@article { author = {Panasenko, Кarina Е. and Voloshina, Ludmila N. and Shinkareva, Ludmila V. and Galimskaya, Оlga G.}, title = {Socialization-Individualization of Preschool Children with Speech Disorders in Motor Activity}, journal = {Journal of Medicinal and Chemical Sciences}, volume = {4}, number = {6}, pages = {538-545}, year = {2021}, publisher = {Sami Publishing Company (SPC)}, issn = {2651-4702}, eissn = {2651-4702}, doi = {10.26655/JMCHEMSCI.2021.6.1}, abstract = {Urgency of the research is driven by the need to solve the problems of integral socialization-individualization of children with speech disorders in the theory and practice of pre-primary education. The purpose of the present research was to deal with the problems of integral socialization-individualization of preschoolers of over five years old with speech disorders in motor activity. The study engaged 100 older preschoolers with a normal level of speech development and 100 over-five group with speech disorders attending compensatory and combined groups of preschool educational organizations in Belgorod. The assessment of the results of testing motor abilities has shown that children with speech disorders have an insufficient level of their development. Low indices have been obtained for motor-coordinating abilities (accuracy – nonsufficient level in 100% of girls and boys; dexterity – in 68.2% of boys and 71.4% of girls), involving strength abilities (in 70.5% of boys and in 72, 3% of girls), tolerance (77.3% of boys and 75% of girls). Qualitative and quantitative analyses of the results of self-assessment of motor abilities of preschoolers with speech disorders revealed inadequately exaggerated self-assessment and overestimation of their abilities in motor activity with peers in 30% of children. 21% of children with speech disorders had inadequately negative self-feeling, lack of self-confidence, showed shyness and timidity.}, keywords = {Socialization and individualization,preschoolers with speech disorders,Motor activity,motor abilities}, url = {https://www.jmchemsci.com/article_136390.html}, eprint = {https://www.jmchemsci.com/article_136390_388a9fda5ab5b0a9e81bca8a44545c1d.pdf} } @article { author = {Melnikov, Dmitry A. and Panteleeva, Larisa A. and Zhigoreva, Marina V. and Prokopenko, Anna Yu.}, title = {Interdisciplinary Approach in Remedial Work on Speech Development for Students with Disabilities}, journal = {Journal of Medicinal and Chemical Sciences}, volume = {4}, number = {6}, pages = {546-553}, year = {2021}, publisher = {Sami Publishing Company (SPC)}, issn = {2651-4702}, eissn = {2651-4702}, doi = {10.26655/JMCHEMSCI.2021.6.2}, abstract = {The success of socialization of children with disabilities is determined by a sufficient level of formation of speech activity. Ideas about difficulties in mastering the language and speech abilities of children with developmental disabilities that hinder their successful socialization serve as the basis for optimizing the learning and upbringing process. The purpose of the article is to consider the features of speech development of students with disabilities and determine the main directions of correctional work based on an interdisciplinary approach. The methodological basis of the study was interdisciplinary, systematic, activity-based, complex and individually differentiated, aiming at the development and improvement of speech among students with disabilities. The data obtained from the study of the speech capabilities of children with disabilities of different nosological groups indicated that they had violations of the formation of various components of the language system that affected the process of speech communication necessary for adaptation, integration and socialization. There was the need to create a correctional speech therapy work with an interdisciplinary nature, containing technologies, methods and techniques aimed at developing the speech of students with disabilities. Based on the results of this study, the directions of correctional speech therapy work, i.e., diagnostic and prognostic, software design, organizational and procedural, advisory and educational, were proposed, revealing the specifics of an interdisciplinary approach that allows optimizing the process of speech development of students with sensory, speech disorders, and mental retardation. }, keywords = {interdisciplinary approach,Correctional speech therapy,Speech,Speech activity,Students with Disabilities,Socialization}, url = {https://www.jmchemsci.com/article_137282.html}, eprint = {https://www.jmchemsci.com/article_137282_dc347db664a71008e48397a25eaf2301.pdf} } @article { author = {N’Guessan, Deto Ursul Jean-Paul and Coulibaly, Songuigama and Kassi, Fulgence Kondo Kassi and Delaye, Pierre-Olivier and Penichon, Melanie and Enguehard-Gueiffier, Cécile and Allouchi, Hassan and Ouattara, Mahama}, title = {Synthesis and SAR of Imidazo[1,2-a] Pyridinyl-Phenylacrylonitrile Derivatives as Potent Anticandidosis Agents}, journal = {Journal of Medicinal and Chemical Sciences}, volume = {4}, number = {6}, pages = {554-563}, year = {2021}, publisher = {Sami Publishing Company (SPC)}, issn = {2651-4702}, eissn = {2651-4702}, doi = {10.26655/JMCHEMSCI.2021.6.3}, abstract = {The increase of immunodeficiency situations such as HIV and cancer is stemmed from the expansion of fungal infections due to the genus Candida. Although Candida albicans remains the most widespread species in pathogenic isolates, its epidemiological impact in human infectiology has declined in favor of new emerging species of Candida refractory to conventional treatment. Faced with this situation, we decided to contribute to the development of some imidazo [1,2-a] pyridinyl-arylacrylonitriles, as potential new anticandidosics. We proposed the design by molecular hybridization and the synthesis of some imidazo [1,2-a]pyridinyl-arylacrylonitriles following a Knoevenagel condensation reaction between aldehydes and various arylacetonitriles. Furthermore, we carried out the evaluation of the antifungal activities of these hybrid derivatives against Candida albicans, Candida tropicalis and Candida glabrata using the microplate dilution methodology. In the end, imidazo[1,2-a]pyridinyl-arylacrylonitriles turned out to be molecules with strong antifungal activities. The best anticandidosis profile on the three Candida species tested was obtained with the 3-chlorinated compound (5), the MICs of which varied between 357.5 - 0.52 µM. Likewise, the doubly modulated derivative (3c), was particularly illustrated by its good efficacy against Candida tropicalis. These two best compounds can be proposed as the "hit molecules" for further pharmacomodulations in order to have a drug candidate for anticandidosis purpose.}, keywords = {anticandidosis,Candida,imidazo[1,2-a]pyridinyl-arylacrylonitriles,SAR}, url = {https://www.jmchemsci.com/article_137496.html}, eprint = {https://www.jmchemsci.com/article_137496_da6c70461c26a449ef6a210eb0a8b33d.pdf} } @article { author = {Ibrahim, Majeda Noori and Mostafa, Evan Mohammed and Toama, Faeza Nasir}, title = {Histological Effects of Monosodium Glutamate on Brain of Infant Albino Swiss Mice Mus Musculus}, journal = {Journal of Medicinal and Chemical Sciences}, volume = {4}, number = {6}, pages = {564-570}, year = {2021}, publisher = {Sami Publishing Company (SPC)}, issn = {2651-4702}, eissn = {2651-4702}, doi = {10.26655/JMCHEMSCI.2021.6.4}, abstract = {Monosodium glutamate (MSG) is one of additive compounds that can easily cross the placenta and affect brain development. The current study aims to investigate the detrimental effects of monosodium glutamate (MSG) on Albino Swiss Mice Mus musculus fetal brain during pregnancy and after delivery. Forty-eight pregnant mice were divided into two groups: control group(24) received only distilled water while the second group (treated group 24 mice) received 0.2ml/daily of MSG solution from the 17th days of pregnancy until the 21st days after birth (lactation period). Infant mice were randomly selected from each group and sacrificed in 15th, 21st, 30th and 60th days after birth. Histopathological examination of brain showed significant differences between treated and control groups. Histological lesions including: megakaryocyte, necrosis, blood capillary stenosis, fraction of nerve fiber and blood capillary collapsing, eosinophil cell, medullary necrosis and necrosis, eosinophilic nerve fiber, horseshoe shape nucleus, rosette shape pattern, acidophilic cytoplasm, swelling cell, gliosis, coalesces and occluded blood vessel. In conclusion, monosodium glutamate has clear histological effects on the brain of infant mice.}, keywords = {Food Additives,Infant mice,Monosodium glutamate,Neurotoxicity}, url = {https://www.jmchemsci.com/article_137536.html}, eprint = {https://www.jmchemsci.com/article_137536_9dde45cd6aa2de1c8e866a781df5bba7.pdf} } @article { author = {Aghili, Sarehnaz and Alirezaei, Toktam and Nikmanzar, Shahin and Salehgargari, Soraya}, title = {Comparing the Inflammatory Markers between Women with Eclampsia- Preeclampsia and Normotensive Pregnant Women in Gynecology}, journal = {Journal of Medicinal and Chemical Sciences}, volume = {4}, number = {6}, pages = {571-578}, year = {2021}, publisher = {Sami Publishing Company (SPC)}, issn = {2651-4702}, eissn = {2651-4702}, doi = {10.26655/JMCHEMSCI.2021.6.5}, abstract = {Hypertension is a medical problem during pregnancy and one of the types of hypertensions during pregnancy is eclampsia-preeclampsia. The aim of this study was to compare inflammatory markers between women with eclampsia - preeclampsia and pregnant women with normal blood pressure admitted to the gynecology ward of Shahada Tarnish and Mehrieh hospitals in 1998-99. This descriptive-analytical study was performed with a cross-sectional design. The study population consisted of all patients diagnosed with eclampsia-preeclampsia and pregnant mothers in Shohada-e-Tajrish and Mahdieh Hospitals in Tehran during 2019 to 2020. The study sample consisted of 400 patients who were selected by convenience or convenience sampling method and 200 patients with a diagnosis of eclampsia-preeclampsia were in the experimental group and 200 pregnant women were in the control group. The subjects completed pre-prepared forms for study variables, i.e. information on maternal age, maternal weight, infant weight, gestational age, neutrophil count and lymphocytes. To analyze the collected data, tests such as Pearson correlation coefficient and independent t-test were used and analyzed by SPSS software version 23. The results showed that a statistically significant difference was found between NLR and PLR MPV. Finally, the results of this study showed that platelet count; MPV, NLR, PLR were significantly different in the two groups of preeclampsia patients and pregnant women with normal blood pressure and that these indicators can be used to predict preeclampsia.}, keywords = {Hypertension,preeclampsia,Eclampsia,pregnant mothers}, url = {https://www.jmchemsci.com/article_138071.html}, eprint = {https://www.jmchemsci.com/article_138071_1aa357fa214695d3ce3812d9ee05aba2.pdf} } @article { author = {Dousti, Masoud and Alizadeh Otaghvar, Hamidreza and Jafarian, Aliakbar and Rokhzadi, Ideh and Mazhari, Najva and Moghaddam, Sepehr}, title = {Evaluation of the Effect of Gummy Candy on Postoperative Ileus and Its Complications}, journal = {Journal of Medicinal and Chemical Sciences}, volume = {4}, number = {6}, pages = {579-585}, year = {2021}, publisher = {Sami Publishing Company (SPC)}, issn = {2651-4702}, eissn = {2651-4702}, doi = {10.26655/JMCHEMSCI.2021.6.6}, abstract = {Prolonged postoperative ileus can delay hospital discharge. According to the reports, diet and in particular gummy candy may strengthen bowel movements and hence eliminate ileus. A total of 149 patients within the age range of 7-60 years who underwent laparotomy were randomly divided into the experimental group that were treated with gummy candy and the control group which included 73 patients. The experimental group chewed gummy candy four times a day,  hours after operation until the first flatulence. The patients in the both groups were checked for bowel movement and flatulence every two hours and it was recorded precisely. Both groups were also divided into 3 subgroups based on surgical incision. On average, the first recorded bowel sound was 10.78 ± 7.66 hours after the surgery. In addition, the first flatulence was recorded on average 2.51 ± 14.32 hours after the surgery. The mean time of hospitalization in both groups was 104.21±7 57.85 hours. The mean duration between the surgical end time, the first recorded bowel sound and the time to first flatulence was significantly lower in the experimental group compared with the control group.}, keywords = {Postoperative Ileus,Gummy Candy,Laparattomy,Hospitalization}, url = {https://www.jmchemsci.com/article_138072.html}, eprint = {https://www.jmchemsci.com/article_138072_2ce8901f571aa6417efbdbf55f038db4.pdf} } @article { author = {Bazgir, Nasrin and Bonyadi, Mahtab and Shafiei, Elham}, title = {Survey Rheumatic Diseases in ILAM Province, Iran (2018-2019)}, journal = {Journal of Medicinal and Chemical Sciences}, volume = {4}, number = {6}, pages = {586-592}, year = {2021}, publisher = {Sami Publishing Company (SPC)}, issn = {2651-4702}, eissn = {2651-4702}, doi = {10.26655/JMCHEMSCI.2021.6.7}, abstract = {Rheumatic diseases are among the most health problems that exert economic and social burden on the general population. Patients’ information based on the inclusion criteria were collected from hospital records in separate questionnaires, that were assessed in terms of age at the time of referral, sex, ethnicity, initial clinical manifestations, involved joints, presence of comorbid disease and extra-articular involvement. The study population was 3049 patients. The mean age of patients was 52.24 ± 12.99 years. 81 % of the patients were female. The prevalence of osteoporosis (OP) was 22.00%, Rheumatoid arthritis (RA) was 21.51%, and Osteoarthritis (OA) was 16.59%. Joint pain (OR 4.21, 95% CI 3.02–4.81, p < 0.001), BMI>25 (OR 3.83, 95% CI 2.01–6.79, p < 0.001), and Lack of physical activity (OR 2.34, 95% CI 1.14–3.75, p = 0.018) were risk factors of osteoporosis. It is recommended to control the known risk factors associated with these diseases, such as lifestyle modifications, and regular and effective exercise, as well as to review the associated risk factors, especially in women.}, keywords = {rheumatic diseases,Epidemiology,Rheumatoid arthritis}, url = {https://www.jmchemsci.com/article_138081.html}, eprint = {https://www.jmchemsci.com/article_138081_6d69f646fc5656c026be5428f6d29651.pdf} } @article { author = {Sayganov, Sergey A. and Mazurov, Vadim I. and Silin, Aleksey V. and Shmatko, Alexey D. and Gaivoronsky, Ivan V.}, title = {Development of Digital Competence of Portable Telemedicine Complex Operators for Optimizing the Provision of Medical Care}, journal = {Journal of Medicinal and Chemical Sciences}, volume = {4}, number = {6}, pages = {593-602}, year = {2021}, publisher = {Sami Publishing Company (SPC)}, issn = {2651-4702}, eissn = {2651-4702}, doi = {10.26655/JMCHEMSCI.2021.6.8}, abstract = {A complex of six advanced training programs for the management of a portable telemedicine complex was developed on the basis of Federal State Budgetary Educational Institution of Higher Education "North-Western State Medical University named after I.I. Mechnikov", the Ministry of Health of the Russian Federation. A pilot training program "Operator of a portable telemedicine complex" was implemented for persons with a full-time graduate degree. 17 trainees took part in the program. According to the results of the program, all the trainees had passed certification testing successfully and demonstrated sufficient development of the digital competence of portable telemedicine complex operators to optimizing the provision of medical care. The results of the program allowed to identify positive aspects of its implementation, namely training in a comfortable and familiar environment by 85.7%; the opportunity to combine work and studies by 57.1%; and the opportunity for repetitive self-assessment by 28.6%. The article presents the results of the study under the additional agreement dated September 24, 2020 No. 075-15-2019-1346/1 to the agreement dated June 13, 2019 No. 075-15-2019-1346 with the Ministry of Science and Higher Education of the Russian Federation as a part of implementing the federal target program "Research and development in priority areas of development of the scientific and technological complex of Russia for 2014-2020", event 1.2, stage 01 Code: 2018-14-000-0001) on the topic "Development of a portable telemedicine complex for optimizing the provision of medical care"(UIP of the project: No. УИП RFMEFI60418X0201).}, keywords = {digital competence,Information technology,portable complex,Telemedicine}, url = {https://www.jmchemsci.com/article_138087.html}, eprint = {https://www.jmchemsci.com/article_138087_57ce8b7a1678acce272a6fdc707980be.pdf} } @article { author = {Gharai, Pragyan and Das, BIswajit}, title = {Decoding Stress of Doctors and Nursing Staff during Covid-19 in Leading Social Entrepreneur Sponsored Hospitals in Odisha}, journal = {Journal of Medicinal and Chemical Sciences}, volume = {4}, number = {6}, pages = {603-611}, year = {2021}, publisher = {Sami Publishing Company (SPC)}, issn = {2651-4702}, eissn = {2651-4702}, doi = {10.26655/JMCHEMSCI.2021.6.9}, abstract = {The present paper is an initiative to understand the various issues related to the stress faced by the doctors and nursing staff during the pandemic. As compared with other professions, the life of medical professionals is different due to their unique job expectation.  A lot of researchers have tried to address this issue but during this period of pandemic very limited research has been undertaken. In this direction, the present paper will provide an additional contribution to the existing literature. The objectives of the study are to decode the dynamics of stress issues faced by these front-line workers and to suggest remedial measures. For this purpose, more focus is made on primary data, and the scope of the study is restricted to selected hospitals around the capital region of Odisha.}, keywords = {Stress Management,Doctors,Nursing staff,COVID-19,Hospitals}, url = {https://www.jmchemsci.com/article_138197.html}, eprint = {https://www.jmchemsci.com/article_138197_dcc819e42f83f565867cfcb2bdf009fa.pdf} } @article { author = {Mustafa, Yasser Fakri}, title = {Classical Approaches and Their Creative Advances in the Synthesis of Coumarins: A Brief Review}, journal = {Journal of Medicinal and Chemical Sciences}, volume = {4}, number = {6}, pages = {612-625}, year = {2021}, publisher = {Sami Publishing Company (SPC)}, issn = {2651-4702}, eissn = {2651-4702}, doi = {10.26655/JMCHEMSCI.2021.6.10}, abstract = {Coumarin chemical nucleus is a gift awarded from nature to humanity. The multifarious derivatives and the broad range of their bio-medicinal potentials are the basis for this description. In the last several decades, though numerous coumarin-based products have been primarily separated from their biological origins, the laboratory synthesis of the coumarins is developing. Various synthetic trails namely Knoevenagel, Claisen, Perkin, Pechmann, Wittig, and Reformatsky have been reported. Several advanced innovations have been created to maximize yield, minimize overall reaction time, avoid side products, and make synthetic reactions environmentally friendly. These include the employment of ultrasonic, microwave, and solvent-free conditions. This brief review focuses on the classic methods for synthesizing coumarins, and the advantages derived from the use of creative catalytic tools.}, keywords = {Coumarins,Chemical synthesis,Recent advances,review}, url = {https://www.jmchemsci.com/article_138430.html}, eprint = {https://www.jmchemsci.com/article_138430_e9101bd98f29d487a0c294e8bc72b6a4.pdf} } @article { author = {Dehno Khalaji, Aliakbar and Emami, Moslem and Mohammadi, Negin}, title = {Antibacterial Activity of Copper (II) Complexes of Maleic Acid: Thermal Studies, and New Precursors for Preparation of CuO}, journal = {Journal of Medicinal and Chemical Sciences}, volume = {4}, number = {6}, pages = {626-634}, year = {2021}, publisher = {Sami Publishing Company (SPC)}, issn = {2651-4702}, eissn = {2651-4702}, doi = {10.26655/JMCHEMSCI.2021.6.11}, abstract = {In this paper, two copper(II) complexes based on maleic acid ligand, namely [Cu(MA)2(H2O)2] (1) and [-{(H2O)4Cu2}(μ-MA)]n (2) have been synthesized from the reaction of CuCl2 and maleic acid in aqueous solution and characterized by CHN, FT-IR, XRD and TGA. In addition, from the calcination of theses complexes at 600 °C for 3 h in air atmosphere, CuO particles were prepared and characterized by FT-IR, XRD and SEM. Furthermore, antibacterial activity of them were tested against two Gram-positive (S. aureus and B. cereus) and two Gram-negative (E. coli and P. aeruginosa) strains. Results shows that the complexes 1 and 2 exhibit enhanced antibacterial activity than CuO particles. }, keywords = {Copper(II) complex,maleic acid,CuO nanoparticles,Antibacterial Activity}, url = {https://www.jmchemsci.com/article_138431.html}, eprint = {https://www.jmchemsci.com/article_138431_48e2998e29a1ff09bcc578e1912b9105.pdf} } @article { author = {Karimzadeh Jouzdani, Mehran and Karimzadeh Jouzdani, Maziar and Mohebbi, Bahram}, title = {The Role of Inflammatory Biomarkers in Predicting in-Stent Restenosis}, journal = {Journal of Medicinal and Chemical Sciences}, volume = {4}, number = {6}, pages = {635-645}, year = {2021}, publisher = {Sami Publishing Company (SPC)}, issn = {2651-4702}, eissn = {2651-4702}, doi = {10.26655/JMCHEMSCI.2021.6.12}, abstract = {The present study aimed to assess the role of inflammatory markers including erythrocyte sedimentation rate (ESR), highly sensitive C-reactive protein (hs-CRP), neutrophils to lymphocytes ratio (NLR), and platelet-to-lymphocyte ratio (PLR) in predicting ISR. This retrospective case-control study was conducted on 818 consecutive patients suffering acute coronary syndrome and underwent coronary stenting and referred to Rajaie Cardiovascular Medical and Research Center due to being suspicion to ISR. By referring to patients' clinical records as well as accessing their angiographic movie via the Cath lab computer system, patients who had ISR over a two-year period were identified from other patients who did not have re-stenosis. Overall, 19.1% were diagnosed to have ISR within a two-year following-up. However, there was no difference in NLR and PLR across the two ISR (+) and ISR (-) groups. In ISR group, the serum levels of ESR and CRP were significantly higher in smokers versus non-smokers, in diabetics versus non-diabetics, and also in those with chronic kidney disease as compared with those without kidney involvement. The levels of inflammatory indices of ESR and CRP were positively associated with the length of stent and negatively associated with the diameter of stent. Assessing the levels of ESR and CRP can successfully predict ISR in the patients initially undergoing coronary stenting. Such predicting role may be influenced by the interfering role of some cardiovascular risk factors such as smoking, diabetes mellitus, and chronic renal failure.  }, keywords = {ISR,CRP,ESR,NRL}, url = {https://www.jmchemsci.com/article_138471.html}, eprint = {https://www.jmchemsci.com/article_138471_b290b03db8010a0263dac963a3cd3d4c.pdf} } @article { author = {Alimoradzadeh, Raheleh and Ranjbar, Hosna and Abbasi, Mohammad Amin and Montazer, Fatemeh}, title = {Prevalence of Cognitive Impairment and Its Associated Factors in Elderly Patients under Chronic Hemodialysis Treatment}, journal = {Journal of Medicinal and Chemical Sciences}, volume = {4}, number = {6}, pages = {646-659}, year = {2021}, publisher = {Sami Publishing Company (SPC)}, issn = {2651-4702}, eissn = {2651-4702}, doi = {10.26655/JMCHEMSCI.2021.6.13}, abstract = {The present study was a cross-sectional investigation carried out on elderly patients under chronic hemodialysis who referred to Firoozabadi Hospital during 2019- 2020. The study population was 80 patients ≥ 60 years. The patients’ cognitive status was determined using MMSE and MOCA tools. The mean age of the candidate patients was 71.71 ± 6.28 years old. Cognitive function was assessed by MMSE and MoCA tests and the mean score of the MMSE test was 20.05 ± 3.50 with the highest score being 26 and the lowest score being 12. Based on the results, these patients were divided into three groups with normal cognitive ­function, mild cognitive impairment, and severe cognitive impairment. According to the results of the MMSE test, 19 patients (23.75%) had a normal cognitive function and 45 patients (56.25%) had impairment. In other words, the older patients, the lower level of education, the longer duration of hemodialysis, and the patients with a history of diabetes were more susceptible to cognitive impairment. Subsequently, there was a positive correlation between the levels of BUN, creatinine, uric acid, and PTH, which means that the higher level of these variables in patients was related to the higher risk of cognitive impairment. The findings of the present investigation revealed that the cognitive function and the studied variables including age, level of education, history of diabetes, hemodialysis duration, BUN, Creatinine, Uric Acid, PTH, Sodium, and Kt/V had a significant difference in patients undergoing hemodialysis. }, keywords = {Elderly,Chronic hemodialysis,Cognitive Impairment,Diabetes}, url = {https://www.jmchemsci.com/article_138486.html}, eprint = {https://www.jmchemsci.com/article_138486_693b38db670af7f2efafac14ac59e9bd.pdf} } @article { author = {Nourmohammadi, Jalal and Behroozfar, Hedieh and Mahmoodi, Samaneh and Rajabiniat, Fereshteh and Sadeghi, Narges and Nourmohammadi, Zahra}, title = {The Impact of Drug on Heart Problems in Children with a Family-Centered Care Approach}, journal = {Journal of Medicinal and Chemical Sciences}, volume = {4}, number = {6}, pages = {660-675}, year = {2021}, publisher = {Sami Publishing Company (SPC)}, issn = {2651-4702}, eissn = {2651-4702}, doi = {10.26655/JMCHEMSCI.2021.6.14}, abstract = {The purpose of this study was to investigate the effects of the drug on children and their lifespan by compiling a clinical guide. The comparative method was multi-stage. The statistical population in this study was the people in the focus group and nurses working in the pediatric ward of hospitals affiliated to Mashhad University of Medical Sciences, Shahid Beheshti Medical Sciences of Tehran, Shiraz Medical Sciences, Isfahan Medical Sciences and Birjand Medical Sciences. Convenient and available sampling method was available as many as 100 people. The data collection instrument was a three-part questionnaire, including pre-mortem, in-child and post-mortem care. Responses were calculated using a round scale from inappropriate to appropriate with a score of one to nine. The content validity method was used to confirm the validity of the questionnaire and the round fit method technique was used for checking the reliability. The results of this study provided nurses with appropriate guidance to make more informed decisions regarding the challenges of providing nursing care in the later stages of children's lives and supporting parents and other family members, and to improve the quality-of-service delivery.}, keywords = {Drug,end of life,Family-centered Care,Hospital}, url = {https://www.jmchemsci.com/article_138613.html}, eprint = {https://www.jmchemsci.com/article_138613_c84f4314e7e45a4635fa720207efae35.pdf} } @article { author = {Abdolrazaghnejad, Ali and Karimi Tezerji, Babak and Miri, Aghil}, title = {Evaluation of the Relationship between ABO Blood Groups and Severity and Mortality in Patients with Covid-19}, journal = {Journal of Medicinal and Chemical Sciences}, volume = {4}, number = {6}, pages = {676-683}, year = {2021}, publisher = {Sami Publishing Company (SPC)}, issn = {2651-4702}, eissn = {2651-4702}, doi = {10.26655/JMCHEMSCI.2021.6.15}, abstract = {The aim of this study was to investigate the relationship between ABO blood groups and the rate and severity of morbidity and mortality in patients with Covid-19 in Zahedan. The present study is a descriptive-analytical study and includes a sample of 349 patients with Covid-19 referred to hospitals in Zahedan from March 2016 to August 2017. The sampling method was census and for data collection, case studies and checklists were used. The data were analyzed by Chi-square test through SPSS software. Among the 328 patients, 132(41%) had blood type O, 92(28%) had blood type A, 80(24%) had blood group B and 24(7%) had AB blood type. There was no significant relationship between blood groups and age (P <0.150). Patients in the age group of 30-60 years with 208 (63.4%) had the highest number, of whom 78 (23.8%) had blood type O. There was a significant relationship between blood groups and gender (P = 0.001), so male patients with 178 (54.3%) were more, of whom 72 (22%) had blood type O. There was no significant relationship between blood groups and place of hospitalization (P <0.121); however, inpatient department patients with 150 (45.7%) had the highest number, of whom 62 (41.3%) had blood type O. There was no significant relationship between blood groups and severity of covid-19 (P <0.121); however, patients with moderate severity had the highest number with 150 (45.7%) patients, of whom 62 (41.3%) had blood type O.}, keywords = {Blood group antigens,mortality,COVID-19}, url = {https://www.jmchemsci.com/article_138701.html}, eprint = {https://www.jmchemsci.com/article_138701_94ac46d56a186771c8ef7218c5a01eff.pdf} }