Document Type : Original Article


Department of Chemistry, College of Arts and Science, University of Benghazi, Al kufra, Libya


Cervical cancer (CC) has imposed a massive global burden. As yet, the first study on the causes and risk factors associated with the CC disease that conducted in Libya aimed at investigating the major cause's CC such as Human papillomavirus (HPV), oral contraceptive, sexually transmitted infections, bisphenol A and nutritional factors might also play a role is the major type, accounting for approximately 16.7% of cases in Libya. The results show the highest incidence of cervical cancer between the ages of ≥95 at 50%, followed by the ages between 55-65 years at 23%, while the lowest rate among women between the ages of 35-45 is 16% and 15- 25 by 11%, respectively. The increase in the infection rate is attributed to several factors as HPV and others.

Graphical Abstract

A new study biological role of hpv infection, oral contraceptive use, sex hormones and bisphenol A and increase rate cancer of cervical in libya


[1] Gustafsson L., Pontén J., Bergstrôm R., Adami, H.O., Int. J. Cancer., 1997, 71:159
[2] Gasparini R., Panatto D. Vaccine, 2009,27:A4
[3] Laara E., Day N.E., Hakama M. Lancet,1987,1:1247
[4] Nyberg R., Tornberg B., Westin B. Acta Obstet Gynecol Scand, 1960, 39:540
[5] Seybolt G.F., Papanicolau G.N. Arch. Med. Cuba., 1953, 4:579
[6] Zur H., Gissmann L., Steiner W., Dippold W., Dreger I. Bibl. Haematol., 1975, 43:569
[7] Munoz N., Bosch F.X., de Sanjose S., Herrero R., Castellsague X., Shah K.V., Snijders P.J., Meijer C.J. N. Engl. J. Med., 2003, 348:518
[8] Woodman C.B., Collins S., Winter H., Bailey A., Ellis J., Prior P., Yates M., Rollason T.P., Young L.S. Lancet., 2001, 357:1831
[9] Hellberg D., Stendahl U. Anticancer Res., 2005, 25:3041
[10] Diamanti-Kandarakis E., Bourguignon J.P., Giudice L.C., Hauser R., Prins G.S., Soto A.M., et al. Endocr Rev., 2009, 30:293
[11] Rachoń D., Vortherms T., Seidlovà-Wuttke D., Wuttke W. Maturitas, 2007, 57:161
[12] Diamanti-Kandarakis E., Palioura E., Kandarakis S.A., Koutsilieris M. Horm. Metab. Res., 2010, 42:543
[13] Crews D., McLachlan J.A. Endocrinology, 2006, 147:S4
[14] Key T.J., Mutat. Res., 1995, 333:59
[15] Thaxton L., Waxman A.G., Med. Clin. North. Am., 2015, 99:469
[16] Remoue F., Jacobs N., Miot V., Boniver J., Delvenne P. Ameri. J. of Obs. and Gyn.,2003,189:1660
[17] Moreno V., Bosch F.X., Muñoz N., Meijer C. J., Shah K.V., Walboomers J.M., Herrero R., Franceschi S. Lancet,2002,359:1085
[18] Muñoz N., Franceschi S., Bosetti C., Moreno V., Herrero R., Smith J.S., Shah K.V., Meijer C.J., Bosch F.X. Lancet., 2002,359:1093
[19] Chung S.H., Wiedmeyer K., Shai A., Korach K.S. Cancer. Research., 2008,68:9928