@article { author = {Mahdi, Mustafa H. and Dawood, Ashour H. and Shaheed, Dhurgham Q.}, title = {Substituted Tetrahydrocarbazole Based on Indomethacin and Diclofenac with Heterocyclic Compound, Synthesis, Spectral and Antimicrobial Studies}, journal = {Journal of Medicinal and Chemical Sciences}, volume = {5}, number = {6}, pages = {933-942}, year = {2022}, publisher = {Sami Publishing Company (SPC)}, issn = {2651-4702}, eissn = {2651-4702}, doi = {10.26655/JMCHEMSCI.2022.6.7}, abstract = {New 6-chloro-1,2,3,4-tetrahydrocarbazole compounds were prepared from the reaction of cyclohexanone with 4-chlorophenylhydrazine. The synthesis of heterocyclic compounds was carried out through the reaction of cyclohexanone with 4-chlorophenylhydrazine, then the produced compound was treated with two NSAIDs (indomethacin, diclofenac) by amide bond formation to form N-substituted THCZ by NSAIDs. The characterization of prepared compounds was identified using the 1H, 13C NMR and FT-IR spectroscopies. The antimicrobial activity of the synthesized compounds was tested in vitro to discover a good activity as antifungal and moderate as antibacterial, which was confirmed by the docking study of the compounds.}, keywords = {Tetrahydrocarbazole,indomethacin,Diclofenac,Cyclohexanone}, url = {https://www.jmchemsci.com/article_148959.html}, eprint = {https://www.jmchemsci.com/article_148959_7e579501cc827fa6ef8f89148c7abb87.pdf} }