Journal of Medicinal and Chemical Sciences

Original Article

Perineural Invasion in Salivary Gland Carcinomas in Relation to Tumor Grade and Histological Subtypes

Alyaa Kadhim Mohammed; Ban Al-Drobie; Bashar H. Abdullah

Volume 6, Issue 7 , July 2023, Pages 1469-1486

https://doi.org/10.26655/JMCHEMSCI.2023.7.1

Abstract

Objectives: Perineural invasion (PNI) in salivary gland carcinomas is a worrying condition that permits tumor cells to travel into and along nerves. The aim of this study was to examine ... Read More

Original Article

Effect of CO2 Laser and Selected Nanoparticles on The Microhardness of Human Dental Enamel In vitro Study

Farah Abdul_Razzak Mahmood Al_Bazaz; Nada Jafer MH. Radhi; Kadhim A. Hubeatir; Maha Waleed Alghazali

Volume 6, Issue 7 , July 2023, Pages 1487-1497

https://doi.org/10.26655/JMCHEMSCI.2023.7.2

Abstract

Lasers have been tested with positive findings for the suppression of incipient caries, and many theories have been offered for this phenomenon. Nevertheless, early caries lesion prevention ... Read More Lasers have been tested with positive findings for the suppression of incipient caries, and many theories have been offered for this phenomenon. Nevertheless, early caries lesion prevention and biomimetic treatment are still difficulties despite massive efforts to promote dental hygiene. Nanoparticles' exceptional qualities make them a promising biomaterial for a variety of medical and dental uses. There are a lot of exciting and promising uses for nanotechnology in the field of tissue repair and replacement, especially in dental mineralized tissues, thanks to the growing interest in this area. This research aimed to examine how certain nanoparticles and CO2 laser radiation affected the microhardness of enamel. In order to conduct the microhardness test, 80 first premolars from the maxilla were randomly split into eight groups, one control group and seven study groups, each containing ten teeth. Each tooth’s buccal (cheeky) side was standardized to have a circular window placed there, measuring 6 mm in diameter. The exposure period was 5 seconds in continuous wave (CW) mode, and the laser power was calculated to be 0.85 W using a unique equation. The concentration of the hydroxyapatite nanoparticles solution employed was 10%, whereas the concentration of the iron oxide nanoparticles solution was 12.5%. In this study, we evaluated the effects of certain agents on the microhardness of enamel before and after inducing a caries lesion by pH cycling techniques. Hardness variation was determined for each sample using a tailored equation. After demineralization, enamel microhardness values were found to be significantly lower across the board compared to healthy teeth’ microhardness values. This was the case across all groups. After treatment with certain agents, there was a marked increase in enamel microhardness values for all groups, with a statistically highly significant difference (p<0.001). The groups treated with laser followed by hydroxyl apatite nanoparticles (HANPs) and those treated with laser followed by iron oxide nanoparticles (IONPs) saw the greatest increases in their microhardness values. Treatment of teeth samples with laser followed by iron oxide nanoparticles (IONPs) induced the greatest change in enamel microhardness, while treatment of teeth samples with IONPs resulted in the lowest change in enamel microhardness compared to all of the other agents. As a potential preventative intervention against dental cavities, enamel treatment with CO2 laser, hydroxyapatite, and iron oxide nanoparticles might be examined.

Original Article

Potential Role of Selenium to Ameliorate Doxorubicin Induced Cardiotoxicity in Male Rats

Rusul Nadheer Albakaa; Fadhil A. Rizij; Rafid M. Ali Hassan

Volume 6, Issue 7 , July 2023, Pages 1498-1505

https://doi.org/10.26655/JMCHEMSCI.2023.7.3

Abstract

Abstract: Selenium (SE) is well known for its immune boosting, antioxidant, and anti-tumor properties. Doxorubicin (DOXO), a commonly used chemotherapy drug, causes cardiac-damage by ... Read More Abstract: Selenium (SE) is well known for its immune boosting, antioxidant, and anti-tumor properties. Doxorubicin (DOXO), a commonly used chemotherapy drug, causes cardiac-damage by increasing the level of reactive oxygen species (ROS). Selenium (SE) is well known for its immune boosting, antioxidant, and anti-tumor properties. Doxorubicin (DOXO), a commonly used chemotherapy drug, causes cardiac-damage by increasing the level of reactive oxygen species (ROS). SE has been shown to improve heart development dysregulation, CMY structural damage, antioxidant enzyme (GSH, and SOD) activity, and caspase-3 (CASP3) levels in the cardiac tissue. Furthermore, SE could reduce the inflammation marker, ICAM-1 activity, and cardiotoxicity marker levels in the serum, cTn-1 serum levels. Finally, SE may protect against cardiotoxicity by inhibiting the oxidative induced by doxorubicin.Objectives: The aim of the study is to investigate if selenium has protective role against the cardiotoxicity induced by DOXO in laboratory rats.Method: A total of 32 male rats were used, and they were randomly divided into 4-groups (8 rats * in each group). The rats in the control group started drinking distilled water for the experiment period. Rats in the doxorubicin group (the induced group) were given 2.5 MG/KG three times per wek, continue for 2-weeks. The second group was treated with SE only had SE administered at a dose of 1 mg/kg, continue for 2-weeks. Results: Doxorubicin induced cardiotoxicity, as shown by a significant increase (~P < 0.001) in the levels of cTnI, ICAM-1, and caspase-3. At the same time, the levels of GSH and SOD when compared to the control group, were significantly reduced (P < 0.001) in the cardiac tissues of rats in the doxorubicin treated group. Histological changes and lesions were also caused by the Doxo. The administration of selenium was found to reduce cardiotoxicity, this can be proved by significant-decreases (p* < 0.001) in cardiac-TnI, ICAM-1, casp-3 and significant-increases (~P < 0.001) in SOD and GSH when compared to the DOXO group; and significant improvements (~P < 0.001) in the score for cardiomyopathy histopathological lesions.Conclusion: At the drugs-doses used in this study, selenium protected the hearts of rats from DOXO-induced cardiotoxicity. This is may related to the interfered and may ameloirate oxidative stress, inflammation, and the apoptotic pathway.

Original Article

Effect of Different Concentrations of Molybdenum on Dental Enamel Microhardness, An In Vitro Study

Raad Salih Al-Ani; Mustafa Jalal Abdul-Hadi Alsaifi; Hiba Kareem; Ali Alsaffar

Volume 6, Issue 7 , July 2023, Pages 1506-1516

https://doi.org/10.26655/JMCHEMSCI.2023.7.4

Abstract

Introduction: Molybdenum is an essential trace element with several biological functions and therapeutic uses, and reported to have a cariostatic effect and is suggested as one of the ... Read More

Original Article

Development of a Bilayer Mutual Tablet of Candesartan and Pioglitazone for Diabetic-Hypertensive Patients

Kola Hephzibah; Sangeetha Shanmugasundaram

Volume 6, Issue 7 , July 2023, Pages 1517-1536

https://doi.org/10.26655/JMCHEMSCI.2023.7.5

Abstract

Background: Diabetes and hypertension are related illnesses that often coexist. Angiotensin receptor blockers like candesartan are typically used to treat Hypertension. A thiazolidinedione-type ... Read More

Original Article

Synthesis, Characterization and Study Biological Activity of Some 1,2,4-Triazin Heterocyclic Derivatives

Safaa Thamer Ahmed; Shireen R. Rasool

Volume 6, Issue 7 , July 2023, Pages 1537-1547

https://doi.org/10.26655/JMCHEMSCI.2023.7.6

Abstract

A series of some new heterocyclic compounds containing triazin derivatives have been synthesized in many steps sequence. Triazine derivatives were prepared through reacting benzil with ... Read More

Original Article

Cancer in Maysan: Mortality, Pattern, and Demographic Characteristics during the Last 4 Decades

Sadiq Musa Ahmed; Hmood Madhi Hasan

Volume 6, Issue 7 , July 2023, Pages 1548-1554

https://doi.org/10.26655/JMCHEMSCI.2023.7.7

Abstract

Cancer is considered as one of the serious diseases recognized by the abnormal cells division which can be invading normal cells and tissues. People can be affected by cancer at any ... Read More

Original Article

Preparation, Characterization, and Biological Study of New Halogenated Azo-Schiff Base Ligands and Their Complexes

Dhekra J. Hashim; Saad M. Mahdi

Volume 6, Issue 7 , July 2023, Pages 1555-1576

https://doi.org/10.26655/JMCHEMSCI.2023.7.8

Abstract

Three of new azo-Schiff base ligands were prepared in this work via the preparation of Schiff base ((E)-2-(((2,5-dichlorophenyl)imino)methyl)phenol DCSS) produced from the condensation ... Read More Three of new azo-Schiff base ligands were prepared in this work via the preparation of Schiff base ((E)-2-(((2,5-dichlorophenyl)imino)methyl)phenol DCSS) produced from the condensation reaction between salicyaldehyde and (2,5-dichloroaniline), this Schiff base was regarded as a coupling component in azo reactions to form the new azo-Schiff ligands [(2-((E)-((2,5-dichlorophenyl)imino)methyl)-4-((E)-(2,4-difluorophenyl)diazenyl)phenol) L1, (4-((E)-(4-chloro-2-fluorophenyl)diazenyl)-2-((E)-((2,5-dichlorophenyl)imino)methyl)phenol) L2, and (4-((E)-(4-bromo-2-fluorophenyl)diazenyl)-2-((E)-((2,5-dichlorophenyl) imino)methyl) phenol) L3], respectively, via the reaction of the diazonium salts of the (2,5-difluoroaniline, 4-chloro-2-fluoroaniline and 4-bromo-2-fluoroaniline) with the previous Schiff base (DCSS). These new Azo-Schiff ligands were characterized with many spectroscopic techniques such as (FT-IR, 1H-NMR, Mass spectra, UV-Visible, and elementary analysis) to ensure their preparation. Five divalent transition ions (Co, Ni, Cu, Pd, and Pt) complexes were prepared for each ligand and characterized (some of them) with the previous techniques, the mole ratio of the cobalt and copper complexes was (1:2), while the rest (Ni, Pd, and Pt) complexes have a (1:1) ratios. In addition, complementary techniques, such as atomic absorption, molar electrical conductivity, and magnetic susceptibility were performed to deduce their geometries and form the collected data. The square planer geometry was examined. The biological study includes the antibacterial screening against two types of bacterial species gram-negative (E.coli) and gram-positive (S. aureus) using tetracycline as a reference antibiotic. Antioxidant assay of some of the prepared ligands and their complexes as well as an MC7 cell line breast cancer assay for two prepared complexes (PdL1 and PtL2) and as compared, they noticed that the platinum azo-Schiff complex has an IC50 = 56.78 a more active anticancer function than the palladium complex with IC50 = 74.64.

Original Article

The Role of Neuregulin 4 Status in Female’s Primary Infertility Patients

Mustafa Saleam Khalaf; Zeena A. Alsaady

Volume 6, Issue 7 , July 2023, Pages 1577-1581

https://doi.org/10.26655/JMCHEMSCI.2023.7.9

Abstract

Background: Female’s primary infertility (FPI) is females who have not pregnant after one year of sexual intercourse without using methods of birth control. Neuregulin 4 (NRG4) ... Read More

Original Article

Impact of RAGE Gene rs80096349(C>T), rs1035798(C>T), and rs184003(G>T) Polymorphisms on Non-Response to Aspirin in Iraqi Patients with Coronary Artery Disease

Faleh A Khudhair; Shatha H Ali; Khalil A Al-Zubeidi

Volume 6, Issue 7 , July 2023, Pages 1582-1597

https://doi.org/10.26655/JMCHEMSCI.2023.7.10

Abstract

Background: Transmembrane multiligand receptor RAGE is a protein found on the surface of cells that binds to the advanced glycation end products. Platelet cyclooxygenase activity is ... Read More Background: Transmembrane multiligand receptor RAGE is a protein found on the surface of cells that binds to the advanced glycation end products. Platelet cyclooxygenase activity is elevated in response to RAGE activation, contributing to the formation of a thrombus.Objectives: To examine the connection between RAGE gene rs80096349(C>T), rs1035798(C>T), and rs184003(G>T) polymorphisms and resistance to aspirin in CAD patients from Iraq.Patients and methods: Patients with coronary artery disease (CAD) (161 males and 64 females) were enrolled in the trial between February 2021 and October 2021. All participants were taking prophylactic Aspirin (100 mg). The control group consisted of 130 individuals, including 97 males and 33 females, who appeared to be in good health and were not taking aspirin. Serum thromboxane B2 levels were used to assess the effectiveness of aspirin (TBX2). Patients were classified as either aspirin sensitive or resistant. The polymorphism of RAGE's most closely related single nucleotide polymorphisms (SNPs) was identified using polymerase chain reaction for amplification of the extracted deoxyribonucleic acid and Sanger's method of sequencing.Results: A total of 225 cardiovascular patients compatible with inclusion criteria were enrolled. There were 161(71.6%) male and 64(28.4%) female patients with a mean age of 56.85±8.11years old. The statistical analysis revealed 17.8% (n = 40) aspirin-resistant cases in the study population. Genotypic analysis of our data showed that participants with the T allele of rs184003(G/T) had an increased prevalence in the aspirin-resistant group compared with the aspirin-sensitive group (p<0.05). In contrast, for rs10835798, the frequency was dramatically higher for T alleles in aspirin sensitive group contrasted with the resistant group (p<0.05). The aspirin-resistant group was found to have significantly greater RAGE levels than the sensitive group.Conclusion: Our results provide evidence that RAGE expression and gene rs1035798(C>T), and rs184003(G>T) polymorphisms could be predictors for CAD patients' resistance to aspirin.

Original Article

Qsar and Docking Studies of New Triazolopiperazine Derivatives as Potent Hypoglycemic Candidates

Swarna Bharathi Kalli; Velmurugan Vadivel

Volume 6, Issue 7 , July 2023, Pages 1598-1613

https://doi.org/10.26655/JMCHEMSCI.2023.7.11

Abstract

Dipeptidyl peptidase 4 (DPP-4) inhibition is a promising therapy for type 2 diabetes. Inhibition of DPP-4 limits the breakdown of glucagon-like peptide 1 (GLP-1), hence increasing functional ... Read More

Original Article

The Effect of Addition Radish Oil on Some Mechanical Properties

Sadeq Aadi Rahi Al-Husseini; Wasmaa Sadik Mahmood

Volume 6, Issue 7 , July 2023, Pages 1614-1620

https://doi.org/10.26655/JMCHEMSCI.2023.7.12

Abstract

The objective of this study is to investigate the effects of radish oil on the transverse strength and surface roughness of polymethyl methacrylate. In this study, a total of sixty ... Read More

Original Article

Synthesis and Characterization with Antimicrobial Studies of mixed Curcumin Schiff Base –L-dopa with Divalent Cations Complexes

Hala Mohammed Salh; Taghreed H Al-Noor

Volume 6, Issue 7 , July 2023, Pages 1621-1630

https://doi.org/10.26655/JMCHEMSCI.2023.7.13

Abstract

In the present article, mixed ligand metal (II) complexes have been synthesized with Schiff base (1E, 5Z, 6E)-1,7 bis (4-hydroxy-3-methoxyphenyl)-5-(3-hydroxyphenyl) imino) hepta-1,6-dien-3-one ... Read More

Original Article

The Placebo and Laughter Therapy Efficacy on Pain Perception, Sleep Quality, and Post-traumatic Growth in Recovering Drug Abusers

Seyed Amir Omrani

Volume 6, Issue 7 , July 2023, Pages 1631-1645

https://doi.org/10.26655/JMCHEMSCI.2023.7.14

Abstract

This research was designed to study the efficacy of placebo and laughter therapy on pain perception, sleep quality, and post-traumatic growth in recovering drug abusers. Thus, among ... Read More This research was designed to study the efficacy of placebo and laughter therapy on pain perception, sleep quality, and post-traumatic growth in recovering drug abusers. Thus, among 1050 patients who had been referred to the Empowerment and Protection Center for Recovered of the Hamrahan Aftab of Sari City in Iran during the last 5 years (2016-2021) 60 recovered were randomly selected. This study was conducted with a quantitative structure in the form of an experimental design with pre-test-post-test and control in three experimental and control groups. Thus, 4 independent groups were selected by simple random assignment and each of them was exposed to placebo, laughter therapy, combination therapy, and neutral approaches (control group), respectively. Findings were presented in two descriptive and analytical sections: the descriptive section addressed the status of each variable in the statistical sample and in the analytical section, the relationship between the independent variables with each of the three dependent variables of the research, including pain perception, sleep quality, and post-traumatic growth, was measured. The statistical tests included univariate regression (to measure the simple relationship between independent and dependent variables) and T-test (comparing the effectiveness of variables). Findings demonstrated that each of the studied factors, placebo and laughter therapy, had an effect on all dependent variables of pain perception, sleep quality, and post-traumatic growth so that both of these factors (independently) reduce pain perception, increase sleep quality, and increase growth after injury. However, the T-test demonstrated that in all groups the effect of laughter therapy was higher than placebo (that is, laughter therapy has been able to reduce pain perception and increase sleep quality and post-injury growth in drug abuse recoveries more than placebo), which can pave the way for drug addiction treatment, life recovery afterward, and complete recovery: Laughter therapy is formed easier than placebo, has lower costs, and higher efficiency. Conclusively, findings were similar in the follow-up period (quarterly).

Original Article

The Effect of Silica Particles Derived from Rice Husk on Some Mechanical Properties of a High Impact Heat Cure Acrylic Resin

Azza Walaaldeen Khairi; Ghassan Abdul-Hamid Naji

Volume 6, Issue 7 , July 2023, Pages 1646-1659

https://doi.org/10.26655/JMCHEMSCI.2023.7.15

Abstract

Background: Despite the fact that the mechanical properties of PMMA appliances and goods are not ideal, the goal of this research was to reinforce high impact acrylic dentures with ... Read More

Original Article

Synthesis, Characterization, and Biological Activity of New Metal Ion Complexes with Schiff Base (Z)-3((E)-2-Hydroxybenzylidene) Hydrazineylidene) Indolin-2-One

Nuha Ayad Abd AL-Qadir; Naser Dheyaa Shaalan

Volume 6, Issue 7 , July 2023, Pages 1660-1674

https://doi.org/10.26655/JMCHEMSCI.2023.7.16

Abstract

The study involved preparing a new compound by combining between 2-hydroxybenzaldehyde and (Z)-3-hydrazineylideneindolin-2-one resulting in Schiff bases and metal ions: Mn(II), Co(II), ... Read More

Original Article

Detection of Some Biochemical Markers in Iraqi Osteoporosis Patients

Shaimaa Hussein Ali; Hussein Jasim Obaid Al-Harbi; Ali Mohammad Hussein Alqazzaz

Volume 6, Issue 7 , July 2023, Pages 1675-1683

https://doi.org/10.26655/JMCHEMSCI.2023.7.17

Abstract

Osteoporosis is not limited to women after menopause. It can also afflict men as well and is a hot issue. Men get osteoporotic fractures around ten years later in life than women, although ... Read More

Original Article

Evaluation of the Effect of Lemongrass Essential Oil on Candida Albicans Adhesion on Heat Cured Acrylic Based Soft Lining Material

Huda Jaafar Naser; Faiza M. Abdul-Ameer

Volume 6, Issue 7 , July 2023, Pages 1685-1695

https://doi.org/10.26655/JMCHEMSCI.2023.7.18

Abstract

Background: Microorganism buildup is one of the most critical issues encountered with soft denture liner materials. The buildup of the fungus Candida albicans results in a disease known ... Read More

Original Article

Effect of Phytosterols on Brain Development in Iodine Deficient Rat Model- A Comparative Study

Rashmi Chandra; Chaiti Ganguly

Volume 6, Issue 7 , July 2023, Pages 1696-1705

https://doi.org/10.26655/JMCHEMSCI.2023.7.19

Abstract

Iodine deficiency leads to insufficient production of thyroid hormone which may cause many harmful consequences in humans. Owing to the cumulative impact of maternal, prenatal, and ... Read More

Original Article

Molecular Detection of bla TEM and bla CTX-M Genes in Clinical and Food-Borne Klebsiella pneumoniae Isolates

Saif Jabbar ALzubaidi; Marwa Hameed Alkhafaji

Volume 6, Issue 7 , July 2023, Pages 1706-1713

https://doi.org/10.26655/JMCHEMSCI.2023.7.20

Abstract

To isolate Klebsiella pneumoniae, two hundred clinical and food samples were cultivated on differential and selective culture media. 120 bacterial isolates were isolated from ... Read More

Volume 7 (2024)

Volume 6 (2023)

Volume 5 (2022)

Volume 4 (2021)

Volume 3 (2020)

Volume 2 (2019)

Volume 1 (2018)

Volume & Issue: Volume 6, Issue 7, July 2023, Pages 1469-1713

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