Recently, nanoparticles have attracted much attention owing to their potential in biomedical applications, such as drug delivery systems, sustained release and controlled release. Various nanocarriers have been employed to ameliorate the efficacy and cytotoxicity of drugs, reducing their side effects through changing their pharmacokinetic properties. A simple and well-known model of pharmaceutical carriers is the layered zinc hydroxide (LZH) compound. In the present research, salicylic acid (Sal)-loaded LZH was synthesized using the ion-exchange method. The resulted nanohybrid (Sal-LZH) was characterized using the PXRD, FT-IR spectroscopy, STA analysis, BET, and SEM. Sal anions were intercalated into the interlayer gallery space of LZH, leading to different drug releases at pH 4.8 and 7.4. It was found that, the release of Sal anions from the synthetic nanohybrid occurred in a controlled manner, and the resulting material is suitable for use as a controlled-release formulation for various kinds of anti-inflammatory agent.