TY - JOUR ID - 139700 TI - Indications and Outcome of Albumin Infusion in a Neonatal Population: A Cross Sectional Study JO - Journal of Medicinal and Chemical Sciences JA - JMCS LA - en SN - AU - Akram, Nabeeha Najatee AU - Abed, Maysam Yusuf AD - Department of Paediatrics, Al-Mustansiriyah University, college of medicine, Iraq AD - Senior Pediatrician, Alramadi Teaching Hospital for Maternity and Childhood, Iraq Y1 - 2022 PY - 2022 VL - 5 IS - 1 SP - 129 EP - 136 KW - Newborn KW - Neonatal hypoalbuminemia KW - Albumin infusions DO - 10.26655/JMCHEMSCI.2022.1.14 N2 - Objective: To determine the indications for human albumin infusion in neonatal units, as well as the neonatal outcomes after receiving human albumin.Study design: A cross sectional study in neonatal ward at child’s central teaching hospital in Baghdad conducted over 12 months period between December 2019 and December 2020 in Iraq. Infants who received albumin infusion for hypoalbuminemia or any other reason during study period were included in the study. Mortality and morbidities were recorded. Alterations in renal and liver function tests and serum albumin level before and after albumin infusion were recorded.Results: 80 neonates required human albumin transfusion therapy 150 times during the study. In (31.25%) the indication for albumin transfusion was the presence of edema, while in (68.75%) the indication was hypoalbuminemia. During 30 days follow up, (82.5%) have survived and discharged well, while (17.5%) died during hospitalization. Four factors were found to be significantly associated with mortality in neonates undergoing albumin transfusion, which are prematurity, low birth weight, presence of comorbidity and higher number of albumin infusions. The mean urea concentration in deceased group was significantly higher than that of survived neonates. There was a significant reduction in blood urea after the last transfusion in survived neonates.Conclusion: In the absence of evidence-based guidelines for albumin infusion in neonatal period, albumin used mainly to correct underlying hypoalbuminemia higher mortality rate was documented in neonate who received albumin infusions in higher number of times. UR - https://www.jmchemsci.com/article_139700.html L1 - https://www.jmchemsci.com/article_139700_ee084eb9976f38f8d1d4c08fb430a39b.pdf ER -