%0 Journal Article %T Expression of MicroRNA-155-5p in Chronic Kidney Disease as a Potential Marker of Cardiovascular Complications %J Journal of Medicinal and Chemical Sciences %I Sami Publishing Company (SPC) %Z 2651-4702 %A Mohamed, Hend Sayed %A M. Alhabibi, Alshaymaa %A Elmaged Donia, Ashraf Abd %A Elsawy, Ghadir Mohamed %A Ibrahim, Nehad Refaat %A Mohamed, Mona A. %D 2023 %\ 08/01/2023 %V 6 %N 8 %P 1737-1745 %! Expression of MicroRNA-155-5p in Chronic Kidney Disease as a Potential Marker of Cardiovascular Complications %K Chronic kidney disease MicroRNA %K 155 %K 5p Cardiovascular complications Glomerular filtration rate Polymerase chain reaction %R 10.26655/JMCHEMSCI.2023.8.3 %X Background: Chronic kidney disease (CKD) is a silent, serious condition requiring reliable non-invasive markers for diagnosing and predicting complications especially cardiovascular (CV)complications.Objectives: This study aims to detect microRNA-155-5p (miR-155-5p) as a potential marker of CKD and a predictor of CV complications.Subjects and methods: 120 participants were included in this study, and they were categorized as; Group I (n=60, healthy age- and sex-matched control group) and Group II (n = 60, CKD patients). Group II was subdivided into: Group IIA (n = 30 CKD patients without CV complications) and Group IIB (n = 30; CKD patients complicated with CV diseases). Using reverse transcription polymerase chain reaction (RT-PCR), miR-155-5p was detected.Results: miR-155-5p was increased in Group IIA and IIB compared with the control group, while miR-155-5p was increased in Group IIB compared with Group IIA.Conclusion: miR-155-5p can be used as a sensitive and specific marker for detecting CKD and discriminating between CKD with and without CV complications. %U https://www.jmchemsci.com/article_163421_270f0529c079a760c9972c30e9b2c5de.pdf