Sami Publishing Company (SPC)
Journal of Medicinal and Chemical Sciences
2651-4702
3
3
2020
07
01
Adsorption of melphalan anticancer drug on the surface of boron nitride cage (B12N12): A comprehensive DFT study
199
207
EN
Elahe Sadat
Mirkamali
Department of Chemistry, Islamic Azad University, Yadegar-e-Imam Khomeini (RAH) Shahre-Rey Branch Tehran, Iran
elahesadat.mirkamali99@yahoo.com
Roya
Ahmadi
Department of Chemistry, Islamic Azad University, Yadegar-e-Imam Khomeini (RAH) Shahre-Rey Branch Tehran, Iran
roya_ahmadi_chem@yahoo.com
10.26655/JMCHEMSCI.2020.3.1
In this study, boron nitride cage (B<sub>12</sub>N<sub>12</sub><strong>) </strong>adsorption with Melphalan anticancer agent in solvent phase (water) was studied using the density function theory (DFT) method. First, the structure of the Melphalan, B<sub>12</sub>N<sub>12</sub> and their derivatives were geometrically optimized in two different configurations, with a base set of 6-31G* and hybrid B3LYP functions. Then, IR calculations, frontier molecule orbital (FMO) studies, and molecular orbital analysis were performed. In addition, thermodynamic parameters including, Gibbs free energy (ΔG<sub>ad</sub>) and enthalpy (ΔH<sub>ad</sub>) variations indicated that the adsorption of Melphalan with B<sub>12</sub>N<sub>12</sub> is intense, spontaneous, one-way and non-equilibrium. The effect of temperature was studied as well. The results proved that at K 305.15 the highest efficiency was achieved.
Boron nitride cage,Density functional theory,Adsorption,Melphalan,Detection
https://www.jmchemsci.com/article_104163.html
https://www.jmchemsci.com/article_104163_3528597a35fd9e9278f79d3c51d496f8.pdf
Sami Publishing Company (SPC)
Journal of Medicinal and Chemical Sciences
2651-4702
3
3
2020
07
01
Chemical screening for codeine and tramadol in urine of anonymous students attending university sick bays
208
218
EN
Rufus
Sha’Ato
Department of Chemistry, Federal University of Agriculture, PMB 2373 Makurdi, Nigeria
rshaato@gmail.com
Adams Udoji
Itodo
0000-0002-4755-2270
Department of Chemistry, Federal University of Agriculture, PMB 2373 Makurdi, Nigeria
itodoson2002@gmail.com
Atumeyi Anthony
Ugbedeojo
Department of Chemistry, Federal University of Agriculture, PMB 2373 Makurdi, Nigeria
tony.atumeyi@gmail.com
10.26655/jmchemsci.2020.3.2
In this study, anonymous chemical screening of psychoactive substances (codeine and tramadol) was carried out on urine collected from some students in two Nigerian Universities, coded UN1 and UN2 for a Federal a State University, respectively. Chloroform was used as the extractant and sodium borate was used to adjust the pH of the urine samples to 9. Thin-layer chromatography (TLC) and UV-Visible spectrophotometer was used as the primary separation and quantification methods, respectively. The concentrations of codeine in the urine samples collected from UN1 sick bay ranged from 2.822 ppm to 44.756 ppm, while that of UN2 ranges from 0.289 ppm to 4.434 ppm. The respective concentrations of tramadol for the institutions are within the range of 0.015 ppm to 34.833 ppm and 0.181 ppm to 37.030 ppm. There was a statistical difference (p<0.05) in the use of codeine and tramadol among students attending the selected clinics. It was suggested that the University students be subjected to continuous routine screening and counseling.
Psychoactive,Screening,Codeine,Drug,Abuse,Tramadol
https://www.jmchemsci.com/article_104165.html
https://www.jmchemsci.com/article_104165_6e4f26f1215ba33b14bf1a24792a0610.pdf
Sami Publishing Company (SPC)
Journal of Medicinal and Chemical Sciences
2651-4702
3
3
2020
07
01
Novel unsymmetric diimines: Synthesis and biological evaluation against pathogenic microorganisms
219
227
EN
Dilek
Nartop
0000-0002-0705-5018
Department of Polymer Engineering, Faculty of Techonology, Düzce University, Düzce, Turkey
dileknartop@duzce.edu.tr
Hatice
Öğütcü
Department of Field Crops, Faculty of Agriculture, Ahi Evran University, Kırşehir, Turkey
hogutcu@gmail.com
10.26655/jmchemsci.2020.3.3
<span lang="TR">In this research study, three new unsymmetric diimines (<strong>3a-3c)</strong> were prepared using a two-step process. The synthesized unsymmetric tetradentate diimines were elucidated by FT-IR, <sup>1</sup>H-NMR, LC-MS, elemental analysis </span><span>techniques. </span><span lang="TR">The antimicrobial and the antifungal properties of newly synthesized unsymmetrical diimines (<strong>3a-3c)</strong> and previously reported by one of us unsymmetrical diimines (<strong>4a-4c)</strong> were evaluated against<em> L. monocytogenes 4b</em>, <em>B. cereus sp.</em>, <em>S. typhi H, Br. abortus, S. epidermis sp.</em>, <em>M. Luteus sp.,</em> <em>E. coli, P. putida sp</em>. <em>Sh. dys. typ. 7 </em>ve <em>C. albicans.</em><strong> 3b</strong>, <strong>3c</strong>, <strong>4a</strong> and <strong>4c</strong> are showed the highest antimicrobial activity against <em>B.cereus sp.</em> <strong>3a</strong> and <strong>4b</strong> are exhibited the highest activity against <em>S.epidermis sp.</em> and <em>Br. abortus, </em>respectively. In addition, all unsymmetrical diimines are showed </span><span>high</span><span lang="TR"> antifungal activity against <em>C. albicans.</em></span>
Antibacterial agents,reduction,Sodium dithionite,Unsymmetric diimine
https://www.jmchemsci.com/article_104166.html
https://www.jmchemsci.com/article_104166_15c732d9fdea172a36835da9aea38b33.pdf
Sami Publishing Company (SPC)
Journal of Medicinal and Chemical Sciences
2651-4702
3
3
2020
07
01
Solar light photo-catalyzed condensation of aldones with 4-phenylthiosemicarbazide, a green chemistry approach
228
234
EN
Steeve M.
Adjibodé
Medicinal Organic Chemistry Laboratory (MOCL), School of Pharmacy, Faculté des Sciences de la Santé, Université d'Abomey-Calavi, Campus du Champ de Foire, 01 BP 188, Cotonou, Bénin
adjibodesteeve@gmail.com
Urbain C.
Kasséhin
Medicinal Organic Chemistry Laboratory (MOCL), School of Pharmacy, Faculté des Sciences de la Santé, Université d'Abomey-Calavi, Campus du Champ de Foire, 01 BP 188, Cotonou, Bénin
urbain.kassehin@gmail.com
Sedami
Fagla Medegan
Medicinal Organic Chemistry Laboratory (MOCL), School of Pharmacy, Faculté des Sciences de la Santé, Université d'Abomey-Calavi, Campus du Champ de Foire, 01 BP 188, Cotonou, Bénin
medegansed@gmail.com
Joëlle
Quetin-Leclercq
Pharmacognosy Research group (GNOS), Louvain Drug Research Institute, Université Catholique de Louvain, 1200 Brussels , Belgium, E.U.
joelle.leclercq@uclouvain.be
Fernand A.
Gbaguidi
Medicinal Organic Chemistry Laboratory (MOCL), School of Pharmacy, Faculté des Sciences de la Santé, Université d'Abomey-Calavi, Campus du Champ de Foire, 01 BP 188, Cotonou, Bénin
ahokannou@yahoo.fr
Jacques H.
Poupaert
Medicinal Chemistry (CMFA), Louvain Drug Research Institute, UCLouvain. 73, B1.73.10Av. E. Mounier B-1200 Brussels, Belgium, E.U.
jhpbdn17@gmail.com
10.26655/jmchemsci.2020.3.4
A significant photo-activating effect was evidenced upon investigating the condensation of aldehydes and ketones with 4-phenylthiosemicarbazide in the absence of any type of catalyst (either acido-basic or nucleophilic catalysis). Actual yields were not found superior to those obtained using nucleophilic catalysts; however, the reaction can be run at room temperature with the absence of an additional solvent. A positive hydrophobic effect was also noted. Furthermore, it was found that, the described photo-chemical method did not require an expensive and energy-consuming photo-chemical equipment since the whole process was carried out using natural solar light in regular laboratory glass ware.
Solar light,aldones,4-phenylthiosemicarbazide,Catalyst,Green chemistry
https://www.jmchemsci.com/article_105978.html
https://www.jmchemsci.com/article_105978_0b746836ac075c9b9b9f0b2d58917f0d.pdf
Sami Publishing Company (SPC)
Journal of Medicinal and Chemical Sciences
2651-4702
3
3
2020
07
01
Nanohybrid based on layered zinc hydroxide with salicylic acid drug: Investigation of the structure and controlled release properties
235
244
EN
Hafezeh
Nabipour
0000-0002-3349-0363
State Key Laboratory of Fire Science, University of Science and Technology of China, 96 Jinzhai Road, Hefei, Anhui 230026, P. R. China
hafezeh@ustc.edu.cn
Yuan
Hu
State Key Laboratory of Fire Science, University of Science and Technology of China, 96 Jinzhai Road, Hefei, Anhui 230026, P. R. China
yuanhu@ustc.edu.cn
10.26655/jmchemsci.2020.3.5
Recently, nanoparticles have attracted much attention owing to their potential in biomedical applications, such as drug delivery systems, sustained release and controlled release. Various nanocarriers have been employed to ameliorate the efficacy and cytotoxicity of drugs, reducing their side effects through changing their pharmacokinetic properties. A simple and well-known model of pharmaceutical carriers is the layered zinc hydroxide (LZH) compound. In the present research, salicylic acid (Sal)-loaded LZH was synthesized using the ion-exchange method. The resulted nanohybrid (Sal-LZH) was characterized using the PXRD, FT-IR spectroscopy, STA analysis, BET, and SEM. Sal anions were intercalated into the interlayer gallery space of LZH, leading to different drug releases at pH 4.8 and 7.4. It was found that, the release of Sal anions from the synthetic nanohybrid occurred in a controlled manner, and the resulting material is suitable for use as a controlled-release formulation for various kinds of anti-inflammatory agent.
Salicylic Acid,Layered zinc hydroxide,Nanohybrid,structure,Controlled release
https://www.jmchemsci.com/article_106583.html
https://www.jmchemsci.com/article_106583_d4fce0d3a2721d8adc4ec8f70d9a5038.pdf
Sami Publishing Company (SPC)
Journal of Medicinal and Chemical Sciences
2651-4702
3
3
2020
07
01
Consideration antimicrobial and antioxidant properties of anbarnesa smoke ointment
245
253
EN
Shaghayegh
Ataei Moghadam
Department of Chemistry, Faculty of Basic Sciences, GonbadKavous University, GonbadKavous, Iran
shaghayegh.ataei.moghadam@gmail.com
Faramarz
Rostami Charati
Department of Chemistry, Faculty of Basic Sciences, GonbadKavous University, GonbadKavous, Iran
f_rostami_ch@yahoo.com
Reza
Akbari
Department of Chemistry, Faculty of Basic Sciences, GonbadKavous University, GonbadKavous, Iran
akbari_reza1979@yahoo.com
Ebrahim
Gholamalipour Alamdari
Department of Rangeland Science, GonbadKavous University, GonbadKavous, Iran
eg.alamdari@gmail.com
Bahareh
Behmanesh
Department. Plant Sciences - Weed Eco physiology, GonbadKavous University, GonbadKavous, Iran
bahareh_behmanesh@yahoo.com
10.26655/jmchemsci.2020.3.6
<em><span>Anbarnesa</span></em><span> or donkey dung is one of the most effective smokes used for treatment of many infectious and viral diseases. It is also used as disinfectants. The purpose of this study was to evaluate the antimicrobial and anti-radical activity of <em>Anbarnesa </em>smoke and to provide ointment. In this research study, the donkey dung was burned by the designed machine and the smoke was collected in a diethyl ether solvent. The solvent evaporated at environment temperature and was used to test the dried specimens. To determine the MIC and MBC of the sample at the presence of bacteria was used Macro broth dilution method. The MIC and MBC of the smoke was shown on Staphylococcus aureus 1.87, 3.75 mg/mL and on Escherichia coli 3.75, 7.5 mg/mL, respectively. The average percentage of the inhibitation of free radicals in concentration of 9, 6, and 3% of smoke, was found to be 28.37, 18.86 and 8.86, respectively</span><em><span lang="TR">.</span></em>
Anbarnesa,Medicinal smoke,Medicinal properties
https://www.jmchemsci.com/article_107800.html
https://www.jmchemsci.com/article_107800_7ffa8062b8f100adb0d84888ee5485ba.pdf
Sami Publishing Company (SPC)
Journal of Medicinal and Chemical Sciences
2651-4702
3
3
2020
07
01
Antiviral activity of isoindole derivatives
254
285
EN
Ferenc
Csende
Taxus Research Laboratory, Bocskai u. 22., H-4080 Hajdúnánás, Hungary
csende@nanaskabel.hu
Andrea
Porkoláb
Taxus Research Laboratory, Bocskai u. 22., H-4080 Hajdúnánás, Hungary
10.26655/jmchemsci.2020.3.7
<span lang="EN-GB">The isoindole scaffolds and their related compounds are very important as they have a wide range of biological activities such as anti-inflammatory, antiarrhythmic, nootropic, anxiolytic, sedative, and antimicrobial activities. The design, synthesis and biological evaluation of novel antiviral agents have seen an increased relevance over the past few years. Several promising and successful results have been collected and reported in this mini review that could be useful for their further development and application in antiviral therapy. Furthermore, the main types of drug targets, the mechanism of actions, and the structure–activity relationship have also been studied to find potent and safe antiviral agents. This review summarises the considerable antiviral activities of isoindoline derivatives against several human viruses. The isoindole framework has and comprises many advantageous physicochemical- and biological properties. Several promising results showed that linkage, fusion, substitution or hybridization of the isoindole ring with various other rings or side chains led to effective antivirals. Results reported refer to versatile mechanism of action of thesecompounds.</span>
antiviral activity,Cytotoxicity,Enzymes,Inhibition,Isoindole,QSAR
https://www.jmchemsci.com/article_107803.html
https://www.jmchemsci.com/article_107803_a9654e2d7c9c30179d8b488d139dc087.pdf
Sami Publishing Company (SPC)
Journal of Medicinal and Chemical Sciences
2651-4702
3
3
2020
07
01
Effectiveness of group logo-therapy program on existential anxiety among patients with metabolic syndrome
286
299
EN
Masoumeh
Alimohammadi
0000-0002-7629-555X
PhD Student of General Psychology, Faculty of Humanities Science, Islamic Azad University, Shahrood branch, Shahrood, Iran
alimohammadim47@gmail.com
Parviz
Sharifi-Daramadi
0000-0002-4608-8453
Professor in Exceptional Child Psychology, Faculty of Humanities Science, Islamic Azad University, Shahrood Branch, Shahrood, Iran
pr-sharifidaramadi@yahoo.com
Shahnaz
Noohi
0000-0003-4569-8265
Assistant Professor in General Psychology, Faculty of Humanities Science, Islamic Azad University, Shahrood branch, Shahrood, Iran
noohishahnaz@hotmail.com
10.26655/JMCHEMSCI.2020.3.8
<span lang="EN-GB">Metabolic syndrome is one of the most common diseases both in Iran and in the world, which has been widely reported to be associated with anxiety and distress in the metabolic syndrome group. The purpose of the present study was to determine the effectiveness of an educational group logotherapy on existential anxiety in patients with metabolic syndrome. This study was a quasi-experimental pretest-posttest with a control group. The study population consisted of adult women aged between 25 to 60 years old with Metabolic Syndrome that referred to the health center of Semnan County in 2018. The sample included 30 (15 for each group) patients with Metabolic Syndrome who were selected as an available and randomly recruits to each of the groups. Then, the participants in the experimental group participated in 10 sessions of 90 min of Group Logo-Therapy Program, while the control group did not receive any intervention. The instrument for gathering data was the Existential Anxiety Questionnaire. To analyze the data, SPSS.v21 software and statistical tests such as MANCOVA and paired t-test were applied. The results indicated that the group logo-therapy program had a statistically significant impact on components of meaning anxiety and death anxiety, but no difference between control and experimental group in term of loneliness anxiety and responsive anxiety was observed. Also, the results indicated that there was stability at the follow-up stage for death anxiety and loneliness anxiety. According to the results, the group logic training program has been effective in changing some of the variable dimensions of existential anxiety and has increased the ability of individuals to face logic and consequently responsibility for life. And, considering the transient existence of the world in place of insecurity and isolation, it calls for human effort and activity, so it is recommended to use this intervention for people with existential anxiety.</span>
Logo-Therapy,Existential anxiety,Metabolic Syndrome
https://www.jmchemsci.com/article_109842.html
https://www.jmchemsci.com/article_109842_a8ec5f784e52734c70f68c2cae32c70d.pdf
Sami Publishing Company (SPC)
Journal of Medicinal and Chemical Sciences
2651-4702
3
3
2020
07
01
Spectrophotometric first order derivative method for simultaneous determination of etoricoxib and paracetamol in tablet dosage form
300
307
EN
Ashok B
Patel
B. K. Mody Government Pharmacy College, Polytechnic Campus, Near Aji Dam, Rajkot, Gujarat, India. Postal Code : 360003
abp2038@gmail.com
Ekta
Vaghasiya
B. K. Mody Government Pharmacy College, Polytechnic Campus, Near Aji Dam, Rajkot, Gujarat, India. Postal Code : 360003
ektavaghasiya016@gmail.com
Amitkumar J
Vyas
B. K. Mody Government Pharmacy College, Polytechnic Campus, Near Aji Dam, Rajkot, Gujarat, India. Postal Code : 360003
amitvyas77@gmail.com
Ajay I
Patel
B. K. Mody Government Pharmacy College, Polytechnic Campus, Near Aji Dam, Rajkot, Gujarat, India. Postal Code : 360003
aipvk84@gmail.com
Nilesh K
Patel
B. K. Mody Government Pharmacy College, Polytechnic Campus, Near Aji Dam, Rajkot, Gujarat, India. Postal Code : 360003
nkpatel99@gmail.com
10.26655/jmchemsci.2020.3.91
This work was aimed to develop a new, sensitive, accurate, precise, and simple UV spectrophotometric method for estimating the Etoricoxib and Paracetamol in tablet dosage form. Firstorder derivative simultaneous estimation was carried out by using the UV-visible double beam spectrophotometer. Etoricoxib and Paracetamol exhibited absorbance at working wavelength 248 nm (Zero crossing point of Paracetamol) and 258.4 nm (Zero crossing point of Etoricoxib), respectively, using methanol as a solvent. Linearity was found 1-8 μg/mL for Etoricoxib and 5.42-43.3 μg/mL for Paracetamol. Accuracy was obtained between 98.96 to 101.38% for Etoricoxib and 98.38 to 101.64% for Paracetamol. LOD an LOQ was found to be 0.122 μg/mL and 0.248 μg/mL for Etoricoxib and 0.075 μg/mL and 0.152 μg/mL for Paracetamol. The developed method was validated as per ICH Guideline. The results confirmed that the proposed method is suitable for the routine analysis for the estimation of Etoricoxib and Paracetamol in tablet dosage form.
Etoricoxib,Paracetamol,UV spectrophotometry,First order derivative method,ICH guideline
https://www.jmchemsci.com/article_109844.html
https://www.jmchemsci.com/article_109844_397f6adf40dcf20cc2af04b52dfc2440.pdf
Sami Publishing Company (SPC)
Journal of Medicinal and Chemical Sciences
2651-4702
3
3
2020
07
01
Determination of tartrazine in some food and medicine samples after solid phase extraction
308
316
EN
Nazan
Sayar
0000-0002-1671-5495
Nevşehir Hacı Bektaş Veli University, Faculty of Arts and Science, Department of Chemistry, 50300 Nevşehir, Turkey
n.syr_33@hotmail.com
Aslihan
Karatepe
0000-0002-9223-6453
Nevşehir Hacı Bektaş Veli University, Faculty of Arts and Science, Department of Chemistry, 50300 Nevşehir, Turkey
akaratepe@nevsehir.edu.tr
10.26655/jmchemsci.2020.3.10
Food dyes are one of the most widely used additives in commercial food products such as beverages, candies, pharmaceuticals, and cosmetics. Despite the laws and regulations which aim to limit the synthetic colourant usage due to their pathogenic effects, they are widely used. Therefore, analyzing these dyes become very important for human health. Tartrazine is one of the commonly used synthetic food dyes and so the development of a new, simple, and accurate separation, preconcentration, and spectrophotometric determination of tartrazine (E 102) was the aim of this work. The method was based on solid-phase extraction by using Diaion SP-207 resin and determination with UV Spectrophotometer. Analytical parameters affecting the recoveries of tartrazine were investigated to find the optimal conditions. The retained tartrazine was removed from the column by 10 mL of 0.01 M HCl in acetone. The recovery values were found as >95%. By this new method, tartrazine contents of various food and medicine samples were determined successfully. TThe recoveries of understudy analytes were found in the range of 93–98%, while the detection limits were calculated in the range of 0.3–2.0 μg L<sup>−1</sup>.he detection limit was found as 3.52 μg/L. Calibration standards used in the experiments were in the range of 10<sup>-7 </sup>-1x10<sup>-5</sup> mol L<sup>-1</sup> with a correlation coefficient of 0.999.
Solid phase extraction,Tartrazine,Diaion SP-207,UV spectrophotometry
https://www.jmchemsci.com/article_109845.html
https://www.jmchemsci.com/article_109845_2c4d278ae592c894de6cd9714831c79c.pdf