TY - JOUR ID - 160313 TI - Synthesis, Structure, and in vitro Cytotoxic Activity of Two Organotin Complexes of 2-[(2, 3-Dimethylphenyl) Amino] Benzoic Acid JO - Journal of Medicinal and Chemical Sciences JA - JMCS LA - en SN - AU - Al-Rikabi, Eman H. AU - Al-Refai, Rana A. K. AU - Baqir, Sadiq J. AU - G. Hadi, Angham AU - Al-Qayyim, Ahmed Kareem AD - Department of Chemistry, College of Science, University of Babylon, Babylon 51002, Iraq AD - Medical Laboratories Techniques Department, Al‐Mustaqbal University College, Babylon, Iraq Y1 - 2023 PY - 2023 VL - 6 IS - 6 SP - 1230 EP - 1238 KW - Antitumor KW - Cytotoxic activity KW - Ligand KW - triorganotin carboxylate DO - 10.26655/JMCHEMSCI.2023.6.3 N2 - Organotin carboxylates have gotten a lot of attention in recent years because of their structural intrigue and several uses. The production and characterization of organotin carboxylates, as well as their action against cancers, fungi, bacteria, and other microbes have been described by a number of researchers. Some di- and triorganotin carboxylates have been found to have the potential as anticancer drugs. The amount and kind of organic groups bound to the tin core and carboxylate ligand appear to have a significant impact on their anticancer efficacy. Two new organotin complexes of di and triorganotin carboxylate were successfully synthesized by refluxing reaction of 2-[(2,3-dimethylphenyl) amino] benzoic acid (ligand) with tri phenyl tin chloride and dimethyl tin dichloride salts to give the corresponding substituted tin complexes with high yields. The chemical structures of the complexes were confirmed by different techniques included elemental analysis, proton, carbon and Sn119-NMR, and FT-IR-spectra. The activity of each complex has been examined against the target cell line A-172 compared with the ligand alone. It was found that the complex 1 and 2 have higher cellular cytotoxicity than ligand. UR - https://www.jmchemsci.com/article_160313.html L1 - https://www.jmchemsci.com/article_160313_5e50b0e51612a28d2847b98303f0d9a2.pdf ER -