@article { author = {Kazemi, Mosstafa and Sajjadifar, Sami and Aydi, Abdelkarim and Mirzaei Heydari, Mohammad}, title = {Biological and Pharmaceutical Organosulfur Molecules}, journal = {Journal of Medicinal and Chemical Sciences}, volume = {1}, number = {1}, pages = {1-4}, year = {2018}, publisher = {Sami Publishing Company (SPC)}, issn = {2651-4702}, eissn = {2651-4702}, doi = {10.26655/jmchemsci.2018.6.1}, abstract = {Organosulfur molecules are prevalent in a broad spectrum of active biological, pharmaceutical and natural molecules. In this category, compounds containing carbon–sulfur bonds occupy a very special place in chemistry science. In this paper, we focused on biologically and pharmaceutically active molecules containing sulfides, disulfide, sulfoxid, sulfone, thiosulfinate, thioester and trithiocarbonate scaffolds. Methionine, Cystine, Pantoprazole, Dapsone, Allicin and Acetyl Co-A are several organosulfur molecules with well-known biological and pharmaceutical activities.}, keywords = {Organosulfur molecules,Sulfides,Disulfides,Sulfoxides}, url = {https://www.jmchemsci.com/article_63164.html}, eprint = {https://www.jmchemsci.com/article_63164_fd6cdca2553ffa7e31c6eb49cfd4275f.pdf} } @article { author = {Mirzaie, Ali}, title = {MNPs-supported acidic catalysts in oxidation of sulfides to sulfoxides}, journal = {Journal of Medicinal and Chemical Sciences}, volume = {1}, number = {1}, pages = {5-8}, year = {2018}, publisher = {Sami Publishing Company (SPC)}, issn = {2651-4702}, eissn = {2651-4702}, doi = {10.26655/jmchemsci.2018.6.2}, abstract = {Sulfoxide derivatives are also prevalent structural motifs in many drugs and biologically active molecules. Oxidation of sulfides is the best strategy for the preparation of the sulfoxides. In recent times, a series of acids supported on magnetic nanoparticles have been reported for the oxidation of sulfides to the sulfoxides. In this paper, attention is focused on the fabrication of MNPs-supported acidic catalysts and their catalytic applications in the oxidation of sulfides to the sulfoxides.}, keywords = {Sulfoxides,oxidation,MNPs-supported acidic catalysts,Biologically molecules}, url = {https://www.jmchemsci.com/article_63160.html}, eprint = {https://www.jmchemsci.com/article_63160_a0761c4ffb227df89aff4492ec841869.pdf} } @article { author = {Sajjadi, Ahmad and Moosavi, Sayed Mojtaba}, title = {Synthesis of polymer-coated RDX/AP nano-composites using supercritical CO2}, journal = {Journal of Medicinal and Chemical Sciences}, volume = {1}, number = {1}, pages = {9-10}, year = {2018}, publisher = {Sami Publishing Company (SPC)}, issn = {2651-4702}, eissn = {2651-4702}, doi = {10.26655/jmchemsci.2018.6.3}, abstract = {The application of nano-explosives is wide in the field of boosters, propellants and explosive logic networks. RDX, a highly energetic compound used in gun and rocket propellants, is one of the most predominant explosives for the integrated properties. The applications of supercritical fluids as solvents for extracting or separating chemicals are increasing as seen in literature. Application of this technique to make RDX/AP nano-composites is the subject of this work. Structural and thermal analysis of the product was performed by SEM and XRD.}, keywords = {RDX,nano-composite,Sol gel,CO2}, url = {https://www.jmchemsci.com/article_63161.html}, eprint = {https://www.jmchemsci.com/article_63161_f7530dc716680ae2ed879e5a8897c743.pdf} } @article { author = {Kamboj, Rohit and kamboj, Sweta and Dhingra, Ashwani Kumar}, title = {Taste-masking assessment of orally disintegrating tablets of valsartan using ion exchange resin}, journal = {Journal of Medicinal and Chemical Sciences}, volume = {1}, number = {1}, pages = {11-17}, year = {2018}, publisher = {Sami Publishing Company (SPC)}, issn = {2651-4702}, eissn = {2651-4702}, doi = {10.26655/jmchemsci.2018.6.4}, abstract = {Oral disintegrating tablets are novel attractive dosage form that disintegrate or dissolve in the buccal cavity within seconds without use of water. The major drawback in designing of this dosage form is unpleasant taste of active entity. Valsartan isan antihypertension drug used in treatment of high blood pressure, congestive heart failure (CHF) and post-myocardial infarction (MI). It is characterized by its bitter taste which effects the patient’scompliance. The aim of present research work is taste-masking assessment of orally disintegrating tablets of valsartan using ion exchange resin(indion 254). The drug was characterized according to different compendia methods, on the basis of identification by UV spectroscopy, pH, organoleptic properties and other tests. Drug-Resin compatibility and drug polymer compatibility was carried out by FTIR. The values of pre-compression parameters assessed, were within specified limits and showed good free flowing properties. The data obtained of post-compression parameters such as weight variation, hardness, friability, wetting time, water absorption ratio, content uniformity, disintegration time and dissolution was found within the prescribed limits. The F10 batch with disintegration time 20 sec and dissolution 97.46 was selected as optimized formulation. Batch F10 was also subjected to stability studies for three months and was tested for its appearance, average weight, hardness, disintegration time, percent friability and its release rate which in prescribed range and satisfactory.}, keywords = {Taste masking,orally disintegrating tablet,Ion exchange resin,valsartan}, url = {https://www.jmchemsci.com/article_63162.html}, eprint = {https://www.jmchemsci.com/article_63162_afc5428d9ab84c93ffb8d2ed9093c52b.pdf} } @article { author = {Dioukhane, Khadim and Touijer, Hanane and Alami, Anouar and Bekkari, Hicham and Benchemsi, Najoua}, title = {Study of the antibacterial effect of 5-(4-chlorophenyl)-1H-tetrazole and its oxime precursor against strains isolated from the hospital environment}, journal = {Journal of Medicinal and Chemical Sciences}, volume = {1}, number = {1}, pages = {18-22}, year = {2018}, publisher = {Sami Publishing Company (SPC)}, issn = {2651-4702}, eissn = {2651-4702}, doi = {10.26655/jmchemsci.2018.6.5}, abstract = {The compounds used in this study, TET and OXM, were tested in vitro for their antibacterial activities against isolated strains from the hospital environment (S. aureus H, E. coli H and K. pneumoniae H) and reference strains (S. aureus A, E. coli A, B. subtilis A and P. aeruginosa A). The calculation of the MBC/minimum inhibitory concentration ratio of the products TET and OXM showed that the two products have a bactericidal effect on the strains tested.}, keywords = {Antibacterial Activity,tetrazole,oxime}, url = {https://www.jmchemsci.com/article_63163.html}, eprint = {https://www.jmchemsci.com/article_63163_db56dfea95719f5651947c0e986f6c17.pdf} } @article { author = {Almasi, Mohammad}, title = {Theoretical and Experimental Methods for Study of Binary mixtures viscosity at T= 303.15}, journal = {Journal of Medicinal and Chemical Sciences}, volume = {1}, number = {1}, pages = {23-25}, year = {2018}, publisher = {Sami Publishing Company (SPC)}, issn = {2651-4702}, eissn = {2651-4702}, doi = {10.26655/jmchemsci.2018.6.6}, abstract = {Molecular interactions in binary mixtures composed of a xylene and selected 1-butanol 1-pentanol, 1-hexanol, 1-heptanol and 1-octanol was investigated by measuring the viscosity at T= 303.15 K. From experimental data, viscosity deviation was calculated. Values of viscosity deviations for all binary mixtures are negative and increase with increase of alcohols chain length. Obtained data were interpreted based on the type and magnitude of the physico-chemical interactions in the binary liquid systems. free volume theory was applied to correlate the viscosities of binary mixtures and correlated values by this model were good enough and obtained data were within the uncertainty region.Keywords: Viscosity; xylene; 1-Alkanol; free volume theory}, keywords = {Viscosity,Xylene,1-Alkanol,free volume theory}, url = {https://www.jmchemsci.com/article_63165.html}, eprint = {https://www.jmchemsci.com/article_63165_c8a7769dd283db38355290a0bae38a40.pdf} }