eng
Sami Publishing Company (SPC)
Journal of Medicinal and Chemical Sciences
2651-4702
2018-07-01
1
1
1
4
10.26655/jmchemsci.2018.6.1
63164
Biological and Pharmaceutical Organosulfur Molecules
Mosstafa Kazemi
mosstafakazemi@gmail.com
1
Sami Sajjadifar
ss.sajjadifar@gmail.com
2
Abdelkarim Aydi
aydiabdelkarim@gmail.com
3
Mohammad Mirzaei Heydari
mirzaeiheydari@yahoo.com
4
Department of Chemistry, Faculty of Basic Sciences, Ilam University, P.O. Box 69315-516, Ilam, Iran
Department of Chemistry, Payame Noor University, Tehran, P.O. Box 19395-4697, Iran
Department of Chemical and Materials Engineering, College of Engineering, National College of Chemical Industry, Nancy, Polytechnic Institute of Lorraine, France Frankfurt Am Main Area, Germany
School of Environment, Natural Resources & Geography, Bangor University, Bangor, Gwynedd, Wales, United Kingdom
Organosulfur molecules are prevalent in a broad spectrum of active biological, pharmaceutical and natural molecules. In this category, compounds containing carbon–sulfur bonds occupy a very special place in chemistry science. In this paper, we focused on biologically and pharmaceutically active molecules containing sulfides, disulfide, sulfoxid, sulfone, thiosulfinate, thioester and trithiocarbonate scaffolds. Methionine, Cystine, Pantoprazole, Dapsone, Allicin and Acetyl Co-A are several organosulfur molecules with well-known biological and pharmaceutical activities.
https://www.jmchemsci.com/article_63164_fd6cdca2553ffa7e31c6eb49cfd4275f.pdf
Organosulfur molecules
Sulfides
Disulfides
Sulfoxides
eng
Sami Publishing Company (SPC)
Journal of Medicinal and Chemical Sciences
2651-4702
2018-07-01
1
1
5
8
10.26655/jmchemsci.2018.6.2
63160
MNPs-supported acidic catalysts in oxidation of sulfides to sulfoxides
Ali Mirzaie
a.mirzaie@gmail.com
1
Young Researchers and Elite Club, Ilam Branch, Islamic Azad University, Ilam, Iran
Sulfoxide derivatives are also prevalent structural motifs in many drugs and biologically active molecules. Oxidation of sulfides is the best strategy for the preparation of the sulfoxides. In recent times, a series of acids supported on magnetic nanoparticles have been reported for the oxidation of sulfides to the sulfoxides. In this paper, attention is focused on the fabrication of MNPs-supported acidic catalysts and their catalytic applications in the oxidation of sulfides to the sulfoxides.
https://www.jmchemsci.com/article_63160_a0761c4ffb227df89aff4492ec841869.pdf
Sulfoxides
oxidation
MNPs-supported acidic catalysts
Biologically molecules
eng
Sami Publishing Company (SPC)
Journal of Medicinal and Chemical Sciences
2651-4702
2018-07-01
1
1
9
10
10.26655/jmchemsci.2018.6.3
63161
Synthesis of polymer-coated RDX/AP nano-composites using supercritical CO2
Ahmad Sajjadi
sajadiahmad64@yahoo.com
1
Sayed Mojtaba Moosavi
smmoosavi26@yahoo.com
2
Departeman of Chemistry, Imam Hossein University, Tehran, Iran
Departeman of Chemistry, Imam Hossein University, Tehran, Iran
The application of nano-explosives is wide in the field of boosters, propellants and explosive logic networks. RDX, a highly energetic compound used in gun and rocket propellants, is one of the most predominant explosives for the integrated properties. The applications of supercritical fluids as solvents for extracting or separating chemicals are increasing as seen in literature. Application of this technique to make RDX/AP nano-composites is the subject of this work. Structural and thermal analysis of the product was performed by SEM and XRD.
https://www.jmchemsci.com/article_63161_f7530dc716680ae2ed879e5a8897c743.pdf
RDX
nano-composite
Sol gel
CO2
eng
Sami Publishing Company (SPC)
Journal of Medicinal and Chemical Sciences
2651-4702
2018-07-01
1
1
11
17
10.26655/jmchemsci.2018.6.4
63162
مقاله پژوهشی
Taste-masking assessment of orally disintegrating tablets of valsartan using ion exchange resin
Rohit Kamboj
rkamboj538@gmail.com
1
Sweta kamboj
swetakamboj20@gmail.com
2
Ashwani Kumar Dhingra
ashwani1683@gmail.com
3
Pharmaceutics, Guru Gobind Singh College of Pharmacy, Yamunanagar, Haryana
Pharmaceutics, Guru Gobind Singh College of Pharmacy, Yamuna Nagar, Haryana, India
Guru Gobind Singh College of Pharmacy, Yamuna Nagar (Haryana), India
Oral disintegrating tablets are novel attractive dosage form that disintegrate or dissolve in the buccal cavity within seconds without use of water. The major drawback in designing of this dosage form is unpleasant taste of active entity. Valsartan isan antihypertension drug used in treatment of high blood pressure, congestive heart failure (CHF) and post-myocardial infarction (MI). It is characterized by its bitter taste which effects the patient’scompliance. The aim of present research work is taste-masking assessment of orally disintegrating tablets of valsartan using ion exchange resin(indion 254). The drug was characterized according to different compendia methods, on the basis of identification by UV spectroscopy, pH, organoleptic properties and other tests. Drug-Resin compatibility and drug polymer compatibility was carried out by FTIR. The values of pre-compression parameters assessed, were within specified limits and showed good free flowing properties. The data obtained of post-compression parameters such as weight variation, hardness, friability, wetting time, water absorption ratio, content uniformity, disintegration time and dissolution was found within the prescribed limits. The F10 batch with disintegration time 20 sec and dissolution 97.46 was selected as optimized formulation. Batch F10 was also subjected to stability studies for three months and was tested for its appearance, average weight, hardness, disintegration time, percent friability and its release rate which in prescribed range and satisfactory.
https://www.jmchemsci.com/article_63162_afc5428d9ab84c93ffb8d2ed9093c52b.pdf
Taste masking
orally disintegrating tablet
Ion exchange resin
valsartan
eng
Sami Publishing Company (SPC)
Journal of Medicinal and Chemical Sciences
2651-4702
2018-07-01
1
1
18
22
10.26655/jmchemsci.2018.6.5
63163
مقاله پژوهشی
Study of the antibacterial effect of 5-(4-chlorophenyl)-1H-tetrazole and its oxime precursor against strains isolated from the hospital environment
Khadim Dioukhane
1
Hanane Touijer
2
Anouar Alami
alamianouar@yahoo.fr
3
Hicham Bekkari
4
Najoua Benchemsi
5
Organic Chemistry Laboratory (LCO), Faculty of Sciences Dhar El Mahraz–Sidi Mohammed Ben Abdellah University, Fez 30000, Morocco
Biotechnology Laboratory, Faculty of Sciences Dhar El Mahraz–Sidi Mohammed Ben Abdellah University, Fez 30000, Morocco
Biotechnology Laboratory, Faculty of Sciences Dhar El Mahraz–Sidi Mohammed Ben Abdellah University, Fez 30000, Morocco
Biotechnology Laboratory, Faculty of Sciences Dhar El Mahraz–Sidi Mohammed Ben Abdellah University, Fez 30000, Morocco
Biotechnology Laboratory, Faculty of Sciences Dhar El Mahraz–Sidi Mohammed Ben Abdellah University, Fez 30000, Morocco
The compounds used in this study, TET and OXM, were tested in vitro for their antibacterial activities against isolated strains from the hospital environment (S. aureus H, E. coli H and K. pneumoniae H) and reference strains (S. aureus A, E. coli A, B. subtilis A and P. aeruginosa A). The calculation of the MBC/minimum inhibitory concentration ratio of the products TET and OXM showed that the two products have a bactericidal effect on the strains tested.
https://www.jmchemsci.com/article_63163_db56dfea95719f5651947c0e986f6c17.pdf
Antibacterial Activity
tetrazole
oxime
eng
Sami Publishing Company (SPC)
Journal of Medicinal and Chemical Sciences
2651-4702
2018-07-01
1
1
23
25
10.26655/jmchemsci.2018.6.6
63165
مقاله پژوهشی
Theoretical and Experimental Methods for Study of Binary mixtures viscosity at T= 303.15
Mohammad Almasi
almasi.mohammad@gmail.com
1
Department of Applied Chemistry, Faculty of Science, Malayer University, Malayer, 65174, Iran
Molecular interactions in binary mixtures composed of a xylene and selected 1-butanol 1-pentanol, 1-hexanol, 1-heptanol and 1-octanol was investigated by measuring the viscosity at T= 303.15 K. From experimental data, viscosity deviation was calculated. Values of viscosity deviations for all binary mixtures are negative and increase with increase of alcohols chain length. Obtained data were interpreted based on the type and magnitude of the physico-chemical interactions in the binary liquid systems. free volume theory was applied to correlate the viscosities of binary mixtures and correlated values by this model were good enough and obtained data were within the uncertainty region.Keywords: Viscosity; xylene; 1-Alkanol; free volume theory
https://www.jmchemsci.com/article_63165_c8a7769dd283db38355290a0bae38a40.pdf
Viscosity
Xylene
1-Alkanol
free volume theory