6, Issue 11 , November 2023, , Pages 2716-2726

https://doi.org/10.26655/JMCHEMSCI.2023.11.16

Abstract

Background: The presence of anti-DFS70 antibodies was considered by some rheumatologists as a tool to help exclude the diagnosis of systemic autoimmune rheumatic diseases (SARDs) such ... Read More

Alterations in Left Ventricular End-Systolic and End-Diastolic Volumes in 12-13-Week-Old Laboratory Rats Subjected to Dosed Swimming Exercise

Nikoloz Vachadze; Anzor Gogiberidze; Ramaz Khetsuriani; Marina Pailodze; Elene Shvangiradze; Nino Pruidze

Volume 6, Issue 11 , November 2023, , Pages 2727-2734

https://doi.org/10.26655/JMCHEMSCI.2023.11.17

Abstract

The objective of this study was to explore the alterations in end-systolic and end-diastolic volumes of the left ventricle in 12-13-week-old rats subjected to a six-week regimen of ... Read More

Volume 7 (2024)

Volume 6 (2023)

Volume 5 (2022)

Volume 4 (2021)

Volume 3 (2020)

Volume 2 (2019)

Volume 1 (2018)

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