Document Type : Original Article

Authors

• Steeve M. Adjibodé ¹
• Urbain C. Kasséhin ^{1, 2}
• Sedami Fagla Medegan ¹
• Joëlle Quetin-Leclercq ³
• Fernand A. Gbaguidi ¹
• Jacques H. Poupaert ²

¹ Medicinal Organic Chemistry Laboratory (MOCL), School of Pharmacy, Faculté des Sciences de la Santé, Université d'Abomey-Calavi, Campus du Champ de Foire, 01 BP 188, Cotonou, Bénin

² Medicinal Chemistry (CMFA), Louvain Drug Research Institute, UCLouvain. 73, B1.73.10Av. E. Mounier B-1200 Brussels, Belgium, E.U.

³ Pharmacognosy Research group (GNOS), Louvain Drug Research Institute, Université Catholique de Louvain, 1200 Brussels , Belgium, E.U.

Abstract

A significant photo-activating effect was evidenced upon investigating the condensation of aldehydes and ketones with 4-phenylthiosemicarbazide in the absence of any type of catalyst (either acido-basic or nucleophilic catalysis). Actual yields were not found superior to those obtained using nucleophilic catalysts; however, the reaction can be run at room temperature with the absence of an additional solvent. A positive hydrophobic effect was also noted. Furthermore, it was found that, the described photo-chemical method did not require an expensive and energy-consuming photo-chemical equipment since the whole process was carried out using natural solar light in regular laboratory glass ware.

Graphical Abstract

Keywords

• Solar light
• Aldones
• 4-Phenylthiosemicarbazide
• Catalyst
• Green chemistry