@article { author = {Farhanah, Nur and Supriadi, Supriadi and Wahjono, Hendro and Hadisaputro, Suharyo and Hussein Gasem, Muhammad}, title = {Predictors of Mortality in Sepsis Patients Resulting from Severe and Critical COVID-19}, journal = {Journal of Medicinal and Chemical Sciences}, volume = {6}, number = {9}, pages = {2018-2027}, year = {2023}, publisher = {Sami Publishing Company (SPC)}, issn = {2651-4702}, eissn = {2651-4702}, doi = {10.26655/JMCHEMSCI.2023.9.10}, abstract = {Patients with severe and critical COVID-19 may exhibit sepsis and mortality resulting from multi-organ failure. Neutrophil-lymphocyte-ratio (NLR) values, C-reactive protein (CRP) levels, sequential organ failure assessment (SOFA), and acute physiology and chronic health evaluation II (APACHE-II) scores were used to assess the risk of mortality in sepsis patients resulting from severe COVID-19 infection. The adequacy of NLR, CRP, SOFA, and APACHE-II scores were evaluated as predictors of mortality in septic COVID-19 patients at Dr. Kariadi Hospital Semarang, Indonesia, between August 2021 and July 2022. The subjects included severe and critical COVID-19 patients who fulfilled the WHO interim guidelines and Sepsis-3 criteria. A total of 211 patients were included, which were divided into survivor (n = 116) and non-survivor (n = 95) groups. NLR values, CRP levels, SOFA, and APACHE-II scores were measured within 24 hours of patient admission. Univariate and multivariate logistic regression analyses were used to identify the risk factors for COVID-19 mortality. Receiver operating characteristic curve analysis was used to predict the mortality of severe COVID-19 patients. The results indicated that the APACHE-II score was an independent predictor of mortality in sepsis patients resulting from severe and critical COVID-19.}, keywords = {Neutrophil,Lymphocyte,ratio (NLR) C,reactive protein (CRP) SOFA score APACHE,II score Mortality COVID,19}, url = {https://www.jmchemsci.com/article_168955.html}, eprint = {https://www.jmchemsci.com/article_168955_daaf1915e855ef1461ae9799206fc3b5.pdf} }