Journal of Medicinal and Chemical Sciences

Neonatal Sickle Cell Disease Assessment in Rural Indian Community: Demand for Point of Care Testing (POCT)

Sarita Anil Shinde; Anita Deepak Deshmukh; Umesh Kisanrao More

Volume 7, Issue 1 , January 2024, , Pages 1-8

https://doi.org/10.26655/JMCHEMSCI.2024.1.1

Abstract

The most prevalent hemoglobinopathy is sickle cell disease, which is followed by β-thalassemia and thalassemia syndrome. The Mediterranean region, Middle East, Indian subcontinent, ... Read More

Haemoglobin Variant Study by HPLC Method at a Tertiary Care Centre

Pradnya Phalak; Abhijit Pratap

Volume 6, Issue 11 , November 2023, , Pages 2841-2848

https://doi.org/10.26655/JMCHEMSCI.2023.11.29

Abstract

Haemoglobinopathies are genetic disorders arising due to defect in the globin chain of haemoglobin. It is relatively common amongst genetic disorders. Beta thalassemia and Sickle cell ... Read More

Upregulation of INSR Gene Expression and Restoration of Melatonin Levels by Tinospora Cordifolia Stem Extract and Alkaloid Rich Fraction against Continuous Light Induced Polycystic Ovary Syndrome in Rodents

Murali Krishna Moka; Sumithra M

Volume 6, Issue 9 , September 2023, , Pages 2198-2217

https://doi.org/10.26655/JMCHEMSCI.20239.25

Abstract

Females of childbearing age often suffer from polycystic ovary syndrome (PCOS), a hormonal condition. Symptoms including insulin resistance, high androgen levels, irregular menstrual ... Read More Females of childbearing age often suffer from polycystic ovary syndrome (PCOS), a hormonal condition. Symptoms including insulin resistance, high androgen levels, irregular menstrual (estrous) cycles, and polycystic ovaries are linked to this condition. The study's objective is to determine the therapeutic effect of Tinospora cordifolia stemextract and Alkaloid Rich Fraction against continuously Light Induced Polycystic Ovary Syndrome in Sprague Dawley (SD) female rats. Animals were grouped into six groups where the control group received only distilled water and the standard group received Clomiphene citrate 20 mg/Kg. The test groups received Tinospora cordifolia Stem Extract (200 mg/kg b.w and 400 mg/kg b.w) and Alkaloid Rich Fraction (10 mg/kg b.w and 20 mg/kg b.w) for the period of 4 weeks after PCOS induction. The results showed a significant reduction in elevated testosterone levels compared to that of the PCOS group (Light Induced Group (L/L 24 hrs Continuous), but follicle-stimulating hormone (FSH), insulin levels reported significant increase compared to that of the L/L PCOS group (Light Induced Group (L/L 24 hrs Continuous) and increased expression of INSR gene and restoration of melatonin levels. From the results, it was concluded that High doses of Tinospora cordifolia Stem Extract (400 mg/kg b.w) and Alkaloid Rich Fraction (20 mg/kg b.w) could be effective against Continuously Light Induced Polycystic Ovary Syndrome in Rodents it has due to decreased testosterone levels and increase insulin sensitivity by up-regulating INSR gene expression followed by restoration of melatonin levels. After treatment period a significant decrease in elevated LH levels, testosterone levels, and a significant increase in insulin and follicle-stimulating hormone (FSH) levels when compared to the L/L PCOS group (Light Induced Group (L/L 24 hrs Continuous), as well as increased INSR gene expression and restored melatonin levels.

Synthesis and Semi-synthesis of Curcumin as a Medical Precursor and Its Derivatives with Desirable Purity and Qualitative and Quantitative Evaluation

Hossein Mighani; Fatemeh Hajiaghaei

Volume 4, Issue 2 , April 2021, , Pages 84-92

https://doi.org/10.26655/JMCHEMSCI.2021.2.1

Abstract

Spices and herbs are considered rich sources of powerful antioxidants. Since 2000 years ago, spices and herbs have been utilized as fragrances, colourants, and medicines. Both natural ... Read More

Development and validation of analytical method for simultaneous estimation of sofosbuvir and velpatasvir by RP-HPLC method in pharmaceutical dosage form

Patel Grishma; Patel Dhara; Reema Mansuri; Sapra Ritu; Meshram Dhananjay

Volume 3, Issue 4 , October 2020, , Pages 329-337

https://doi.org/10.26655/JMCHEMSCI.2020.4.2

Abstract

In this work, a simple, rapid, accurate, precise, specific, and sensitive RP-HPLC method was developed and validated for the simultaneous estimation of the Sofosbuvir and Velpatasvir ... Read More

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Keywords = HPLC

Neonatal Sickle Cell Disease Assessment in Rural Indian Community: Demand for Point of Care Testing (POCT)

Abstract

Haemoglobin Variant Study by HPLC Method at a Tertiary Care Centre

Abstract

Upregulation of INSR Gene Expression and Restoration of Melatonin Levels by Tinospora Cordifolia Stem Extract and Alkaloid Rich Fraction against Continuous Light Induced Polycystic Ovary Syndrome in Rodents

Abstract

Synthesis and Semi-synthesis of Curcumin as a Medical Precursor and Its Derivatives with Desirable Purity and Qualitative and Quantitative Evaluation

Abstract

Development and validation of analytical method for simultaneous estimation of sofosbuvir and velpatasvir by RP-HPLC method in pharmaceutical dosage form

Abstract