%0 Journal Article %T Solvent-free Synthesis and Antimicrobial Activity of Dihydroquinazolinone Derivatives %J Journal of Medicinal and Chemical Sciences %I Sami Publishing Company (SPC) %Z 2651-4702 %A Keikhosravi, Navid %A Dehghan-Ghahfarokhi, Esmaeil %A Abdollahi, Soosan %A Piramoon, Majid %A Ghasemian-Yadegari, Javad %A Rezaeinasab, Rezvan %D 2022 %\ 05/01/2022 %V 5 %N 3 %P 308-314 %! Solvent-free Synthesis and Antimicrobial Activity of Dihydroquinazolinone Derivatives %K One-pot synthesis %K Quinazolinones %K Solvent-free %K Antimicrobial activity %R 10.26655/JMCHEMSCI.2022.3.3 %X In this research, a new series of dihydroquinazolinone analogs (4a-f) was synthesized using a one-pot reaction supporting solvent-free conditions at the presence of SnCl2.2H2O as catalyst. All final products were proved by FT-IR, 1H-NMR, and 13C-NMR analysis. The preliminary antimicrobial activity was assessed against Gram-negative (Escherichia coli, Pseudomonas aeruginosa), Gram-positive (Staphylococcus aureus, Bacillus subtilis, Lactobacillus rhamnosus), and antifungal activities against Candida albicans. Most of the synthesized derivatives revealed considerable activity, significantly compounds 4d and 4e at 0.25 mg/mL concentration had the highest activity against P. aeruginosa. Also, the MIC of compound 4d was 0.25 mg/mL against B. subtilis, and L. rhamnosus. Furthermore, the tested molecules demonstrated moderate antifungal activities against the C. albicans. %U https://www.jmchemsci.com/article_141312_e7bdf23a7338e34669164b3a6bb65bc4.pdf