Sami Publishing Company (SPC)
Journal of Medicinal and Chemical Sciences
2651-4702
2
1
2019
01
01
Solvent-Free Acylation of Alcohols, Phenols, Thiols and Amines
1
8
EN
Mosstafa
Kazemi
0000-0003-4676-720X
Department of Chemistry, Payame Noor University, Tehran, P.O. Box 19395-4697, Iran
mosstafakazemi@gmail.com
Alberto
Sanchez-Mendoza
Faculty of Chemical Sciences, Complutense University of Madrid, Spain
albertosanchezm@yahoo.com
Massoud
Ghobadi
Department of Chemistry, Faculty of Basic Sciences, Ilam University, P.O. Box 69315-516, Ilam, Iran
massoud.ghobadi@gmail.com
10.26655/jmchemsci.2019.6.1
The hazardous and toxic nature of many solvents, in particular organic solvents that are extensively used in large scale for organic reactions have transformed a serious threat to the environment. Therefore, the design of solvent-free catalytic reaction has received considerable attention during recent times in the field of green synthesis. A solvent-free or solid state reaction may be accomplished using the reactants single or merge them in clays, zeolites, silica, alumina or other substrates. Esters, thioesters and amides are important and valuable compounds in the area of industry, medicine, pharmaceutical and heterocyclic chemistry. In this paper, various solvent-free systems to synthesize esters, thioesters and amides via the acylation of alcohols, phenols, thiols and amines are described. In this review we summarized the activities presented mainly the recent years.
Solvent-free,Acylation,Alcohols,Phenols,Thiols,Amines
https://www.jmchemsci.com/article_68638.html
https://www.jmchemsci.com/article_68638_1e9587523339a102f3a3d35f480d7847.pdf
Sami Publishing Company (SPC)
Journal of Medicinal and Chemical Sciences
2651-4702
2
1
2019
01
01
Scope of Nanotechnology in Cosmetics: Dermatology and Skin Care Products
9
16
EN
Awais
Hameed
Department of Chemistry, University of Education, Lahore-Vehari Campus, VEHARI, Punjab, Pakistan
awaishameed767@gmail.com
Gull Rida
Fatima
Department of Chemistry, University of Education, Lahore-Vehari Campus, VEHARI, Punjab, Pakistan
fatimagullride@gmail.com
Kainat
Malik
Department of Chemistry, University of Education, Lahore-Vehari Campus, VEHARI, Punjab, Pakistan
km78043@gmail.com
Ayesha
Muqadas
Department of Chemistry, University of Education, Lahore-Vehari Campus, VEHARI, Punjab, Pakistan
ayeshachawla5@gmail.com
M.
Fazal-ur-Rehman
0000-0003-0265-4465
Department of Chemistry, Faculty of Science & Technology, University of Education, Lahore-Vehari Campus, Vehari-61100, Punjab, Pakistan
fazalurrehman517@gmail.com
10.26655/jmchemsci.2019.6.2
Women and men have been wearing cosmetics for centuries, although the styles have certainly undergone some dramatic changes over time. Cosmetics is a very vast field which has served humanity throughout the course of history.In old age, it was believed that there is no chemical product in the world that can be at all-natural. Industrialization has revolutionized the field.So, then nanotechnology is evolved and cosmetics become environmentally friendly. Different nanomaterial liposomes, solid lipid Nanoparticle, cubosomes, dendrimers etc. have advance properties for skin care. Nano emulsion is the most important part in this regard. They are widely used in gel, lotion, creams emulsions is replaced with vitamin A and its derivative for more efficient work. Sunscreen with inorganic material such as metal TiO<sub>2 </sub>and ZnO<sub>2</sub> is better in skin care products. In this short review, some nanotechnology scope in cosmetics, in terms of dermatology and skin care products, has been significantly particularized.
Cosmeceuticals,Dermatology,Nano emulsions,Skin Care Products
https://www.jmchemsci.com/article_68859.html
https://www.jmchemsci.com/article_68859_eea7053f5914c4e3f29aee91c77fdbc6.pdf
Sami Publishing Company (SPC)
Journal of Medicinal and Chemical Sciences
2651-4702
2
1
2019
01
01
Anomalous reactivity of benzopinacolone towards 4-phenylthiosemicarbazide, a nucleophile endowed with alpha-effect
17
20
EN
Urbain C.
Kassehin
Medicinal Organic Chemistry Laboratory (MOCL), School of Pharmacy, Faculté des Sciences de la Santé, Universitéd'Abomey-Calavi, Campus du Champ de Foire, 01 BP 188, Cotonou, Bénin
urbain.kassehin@gmail.com
Steeve A.
Adjibode
Medicinal Organic Chemistry Laboratory (MOCL), School of Pharmacy, Faculté des Sciences de la Santé, Universitéd'Abomey-Calavi, Campus du Champ de Foire, 01 BP 188, Cotonou, Bénin
adjibodesteeve@gmail.com
Oscar
Bautista
Medicinal Chemistry (CMFA), Louvain Drug Research Institute, UCLouvain. 73, Av. E. Mounier B-1200 Brussels, Belgium, E.U.
oscar.bautista@uclouvain.be
Fernand A.
Gbaguidi
Medicinal Organic Chemistry Laboratory (MOCL), School of Pharmacy, Faculté des Sciences de la Santé, Universitéd'Abomey-Calavi, Campus du Champ de Foire, 01 BP 188, Cotonou, Bénin
ahokannou@yahoo.fr
Joëlle
Quetin- Leclercq
Pharmacognosy Recherch Group (GNOS), Louvain Drug Research Institute, UCLouvain. 72, Bte B1.72.03, Av. E. Mounier B-1200 Brussels, Belgium, E.U.
joelle.leclercq@uclouvain.be
Christopher R.
McCurdy
Medicinal Chemistry, College of Pharmacy. Medical Science Building, P6-33, PO. Box 100485, University of Florida, Gainesville, FL 32610, USA
cmccurdy@ufl.edu
Raphaël
Frédérick
Medicinal Chemistry (CMFA), Louvain Drug Research Institute, UCLouvain. 73, B1.73.10 Av. E. Mounier B-1200 Brussels, Belgium, E.U.
raphael.frederick@uclouvain.be
Jacques H.
Poupaert
Medicinal Chemistry (CMFA), Louvain Drug Research Institute, UCLouvain. 73, B1.73.10 Av. E. Mounier B-1200 Brussels, Belgium, E.U.
jhpbdn17@gmail.com
10.26655/jmchemsci.2019.6.3
<span lang="EN-US">In a medicinal chemistry-driven drug discovery program aimed at synthesizing new topically-acting trypanocidal chemotherapeutic agents to treat the African trypanosomiasis, our research group became interested in new chemical entities bearing in their center a thiohydrazide (C=S) NHNH or thiosemicarbazide NH(C=S) NHNH central template flanked on both sides by lipophilic aryl moieties. In this context, benzopinacolone was found to react as a rather unusual acylating agent <em>via</em> a mechanism (addition/elimination) involving addition of the nucleophile (a thiosemicarbazide derivative), formation of a resulting tetrahedral adduct, and expulsion of a trityl anion moiety as leaving group, presumably through an anchimeric assistance effect by intram-olecular participation of the thioureido side-chain <em>via</em> hydrogen bond formation. The present incidental discovery should be considered at this level as a first inception and further work is now being directed at closely examining the detailed mechanism of this exceptional chemical pathway; in a reaction involving the unusual breaking of a carbon-carbon bond (carbon acid as leaving group) in the rate-determining step and involving the decomposition of the intermediate tetrahedral adduct to get the final unexpected <em>N</em>-thiobenzoyl-thiosemicarbazide.</span>
Benzopinacolone,Green chemistry,N-thiobenzoyl-thiosemicarbazide,Photochemistry,Trypanocidal chemotherapeutic
https://www.jmchemsci.com/article_69027.html
https://www.jmchemsci.com/article_69027_5639c2a37b9cf2b4101af076433bfb07.pdf
Sami Publishing Company (SPC)
Journal of Medicinal and Chemical Sciences
2651-4702
2
1
2019
01
01
Polluted Water Borne Diseases: Symptoms, Causes, Treatment and Prevention
21
26
EN
M.
Fazal-ur-Rehman
0000-0003-0265-4465
Department of Chemistry, Faculty of Science & Technology, University of Education, Lahore-Vehari Campus, Vehari-61100, Punjab, Pakistan
fazalurrehman517@gmail.com
10.26655/jmchemsci.2019.6.4
Polluted and dirty water is very harmful for living organisms especially for health of humans. It causes many serious health problems which can ultimately lead to death if not treated at early stages. Water borne diseases including cholera, Dracunculiasis, Typhoid fever, Diarrhea, Ulcers, Hepatitis, Arsenicosis, Respiratory Tract Infection, Kidney Damage, and Endocrine Damages are very risky for lives of individuals and especially for humans ultimately leading to death. These diseases are mainly due to drinking water problems because of presence of different harmful bacteria and germs which may cause these drugs. These diseases can be cured with proper medications and treatment courses. Along the treatment, there are different ways to prevent from these diseases. So, the lives of human beings can be protected from these water borne-disease. The water treatment can also be used so no one can drink or use dirty or untreated water and can be saved from these effects. So, in this article, causes of these diseases, factors increasing the risks, treatment and prevention ways are summarized briefly.
Dirty Water,Water Born Diseases,Antibiotics,Painkillers
https://www.jmchemsci.com/article_75633.html
https://www.jmchemsci.com/article_75633_2bca963fdcfabb110d0feaf58b603481.pdf
Sami Publishing Company (SPC)
Journal of Medicinal and Chemical Sciences
2651-4702
2
1
2019
01
01
Ultrasound assisted synthesis of N-aryl indole under multi-site phase-transfer catalyst: A kinetic study
27
34
EN
Manickam
Sathiyaraj
Department of Chemistry, Pachaiyappa’s College Chennai, Tamil Nadu, India-600030
manicsathya@gmail.com
PERUMAL
VENKATESH
Department of Chemistry, Pachaiyappa’s College Chennai, Tamil Nadu, India-600030
venkat_28@hotmail.com
10.26655/jmchemsci.2019.6.5
The ultrasound assisted preparation of 1-benzyl-1-indole (arylation) from the reaction of benzyl chloride (BC) and indole was carried out successfully using solid sodium hydroxide and catalyzed by multi-site phase-transfer catalyst (MPTC) viz., 1,4-benzyl-1,4-diazoniab-icyclo[2.2.2]octanium dichloride in a solid–liquid reaction condition (SL-PTC). Water was introduced in a trace quantity to the reaction system to avoid a serious hydration of active intermediate. The potentiality of the multi–site phase-transfer catalyst was demonstrated by following the kinetics arylation of indole under pseudo–first order conditions by employing aqueous sodium hydroxide and indole in excess. The reaction was monitored by gas Chromatography. The synthesized MPTC and 1-benzyl-1-indole were characterized by <sup>1</sup>H NMR and <sup>13</sup>C NMR. The reaction is greatly enhanced in the solid–liquid system, catalyzed by multi-site quaternary ammonium salt (MPTC) and ultrasound irradiation (28 kHz, 300W) in a batch reactor.
Ultrasound,Interfacial reactions,Indole,Kinetics,Benzyl chloride
https://www.jmchemsci.com/article_74167.html
https://www.jmchemsci.com/article_74167_0eba3e1bffc4541061cf91ec5ee1ee34.pdf
Sami Publishing Company (SPC)
Journal of Medicinal and Chemical Sciences
2651-4702
2
1
2019
01
01
One-Pot synthesis of 2-amino-4H-chromenes using L-Prolineas a reusable catalyst
35
37
EN
Zahra
Moghadasi
oung Researchers and Elite Club, Ilam Branch, Islamic Azad University, Ilam,
Iran
z_moghadasi@gmail.com
10.26655/jmchemsci.2019.6.6
A new and efficient synthesis of2-amino-chromenes is achieved by one pot three-component reaction of aldehydes, malononitrile, and resorcinol using <em>L-</em>proline as a reusable catalyst.The key advantages of the present process are the use of a bioorganic and reusable catalyst, high yields of products, using green solvent and short reaction times from the principles of green chemistry point of view.
2-amino-chromenes,Three-component reaction,L-proline,Reusable catalyst,Green solvent
https://www.jmchemsci.com/article_74788.html
https://www.jmchemsci.com/article_74788_34ca483dac853c0afa3fcdff3a0ccfb3.pdf
Sami Publishing Company (SPC)
Journal of Medicinal and Chemical Sciences
2651-4702
2
1
2019
01
01
Copper-catalyzed Ligand-Free Suzuki–Miyaura Coupling Reaction of Aryl Halides with Arylboronic Acid
38
40
EN
Hua-Feng
Zhang
School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, P. R. China
zhanghf.chem11@gmail.com
10.26655/jmchemsci.2019.6.7
A highly efficient and ligand-free approach for the Suzuki–Miyaura cross-coupling reaction of aryl halides with arylboronic acid catalyzed by CuI/Cs2CO3 in DMF has been developed. Under the described conditions, a category of aryl halides including iodides and bromides, whether electron-rich or electron-deficient, were coupled with arylboronic acid to give the target products (moderate to excellent yields). This catalytic system was less efficient in the reactions of aryl bromides as a higher reaction temperature was required to improve the yield.
CuI,ligand-free,Suzuki–Miyaura Coupling,Aryl halides,Arylboronic acid
https://www.jmchemsci.com/article_75102.html
https://www.jmchemsci.com/article_75102_3053d29f5f6853638eac115f8934b1ec.pdf