TY - JOUR ID - 75102 TI - Copper-catalyzed Ligand-Free Suzuki–Miyaura Coupling Reaction of Aryl Halides with Arylboronic Acid JO - Journal of Medicinal and Chemical Sciences JA - JMCS LA - en SN - AU - Zhang, Hua-Feng AD - School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, P. R. China Y1 - 2019 PY - 2019 VL - 2 IS - 1 SP - 38 EP - 40 KW - CuI KW - ligand-free KW - Suzuki–Miyaura Coupling KW - Aryl halides KW - Arylboronic acid DO - 10.26655/jmchemsci.2019.6.7 N2 - A highly efficient and ligand-free approach for the Suzuki–Miyaura cross-coupling reaction of aryl halides with arylboronic acid catalyzed by CuI/Cs2CO3 in DMF has been developed. Under the described conditions, a category of aryl halides including iodides and bromides, whether electron-rich or electron-deficient, were coupled with arylboronic acid to give the target products (moderate to excellent yields). This catalytic system was less efficient in the reactions of aryl bromides as a higher reaction temperature was required to improve the yield. UR - https://www.jmchemsci.com/article_75102.html L1 - https://www.jmchemsci.com/article_75102_3053d29f5f6853638eac115f8934b1ec.pdf ER -