CiteScore: 1.5     h-index: 24

Document Type : Original Article


School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, P. R. China


A highly efficient and ligand-free approach for the Suzuki–Miyaura cross-coupling reaction of aryl halides with arylboronic acid catalyzed by CuI/Cs2CO3 in DMF has been developed. Under the described conditions, a category of aryl halides including iodides and bromides, whether electron-rich or electron-deficient, were coupled with arylboronic acid to give the target products (moderate to excellent yields). This catalytic system was less efficient in the reactions of aryl bromides as a higher reaction temperature was required to improve the yield.

Graphical Abstract

Copper-catalyzed Ligand-Free Suzuki–Miyaura Coupling Reaction of Aryl Halides with Arylboronic Acid


Main Subjects

1. A. Suzuki, Angew. Chem. Int. Ed. 2011, 50, 6722.
2. J.J. Lennox, G.C. Lloyd‐Jones, Chem. Soc. Rev. 2014, 43, 4 12.
3. R. Jana, T.P. Pathak, M.S. Sigman, Chem. Rev. 2011, 111, 1417.
4. C. Valente, S. Çalimsiz, K. H. Hoi, D. Mallik, M. Sayah, M. G. Organ, Angew. Chem. Int. Ed. 2012, 51, 3314.
5. T. P. Blaisdell, J. P. Morken, J. Am. Chem. Soc. 2015, 137, 8712.
6. D. N. Primer, I. Karakaya, J. C. Tellis, G. A. Molander, J. A m. Chem. Soc. 2015, 137, 2195.
7. L.S. Zhao, A. Joshi‐Pangu, M. Diane, M. R. Biscoe, J. Am. Chem. Soc. 2014, 136, 14027.
8. S. Thapa, B. Shrestha, S. K. Gurung, R. Giri, Org. Biomol. Chem. 2015, 13, 4816.
9. I. P. Beletskaya, A. V. Cheprakov, Coord. Chem. Rev. 2004, 248, 2337.
10. M. B. Thathagar, J. Beckers, G. Rothenberg, J. Am. Chem. Soc. 2002, 124, 11858.
11. J.‐H. Li, D.‐P. Wang, Eur. J. Org. Chem. 2006, 2006, 2063.
12. C. Torborg and M. Beller, Adv. Synth. Catal. , 2009, 351, 3027.