Journal of Medicinal and Chemical Sciences

Oxidative Stress and Cognitive Performance in Children with Temporal Lobe Epilepsy

Marwa Elhady; Heba Tawfik Okda; Mohamed Farouk Ahmed; Rasha M. Gouda; Rasha Sobhy Elattar; Seham Eelsaid Abdelsadek; Talal Abd Allah Mohammed Dawa; Mohammad Fathi Abdulsalam; Fathy Mahmoud Mansour; Adel M. Othman; Doaa Ibrahim Hassan Ibrahim; Shaimaa A. Maklad; Shahinaz El Attar; Walaa Shipl; Rayyh A.M. Saleh; Esraa Ali

Volume 7, Issue 1 , January 2024, , Pages 24-33

https://doi.org/10.26655/JMCHEMSCI.2024.1.3

Abstract

Background: Cognitive impairment represents a major but under-determined comorbidity in children with temporal lobe epilepsy. Exposure to oxidation stress may induce cellular damage ... Read More

Motherhood Capacity in Women with Schizophrenia

Embun Kumalaratih; Erikavitri Yulianti Yulianti

Volume 6, Issue 12 , December 2023, , Pages 3026-3035

https://doi.org/10.26655/JMCHEMSCI.2023.12.18

Abstract

Background: In comparison to the general adult female population, women afflicted by schizophrenia exhibit higher rates of unintended and undesired pregnancies. Maternal individuals ... Read More Background: In comparison to the general adult female population, women afflicted by schizophrenia exhibit higher rates of unintended and undesired pregnancies. Maternal individuals grappling with severe mental health challenges face an increased susceptibility to postpartum psychosis, depression, and anxiety stemming from the presence of a child. Psychotic conditions often lead to the rejection of pregnancy, subsequently impinging upon maternal parenting capabilities. The predominant source of support for women with schizophrenia emanates from their familial networks.Case illustration: This paper presents the case of a 41-year-old adult female diagnosed with paranoid schizophrenia that was 40 weeks pregnant and admitted for medical care. The patient received treatment for restlessness and speech slurring. Comprehensive evaluations were conducted by healthcare professionals from the obstetrics and gynecology as well as psychiatry departments, leading to a decision to proceed with a cesarean section to terminate the pregnancy.Methods: Patients receive medical interventions and psychological assistance to stabilize their mental health conditions and avert relapses. Supportive psychotherapy and family psychoeducation, coupled with a collaborative approach involving discussions with obstetrician colleagues regarding childcare plans and supplementary psychiatric treatment, are implemented to enhance maternal well-being while attending to infant care.Conclusion: The obstetric team extensively deliberated the advantages and disadvantages of terminating the pregnancy, considering the provision of sustained care for both the patient and her unborn child. Given that the pregnancy termination was facilitated via cesarean section due to the patient's mental health concerns and the potential adverse effects of antipsychotic medication, the patient's family plays a pivotal role in providing assistance for infant care. Consequently, breastfeeding is contraindicated concerning the patient's mental health status and the potential consequences of antipsychotic treatment.

Comparison of Complication between Autograft and Xenograft Duraplasty: A Systematic Review and Meta-Analysis

Muhammad Irfan Rahmatullah; Asra Al Fauzi; Nur Setiawan Suroto; Muhammad Arifin Parenrengi; Wihasto Suryaningtyas; Dyah Fauziah; Budi Utomo; Billy Dema Justia Wahid; I Wisnawa

Volume 6, Issue 11 , November 2023, , Pages 2793-2803

https://doi.org/10.26655/JMCHEMSCI.2023.11.24

Abstract

Background: Cerebrospinal fluid (CSF) leakage is a well-documented and significant complication that can occur following neurosurgical procedures. The association between CSF leakage ... Read More Background: Cerebrospinal fluid (CSF) leakage is a well-documented and significant complication that can occur following neurosurgical procedures. The association between CSF leakage and various morbidities has been extensively studied. Research on different materials as potential dura mater grafts has been conducted since 1890. The search for the optimal material for dura mater grafts remains ongoing in current research. This investigation aims to assess the incidence of CSF leakage and infection subsequent to duraplasty using xenografts in comparison to autografts.Methods: This study aims to systematically analyze the CSF leakage and infection rates following duraplasty procedures utilizing xenografts and autografts. The research methodology includes a comprehensive search of the PubMed electronic database and a manual search of Google Scholar, adhering to the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines.Results: Among the patients in the xenograft group, a total of 90 individuals out of 452 experienced complications in the form of CSF leaks and complicated pseudo-meningoceles. This study was conducted to investigate the incidence of CSF leaks and complicated pseudo-meningoceles in autografts, with a sample size of 540 patients. The results showed that 79 patients experienced these complications, with a statistically significant p-value of 0.05 and an odds ratio of 1.45 (95% confidence interval 1.00-2.10). Another aspect of the study examined the incidence of meningitis complications in xenografts, with a sample size of 400 patients. The results showed that 25 patients experienced meningitis. Among the 446 patients who underwent autografts, 11 patients (p=0.05; OR 2.10, 95% CI 1.01-4.36) experienced meningitis complications.Conclusion: The analysis of duraplasty techniques shows that the use of xenografts increases the incidence of CSF leaks and pseudo-meningocele complications while raising the risk of meningitis.

Prevalence of Iron Overload in Patients with Multiple Sclerosis

Asma Alanazi; Ayah Ogailan; Jenan Alnamassi; Haya Alrakban; Taif Almutairi; Nouf Almousa; Yaser Almalik; Asma Eltaweel

Volume 6, Issue 11 , November 2023, , Pages 2832-2840

https://doi.org/10.26655/JMCHEMSCI.2023.11.28

Abstract

Background: Multiple sclerosis (MS) is a chronic autoimmune inflammatory condition results in dysfunction of the central nervous system. There are multiple causes linked to the development ... Read More

First Unprovoked Seizure in Indonesian Children

Prastiya Indra Gunawan; Riza Noviandi; Sunny Mariana Samosir

Volume 6, Issue 8 , August 2023, , Pages 1909-1914

https://doi.org/10.26655/JMCHEMSCI.2023.8.19

Abstract

Introduction: First unprovoked seizure (FUS) in children is a frightening health problem that often to be taken to emergency room. EEG is absolutely required to determine seizure activity ... Read More

Identification of Significant Instants of Voxels for Cognitive State Classification Using Interpretable Machine Learning Models

Siva Ramakrishna Jeevakala; Hariharan Ramasangu

Volume 6, Issue 6 , June 2023, , Pages 1291-1301

https://doi.org/10.26655/JMCHEMSCI.2023.6.9

Abstract

Despite decades of significant research, task-based functional MRI cannot reliably predict individual differences in cognition. Furthermore, searching for methods with greater predictability ... Read More

Journal of Medicinal and Chemical Sciences

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Volume 7 (2024)

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Volume 2 (2019)

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Main Subjects = Neurology

Oxidative Stress and Cognitive Performance in Children with Temporal Lobe Epilepsy

Abstract

Motherhood Capacity in Women with Schizophrenia

Abstract

Comparison of Complication between Autograft and Xenograft Duraplasty: A Systematic Review and Meta-Analysis

Abstract

Prevalence of Iron Overload in Patients with Multiple Sclerosis

Abstract

First Unprovoked Seizure in Indonesian Children

Abstract

Identification of Significant Instants of Voxels for Cognitive State Classification Using Interpretable Machine Learning Models

Abstract