Journal of Medicinal and Chemical Sciences

Safety and Efficacy of Popular Iranian Herbal Cold Remedy for COVID-19: A Randomized Clinical Trial in Mild to Moderate COVID-19 Cases

Samaneh Abiri; Alireza Hashemi Shiri; Mohammad Sadegh Sanie Jahromi; Esmaeil Rayatdoost; Hamid Afkhami; Ruhollah Ravanshad; Seyed Ehsan Hosseini; Navid Kalani; Parasta Heidari; Rahim Raoufi

Volume 6, Issue 8 , August 2023, , Pages 1799-1809

https://doi.org/10.26655/JMCHEMSCI.2023.8.8

Abstract

Background: In traditional Persian medicine, an herbal cold remedy containing Sugarcane, Black Myrobalan, and mastic is mentioned and it was being widely provided by grocery stores. ... Read More Background: In traditional Persian medicine, an herbal cold remedy containing Sugarcane, Black Myrobalan, and mastic is mentioned and it was being widely provided by grocery stores. With the advent of the COVID-19 pandemic, the increased desire for this traditional remedy has led to a debate in society. Huge parts of the Iranian population have started using this remedy for the treatment of COVID-19; while no study has evaluated its efficiency and possible side effects. Thus, we aimed to evaluate the effects of Sugarcane, Black Myrobalan, and Mastic‏ ‏herbal medications for COVID-19 patients.Methods: This was a double-blinded randomized clinical trial study conducted over three months from May 2020 to July 2020 in SARS-COV2 PCR positive patients admitted in the COVID-19 ward of Peymaniyeh Hospital in Jahrom, Iran. Patients with severe COVID-19 infection were not recruited. The intervention group received the routine COVID-19 treatment protocol and the herbal supplement received the combination of black myrobalan and mastic and sugarcane, twice a day (3 g of herbal supplement). Study groups were compared in terms of demographic variables, vital signs, and clinical and laboratory variables for safety and efficiency assessment.Results: Seventy-two patients with COVID-19, divided into intervention (n=37) and control (n = 35) groups were studied. Intervention and control groups had not any significant difference in terms of baseline characteristics. The time-to-event analysis revealed a statistically significant difference in 4 symptoms of cough, fever, dyspnea, and myalgia (P<0.05). There was no significant difference in averaged O2 vital signs between the two groups (P>0.05). The Control group in comparison to the intervention group had a significantly lower decrease in C-reactive protein during 7 days (P<0.05). Patients in the herbal supplement group were hospitalized for 4.12 days and patients in the control group were hospitalized for 8.37 days (P=0.001). ICU admission and death only happened in 3 (8.6%) patients of the control group.Conclusion: This study showed that the proposed herbal remedy could be applied as supplementation to conventional management of COVID-19 patients with mild disease, while more research is needed for clinical application of this remedy.

Intravenous Lidocaine in Management of Acute Pain in Traumatic Limb: Evidence-Based Systematic Review

Roohie Farzaneh; Mohammad Sadegh Sanie Jahromi; Samaneh Abiri; Behrang Rezvani Kakhki; Shahram Shefa; Reza Akhavan; Somayeh Ahmadnezhad; Bita Abbasi; Hossein Akhavan; Fatemeh Maleki; Mahdi Foroughian

Volume 6, Issue 5 , May 2023, , Pages 1145-1154

https://doi.org/10.26655/JMCHEMSCI.2023.5.20

Abstract

Lidocaine is one of the medications that is proposed as an alternative in acute pain management. Lidocaine is routinely used in topical and dental anesthesia and is known for its analgesic ... Read More

Prognostic Value of Immune Checkpoints in Prostate Cancer: A Systematic Review and Meta-Analysis of Reconstructed Time to Event Data

Hossein Hakimelahi; Alireza Yousefi; Marzieh Haghbeen; Mohammad Sadegh Sanie Jahromi; Hasan Zabetian; Reza Inaloo

Volume 6, Issue 1 , January 2023, , Pages 142-151

https://doi.org/10.26655/JMCHEMSCI.2023.1.17

Abstract

Introduction: Various molecular pathways are proposed to predict the prognosis of prostate cancer. However, due to previous achievements in prostate cancer management by immune checkpoint ... Read More

Effect of Oral Clonidine as a Premedication on Hemorrhage during Septorhinoplasty: A Double-Blind Randomized Clinical Trial

Mojtaba Sohrabpour; Seyed Ebrahim Sadeghi; Mojtaba Ghaedi; Navid Kalani; Mohammad Sadegh Sanie Jahromi

Volume 5, Issue 6 , November and December 2022, , Pages 1001-1007

https://doi.org/10.26655/JMCHEMSCI.2022.6.13

Abstract

Introduction: Intraoperative hemorrhage is one of the most important complications of septorhinoplasty surgery. Many techniques and drugs are used to reduce this problem. Accordingly, ... Read More

A Comparative Study on the Effects of Propofol and Thiopental on the Apgar score of Neonates Undergoing Cesarean Section under General Anesthesia: A Systematic Review Study

Seyed Ebrahim Sadeghi; Mehrdad Malekshoar; Majid Vatankhah; Pourya Adibi; Elham Rahmanian; Mohammad Sadegh Sanie Jahromi; Maryam Nemati

Volume 5, Issue 6 , November and December 2022, , Pages 1008-1017

https://doi.org/10.26655/JMCHEMSCI.2022.6.14

Abstract

Introduction: Apgar score of neonates at birth is one of the determinants of postnatal mortality and one of the effective factors in Apgar score of cesarean section neonates that is ... Read More Introduction: Apgar score of neonates at birth is one of the determinants of postnatal mortality and one of the effective factors in Apgar score of cesarean section neonates that is the type of drug used for maternal anesthesia. Owing to the disagreement on the benefits and possible side effects of anesthetics, the present study was an attempt to evaluate and compare the effects of propofol and thiopental on the Apgar score of neonates undergoing cesarean section under the general anesthesia.Methods: The present study is a systematic review. Persian articles were searched in databases such as SID, Iranmedex, Magiran, and English articles were searched in databases such as Science Direct, PubMed, ProQuest, Cochrane Library, Embase, Scopus, and Google Scholar search engine without any time limitation. To access the full text of articles, the keywords of propofol, thiopental, general anesthesia, neonatal Apgar score, cesarean section, and their combination, the Boolean search methods, and conjunctions of “And” and “Or” were used. The information of reviewed articles included the first author, year of publication, the country of study, the sample size, and the outcome of the study.Results: A total of 27 articles were included to the study. In 22 studies, no statistically significant difference was found between thiopental and propofol effects on neonatal Apgar score at minutes 1 and 5. Also, in 4 studies, Apgar scores at minutes 1 and 5 were reported higher in the propofol group than the thiopental group. Furthermore, in one study, Apgar score at minute 1 was reported higher in the propofol group than the thiopental group. In three studies, Apgar score of neonates at the minute 1 in thiopental group was reported higher than the propofol group.Conclusion: It seems that neonates whose mothers underwent the general anesthesia with propofol for cesarean section have better Apgar scores than those who received thiopental. One of the effects of propofol is its shorter duration of action, and if the patient has a problem with difficult intubation, the effect of the drug ends sooner and the patient’s breathe returns as soon as possible. Likewise in this regard, compared to thiopental, which has a longer effect, Propofol is a more effective drug in cesarean section women under the general anesthesia.

Investigating the Effect of Oral Clonidine on Surgeon Satisfaction from Surgical Field in Septorhinoplasty

Mojtaba Ghaedi; Lohrasb Taheri; Mojtaba Sohrabpour; Navid Kalani; Mohammad Sadegh Sanie Jahromi

Volume 5, Issue 6 , November and December 2022, , Pages 1085-1093

https://doi.org/10.26655/JMCHEMSCI.2022.6.21

Abstract

Introduction: Haemorrhage during septorhinoplasty surgery is challenging for the surgeons since it can reduce the visibility of the surgical site. Thus, the present study aimed to investigate ... Read More

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Author = Mohammad Sadegh Sanie Jahromi

Safety and Efficacy of Popular Iranian Herbal Cold Remedy for COVID-19: A Randomized Clinical Trial in Mild to Moderate COVID-19 Cases

Abstract

Intravenous Lidocaine in Management of Acute Pain in Traumatic Limb: Evidence-Based Systematic Review

Abstract

Prognostic Value of Immune Checkpoints in Prostate Cancer: A Systematic Review and Meta-Analysis of Reconstructed Time to Event Data

Abstract

Effect of Oral Clonidine as a Premedication on Hemorrhage during Septorhinoplasty: A Double-Blind Randomized Clinical Trial

Abstract

A Comparative Study on the Effects of Propofol and Thiopental on the Apgar score of Neonates Undergoing Cesarean Section under General Anesthesia: A Systematic Review Study

Abstract

Investigating the Effect of Oral Clonidine on Surgeon Satisfaction from Surgical Field in Septorhinoplasty

Abstract