Journal of Medicinal and Chemical Sciences

Tofacitinib in Pharmaceutical Solid Dosage from Dissolution Study: Development and Validation of RP-HPLC Method

Krishna Prasad Narapereddy; Devi Sravanthi Alladi

Volume 6, Issue 9 , September 2023, , Pages 2218-2227

https://doi.org/10.26655/JMCHEMSCI.2023.9.26

Abstract

A simple, sensitive, precise, and accurate reversed phase high performance liquid chromatographic (RP-HPLC) method has been developed for the dissolution study of Tofacitinib in Tofacitinib ... Read More

Demographic Characteristics, Clinical Features, Laboratory, and Radiological Findings in Children Admitted to COVID19 Center in Amara City, Misan Province, Iraq

Eman Khammas AlSaadi; Mohammed A. Darweesh; Hussain Fadel Al Jawadi; Mohammed Abdul-Mounther Othman

Volume 6, Issue 1 , January 2023, , Pages 34-43

https://doi.org/10.26655/JMCHEMSCI.2023.1.5

Abstract

Background:Most pediatric patients with covid 19 had mild to moderate infection and some had severe challenging infection. Generally, they had variable signs and symptoms, laboratory, ... Read More Background:Most pediatric patients with covid 19 had mild to moderate infection and some had severe challenging infection. Generally, they had variable signs and symptoms, laboratory, and radiological findings correlated with the patient age, the involved system, disease severity and probably any underlying disease.Aim:To identify the most common clinical features, the frequency of positive radiological findings, and laboratory results of the infected children hospitalized in Misan COVID-19 Center.Materials and method:A retrospective descriptive with some analytic study applied on 100 pediatric patients in the age range of (0-16) years, diagnosed with COVID-19 or were highly suspected cases, depending on clinical findings, laboratory tests, COVID-19 RT-PCR and/or chest (X-ray + CT), whom were admitted to the Pediatric Covid -19 Center in Amara City, Iraq during the time period of (February-June, 2021). Their medical records were reviewed for demographic information, (gender, age, and residence), medical history, clinical examination, laboratory and imaging studies, (X-ray + CT), O saturation, the duration of illness before admission of any underlying chronic diseases as well as the most common presenting signs and symptoms.Results:Children infected slightly more in the age range of (5-10 years), boys slightly more infected than girls as (54%) and (46%), respectively. The urban residents suffered more than the rural ones, 4% of all cases had low O2 saturation. Fever and malaise were the most common presenting symptoms as (93%) and (68%), respectively. The illness duration before hospitalization commonly was (<5days), (RT-PCR) was negative in 45% of patients, 54% had anemia with or without leukopenia and lymphopenia, CTs were positive in (62%) and CXR was positive in (53%), while the underlying chronic diseases were found in (23%) of the cases.Conclusion: Children of ages between (5-<10 years) were slightly more infected than others, fever, malaise, and cough were the most common manifestations, the urban predominance is high, and half of patients had anemia about one third and had lymphopenia. Likewise, one forth had thrombocytopenia, negative Covid-19 (RT-PCR), and/or CXR. The CT results did not exclude infection. Thus, we need further local studies to support our results.

Microcapsules of Protein-Polysaccharide Complexes Produced on a Variety of Matrices

Ali L Alfalluji; Fadhel Omran Essa

Volume 6, Issue 9 , September 2023, , Pages 2228-2233

https://doi.org/10.26655/JMCHEMSCI.2023.9.27

Abstract

In this work, the chance of the microcapsules development by layer-by-layer adsorption of biopolyelectrolytes was investigated on the cores of inorganic (particles CaCO3) and polymer ... Read More

Could Mean Platelet Volume Differentiate Acute Coronary Syndrome (ACS) Types?

Seyed Amir Masoud Hashemian; Javad Ramezani; Mohammad Ali Ahmadian; Maliheh Ziaee; Mohammad Davood Sharifi; Hamid Zamani Moghadam; Roohie Farzaneh; Fatemeh Maleki; Mahdi Foroughian

Volume 6, Issue 1 , January 2023, , Pages 44-54

https://doi.org/10.26655/JMCHEMSCI.2023.1.6

Abstract

Introduction: Evaluation of platelet volume indices is proposed by literature in predicting and differentiating coronary diseases. Therefore, this study aimed to compare the mean number ... Read More

Evaluation of Relationship between Serum Hemoglobin A1C Level and Severity of Diabetic Foot Ulcers Based on Wagner Criteria

Alireza Ghanbari; Majid Nouri; Mohammad Darvishi

Volume 6, Issue 9 , September 2023, , Pages 2234-2241

https://doi.org/10.26655/JMCHEMSCI.2023.9.28

Abstract

Introduction: One of the important risk factors for diabetic patients, including foot ulcers, is lack of blood sugar control, the standard criterion for which in the long run is the ... Read More

Vitamin D in Mild to Moderate COVID-19: A Retrospective Cross-Sectional Study

Reza Sahraeai; Farhang Hooshmand; Mojtaba Ghaedi; Shahram Shafa; Fatemeh Eftekharian; Samira Farrokhi

Volume 6, Issue 1 , January 2023, , Pages 55-61

https://doi.org/10.26655/JMCHEMSCI.2023.1.7

Abstract

Background: Vitamin D linkage with COVID-19 is investigated in many studies, but there is still no single summation. Thus, this study aimed to evaluate the relationship between Vitamin ... Read More

Antimicrobial and Antioxidant Activity of Heterocyclic Compounds Derived from New Chalcones

Raed Muslim Mhaibes

Volume 6, Issue 4 , April 2023, , Pages 931-937

https://doi.org/10.26655/JMCHEMSCI.2023.4.25

Abstract

In this study, new Chalcones was prepared from reaction of 4-hydroxy acetophenone with different aldehydes in a basic medium, then new pyrimidine derivatives were synthesized from reaction ... Read More

Effects of Dietary Supplements and Anabolic Hormones on Hematological and Biochemical Parameters among Young Bodybuilders in Kurdistan Region of Iraq

Saman Sulaiman; Safin Hussein; Karzan Qurbani; Kale Husen; Shara Rasul; Avesta Mustafa

Volume 6, Issue 9 , September 2023, , Pages 2242-2248

https://doi.org/10.26655/JMCHEMSCI.2023.9.29

Abstract

Athletes and bodybuilders frequently utilize vitamins and anabolic hormones. Utilizing these substances, gymgoers can achieve their goals faster by consuming a combination of supplements ... Read More

A Core-extended Pyromellitic Diimide as A p-Channel Semiconductor

Ahmed Khudhair Kadhim; Muna Ismael Khalaf

Volume 6, Issue 1 , January 2023, , Pages 62-70

https://doi.org/10.26655/JMCHEMSCI.2023.1.8

Abstract

New π-conjugated system compounds were synthesized by pyromellitic diimide core coupled with side chain containing 1,2,4-triazole rings. The new compounds were characterized by some ... Read More

Moral Distress, COVID-19, and Healthcare Workers, a Systematic Review and Meta-Synthesis: Solutions by JUMS Clinical Decision-making Scheme

Marzieh Haghbeen; Hossein Hakimelahi; Mansour Tafvizi; Naser Hatami; Navid Kalani; Lotfollah Dezhkam

Volume 6, Issue 1 , January 2023, , Pages 71-78

https://doi.org/10.26655/JMCHEMSCI.2023.1.9

Abstract

Background: Although studies are conducted on moral distress during the COVID-19 period, those being conducted by using various methods of moral distress assessment, the majority of ... Read More

Extreme Hypertension Associated with SARS-COVID-19 Infection in Pediatrics with Kidney Disease: A Retrospective Observational Study

Masoud Hashemzadeh Esfahani; Behzad Haghighi Aski; Ali Manafi Anari; Golnaz Gharehbaghi; Maryam Sakhaei; Eslam Shorafa; Nakysa Hooman

Volume 6, Issue 1 , January 2023, , Pages 79-85

https://doi.org/10.26655/JMCHEMSCI.2023.1.10

Abstract

Introduction: There are no reports of hypertensive emergency as a manifestation or comorbidity of the COVID-19 infection in pediatric patients.Method: In this retrospective observational ... Read More

Hypothyroidism Risk and Its Correlation to Metabolic Parameters

Mahmood Hasen Shuhata Alubiady

Volume 6, Issue 1 , January 2023, , Pages 86-92

https://doi.org/10.26655/JMCHEMSCI.2023.1.11

Abstract

Hypothyroidism has become more prevalent in recent years. This rise might be attributed to changes in the metabolic features of the individuals. The goal of this study was to see if ... Read More

The Effects of Celery (Apium graveolens L.) Extract on Some Biochemical Parameters in Rats That Consume a Concentrated Feed

Sudad Jasim Mohammed; Adil Turki Al-Musawi; Raafat A. Abu-Almaaly

Volume 6, Issue 1 , January 2023, , Pages 93-97

https://doi.org/10.26655/JMCHEMSCI.2023.1.12

Abstract

The purpose of this study was to examine the liver function effects of aqueous celery extracts on liver function tests and lipid profile in rats. A total of forty rats were split into ... Read More

Comparative Study of Histological and Histomorphometric Changes between Amitriptyline and Escitalopram in Testis and Epididymis of Male Mice

Israa Abdulameer Naeem; Ali Ali Khalaf

Volume 6, Issue 1 , January 2023, , Pages 98-111

https://doi.org/10.26655/JMCHEMSCI.2023.1.13

Abstract

The study aimed to discover the effect of Amitriptyline and Escitalopram on body weight and their effects on tissues of the testis and epididymis. These drugs were hypothesized to affect ... Read More

Three Little-known Medicinal Plants Growing in the State National Natural Park "Tarbagatai" (Republic of Kazakhstan): Their Ethnobotany, Phytochemistry, and Pharmacology

Baltabay Bekbolat Saparbayuly; Abilkassymova Alima Maratkyzy; Majitova Mariyam Akhiyatkyzy; Satmbekova Dinara Kanatovna; Datkhayev Ubaidilla Makhambetovich; Sarsenova Lazzat Kadyrgaliyevna

Volume 6, Issue 1 , January 2023, , Pages 112-120

https://doi.org/10.26655/JMCHEMSCI.2023.1.14

Abstract

The review article presents the results of studying plants growing on the territory of the State National Natural Park Tarbagatai, on the basis of which it will be possible to develop ... Read More The review article presents the results of studying plants growing on the territory of the State National Natural Park Tarbagatai, on the basis of which it will be possible to develop new medicines. In recent years, the popularity of herbal medicine, despite a great success in the creation of chemical drugs, has been growing. Interest in natural healing substances and drugs created on their basis is increasing due to both the unique properties of herbal remedies and rapidly developing research technologies in biology, medicine, and the production of drugs. The analysis and structuring of literature sources contain some information about herbal medicines, such as Corydalis ledebouriana Kar. et Kir., Malus sieversii, and Daphne altaica Pall. were carried out. They were grown in Asian countries, mainly in China and Kazakhstan. Many Corydalis species are rich in alkaloids that have a positive effect on the central nervous, digestive, cardiovascular, and pituitary-adrenal systems. Malus sieversii has a high antioxidant activity, it can inhibit cancer cell proliferation, reduce lipid oxidation, and lower cholesterol levels according to in vitro studies of animals, which may explain their roles in reducing the risk of chronic diseases. Daphne have a wide range of pharmacological activity, including anticancer, anti-inflammatory, anti-HIV, hypocholesterolemic, neurotrophic, anti-fertile, skin irritant, nematocidal activity, and pesticide activity. Phytopreparations have some advantages such as low toxicity with sufficiently high efficiency, a wide range of therapeutic action, complex organ protective effect, harmonizing effect on all organs and systems of the body, the minimum number of side effects, relative cheapness compared to synthetic drugs, and the possibility of cooking at home. Phytotherapy has some applications such as primary and secondary preventions of various diseases, health improvement, and rehabilitation of the general population under the influence of negative environmental factors, as a means of increasing the adaptive reserves of a healthy body in sports medicine.

Synthesis, Characterization and Thermal Study of Some New Metal Ions Complexes with a New Azo 2-((2-(1H-Indol-2-yl)ethyl)diazinyl)-5-aminophenol

Myasim Qasim Abdulridha; Abbas Ali Salih Al-Hamdani; Waleed Ali Mahmoud

Volume 6, Issue 1 , January 2023, , Pages 121-131

https://doi.org/10.26655/JMCHEMSCI.2023.1.15

Abstract

This research includes the preparation of a new azo 2-((2-(1H-indol-2-yl)ethyl)diazinyl)-5-aminophenol, in which the diazonium salt of 2(1H– Indole–3yl)- ethylamine reacts ... Read More

Synthesis, Characterization, and Anti-parasitic Activity Evaluation of the Synthesized Chalcone against Toxoplasma Gondii Isolated from Cases of Abortion in Al-Najaf City

Muna Hashim Ghazzay; Samer Ali Hasan; Oun Deli Khudhair; Khalida Kadhim Abbas Al-Kelaby; Emad Sadiq Ali Al-Hilli

Volume 6, Issue 1 , January 2023, , Pages 132-141

https://doi.org/10.26655/JMCHEMSCI.2023.1.16

Abstract

Toxoplasmosis is a well-known and widespread parasite infection. Although diagnosis has come a long way, therapeutic approaches have not changed since the 1940s. Using SOCl2/EtOH as ... Read More

Prognostic Value of Immune Checkpoints in Prostate Cancer: A Systematic Review and Meta-Analysis of Reconstructed Time to Event Data

Hossein Hakimelahi; Alireza Yousefi; Marzieh Haghbeen; Mohammad Sadegh Sanie Jahromi; Hasan Zabetian; Reza Inaloo

Volume 6, Issue 1 , January 2023, , Pages 142-151

https://doi.org/10.26655/JMCHEMSCI.2023.1.17

Abstract

Introduction: Various molecular pathways are proposed to predict the prognosis of prostate cancer. However, due to previous achievements in prostate cancer management by immune checkpoint ... Read More

Modification, Preparation, and Characterization, Low-Cost Hydrogel Nano/Micro Composite: Regeneration and Isotherm Models

Zainab D. Alhattab; Aseel M. Aljeboree

Volume 6, Issue 1 , January 2023, , Pages 152-159

https://doi.org/10.26655/JMCHEMSCI.2023.1.18

Abstract

In this paper, a new method was used to prepare the SA-g-(PAA-co-AM)/CdS, which is an environmentally friendly, inexpensive, available, and highly efficient absorbent material in the ... Read More

Periodontitis Therapy with Periodontal-derived Stem Cells (PDSCs) for Dental Tissue Regeneration

Mukhalled Salim Alasady; Abd El Hadi Kanj; Amer Kanj

Volume 6, Issue 1 , January 2023, , Pages 160-167

https://doi.org/10.26655/JMCHEMSCI.2023.1.19

Abstract

Periodontitis is a severe gum infection that can lead to tooth loss and other serious health complications. Periodontal ligament stem cells (PDLSCs), which reside in the perivascular ... Read More

Correlation between Placental Thickness and Estimated Fetal Weight in Women with Hypertension in Third Trimester: A Case Control Study

Nawar Yousif Noori Alsaegh; Ban J. Edan; Zinah Hammad

Volume 6, Issue 1 , January 2023, , Pages 168-176

https://doi.org/10.26655/JMCHEMSCI.2023.1.20

Abstract

Pregnancy-induced hypertension (PIH) as a rapid consequence of gestation consists of gestational hypertension. In this study, we decided to inspect the association between the placental ... Read More

Corona Virus and Salt Intake

Hossein Kheirandish

Volume 4, Issue 1 , January 2021, , Pages 1-7

https://doi.org/10.26655/JMCHEMSCI.2021.1.1

Abstract

Coronavirus is one of the main pathogens that targets the human respiratory system in the first place and since common treatments for coronavirus, including hydroxychloroquine are mostly ... Read More

Silica Supported 1-(2-(Sulfooxy)ethyl)pyridin-1-ium Chloride (SiO2/[SEP]Cl) as an Efficient and Solid Acid Catalyst for the Synthesis of Quinoxaline Derivatives

Sami Sajjadifar; Ghobad Mansouri; Issa Amini; Maryam Yari

Volume 4, Issue 1 , January 2021, , Pages 8-16

https://doi.org/10.26655/JMCHEMSCI.2021.1.2

Abstract

Silica supported 1-(2-(sulfooxy)ethyl)pyridin-1-ium chloride has been explored as highly efficient catalyst for reactions under mild and green conditions for the synthesis of quinoxaline ... Read More

Stability Indicating Planar Chromatographic method for Estimation of Minoxidil and Finasteride Combination used in the treatment of Hair loss

Jay Patel; Jinal Tandel; Usmangani Chhalotiya; Kirtan Patel

Volume 4, Issue 1 , January 2021, , Pages 17-28

https://doi.org/10.26655/JMCHEMSCI.2021.1.3

Abstract

Alopecia areata is a typical non-scarring alopecia that happens in 0.1-0.2% of everybody and records for 0.7-3% of all cases found in dermatology practice. A vital quantitative examination ... Read More

Genetic Detection of Some Bacterial Species Associated with Bovine Keratoconjunctivitis Infections in Basra Governorate

Nawres N. Jaber; Moaed H. Sayhood; Nada Salih Hadi; Basil A. Abbas; Noor Amjad Kazem

Volume 5, Issue 1 , January and February 2022, , Pages 19-26

https://doi.org/10.26655/JMCHEMSCI.2022.1.3

Abstract

Veterinary chemicals are pharmaceuticals or treatments that are used in cattle to treat or prevent disease, injury, and pests. Livestock survival and productivity would be severely ... Read More

Volume 7 (2024)

Volume 6 (2023)

Volume 5 (2022)

Volume 4 (2021)

Volume 3 (2020)

Volume 2 (2019)

Volume 1 (2018)

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