Synthesis of icosadeuterio-benzopinacol (benzopinacol-d20)

Adjibodéa, Steeve M.; Kasséhin, Urbain C.; Gbaguidi, Fernand A.; Poupaert, Jacques  H.

doi:10.26655/JMCHEMSCI.2020.1.4

Document Type : Original Article

Authors

¹ Medicinal Organic Chemistry Laboratory (MOCL), School of Pharmacy, Faculté des Sciences de la Santé, Universitéd'Abomey-Calavi, Campus du Champ de Foire, 01 BP 188, Cotonou, Bénin

² Medicinal Chemistry (CMFA), Louvain Drug Research Institute, UCLouvain. 73, B1.73.10Av. E. Mounier B-1200 Brussels, Belgium, E.U.

https://doi.org/10.26655/JMCHEMSCI.2020.1.4

Abstract

This work reports on synthesis of high yield (92%) of isosadeuterio-benzopinacol (benzopinacol-d20) via photo-reductive dimerization of benzophenone-d10. The latter compound was obtained using an improved method to achieve a material with high isotopic purity (> 99%). This material can be served for calibration of Mass spectrometric assays. In this study, it was also observed that benzophenone-d10 reacts faster than its natural abundance counterpart. However, elucidating the origin of this phenomenon will require additional work.

Graphical Abstract

Keywords

Main Subjects

Photochemistry

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Journal of Medicinal and Chemical Sciences

Synthesis of icosadeuterio-benzopinacol (benzopinacol-d20)

References

References

Volume 3, Issue 1
January 2020
Pages 35-40

Synthesis of icosadeuterio-benzopinacol (benzopinacol-d20)

References

References

Volume 3, Issue 1January 2020Pages 35-40

Volume 3, Issue 1
January 2020
Pages 35-40