Journal of Medicinal and Chemical Sciences

Original Article

Estimation of Serum Ferritin, LDH and Some Biomarker in Patients with COVID19 and Their Relation to Severity of Infection

Noor Mohammed AbdulKader; Ammar Lateef Hussein; Israa Hashim Saadoon; Ahlam Mahmod Abood

Articles in Press, Accepted Manuscript, Available Online from 16 September 2022

https://doi.org/10.26655/JMCHEMSCI.2023.3.1

Abstract

Hyper inflammation is found in severely ill COVID-19 sufferers; corresponding biomarkers may be helpful for risk classification. Our goal was to look at examine the correlation between ... Read More

Original Article

Antibacterial Effect of Aqueous Extract of Theobroma Cacao Against Gram-Negative and Gram-Positive Bacteria: An in Vitro Study

Lubna Abdul Muttalib Al-Shalah; Baraa Hamid Hadi; Fatima M. Abood; Nada Khazal K. Hindi; Sura Ali Hamza; Ansaf Nsaif Jasim; Abduladheem Turki Jalil

Articles in Press, Accepted Manuscript, Available Online from 13 September 2022

https://doi.org/10.26655/JMCHEMSCI.2023.3.2

Abstract

Theobroma Cacao has a wide range against a range of diseases and an antimicrobial activity toward various pathogenic microorganisms which estimated of medicinal properties for the treatment ... Read More

Original Article

P53/P21 Expression Increment as Predisposing Factor for Cancer Development in Hypertensive Patients in Al-Diwaniyah Province, Iraq

Zainab Adnan Hatem Alebady; Oraas Adnan Hatem; Tabarak Abd AL-Hamza; Fatima Mushtaq Sarhan; Mohammed Mrauh Raham

Articles in Press, Accepted Manuscript, Available Online from 13 September 2022

https://doi.org/10.26655/JMCHEMSCI.2023.3.3

Abstract

Hypertension has been linked to a higher risk of getting some malignancies and a higher cancer-related mortality rate. Furthermore, many anticancer medicines have been linked to developing ... Read More

Original Article

Synthesis of New β-Lactam, Tetrazole, Thiazolidinone, and Oxazepine Compounds from Schiff Bases and Study of Their Biological Activity

Raghad Abdalrazaq Ibrahem; Shetha F. N. Al.Zobadyi

Articles in Press, Accepted Manuscript, Available Online from 16 September 2022

https://doi.org/10.26655/JMCHEMSCI.2023.3.4

Abstract

In this research, the first Schiff bases (1) were prepared from the reaction of 4-dimethyl amino benzaldehyde with hydrazine derivative in the presence of glacial acetic acid, and then, ... Read More

Original Article

Using GC-MS Technology to Identify the Compounds Resulting from Mixing of Alcoholic Extracts of Some Medicinal Plants

Maryam Mansoor Mathkoor; Eussur Noory Alkhfaji; Noor Abd-Ulamer Oda

Articles in Press, Accepted Manuscript, Available Online from 16 September 2022

https://doi.org/10.26655/JMCHEMSCI.2023.3.5

Abstract

Phytochemicals are considered as one of the most important pharmaceutical compounds used in pharmacy at all, due to their high therapeutic efficacy and few side effects compared with ... Read More

Original Article

Effects of Body Image Disturbances on the Psychological Status of Woman With Mastectomy at Al Amal Hospital

Nuha Adel Ibrahim

Articles in Press, Accepted Manuscript, Available Online from 16 September 2022

https://doi.org/10.26655/JMCHEMSCI.2023.3.6

Abstract

This study aimed to assess the effects of body image disturbances on psychological status. Methodology: A descriptive design was conducted on the effects of body image disturbances ... Read More

Original Article

Assessing Mental Health of Women Working as Front-Line Health Workers in Self-Help Groups in Odisha During COVID-19 Outbreak

Pratyuesha Behera; Ipseeta Satpathy; B. Chandra Mohan Patnaik

Articles in Press, Accepted Manuscript, Available Online from 18 September 2022

https://doi.org/10.26655/JMCHEMSCI.2023.3.7

Abstract

COVID-19 pandemic has taken a toll on the mental condition of the people globally and the more affected are women as compared to men. Women engaged in self-help groups also suffering ... Read More

Original Article

Study of Diabetic Imbalance During Acute Phase and Recovery in Patients with COVID-19 in Baghdad/Iraq

Ali Muhsin Hasan; Ahmed Saadi Hassan; Amal Hasan Atiyah

Articles in Press, Accepted Manuscript, Available Online from 18 September 2022

https://doi.org/10.26655/JMCHEMSCI.2023.3.8

Abstract

This study aims to investigate traces of COVID-19 on diabetic profile during infection and after recovery to manifest the effects of disease upon pancreas due to uncensored elevation ... Read More

Original Article (Special Issue)

Potential Role of NLRP3 Inflammasome Activation in the Pathogenesis of Periodontitis Patients with Type 2 Diabetes Mellitus

Mohammed Jasim Al-Obaidi; Batool Hassan Al-Ghurabi

Articles in Press, Accepted Manuscript, Available Online from 21 September 2022

https://doi.org/10.26655/JMCHEMSCI.2023.3.9

Abstract

Background: In response to microbial infection and cellular injury, the NLRP3 inflammasome, an essential part of the innate immune system, causes caspase-1 activation and the release ... Read More Background: In response to microbial infection and cellular injury, the NLRP3 inflammasome, an essential part of the innate immune system, causes caspase-1 activation and the release of the proinflammatory cytokines IL-1 β and IL-18. However, various inflammatory diseases, including periodontal disease, have been linked to the abnormal activation of the NLRP3 inflammasome.Aim of study: This study was conducted to investigate the crucial role of NLRP3 inflammasome activation and IL-18 in the pathogenesis of periodontitis patients with type 2 diabetes mellitus.Materials and Methods: This case control study included eighty-five participants., their age range (23-55) years, they divided into three groups: two groups had periodontitis one of them with type two diabetic mellitus and the other one systemically healthy, the third group was the control group with clinically healthy periodontium and systemically healthy. Serum samples from both patients and controls were analyzed using an ELISA kit designed to detect NLRP3 inflammasome activity and interleukin-18.Results: Conclusions: Elevated NLRP3 and IL-18 levels in PD +T2DM patients, as well as their positive correlation with clinical parameters, suggest a critical role in the pathogenesis of PD with and without diabetes.. A significant positive correlation also noticed between NLRP3 and each of (GI, PPD, CAL and BOP) in PD+T2DM patients. Regarding the group of PD patients there was no significance correlation between NLRP3 and clinical parameters. Additionally, IL-18 was discovered to have a positive correlation with GI, PPD, CAL, and BOP in PD+T2DM patients, w. Meanwhile, there is a significant correlation between NLRP3 as well as interleukin-18 in patients with and without type 2 diabetic mellitus.Conclusions: Elevated NLRP3 and IL-18 levels in PD +T2DM patients, as well as their positive correlation with clinical parameters, suggest a critical role in the pathogenesis of PD with and without diabetes.

Original Article

Synthesis, Examination of Various Seven Rings, and Effects on Corrosion and Fungus

Aziz Latif Jarallah; Aseel Fadhil Kareem

Articles in Press, Accepted Manuscript, Available Online from 21 September 2022

https://doi.org/10.26655/JMCHEMSCI.2023.3.10

Abstract

The majority of benzodiazepines is administered orally and has various beneficial effects, including psychotropic, anxiolytic, hypnotic, sedative, muscle relaxing, anticonvulsant, and ... Read More

Original Article

Development of Nail Henna (Lawsonia Inermis Linn.) Leaf Powder as a Latent Fingerprint Visualization on Non-Porous and Porous Surfaces

Sri Adelila Sari; Desi Heriyanti Nasution

Articles in Press, Accepted Manuscript, Available Online from 21 September 2022

https://doi.org/10.26655/JMCHEMSCI.2023.3.11

Abstract

The current study aimed to present a simple, non-toxic, inexpensive, and easy-to-use fingerprint powder extracted from nail henna leaf to identify latent fingerprints on porous and ... Read More

Original Article

Synthesis, Characterization of Azetidine Derivative and Studying the Antioxidant Activity

Osama S.Hashim

Articles in Press, Accepted Manuscript, Available Online from 24 September 2022

https://doi.org/10.26655/JMCHEMSCI.2023.3.12

Abstract

In this study, a derivative of azetidine was obtained by refluxing Schiff-base with an aromatic aldehyde. Schiff-base was prepared by reaction of hydrazine hydrate with chloroacetylchloride ... Read More

Original Article

Evaluation of Anti-atherosclerotic Effects of Melatonin Interference with Inflammatory and Oxidative Stress Pathway in Male Rabbits

Hajar Nazar Hashem; Fadhil A. Rizij

Articles in Press, Accepted Manuscript, Available Online from 25 September 2022

https://doi.org/10.26655/JMCHEMSCI.2023.3.13

Abstract

Atherosclerosis is the primary cause of death worldwide. It is now commonly acknowledged that it is a persistent inflammatory process. Minor inflammation, increased oxidative stress, ... Read More Atherosclerosis is the primary cause of death worldwide. It is now commonly acknowledged that it is a persistent inflammatory process. Minor inflammation, increased oxidative stress, and lipid peroxidation all play the essential roles in the atherosclerosis progression. Melatonin (N-acetyl-5-methoxytryptamine) is a neuroendocrine hormone discovered in the bovine pineal gland. The antioxidant action of melatonin is manifested to its direct effects via M1,2 receptors. It not only increases antioxidant enzymes, but also suppresses mesenchymal cell apoptosis. Melatonin is anti-inflammatory and anti-oxidant. In contrast to well-known Instead of following an enzymatic pathway of reduction after oxidation, as do endogenous antioxidants such carotene and vitamins E and C, melatonin binds permanently to free radicals, which the kidneys eliminate. In comparison to the induced untreated group, melatonin has a significant impact on lipid parameters (P>0.001). Melatonin significantly reduced the elevation in ICAM and a mild effect on the aorta thickness compared with induced untreated groups (P<0.05). The drug restores aortic GSH and SOD level (P<0.001). The aim of this research is to evaluate whether melatonin can protect rabbits against atherosclerosis and their role in inflammatory and oxidative pathway. Twenty-four domestic male rabbits from the surrounding area were divided into three groups: Group One, normal Control group (n = 8). Group Two (n = 8): Rabbits were fed a 1% cholesterol diet (induced untreated group). Group Three (n = 8): 1% cholesterol diet + oral melatonin 10 mg/kg once per day before breakfast. Animals fed with an atherogenic diet had lower levels of GSH, SOD, and higher levels of total cholesterol, triglyceride, high-density lipoprotein cholesterol, low-density cholesterol, very low-density cholesterol, a therogenic index, iCAM, and intimal thickness of the aorta, as compared with controls (P<0.001). In comparison with the induced untreated group, melatonin has a significant impact on lipid parameters (P>0.001). Melatonin significantly reduced the ICAM elevation and a mild effect on aorta thickness compared with induced untreated groups (p<0.05). The drug restore aortic GSH and SOD level (P<0.001). The findings of the current study suggest that melatonin reduce the evolution of atherosclerosis in by meddling with inflammatory and oxidative processes and affecting lipid parameters, it was possible to treat hypercholesterolemic rabbits.

Original Article

Evaluation of 2(3H)-Benzoxazolone Derivatives Containing Piperidine Substituents as Cytotoxic and Apoptotic Agents: An in vitro and in silico Study

Emine Erdag

Articles in Press, Accepted Manuscript, Available Online from 26 September 2022

https://doi.org/10.26655/JMCHEMSCI.2023.3.14

Abstract

To create chemical structures with various pharmacological actions, heterocyclic compounds play a key role as pharmacophores. The pharmacological effects of derivatives of 2(3H)-benzoxazolone ... Read More

Original Article

Appraisal of the Role of Apelin and Visfatin in Ischemic Heart Patients

Lelas Farhan Bdaiwi; Luma Abd Almunim Baker; Yusur Farhan Bdaiwi; Shihabahmed Al-Bajary

Articles in Press, Accepted Manuscript, Available Online from 27 September 2022

https://doi.org/10.26655/JMCHEMSCI.2023.3.15

Abstract

The disease of the ischemic heart is still a severe burden on individuals and healthcare resources all over the world. Flow-limiting obstruction in large–medium-sized coronary ... Read More

Original Article

Hormonal, Histological, and Sperm Parameters: A Comparative Study between Amitriptyline and Escitalopram in Male Mice

Israa Abdulameer Naeem; Ali Ali Khalaf

Articles in Press, Accepted Manuscript, Available Online from 28 September 2022

https://doi.org/10.26655/JMCHEMSCI.2023.3.16

Abstract

This study was designed to compare between anti-depressants (amitriptyline and escitalopram) in terms of their impacts on sperm concentration, motility, and vitality, as well as their ... Read More

Original Article

Quality Control and Testing Evaluation of Various Metoprolol Tartrate (50 mg) Tablets Available in Iraq Market

Yasmien A. Salal; Hayder K. Abbas; Inas F. Abdul Razzaq

Articles in Press, Accepted Manuscript, Available Online from 28 September 2022

https://doi.org/10.26655/JMCHEMSCI.2023.3.17

Abstract

This study was done to assess the effectiveness of commercially available tablets of metoprolol tartrate (50 mg). The specified tablets were manufactured in different companies and ... Read More

Original Article

Potential Role of Empagliflozin to Ameliorate Doxorubicin Induced Cardiotoxicity in Male Rats

Rusul Nadheer Albakaa; Fadhil A. Rizij; Rafid M.Ali Hassan

Articles in Press, Accepted Manuscript, Available Online from 29 September 2022

https://doi.org/10.26655/JMCHEMSCI.2023.3.18

Abstract

Empagliflozin (EMPA), a selective inhibitor of sodium-glucose cotranspoter2 (SGLT2), mainly regulates blood glucose levels. Many different mechanisms illustrated the significant impact ... Read More

Original Article

Isolation, Screening, and Identification of Local Bacterial Isolates Producing Bio-Cellulose

Tayseer Shamran Al-Deresawi; Melad Khalaf Mohammed; Saad Hussein Khudhair

Articles in Press, Accepted Manuscript, Available Online from 30 September 2022

Abstract

The current study aims to easily, quickly, and cheaply select the local bacterial isolate that produces bacterial cellulose. Ten samples of spoiled fruits (triplicate for each) were ... Read More The current study aims to easily, quickly, and cheaply select the local bacterial isolate that produces bacterial cellulose. Ten samples of spoiled fruits (triplicate for each) were taken in Al-Kut City/ Wasit Province/ Iraq. A modified H-S medium was used to isolate the local bacteria from spoiled fruit samples. One-hundred and twelve bacterial isolates were obtained from all samples, where the lemon sample give the highest number of isolates, as it reached 20 isolates, while the banana sample gives the lowest number of isolates reached to 6 isolates. The two steps of screening were achieved to select the best cellulose-producing local isolate, results from the primary screening indicated that only 18 isolates appeared a clear ability to create clear zones as an indicator to produce bacterial cellulose, and the isolates TELE8, TELE11, TEKI4, and TEAP5 gave the highest clear zones of 7.5, 6.1, 6.2, and 6.5 cm, respectively. Also, the second screening step confirmed the results collected from the first step, as the results hydrogel test indicated that only 18 strains showed the ability to produce bacterial cellulose, while the other isolates were unable to do so, as the results showed that the isolate TELE8 was superior in its ability to produce bacterial cellulose than isolates TEK11, TEKI4, and TEAP5. Therefore, the local isolate TELE8 was chosen as the best isolate that produces bacterial cellulose. Thereafter, the phenotype and genotype characteristics were used to identify the TELE8 isolate; its results indicated that the isolate belongs to Komagataeibacter xylinum (previously named first Acetobacter xylinum, and then Gluconacetobacter xylinus). The three methods (static, shaker, and fermenter) were used to produce the bacterial cellulose by using the best local bacterial isolate Acetobacter xylinum TELE8 in HS medium. The results revealed that the highest production of BC (22.8 g/200 ml medium) was obtained when using the fermenter method, while the shaker method did not give the productivity of bacterial cellulose.

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Original Article

The Effects of Levosimendan Against Sepsis-Induced Cardiotoxicity in Mice Model

Qassim A Zigam; Adeeb A. Al-Zubaidy; Zahraa Sami; Weaam J Abbas

Articles in Press, Accepted Manuscript, Available Online from 30 September 2022

Abstract

Sepsis is an upregulated systemic inflammatory reaction that has been identified as a global health concern. It can lead to multiple organ toxicity, including cardiac, hepatic, and ... Read More Sepsis is an upregulated systemic inflammatory reaction that has been identified as a global health concern. It can lead to multiple organ toxicity, including cardiac, hepatic, and renal dysfunction. Sepsis can result in cardiomyocyte impairment, hypertrophy, and heart failure by increasing oxidative stress and the expression of pro-inflammatory cytokines. Furthermore, elevated cardiac troponin-I (cTn-I) during sepsis impairs heart contractile performance by decreasing myofilament response to calcium. The current study aimed to examine the possible effects of levosimendan against sepsis-induced cardiotoxicity. Forty male mice 8-12 weeks old and weighing 25-30 grams. After two weeks of acclimation, the mice were separated into four groups (n = 10): (1) Healthy group (n = 10). (2) CLP group: CLP operation was performed on mice. (3) DMSO group (4) Levosimendan group: 10 mg/kg intraperitoneally (IP) in 2 divided doses for 5 consecutive days. All groups underwent the CLP procedure on the fourth day, were sacrificed on the fifth day, and then samples were taken. The Levosimendan group exhibited a significant (p < 0.05) decrease in myocardial troponin-I concentration compared to the CLP group. In addition, the inflammatory cytokines (TNF-α, IL-6, and IL-1β) serum levels in the levosimendan group were significantly (p < 0.05) lower than in the CLP group. In addition, the levosimendan group demonstrated a significant (p0.05) increase in myocardial SOD activity and a decrease in MDA level compared to the CLP mice. Histopathologically, the levosimendan group demonstrated a statistically significant (p0.05) reduction in cardiac tissue damage. Levosimendan attenuates sepsis-induced cardiotoxicity via multiple protective effects, including anti-inflammatory and antioxidant effects, according to the findings of the present study. In addition, the direct cardiac protective effect via the decreased cardiac troponin-I level and the attenuation of histopathological alterations during sepsis-induced cardiotoxicity.

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Volume 6 (2023)

Volume 5 (2022)

Volume 4 (2021)

Volume 3 (2020)

Volume 2 (2019)

Volume 1 (2018)

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