Dementia is a progressive disorder with severe cognitive decline, behavioral problems, and lack of movement in daily life activities. Simultaneous resistance training and active participation in mental, physical, and emotional activities can delay the onset of dementia in the elderly.In explaining brain-compatible teaching methods, the combination of cognitive learning effects, physical activity, and the role of emotion in learning should be considered.The aim of this study was to evaluate the effectiveness of the training package based on increased cognitive, emotional and neuromuscular activity in the daily activities of the elderly with mild cognitive impairment.In this research study with pre-test and post-test design and control group, 30 elderly people with mild cognitive impairment residing in Kahrizak elderly sanatorium were selected by simple sampling and randomly divided into two experimental groups. The participant’s mini mental state examination questionnaire, depression, and social isolation were implemented. Rehabilitation program was conducted in 18 sessions over 8 weeks and 2-3 weeks. Data were analyzed with analysis of covariance model. The experimental group received cognitive rehabilitation intervention and compared with the control group based on the mental state examination scores[F=24, 30, p £0, 01] significantly better cognitive function; depression ratings [F=17, 67, p £0, 01] lower depression rates and based on Barthel's scores [F=29, 78, p £0, 01], they performed better on a daily basis. The results showed that response-based intervention based on enhanced cognitive, emotional, and neuro-muscular activity was effective in improving the cognitive function, reducing depression, and improving the daily activities. Therefore, it is recommended that elderly caregivers use the training program designed in this study to improve the daily functioning of the elderly.In future studies, by examining the neural and infrastructural mechanisms of interventions, educational programs is generalized to the elderly.