TY - JOUR ID - 140013 TI - Coupled Plasma Filtration Adsorption as a Potential Therapy for Critically III Covid-19 Patients JO - Journal of Medicinal and Chemical Sciences JA - JMCS LA - en SN - AU - Jonny, Jonny AU - Violetta, Laurencia AD - Division of Nephrology, Internal Medicine Department, Presidential Central Army Hospital, Jakarta, Indonesia Y1 - 2022 PY - 2022 VL - 5 IS - 2 SP - 197 EP - 203 KW - COVID-19 KW - Cytokine Storm KW - extracorporeal therapy KW - hemofiltration KW - plasma exchange DO - 10.26655/JMCHEMSCI.2022.2.7 N2 - The Corona-19 virus disease (Covid-19) continues to cause an increasing number of deaths, mainly due to acute respiratory disorders. The high pandemic mortality and morbidity prompted clinicians to seek suitable adjunctive therapeutic methods to eliminate high cytokine levels effectively. This study aimed to review the combined plasma filtration adsorption (CPFA) technology and its potential efficacy in treating critically ill Covid-19. CPFA combines plasma separation, adsorption, and hemofiltration techniques that meet the need to remove substances such as cytokines. Findings from the report suggest an immune dysregulation known as cytokine storm syndrome plays a role in severe and critically ill Covid-19 patients. Extracorporeal blood purification targets cytokine elimination and is preferred as a bridging strategy to improve survival. Combined adsorption plasma filtration (CPFA) can remove various substances, including cytokines, without depleting physiologically essential proteins. CPFA can be considered and assessed in clinical trials to treat critically ill Covid-19 patients. Paired Plasma Filtration Adsorption (PPFA) can be viewed as a potentially effective therapy in treating Covid-19 patients in critical condition. UR - https://www.jmchemsci.com/article_140013.html L1 - https://www.jmchemsci.com/article_140013_cfb70f9af55a20638ab7ee400616f47b.pdf ER -