Scopus (SJR=0.2, Q3), ISC, CAS, ....

Document Type : Original Article

Authors

1 Natural Product and Polymer Chemistry Laboratory, Department of Chemistry, University of North Bengal, Darjeeling, 734013, India

2 Department of Biochemistry, College of Dentistry, Qaseem Private Colleges, Buraidah- SaudiArabia

Abstract

Phytochemical investigation of the pet-benzene extract of the leaves of Psidiumguajava was yielded the triterpenoids, olean-12(13), 15(16)-diene, olean-12(13), 15(16)-dien-3β-oland olean-15(16)-en-11α-ol. All the three compounds are reported for the first time from Psidiumguajava. The compounds were established by chemical characterized using IR, NMR, and Mass analysis by comparison with authentic sample. All the three triterpenoids showed moderate to good biocidal activity against some bacterial and fungal pathogens.

Graphical Abstract

Isolation of olean-12(13), 15 (16)-diene, olean-12(13), 15(16)-dien-3β-oland olean-15(16)-en-11α-ol from the pet-benzene extract of Psidiumguajava and their biocidal activity

Keywords

1. Altemimi A., Lakhssassi N., Baharlouei A., Dennis G., Watson D., David A., Lightfoot D., Plants, 2017, 6:42
2. Sasidharan S., Chen Y.  , Saravanan D., Sundram K.M., Latha L.Y., Afr. J. Tradit. Complement Altern. Med., 2011, 8:10
3. Newman D.J., Cragg G.M., J. nat.  prod., 2007, 3:354
4. Zhou X., Gong Z., Su Y., Linb J., Tang K., J. Pharm. Pharmacol., 2009, 61:291
5. Ghosh P., Mandal A., Ghosh J., Pal C., Nanda A.K.,  J. Asian Nat. Prod. Res., 2012, 14:153
6. Kommera H, Liuderavic G.N., Kalbitz J., Paschke R., Arch Pharm. Chem. Life Sci., 2010, 8:457
7. Krasutsky P.A., Nat. Prod. Rep., 2006, 23:942
8. Kvasnica M., Sarek J., Klinotova E., Dzubakb P., Hajduch M., Bioorg. Med. Chem., 2005, 13:3447
9. Kim Y.K., Yoon S.K., Ryu S.Y., Planta Med., 2000, 66:486
10. Schmidt M.L., Kuzmanoff K.L., Ling-Indeck L., Pezzuto J.M., Eur. J. Cancer , 1997, 33:2010
11. Fulda S., Jeremias I., Pietsch T., Debatin K.M., Int. J. Cancer, 1999, 82:441
12. Hata K., Hori K., Ogasawara H, Takahashi S., Toxicol. Lett., 2003, 143:7
13. Reyes C.P., Nunez M.J., Jime´nez I.A.  , Busserolles J., Alcaraz M.J., Bazzocchi I.L., Bioorg. Med. Chem., 2006, 14:1579
14. Lee K.H, J. Nat. Prod., 2010, 73:516
15. Danz Z., Lai W., Qian K., Ho P., Lee K.H, Chen C.H, Huang L., J. Med. Chem., 2009, 52:7887
16. Genet C., Strehle A., Schimdt C., Boudjelal G., Lobstein A., Schoonjans A., Souchet M., Auwerx J., Wagner A., J. Med. Chem., 2010, 53:190
17. Mathers M., Colin D., Boschi-Pinto C., Lopez A.D., Murray C.J.L., Cancer incidence, mortality and survival by site for 14 regions of the world, Global programme on evidence for health policy discussion paper no. 13, (World Health Organization,), 2001
18. Wu Q., He J., Fang J., Hong M., Huazhong J., Univ. Sci. Technol. (Med. Sci.), 2010, 30:457
19. Steller H, Science, 1995, 267:1449
20. Mar A.A., Koohang A., Majewski N.D., Szotek E.L., Eiznhamer D.A., Flavin M.T., Xu Z.Q., Chin. Chem. Lett., 2009, 20:1144
21. Mutaia C., Abatisa D., Vagiasa C., Moreauc D., Roussakisc C., Roussisa V.  , Phytochemistry, 2004, 65:1159
22. Chen I.H, Du Y.C., Lu M.C., Lin A.S., Hsieh P.W., Wu C.C.,  Chen S.L., Yen HF., Chang F.R., Wu Y.C., J. Nat. Prod., 2008, 71:1357
23. Pradhan B.P., Ghosh P., Chakraborty S., Ind. J. Chem., 1991, 30B:553
24. Carruthers W., Modern methods ohorganic synthesis. Cambridge University Press, Cambridge: UK, 2004, 384
25. Mckillop A., Young D.W., Synthesis, 1979, 11:422
26. Santos R.C., Salvador J.A., Marin S., Cascante M., Bioorg. Med. Chem., 2009, 17:6250
27. Yili A., Aisa HA., Isaev M.I., Chem. Nat. Compd., 2009, 45:594
28. Burns D., Reynolds W.F., Buchanan G., Reese P.B., Enriquez R.G., Magn. Reson.Chem., 2000, 38:493
29. Newman D.J., Cragg G.M., J. Nat. Prod., 2007, 70:477
30. Gransalke K., Lab Times, 2011, 11:16
31. Basnet D., Chiu P.F., Kalikotay S., Chhetri G., Parajuli S., Chhetri D.R., Current status of ethnomedicinal plants in the Darjeeling Himalaya. Current Science (India), 2005
32. Ghosh P., Mandal A., Chakraborty P., Rasul M.G., Chakraborty M., Saha A., Indian J. Pharm. Sci.,2010, 72:507
33. Prajapati N.D., Purohit S.S., Sharma A.K., Kumar T., Medicinal plants. Agrobios published company, 3rd edition, India, 2003,353
34. Prajapati N.D., Kumar U.. Agro’s dictionary of medicinal plants. Jodhpur: Agro bios, 2003
35. Krishnamurti A., The Wealth of India. New Delhi: Publication and Information Directorate, 1969, 8:293
36. Perry M.L., Medicinal Plants of East and south East Asia. Cambridge: MIT Press, 1980 285
37. Begum S., Hasan S.I., Ali S.N., Siddiqui B.S., Nat. Prod. Res., 2004, 18:140
38. Jairaj P., Khoohaswan P., Wongkrajang Y., Peungvicha P., Suriyawong P., Saraya M.L., Ruangsomboon O., J. Ethnopharmaco, 1999, 67:212
39. Jairaj P., Wongkrajang Y., Thongpraditchote S., Peungvicha P., Bunyapraphatsara N., Opartkiattikul N., Phytother. Res., 2000, 14:391
40. Lozoya X., Bercerril G., Martinez M., Arch Invest. Med. (Mex), 1990, 21:162
41. Pradhan B.P., Mukherjee M.M., Chakravarti D.K., Shoolery J.N., Tetrahedran, 1983, 39:2819
42.  Ghosh P., Mandal A., Chakraborty P., Rasul M.G., Chakraborty M., Saha A.,  Indian J. Pharm. Sci., 2010, 72:507
43. Portillo A., Vila R., J. Ethnopharmacol., 2005, 97:52
44. Eloff J.N., J. Ethnopharmacol., 1998, 67:360