@article { author = {Jasim, Sara Firas and Mustafa, Yasser Fakri}, title = {Synthesis and Antidiabetic Assessment of New Coumarin-Disubstituted Benzene Conjugates: An In Silico–In Virto Study}, journal = {Journal of Medicinal and Chemical Sciences}, volume = {5}, number = {6}, pages = {887-899}, year = {2022}, publisher = {Sami Publishing Company (SPC)}, issn = {2651-4702}, eissn = {2651-4702}, doi = {10.26655/JMCHEMSCI.2022.6.3}, abstract = {Even with the significant advancements in medical and therapeutical fields, finding efficient anti-diabetic and anti-oxidative entities is of high significance in the recent era. New coumarin-disubstituted benzene conjugates were prepared to evaluate their antidiabetic and antioxidative effects. The prepared conjugates (MT0-MT7) were characterized utilizing various analytical techniques, including FTIR, UV–Vis, 1H-NMR, and 13C-NMR. Also, the drug-likeness properties of conjugates were assessed in-silico. The antidiabetic effect of the prepared conjugates was estimated in-vitro based on their inhibitory impact on porcine α-amylase and yeast α-glucosidase enzymes; whereas their antioxidative effect was appraised in-vitro based on their snaring impact on hydroxide and DPPH radicals. The findings of evaluating these effects demonstrated that the MT2 and MT3 conjugates had a prominent antidiabetic effect related to the standard. In addition, the MT0 conjugate showed a distinct antioxidative effect comparable to that of the standard. Thus, MT2, MT3, and MT0 conjugates could be used as scaffolds to develop a new class of antidiabetic and antioxidative entities. Moreover, the in-silico analysis revealed that the majority of the prepared conjugates had convenient drug-likeness properties for the oral drug-delivery system.}, keywords = {Coumarin-disubstituted benzene conjugates,Antidiabetic,Antioxidative,In-silico}, url = {https://www.jmchemsci.com/article_148584.html}, eprint = {https://www.jmchemsci.com/article_148584_e4c4ae3f8abde97a12a36343620a4e09.pdf} }