TY - JOUR ID - 149583 TI - Effect of Oral Clonidine as a Premedication on Hemorrhage during Septorhinoplasty: A Double-Blind Randomized Clinical Trial JO - Journal of Medicinal and Chemical Sciences JA - JMCS LA - en SN - AU - Sohrabpour, Mojtaba AU - Sadeghi, Seyed Ebrahim AU - Ghaedi, Mojtaba AU - Kalani, Navid AU - Sanie Jahromi, Mohammad Sadegh AD - Noncommunicable diseases Research Center, Fasa University of medical sciences, Fasa, Iran AD - Department of Anesthesiology, Faculty of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran AD - Department of Plastic Surgery, Jahrom University of Medical Sciences, Jahrom, Iran AD - Research Center for Noncommunicable Diseases, Jahrom University of Medical Sciences, Jahrom, Iran Y1 - 1999 PY - 1999 VL - 5 IS - 6 SP - 1001 EP - 1007 KW - Septorhinoplasty KW - Clonidine KW - hemorrhage KW - plastic surgery DO - 10.26655/JMCHEMSCI.2022.6.13 N2 - Introduction: Intraoperative hemorrhage is one of the most important complications of septorhinoplasty surgery. Many techniques and drugs are used to reduce this problem. Accordingly, the present study was conducted to investigate the effect of oral clonidine as a premedication on hemorrhage during septorhinoplasty surgery.Methods: In this double-blind randomized clinical trial, 53 patients undergoing septorhinoplasty at Motahari Hospital in Jahrom were studied. Patients were randomly divided into oral clonidine and placebo groups. Intraoperative hemorrhage was measured based on the blood in the suction. The data were analyzed in SPSS-21 and both descriptive and inferential statistical tests were computed.Results: Both groups were homogenous in terms of demographic variables of age, weight, gender and the level of fluid received during the surgery. Mean hemorrhage (P = 0.001) and total duration of surgery (P = 0.031) in the clonidine group were significantly lower than the control group.Conclusion: The results of the present study revealed that oral clonidine as a premedication for anesthesia can reduce hemorrhage and the duration of septorhinoplasty surgery. It is recommended that future studies be performed with a larger sample size and compare with other drugs. UR - https://www.jmchemsci.com/article_149583.html L1 - https://www.jmchemsci.com/article_149583_1b88d32dc60962cb26172507f65585a6.pdf ER -