Document Type : Review Article
Authors
1 School of Pharmaceutical Sciences, Apeejay Stya University, Sohna-Palwal Road, Sohna, Gurgaon, Haryana-122103, India
2 Department of Pharmaceutical Chemistry, Indo-Soviet Friendship College of Pharmacy (ISFCP), Moga,Punjab-142001, India
3 National Institute of Phramaceutical Education and Research, Sector-67, S.A.S. Nagar, Mohali, Punjab-160062, India
Abstract
An efficient procedure was developed for the synthesis of different derivatives of 3,4-disubstituted pyrrole using TosMIC with ethyl cinnamate in DMF using lithium hydroxide monohydrate as a base. Further, trisubstituted pyrrole was synthesized using nitrostyrene, ethyl-propiolate and benzylamine in toluene as a reaction medium. This reaction was catalysed by lewis acid FeCl3. This strategy was further modified to synthesized tetra and penta substituted pyrrole using ethanol as a reaction medium keeping other conditions intact. This method is very economical and was successfully utilized for the synthesis of its derivatives with moderate to good yields.
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