TY - JOUR ID - 161797 TI - Synthesis and Characterization with Antimicrobial Studies of mixed Curcumin Schiff Base –L-dopa with Divalent Cations Complexes JO - Journal of Medicinal and Chemical Sciences JA - JMCS LA - en SN - AU - Salh, Hala Mohammed AU - H Al-Noor, Taghreed AD - Department of Chemistry, College of Education for Pure Science Ibn -Al-Haithem, University of Baghdad, Baghdad, Iraq Y1 - 2023 PY - 2023 VL - 6 IS - 7 SP - 1621 EP - 1630 KW - Antimicrobial activity L KW - dopa Schiff base Curcumin Complexes DO - 10.26655/JMCHEMSCI.2023.7.13 N2 - In the present article, mixed ligand metal (II) complexes have been synthesized with Schiff base (1E, 5Z, 6E)-1,7 bis (4-hydroxy-3-methoxyphenyl)-5-(3-hydroxyphenyl) imino) hepta-1,6-dien-3-one derived from Curcumin and 3-aminophenol as primary ligand and L-dopa as a secondary ligand. The Schiff base act as bidentate and arrange to the metals through the azomethine (C=N) nitrogen and (C=O) oxygen atom. The mode of bonding of the Schiff base has been affirmed on the infrared by the UV-Visible, 1H, and 13C NMR spectroscopic techniques. The magnetic susceptibility and the UV-Vis data of the complexes propose octahedral geometry around the central metal ion. The information appears that the complexes have the structure of [L-M-(L-dopa)] system, where M=Mn(II), Ni(II), Cu(II), Zn(II) and Cd(II). The low conductance of all complexes supports the non-electrolytic nature of the complexes. The biological activity of the complexes was screened against bacteria, (Klebsiella and P. Staphylococuse and gives a good results anti-fungus C. Albicans). All complexes possess the biological activity which has the same activities, and good antimicrobial activity that displays higher activities against fungus compared with bacteria. UR - https://www.jmchemsci.com/article_161797.html L1 - https://www.jmchemsci.com/article_161797_352391e9e5b62e9bebc91ff493bb5d05.pdf ER -