Document Type : Original Article
1 Medicinal Organic Chemistry Laboratory (MOCL), School of Pharmacy, Faculté des Sciences de la Santé, Universitéd'Abomey-Calavi, Campus du Champ de Foire, 01 BP 188, Cotonou, Bénin
2 Medicinal Chemistry (CMFA), Louvain Drug Research Institute, UCLouvain. 73, B1.73.10Av. E. Mounier B-1200 Brussels, Belgium, E.U.
This work reports on synthesis of high yield (92%) of isosadeuterio-benzopinacol (benzopinacol-d20) via photo-reductive dimerization of benzophenone-d10. The latter compound was obtained using an improved method to achieve a material with high isotopic purity (> 99%). This material can be served for calibration of Mass spectrometric assays. In this study, it was also observed that benzophenone-d10 reacts faster than its natural abundance counterpart. However, elucidating the origin of this phenomenon will require additional work.