Document Type: Original Article

Authors

1 Department of Microbiology, Faculty of Biological Sciences, Modibbo Adama University of Technology, Yola-Nigeria

2 CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, CAS Centre for Excellence in Nanoscience, National Centre for Nanoscience and Technology, University of Chinese Academy of Sciences, Beijing 100191, China

3 Institute of Chemistry, Chinese Academy of Sciences, Beijing, China

4 Department of Biochemistry, Faculty of Life Sciences, Modibbo Adama University of Technology, Nigeria

Abstract

Curcumin which is an active component of tumeric, derived from the dried rhizome of curcuma longa plant has been known for its medicinal values in wound healing, treatment of inflammatory disease, urinary tract infections, biliary disease, and liver ailments. This medicinal property has been recently exploited in cancer prevention and therapy since extensive studies have revealed the mechanisms of action of curcumin as an anti-cancer agent, in which transcription factors, anti-apoptotic proteins, growth factor receptors and multi-drug resistance proteins are involved. In order to improve the medicinal value of curcumin in cancer prevention and therapy, novel nanoformulations of curcumin have been synthesized, ranging from nanoparticles, nanolipids, chitosan, and nanofibers. Here, the recent method of curcumin synthesis using nanotechnology and the mechanisms by which they exert their anti-cancer effects will be reviewed. 

Graphical Abstract

Keywords

Main Subjects

1. G.V. Natalia, E. Angelos, S. Nikos, K. Christos. Anticancer Res. 2015, 35, 645.
2. E.J. Lozzo, R.C. Moledo, C.D. Faraco, C.F. Ortolani, T.M. Bresolin, J.M. Silveira. Carbohydr. Polym. 2010, 93, 279.
3. C.H. Hsu, A.L. Chang .Adv. Exp. Med Biol. 2007, 595, 471.
4. G. Kapakos, V. Youreva, A.K. Srivastava. Molecular Aspects. Indian Jour. Biochem. Biophys. 2012, 49, 306.
5. H. Zhou, C.S. Beevers, S. Huang. Curr. Drug Targets. 2011, 12, 332.
6. P. Anand, N.G. Thomas, N.G. Kunumakara. Biochem. Pharmacol. 2008, 76, 1590.
7. X.L. Jun, H. Xiang-Fe, L.Z. Hang. Anti-Cancer Agents in Medical Chem. 2012, 12, 210.
8. Y.S. Kim, Y. Ahn, S.H. Hong, S.Y. Joo,K.H. Kim, I.S. Sohn, H.W. Park, Y.J. Hong, J.H. Kim, W. Kim, M.H.
Jeong, J.G. Cho, J.C. Park, J.C. Kang. Jour. Cadoivasc.
Pharmacol. 2007, 50, 41.
9. A.C. Huang, S.Y. Lin, C.C. Su, S.S. Lin, C.C. Ho, T.C. Hsia, C.S. Yu, S.W. Ip, T.P. Ling, J.G. Chung.In Vivo. 2018 22, 781.
10. P. Anand, C. Sundaram, S. Jhurani, A.B. Kunnumakara, B.B. Aggarwal, Cancer Lett. 2008, 267, 133.
11. S. Gafner, S.K Lee, M. Cuendet, S. Barthelemi, L. Vergnes, S. Labidalle, R.G Mehta, C.W. Boone, J.M.
Pezutto, Phytochemistry. 2004, 65, 2849.
12. L. Hong, M. Bose, J. Ju, J.H. Ryu, X. Chang, S. Sang, M.J. Lee, C.S. Yang, Carcinogennesis. 2004, 25, 1671.
13. N. Suwannateep, W. Banlunara, S.P. Wanichwecharungruang, K. Chiablaem, K. Lirdprapamongkol, J.
Svasti, J control reelease. 2011, 121, 176.
14. C. Mohanty, S.K. Sahoo, Biomaterials. 2010, 31, 6597.
15. J. Shaihk, D.D. Ankola, V. Beniwal, D. Singh, M.N. Kumar, Eur. J. Pharm. Sci. 2009, 37, 223.
16. A. Anitha, V.G. Deepagan, V.D. Rani, Carbohydrate polym. 2011, 84, 1158.
17. J. Duan, Y. Zhang, S. Han, Intl. Jour. of Pharm. 2010, 400, 211.
18. L. Jieying, C. Seyun, L.V. Li, S. Le, G. Shengrong, H. Shentang H. Curr. Pharm. Design. 2013, 19, 1974.
19. T.H. Kim, H.H. Jiang, Y.S. Youn, Intl. Jour. of Pharm. 2011, 403: 285-291.
20. V. Kakkar, S. Singh, D. Singlar, I.P. Kaur, Mol. Nutr. Food Res. 2011, 55, 495.
21. Z. Song, R. Feng, M. Sun, J. Colloid Interface Sci. 2011, 354, 116.
22. R. Raveentran, G.S. Bhuvaneshwar, C.P. Sharma, J Biomater Appl. 2013, 27, 811.
23. A. Sahu, U. Bora, N. Kasoji, P. Goswami, ActaBiomater. 2008, 4, 1752.
24. D. Wang, M.S. Veena, K. Stevenson, Clinical cancer Res. 2008, 14, 6228.
25. S. Anuchapreeda, Y. Fukumori, S. Okonogi, H. Ichikawa, J Nanotechnol. 2012, 2012, 1.
26. M.M. Yallapu, M. Jaggi, S.C. Chauhan, Colloids Surf B Biointerfaces. 2010, 79, 113.
27. G. Gou, S. Fu, L. Zhou, Nanoscale. 2011, 3, 3825.
28. H. Tang, C.J. Murphy, B. Zhang, Nanomedicine. 2010, 5, 855.
29. H. Tang, C.J.Murphy, B. Zhang, Biomaterials. 2010, 31, 7139.
30. V.R. Yadav, S. Prasad, R. Kannapan, J. Ravindran, M.M. Chaturvedi, L. Vaahtera, J. Parkkinen, B.B. Aggarwal, Biochem Pharmacol. 2010, 80, 1021.
31. J.G. Marrelle, S.W. McLaughlin, L. Tie, C.T. Laurencin, A.F. Chen, A.S. Nair, Clin Exp Pharmacol Physiol. 2009, 36, 1149.
32. B.R. William, patent US, eds.2011, US/0263500 A1.
33. J. Chen, X.Q. Tang, J.L. Zhi, Y. Cui, H.M. Yu, E.M. Tang, S.M. Sun, J.Q. Feng, P.S. Cheng, Apoptosis. 2006, 11, 943.
34. C.S. Divya, M.R. Pillai, Mol. Carcinog. 2006, 45, 320.
35. P. Chanvorachote, V. Pongrakhananon, S. Wannachaiyasit, S. Luanpitpong, Y. Rojanasakul, U. Nimmannit, Cancer Invest. 2009, 27, 624.
36. S.V. Bava, V.T. Pulliapadamba, A. Deepti, A. Nair, D. Karunagaran, R.J. Anto, J. Biol. Chem. 2005, 280, 6301.
37. C.L. Yang, Y.G. Ma, Y.X. Xue, Y.Y. Liu, H. Xie, G.R. Qui, DNA Cell Biol. 2012, 31, 139.
38. S.H. Wu, L.W. Hang, J.S. Yang, H.Y. Cheng, H.Y. Lin, J.H. Chiang, C.C. Lu, J.L. Yang, T.Y. Lai, Y.C. Ko, J. Chung, Anticancer Res. 2010, 30, 2125.
39. A.C. Bharti, B.B. Aggarwal, Biochem. Pharmacol. 2002, 63, 883.
40. A.C. Bharti, B.B. Aggarwal, Ann NY Acad Sci. 2002, 973, 392.
41. C.Y. Wang, M.W. Mayo, A.S. Baldwin, Science. 1996, 274, 784.
42. R. Piva, G. Belardo, M.G. Santoro, Antioxid. Redox Signal. 2006, 8, 478.
43. C. Jobin, C.A. Bradham, M.P. Russo, B. Juma, A.S. Narula, D.A. Brenner, R.B. Sarto, J. Immunol. 1999, 163, 3474.
44. J. Cou, Y. Liu, L. Jia, H.M. Zhou, Y. Kong, G. Yang, L.P. Jiang, Q.J. Li, L.F. Zhong, Free Radic Biol Med. 2007, 43, 968.
45. B. Tiang, Z. Wang, Y. Zhao, D. Wang, Y. Li, L. Ma, X. Li, J. Li, N. Xiao, J. Tian, R. Rodriguez,. Cancer Lett. 2008, 264, 299.
46. S. Lev-Ari, A. Vexler, A. Starr, V.M. Ashkenazy, J. Greif, D. Aderka, Y.R. Ben, Cancer Invest. 2007, 25, 411.
47. A.B. Kunnumakkara, S. Guha, S. Krishnan,. P. Diagaradjane, J. Gelovani, B.B Aggarwal, Cancer Res. 2007, 67, 3853.

48. D.E Levy, J.E Darnell, Nat. Rev. Mol. Cell Biol. 2002, 3, 651.
49. K. Schlessinger, D.E Levy, Cancer Res. 2005, 65, 5828.
50. A.M. Gamero, H.A. Young, R.H. Wiltrout, Cancer Cell.
2004, 5, 111.
51. J.R. Davie, S. He, L. Li, A. Sekhavat, Adv. Enz. Reg. 2008, 48, 189.
52. J.H. Woo, Y.H. Kim, Y.J. Choi, D.G. Kim, K.S. Lee, J.H. Bae, D.S. Min, J.S. Chang, Y. Jiong, J.Y.H. Lee, J.W. Park, T.K. Kwon, Carcinogenesis. 2003, 24, 1199.
53. M. Singh, A. Pandey, C.A. Karikari, G. Singh, D. Rakheja, Medical Oncology. 2010, 27, 1093.
54. S. Pal, T. Choudhuri, S. Chattopadhyay, A. Bhattacharya, G.K. Datta, T. Das, G. Sa, K.P. Claffey, Growth Factors. 2001, 19, 19-.
55. S. Narayan, J Mol Histol. 2004, 35, 301.
56. D.W. Seol, Q. Chen, R. Zarnegar, Oncogene. 2000, 19, 1132.
57. J.L. Arbiser, N. Klauber, R. Rohan, R.L. Van, M.T. Huang, C. Fisher, E. Flynn, H.R. Byers, Mol. Med. 1998, 4, 376.
58. X.Y. Ming, L. Yan, Y. Hong, Z. Jiang, Int. J. Mol. Sci. 2012, 13, 3959.
59. S. Kim, D.C. Domon, Q. Wang, D.H. Chung, D.A. Critofano, P.P. Pandolfi, J.N. Freund, B.M. Evers, 2002, 123, 1163.
60. A. Banerji, J. Chakrabarti, A. Mintra, A. Charterjee,
Cancer Lett. 2004, 211, 235.
61. D.Y. Zhou, K. Zhang, A.H. Conney, Chem. Pharm. Bull. 2013, 64, 1149.
62. J.H. Hong, K.S. Ahn, E. Bae, S.S. Jeon, H.Y. Choi, Prostate Cancer Prostatic Dis. 2006, 9, 147.
63. J.T. Moubarak, Interv Med Appl Sci. 2014, 6, 139.
64. P. Limtrakul, S. Anuchapreeda, D. Buddhasukh, BMC Cancer. 2004, 4, 13.
65. Q.B. Tang, H. Bi, J.Q. Feng, J.G. Coa, Acta. Pharmacol Sin. 2005, 269, 1009.
66. J. Qiu, Y.F. Fu, Q. Cheng, S.D.  Cheng, X. Xie, W.G. Lu, Y. Zhonghua, 2012, 92, 1926.