Document Type: Original Article

Authors

1 Department of Chemistry, Federal University of Agriculture, PMB 2373 Makurdi, Nigeria

2 Centre for Agrochemical Technology & Environmental Research (CATER), Federal University of Agriculture, PMB 2373 Makurdi

Abstract

Acetaminophen overdose is one of severe global health challenges. In this study, adsorption technique was used to reduce acetaminophen overdose. Carbo tablets derived by wet granulation technique, coded as formulated carbo tablet (FCT) and alginated formulated carbo tablets (FCT-Alg), were characterized using the pharmaceutical drug procedures (hardness, disintegration time, tablet strength, friability) and instrumental techniques including, FTIR, SEM, and DSC analysis. DSC thermogram revealed that, the excipients were compatible with the active pharmaceutical ingredient (API). Batch adsorption experiments were carried out in the simulated gastric fluid (SGF) to monitor the role of some parametric factors (pH, concentration, carbo dosages, and PCM dosages). The tablet displayed favorable hardness and disintegration time (3.40 min). Optimum adsorption was observed at pH 1.2 for FCT in SGF (RE of 92.80%); FCT-Alg in SGF (RE of 99.17%). The results depicted that, the adsorption of the acetaminophen in SGF gave up to 99.65% removal efficiency, and compared with the commercial carbo tablet (CCT) with adsorption efficiency of 96.44%.

Graphical Abstract

Keywords

Main Subjects

[1]. Ferner R.E., Dear J.w., Bateman D.N.  British Med., 2011, 19:342

[2]. Ilomuanya M., Billa N., Uboh C., Ifudu N., Ciallella J., Igwilo C. Int. J Pharm Sci Res., 2017, 8:45

[3]. Panthee S., Lohani S.P. Open Tox. J., 2008, 2:22

[4]. Ogunneye A.L., Adewuyi G. O., Omoboyowa D.A., Saraye T.K. J. res. Env. Sci. Tox., 2012, 1:251W

[5]. Itodo A.U., Abdulrahman F.W., Hassan L. Maigandi G. Int. j. Pure Appl Sci., 2008, 1 :214

[6]. Kenta Y., Hiraku O., Akihiko I., Yoshiharu M. Chem. Pharm. Bull., 2017, 54: 359

[7]. Tanaka C., Yagi H., Sakamoto M., Koyama Y., Ohmura T., Ohtani H., Sawada Y. An. Pharm., 2004, 38:73

[8]. Alegakis A.K., Tzatzarakis M.N.,Tsatsakis A. M., Vlachonikolis I. G., Liakou V. Act. Carbon Med., 2000, 35: 551

[9]. Iwata M., Takahashi T., Takahashi Y., Ito A., Machida Y. Jpn. J. Pharm. Health Sci., 2001, 63: 6

[10]. Ebay.com https://www.thaietcgroup.com

[11]. Suman S., Ashutosh P., Richa J., Yashumati R., Bhardwaj V. and Gunjan J., Ortl. J. Chem., 2013, 29: 787

[12]. Akihiko I., Hiraku O., Yamamoto, K., Yoshiharu M. J. Pharm.  Soc. Japan, 2006, 126:315

[13]. Rhonalyn V.M., Sheila A.A., Gerald G.A., Cherrielyne S.U. A. P J. Mult. Res., 2015, 3:146

[14]. Stephanie M. C., Disint. Tab., 2013

[15]. Patel M., Jitendra k. P., Umesh M. Upadhyay, Int.  J. Pharm & life sci., 2012, 3: 23

[16]. Itodo A.U., Abdulrahman F.W., Hassan L.G, Maigandi S.A., Itodo H.U. NY Sci., 2010, 15:17.

[17]. Joseph D., livestrong.com./ wikepedia 2017

[18]. Jana S., Jana S., Prep and charact., 2017:289

[19]. Itodo A.U, Khan M.E., Feka D.P.,  Ogoh B. J. Wat. Technol. Treat Meth., 2018, 1:104

[20]. Wyasu G., Gimba C. E., Agbaji E. B., Ndukwe G. I. Adv. Appl. Sci. Res., 2016, 7: 109

[21]. Nakamura T., Oida Y., Matsumoto K., Kawasaki N., Tanada S. Environ. Eng., 2002, 37: 905

[22]. Jana S., Trivedi M.K., Patil S., Shettigar H., Bairwa K., Chem Sci J., 2015, 6:098