@article { author = {Gomaa, Esam A. and Diab, Moustafa A. and El Sonbati, Adel Z. and Abuo Elnader, Hamed M. and Abd Elraoof, Gannat S.}, title = {Solvation Parameters for The Interaction of HgCl2 with Valporic Acid (VaA) in KNO3 Using Silver Working Electrode (Cyclic Voltammetry)}, journal = {Journal of Medicinal and Chemical Sciences}, volume = {2}, number = {2}, pages = {41-45}, year = {2019}, publisher = {Sami Publishing Company (SPC)}, issn = {2651-4702}, eissn = {2651-4702}, doi = {10.26655/jmchemsci.2019.3.1}, abstract = {Redox reaction mechanism in absence and presence of Valporic Acid (VaA) was Studied in cyclic voltammetry, we used a new silver electrode made from pure Silver piece jointed to Copper wire and isolated by heat shrink polymer to insure Complete isolation, during measurments. The Silver electrode was polished with Al2O3 in woolen piece, washed and used for the cyclic voltammetric Study. The stability constants and Gibbs free energies of Complex reactions between HgCl2 and Valproic acid (VaA) in 0.01 M KNO3 at 22˚C were evaluated and their results were discussed.}, keywords = {Cyclic Voltammetry,Thermodynamic parameter,Copper bromide,Solvation parameters,Stability Constants}, url = {https://www.jmchemsci.com/article_79584.html}, eprint = {https://www.jmchemsci.com/article_79584_c9ab5336bfb748c0aa11397d74112e80.pdf} } @article { author = {Latha, N.L. and Gyananath, G. and Kasa, Anjaneyalu and Zubaidha, P. K.}, title = {Validation of Sigma I Receptor Occupancy with Antipsychotic Ligands: A Molecular Perspective}, journal = {Journal of Medicinal and Chemical Sciences}, volume = {2}, number = {2}, pages = {46-50}, year = {2019}, publisher = {Sami Publishing Company (SPC)}, issn = {2651-4702}, eissn = {2651-4702}, doi = {10.26655/jmchemsci.2019.3.2}, abstract = {Sigma-1 receptors are unique and distinct class of receptors widely expressed in the central nervous system with involvement in regulation of various neutransmitters and are often over expressed in tumor cell lines of various tissues, such as melanoma, breast cancer, small lung carcinoma and prostate cancer. Accordingly, sigma ligands display anticancer activity in- vivo and in-vitro. In the present study, an attempt has been made to validate sigma-1receptor and study its antipsychotic ligand interactions in a molecular perspective. C6 cells (rat glioma)  grown in monolayers were exposed to haloperidol (sigma-1 antagonist) and other anti-psychotic ligands and their relative cytotoxicity was determined by MTT assay to be 42.79 %, 18.96 %, 24.95 and 22.72% for haloperidol, ligand 1, ligand 2 and ligand 3 respectively. Occupancy of sigma receptors with ligands through DNA laddering studies reveal the antipsychotic ligands modulate psychosis via sigma-1receptor.}, keywords = {Haloperidol,antipsychotic ligands,Psychosis,Ssigma-1 receptor,Anticancer}, url = {https://www.jmchemsci.com/article_79585.html}, eprint = {https://www.jmchemsci.com/article_79585_e3f4ef622f00c03e1984a1e27eba4c65.pdf} } @article { author = {Gupta, Srinivasa and Lakshman, Manisha}, title = {Magnetic Nano Cobalt Ferrite: An efficient recoverable catalyst for synthesis of 2,4,5-trisubstituted imidazoles}, journal = {Journal of Medicinal and Chemical Sciences}, volume = {2}, number = {2}, pages = {51-54}, year = {2019}, publisher = {Sami Publishing Company (SPC)}, issn = {2651-4702}, eissn = {2651-4702}, doi = {10.26655/jmchemsci.2019.3.3}, abstract = {An efficient three-component synthesis of 2,4,5-trisubstituted imidazolesis described by one-pot condensation of aldehydes, diketones and ammonium acetate using CoFe2O4 magnetic nanoparticles as an efficient  and environmentally benign catalyst.The easy recovery of the catalyst and reusability, broad substrate scopes, high yields of products and ethanol as solvent make this protocol practical, environmentally friendly and economically attractive.}, keywords = {Cobalt ferrite,2,4,5-Trisubstituted imidazoles,Three-component,Ethanol}, url = {https://www.jmchemsci.com/article_79586.html}, eprint = {https://www.jmchemsci.com/article_79586_453c22dcfdc2c8ed6e2a3ba3b9b2adf9.pdf} } @article { author = {Sajjadi, Ahmad and Mohammadi, Reza}, title = {Fe3O4 magnetic nanoparticles (Fe3O4 MNPs): A magnetically reusable catalyst for synthesis of Benzimidazole compounds}, journal = {Journal of Medicinal and Chemical Sciences}, volume = {2}, number = {2}, pages = {55-58}, year = {2019}, publisher = {Sami Publishing Company (SPC)}, issn = {2651-4702}, eissn = {2651-4702}, doi = {10.26655/jmchemsci.2019.3.4}, abstract = {In this paper, Fe3O4 magnetic nanoparticles (Fe3O4 MNPs) were prepared and intro-duced as an efficient and eco-friendly catalyst for the synthesis of benzimidazole derivatives. The as-synthesized Fe3O4 magnetic nanoparticles were characterized by FT-IR spectroscopy and scanning electron microscopy (SEM).This method afforded the target products in high yields and the catalytic system could be recycled and reused without significant loss of catalytic activity.}, keywords = {Fe3O4 MNPs,FT-IR,SEM,Benzimidazoles,Reusable catalyst}, url = {https://www.jmchemsci.com/article_79587.html}, eprint = {https://www.jmchemsci.com/article_79587_6f6b9c89f43e52389f195ba98581c25c.pdf} } @article { author = {Fidelis, Grace Kwata and Louis, Hitler and Tizhe, Timothy Fidelis and Onoshe, Solomon}, title = {Curcumin and Curcumin-based derivatives as anti-cancer agents: Recent Nano-Synthetic Methodologies and Anti-cancer Therapeutic Mechanisms}, journal = {Journal of Medicinal and Chemical Sciences}, volume = {2}, number = {2}, pages = {59-63}, year = {2019}, publisher = {Sami Publishing Company (SPC)}, issn = {2651-4702}, eissn = {2651-4702}, doi = {10.26655/jmchemsci.2019.3.5}, abstract = {Curcumin which is an active component of tumeric, derived from the dried rhizome of curcuma longa plant has been known for its medicinal values in wound healing, treatment of inflammatory disease, urinary tract infections, biliary disease, and liver ailments. This medicinal property has been recently exploited in cancer prevention and therapy since extensive studies have revealed the mechanisms of action of curcumin as an anti-cancer agent, in which transcription factors, anti-apoptotic proteins, growth factor receptors and multi-drug resistance proteins are involved. In order to improve the medicinal value of curcumin in cancer prevention and therapy, novel nanoformulations of curcumin have been synthesized, ranging from nanoparticles, nanolipids, chitosan, and nanofibers. Here, the recent method of curcumin synthesis using nanotechnology and the mechanisms by which they exert their anti-cancer effects will be reviewed. }, keywords = {curcumin,Synthesis,Nanotechnology,Anticancer,Mechanism}, url = {https://www.jmchemsci.com/article_79588.html}, eprint = {https://www.jmchemsci.com/article_79588_9d416e01b08da5d8a0e3fe52afaafa85.pdf} } @article { author = {Sakamoto, Keiichi and Sakaguchi, Yuma and Watabiki, Syota and Igarashi, Yumiko and Komoriya, Tomoe and Yoshino, Satoru}, title = {Synthesis of phthalocyanines having thio-alkyl substituents at non-peripheral positions and their photochemical and photophysical properties}, journal = {Journal of Medicinal and Chemical Sciences}, volume = {2}, number = {2}, pages = {64-70}, year = {2019}, publisher = {Sami Publishing Company (SPC)}, issn = {2651-4702}, eissn = {2651-4702}, doi = {10.26655/jmchemsci.2019.3.6}, abstract = {Phthalocyanines possess similar structure of natural chromophore porphyrins. The phthalocyanines are known to utilize in important functional colorants for many fields. The phthalocyanines are especially expected to use photosensitizers for both dye-sensitized solar cells and photodynamic therapy of cancer. In the present study, novel non-peripheral substituted thio-alkyl zinc phthalocyanines were synthesized in order to develop second-generation photosensitizer for photodynamic therapy of cancer.In order to evaluate the influence of heteroatom existence and chain length, synthesized non-peripheral substituted thio-alkyl phthalocyanines were reported photoexcited triplet lifetime using laser-flash photolysisand singlet oxygen quantum yieldsby 1,3-diphenylbenzofuranemethod. Of synthesized non-peripheral substituted phthalocyanines, ultraviolet-visible spectra showed around 780 nm, photoexcited triplet lifetimes were estimated around 1 as and singlet oxygen quantum yields. It is thought that synthesized non-peripheral hetero-alkyl substituted phthalocyaines had enough ability for photodynamic therapy of cancer.}, keywords = {Phthalocyanines,Thio-alkyl substituents,Singlet oxygen,PTDF method,Photodynamic therapy of cancer}, url = {https://www.jmchemsci.com/article_79589.html}, eprint = {https://www.jmchemsci.com/article_79589_f2d229f6356e9bee2beab73e0fedd759.pdf} } @article { author = {Gomaa, Esam A. and Diab, Moustafa A. and El Sonbati, Adel Z. and Abou El-Nader, Hamed M. and Helmy, Asmaa M.}, title = {Electrochemical Solvation Parameters for The Interaction of CuBr2 With Carbazine 720 (LC) in NaClO4 Using Glassy Carbon working electrode (cyclic voltammetry)}, journal = {Journal of Medicinal and Chemical Sciences}, volume = {2}, number = {2}, pages = {71-75}, year = {2019}, publisher = {Sami Publishing Company (SPC)}, issn = {2651-4702}, eissn = {2651-4702}, doi = {10.26655/jmchemsci.2019.3.7}, abstract = {he redox mechanisms were examined for Copper bromide in the absence and presence of (LC) using cyclic voltammetry. The mechanisms of reduction and oxidation were examined  while using new glassy carbon electrode prepared in laboratory from pure carbon piece jointed with copper wire and isolated by heat shrink polymer to avoid contact with solutions. In order to explain the type of the used reaction in electrochemical study, the complexation stability constants and Gibbs free energies of complex formation obtained from the interaction of CuBr2 with (LC) were obtained from the experimental part and their values were discussed. The prepared galssy carbon electrode was polished with Al2O3 andput in a woolen clear piece, washed and used for cyclic voltammetry measurements.}, keywords = {Cyclic Voltammetry,CuCl2,Carbazine,redox parameters,Kinetic parameters}, url = {https://www.jmchemsci.com/article_79590.html}, eprint = {https://www.jmchemsci.com/article_79590_3ca78959c921994a373319b5c543a8e4.pdf} }