%0 Journal Article %T Copper-catalyzed Ligand-Free Suzuki–Miyaura Coupling Reaction of Aryl Halides with Arylboronic Acid %J Journal of Medicinal and Chemical Sciences %I Sami Publishing Company (SPC) %Z 2651-4702 %A Zhang, Hua-Feng %D 2019 %\ 01/01/2019 %V 2 %N 1 %P 38-40 %! Copper-catalyzed Ligand-Free Suzuki–Miyaura Coupling Reaction of Aryl Halides with Arylboronic Acid %K CuI %K ligand-free %K Suzuki–Miyaura Coupling %K Aryl halides %K Arylboronic acid %R 10.26655/jmchemsci.2019.6.7 %X A highly efficient and ligand-free approach for the Suzuki–Miyaura cross-coupling reaction of aryl halides with arylboronic acid catalyzed by CuI/Cs2CO3 in DMF has been developed. Under the described conditions, a category of aryl halides including iodides and bromides, whether electron-rich or electron-deficient, were coupled with arylboronic acid to give the target products (moderate to excellent yields). This catalytic system was less efficient in the reactions of aryl bromides as a higher reaction temperature was required to improve the yield. %U https://www.jmchemsci.com/article_75102_3053d29f5f6853638eac115f8934b1ec.pdf