Document Type: Original Article

Authors

1 School of Chemistry, Bangor University, Bangor LL 57 2UW, United Kingdom

2 Department of Chemistry, Faculty of Natural and Applied Sciences, Nasarawa State University, P.M.B. 1022 Keffi, Nigeria

3 Department of Pharmacognosy, College of Pharmacy, King Saud University, P.O.Box 2457, Riyadh 11451, Saudi Arabia

Abstract

A new compound, catechin-3-O-α-L-rhamnopyranosyl (1→4) β-D-glucopyranoside was isolated from the ethylacetate soluble fraction of the aqueous extract of the whole seeds of Trichilia emetica (Family: Meliaceae). The structure of this compound was established on the basis of nuclear magnetic resonance (NMR), Infrared (IR) spectroscopy and ultraviolet-visible (UV-vis) spectrophotometry. The compound was also subjected to antimicrobial activity and brine shrimp lethality bioassay. The pure compound showed either no or reduced activity against microorganisms tested, it also showed no cytotoxicity.

Graphical Abstract

Keywords

Main Subjects

 

  1. L. R. Ferguson, Mutat, Res. 2001, 475, 89.
  2. D. Marinova, F. Ribarova, M. Atanassova, Journal of the University of Chemical Technology and Metallurgy, 2005, 40, 255.
  3. M. P. Germanò, V. D’Angelo, R. Sanogo, S. Catania, R. Alma, R. De Pasquale, G. Bisignano, J. Ethnopharmacol. 2005, 96, 227.
  4. M. P. Germanò, V. D’Angelo, T. Biasini, R. Sanogo, R. De Pasquale, S. J. Catania, Ethnopharmacol. 2006,105, 368.
  5. Y. Frum, A. M. Viljoen, Pharmacol. Physiol. 2006, 19, 329.
  6. S. G. Sparg, J. van Staden, A. K. Jager. J. Ethnopharmacol. 2000, 73, 209.
  7. K. K. Atindehou, C. Schmid, R. Brun, M. W. Kone, D. Traore, J. Ethnopharmacol. 2004, 90, 221.
  8. S. Hoet, F. Opperdoes, R. Brun, V. Adjakidje, J. Quetin-Leclercq, J. Ethnopharmacol. 2004, 91, 37.
  9. L. Verschaeve, J. Van Staden, J. Ethnopharmacol. 2008, 119, 575
  10.  L. Li‑Jing, H. Xiao‑Bing, L. V. Zhen‑Cheng, Springer Plus. 2016, 5,1649.
  11.  D. Diallo, B. S. Paulsen, T. H. A. Liljeback, T. E. Michaelsen, J. Ethnopharmacol. 2003, 84, 279.
  12.  B. M. Komane, E. I. Olivier, A. M. Viljoen, Phytochem. Lett. 2011, 4, 1.
  13.  M. Nakatani, J. C. James, K. Nakanishi, Phytochemistry. 1985, 24, 195.
  14.  M. Nakatani, J. C. James, K. Nakanishi, J. Am. Chem. Soc. 1981,103, 1228.
  15.  A. A. L. Gunatilaka, V. S. Bolzani, E. Dagne, G. A. Hofmann, R. K. Johnson, F. L. Mccabe, M. R. Mattern, D. G. I. Kingston, J. Nat. Prod. 1998,61, 179.
  16.  M. Traore, L. Zhai, M. Chen, C. E. Olsen, N. Odile, G. I. Pierre, O. J. Bosco, G. T. Robert, S. B. Christensen, Nat. Prod. Res. 2007, 21, 13.
  17.  A. Usman, V.Thoss, M. Nur-e-Alams, J. Nat. Prod. Resour. 2018, 4, 179.
  18. S. P. V. Chaturvedula, I. Prakash, Journal of Applied Pharmaceutical Science. 2011, 1,104.
  19. E. Bedir, N. J. Toyang, I. A. Khan, L. A. Walker, A. M. Clark, J. Nat. Prod. 2001,64, 95
  20. I. A. Ruiz-Matutea, O. Hernandez-Hernandezb, S. Rodriguez-Sanchezb, M. L. Sanzb, I. Martinez-Castrob, Journal of Chromatography B, 2011,8791,226.
  21. K. Nahar, M. G. U. Khan, M. S. Rahman, B. Begum, M. A. Rashid, Dhaka Univ. J. Pharm. Sci. 2008, 7, 99.
  22. B. N. Meyer, N. R. Ferringni, J. E. Puam, L. B. Lacobsen, D. E. Nichols. J. L. McLaughlin Planta Med. 1982, 45, 31.
  23. S. Nishat, N. Nahar, M. Mamun, M. Mosihuzzaman, N. Sultana, Dhaka Univ. J. Pharm. Sci. 2006, 54, 229.
  24. L. Y. Foo, J. J. Karchesy, Phytochemistry. 1989, 28, 1237
  25. K. Ishimaru, G. Nonaka, I. Nishioka, Phytochemistry 1987, 26, 1167.
  26. U. Takahama, R. Yamauchi, S. Hirota, Food Chem. 2013, 141, 282.
  27. (a) S. Sajjadifar, Chem. Methodol. 2019, 1, 1-11; (b) H. Veisi, A. Sedrpoushan, P. Mohammadi, A.R. Faraji, S. Sajjadifar, RSC Advances 2014, 4, 25898; (c) S. Sajjadifar, M.A. Zolfigol, G. Chehardoli, S. Miri, International Journal of ChemTech Research 2013, 5, 422; (d) E.R. Nezhad, S. Sajjadifar, Z. Abbasi, S. Rezayati, Journal of Sciences, Islamic Republic of Iran, 2013, 25, 127.