Journal of Medicinal and Chemical Sciences

Using GC-MS Technology to Identify the Compounds Resulting from Mixing of Alcoholic Extracts of Some Medicinal Plants

Maryam Mansoor Mathkoor; Eussur Noory Alkhfaji; Noor Abd-Ulamer Oda

Articles in Press, Accepted Manuscript, Available Online from 16 September 2022

https://doi.org/10.26655/JMCHEMSCI.2023.3.5

Abstract

Phytochemicals are considered as one of the most important pharmaceutical compounds used in pharmacy at all, due to their high therapeutic efficacy and few side effects compared with ... Read More

Evaluation of Anti-atherosclerotic Effects of Melatonin Interference with Inflammatory and Oxidative Stress Pathway in Male Rabbits

Hajar Nazar Hashem; Fadhil A. Rizij

Articles in Press, Accepted Manuscript, Available Online from 25 September 2022

https://doi.org/10.26655/JMCHEMSCI.2023.3.13

Abstract

Atherosclerosis is the primary cause of death worldwide. It is now commonly acknowledged that it is a persistent inflammatory process. Minor inflammation, increased oxidative stress, ... Read More Atherosclerosis is the primary cause of death worldwide. It is now commonly acknowledged that it is a persistent inflammatory process. Minor inflammation, increased oxidative stress, and lipid peroxidation all play the essential roles in the atherosclerosis progression. Melatonin (N-acetyl-5-methoxytryptamine) is a neuroendocrine hormone discovered in the bovine pineal gland. The antioxidant action of melatonin is manifested to its direct effects via M1,2 receptors. It not only increases antioxidant enzymes, but also suppresses mesenchymal cell apoptosis. Melatonin is anti-inflammatory and anti-oxidant. In contrast to well-known Instead of following an enzymatic pathway of reduction after oxidation, as do endogenous antioxidants such carotene and vitamins E and C, melatonin binds permanently to free radicals, which the kidneys eliminate. In comparison to the induced untreated group, melatonin has a significant impact on lipid parameters (P>0.001). Melatonin significantly reduced the elevation in ICAM and a mild effect on the aorta thickness compared with induced untreated groups (P<0.05). The drug restores aortic GSH and SOD level (P<0.001). The aim of this research is to evaluate whether melatonin can protect rabbits against atherosclerosis and their role in inflammatory and oxidative pathway. Twenty-four domestic male rabbits from the surrounding area were divided into three groups: Group One, normal Control group (n = 8). Group Two (n = 8): Rabbits were fed a 1% cholesterol diet (induced untreated group). Group Three (n = 8): 1% cholesterol diet + oral melatonin 10 mg/kg once per day before breakfast. Animals fed with an atherogenic diet had lower levels of GSH, SOD, and higher levels of total cholesterol, triglyceride, high-density lipoprotein cholesterol, low-density cholesterol, very low-density cholesterol, a therogenic index, iCAM, and intimal thickness of the aorta, as compared with controls (P<0.001). In comparison with the induced untreated group, melatonin has a significant impact on lipid parameters (P>0.001). Melatonin significantly reduced the ICAM elevation and a mild effect on aorta thickness compared with induced untreated groups (p<0.05). The drug restore aortic GSH and SOD level (P<0.001). The findings of the current study suggest that melatonin reduce the evolution of atherosclerosis in by meddling with inflammatory and oxidative processes and affecting lipid parameters, it was possible to treat hypercholesterolemic rabbits.

The Importance of Early Diagnosis of Systemic Scleroderma

A.Sh. Baimashev; E.R. Agisheva; A.E. Simonova; O.A. Sorokina; D.A. Prokofiev

Volume 6, Issue 2 , February 2023, , Pages 177-185

https://doi.org/10.26655/JMCHEMSCI.2023.2.1

Abstract

Systemic scleroderma (SSc) is a progressive and severely debilitating autoimmune disease characterized by inflammation, vasculopathy, and extensive fibrosis. SSc is highly heterogeneous ... Read More

Wounding-To-Door Time Metrics Outcome of Traumatic Simple Wounds in Emergency Department

Roohie Farzaneh; Mohadese Arvan; Nazgol Khodaie; Sara Rahsepar; Arman Hakemi; Fatemeh Maleki; Mahdi Foroughian; Somayyeh Ahmadnezhad

Volume 6, Issue 2 , February 2023, , Pages 304-312

https://doi.org/10.26655/JMCHEMSCI.2023.2.11

Abstract

Objective: To examine the relationship between wounding-to-door time and wound healing duration in patients with simple traumatic wounds admitted to Shahid Rajaei Emergency Department ... Read More

Uterine Adenomyosis Relationship with Gravidity, Parity, and Abortion in Women with a History of Infertility: A Case-Control Retrospective Study

Athar Rasekhjahromi; Tanaz Torabi; Farideh Mogharab; Mahshid Alborzi; Navid Kalani

Volume 6, Issue 1 , January 2023, , Pages 1-8

https://doi.org/10.26655/JMCHEMSCI.2023.1.1

Abstract

Introduction: Adenomyosis is reported to be increasingly diagnosed in young women and affects 20 to 35% of women of reproductive age. This study aimed to evaluate the relationship between ... Read More

Conjugation of Cortistatin Peptide with Gold Nanoparticles Synthesized to Investigate Anti-Inflammatory Effects in Allergic Asthma

Didar Mehrabi Nasab; Alireza Taheri; Seyyed Shamsadin Athari

Volume 6, Issue 1 , January 2023, , Pages 20-28

https://doi.org/10.26655/JMCHEMSCI.2023.1.3

Abstract

In this study, conjugation between Cortistatin peptide and gold nanoparticles was performed for effective drug delivery of peptide to lung tissue to investigate its anti-inflammatory ... Read More

Demographic Characteristics, Clinical Features, Laboratory, and Radiological Findings in Children Admitted to COVID19 Center in Amara City, Misan Province, Iraq

Eman Khammas AlSaadi; Mohammed A. Darweesh; Hussain Fadel Al Jawadi; Mohammed Abdul-Mounther Othman

Volume 6, Issue 1 , January 2023, , Pages 34-43

https://doi.org/10.26655/JMCHEMSCI.2023.1.5

Abstract

Background:Most pediatric patients with covid 19 had mild to moderate infection and some had severe challenging infection. Generally, they had variable signs and symptoms, laboratory, ... Read More Background:Most pediatric patients with covid 19 had mild to moderate infection and some had severe challenging infection. Generally, they had variable signs and symptoms, laboratory, and radiological findings correlated with the patient age, the involved system, disease severity and probably any underlying disease.Aim:To identify the most common clinical features, the frequency of positive radiological findings, and laboratory results of the infected children hospitalized in Misan COVID-19 Center.Materials and method:A retrospective descriptive with some analytic study applied on 100 pediatric patients in the age range of (0-16) years, diagnosed with COVID-19 or were highly suspected cases, depending on clinical findings, laboratory tests, COVID-19 RT-PCR and/or chest (X-ray + CT), whom were admitted to the Pediatric Covid -19 Center in Amara City, Iraq during the time period of (February-June, 2021). Their medical records were reviewed for demographic information, (gender, age, and residence), medical history, clinical examination, laboratory and imaging studies, (X-ray + CT), O saturation, the duration of illness before admission of any underlying chronic diseases as well as the most common presenting signs and symptoms.Results:Children infected slightly more in the age range of (5-10 years), boys slightly more infected than girls as (54%) and (46%), respectively. The urban residents suffered more than the rural ones, 4% of all cases had low O2 saturation. Fever and malaise were the most common presenting symptoms as (93%) and (68%), respectively. The illness duration before hospitalization commonly was (<5days), (RT-PCR) was negative in 45% of patients, 54% had anemia with or without leukopenia and lymphopenia, CTs were positive in (62%) and CXR was positive in (53%), while the underlying chronic diseases were found in (23%) of the cases.Conclusion: Children of ages between (5-<10 years) were slightly more infected than others, fever, malaise, and cough were the most common manifestations, the urban predominance is high, and half of patients had anemia about one third and had lymphopenia. Likewise, one forth had thrombocytopenia, negative Covid-19 (RT-PCR), and/or CXR. The CT results did not exclude infection. Thus, we need further local studies to support our results.

Vitamin D in Mild to Moderate COVID-19: A Retrospective Cross-Sectional Study

Reza Sahraeai; Farhang Hooshmand; Mojtaba Ghaedi; Shahram Shafa; Fatemeh Eftekharian; Samira Farrokhi

Volume 6, Issue 1 , January 2023, , Pages 55-61

https://doi.org/10.26655/JMCHEMSCI.2023.1.7

Abstract

Background: Vitamin D linkage with COVID-19 is investigated in many studies, but there is still no single summation. Thus, this study aimed to evaluate the relationship between Vitamin ... Read More

Moral Distress, COVID-19, and Healthcare Workers, a Systematic Review and Meta-Synthesis: Solutions by JUMS Clinical Decision-making Scheme

Marzieh Haghbeen; Hossein Hakimelahi; Mansour Tafvizi; Naser Hatami; Navid Kalani; Lotfollah Dezhkam

Volume 6, Issue 1 , January 2023, , Pages 71-78

https://doi.org/10.26655/JMCHEMSCI.2023.1.9

Abstract

Background: Although studies are conducted on moral distress during the COVID-19 period, those being conducted by using various methods of moral distress assessment, the majority of ... Read More

Synthesis, Characterization, and Anti-parasitic Activity Evaluation of the Synthesized Chalcone against Toxoplasma Gondii Isolated from Cases of Abortion in Al-Najaf City

Muna Hashim Ghazzay; Samer Ali Hasan; Oun Deli Khudhair; Khalida Kadhim Abbas Al-Kelaby; Emad Sadiq Ali Al-Hilli

Volume 6, Issue 1 , January 2023, , Pages 132-141

https://doi.org/10.26655/JMCHEMSCI.2023.1.16

Abstract

Toxoplasmosis is a well-known and widespread parasite infection. Although diagnosis has come a long way, therapeutic approaches have not changed since the 1940s. Using SOCl2/EtOH as ... Read More

Periodontitis Therapy with Periodontal-derived Stem Cells (PDSCs) for Dental Tissue Regeneration

Mukhalled Salim Alasady; Abd El Hadi Kanj; Amer Kanj

Volume 6, Issue 1 , January 2023, , Pages 160-167

https://doi.org/10.26655/JMCHEMSCI.2023.1.19

Abstract

Periodontitis is a severe gum infection that can lead to tooth loss and other serious health complications. Periodontal ligament stem cells (PDLSCs), which reside in the perivascular ... Read More

Correlation between Placental Thickness and Estimated Fetal Weight in Women with Hypertension in Third Trimester: A Case Control Study

Nawar Yousif Noori Alsaegh; Ban J. Edan; Zinah Hammad

Volume 6, Issue 1 , January 2023, , Pages 168-176

https://doi.org/10.26655/JMCHEMSCI.2023.1.20

Abstract

Pregnancy-induced hypertension (PIH) as a rapid consequence of gestation consists of gestational hypertension. In this study, we decided to inspect the association between the placental ... Read More

Intravenous Pethidine versus Diclofenac Suppository in Shivering after Cesarean Section under Spinal Anesthesia

Pourya Adibi; Majid Vatankhah; Bibi Mona Razavi; Farnaz Fendereski; Mehrdad Malekshoar

Volume 5, 7 (Special Issue) , November and December 2022, , Pages 1142-1149

https://doi.org/10.26655/JMCHEMSCI.2022.7.1

Abstract

Introduction: One of the most common surgeries on women is a cesarean section. Shivering is a prevalent adverse effect of spinal anesthesia following surgery. This study aimed to evaluate ... Read More

Post Cesarean Section Analgesic Effects of Intravenous Pethidine and Diclofenac Suppository after Spinal Anesthesia: A Randomized Clinical Trial

Pourya Adibi; Majid Vatankhah; Mehrdad Malekshoar; Bibi Mona Razavi; Tayyebeh Zarei

Volume 5, 7 (Special Issue) , November and December 2022, , Pages 1150-1155

https://doi.org/10.26655/JMCHEMSCI.2022.7.2

Abstract

Introduction: One of the most difficult challenges after a C-section is minimizing pain. The goal of this study was to see how intravenous pethidine and diclofenac suppository altered ... Read More

The Effect of Heat Variable on the Chemical Composition and Bioactivities of a Citrullus lanatus Seed Aqueous Extracts

Noora Thamer Abdulaziz; Yasser Fakri Mustafa

Volume 5, 7 (Special Issue) , November and December 2022, , Pages 1166-1176

https://doi.org/10.26655/JMCHEMSCI.2022.7.4

Abstract

Citrullus lanatus (Citrullus L.) co-products have been shown in multiple studies to have biological attributes, attempting to make them a naturally-derived source for medicinal products. ... Read More

A Preliminary Protocol for Induction of Tuberculosis Spondylitis by Mycobacterium Tuberculosis Strain H37R: In-vivo New Zealand White Rrabbits Model

Otman Siregar; Aznan Lelo; . Rahyussalim; Syafruddin Ilyas; . Benny; Tri Kurniawati; Yohanes Augustinus; . Hendra; Tommy Mandagi; Muhammad Luqman Labib Zufar

Volume 5, 7 (Special Issue) , November and December 2022, , Pages 1299-1310

https://doi.org/10.26655/JMCHEMSCI.2022.7.19

Abstract

Background: Proper animal model is a critical prerequisite of any experimental study, while it is a lack for tuberculosis spondylitis. This study aimed to validate a protocol for induction ... Read More

Transforming Health Care Services through Knowledge Management during COVID-19 in India

Lakshmi Prasad Padhy; Ipseeta Satpathy; B. Chandra Mohan Patnaik

Volume 5, Issue 6 , November and December 2022, , Pages 900-914

https://doi.org/10.26655/JMCHEMSCI.2022.6.4

Abstract

Knowledge management (KM) is considered to be an important intervention in improving health care services. KM facilitates the transfer of the existing knowledge and the development ... Read More

Early Renal Effects of Chronic Co-Exposure to a Mixture of Toxic Metals in two Pediatric Age Groups

Jawhar Laamech; Abdelkader Jalil El Hangouche; Youssra Amekran; Said Bakkali; Saad Chakkor

Volume 5, Issue 6 , November and December 2022, , Pages 943-953

https://doi.org/10.26655/JMCHEMSCI.2022.6.8

Abstract

Sources of contamination by lead (Pb), cadmium (Cd), and mercury (Hg) are not regulated in Morocco, and have been reported to be responsible for renal effects in two separate cohorts ... Read More

The in vitro Effects of New Albocarbon-based Coumarins on Blood Glucose-controlling Enzymes

Sarah Ahmed Waheed; Yasser Fakri Mustafa

Volume 5, Issue 6 , November and December 2022, , Pages 954-967

https://doi.org/10.26655/JMCHEMSCI.2022.6.9

Abstract

The majority of the world’s most hazardous pathologies are linked to the oxidative damaging effect of free moieties. One of the diseases associated with these damaging radicals ... Read More The majority of the world’s most hazardous pathologies are linked to the oxidative damaging effect of free moieties. One of the diseases associated with these damaging radicals is diabetes. This disease is widely distributed among people of all ages, with the elderly being the most affected. Therefore, it is essential to conduct comprehensive investigations in order to promote the creation of the novel free radical-housing and hypoglycemic compounds. This study involves the synthesis of eight novel albocarbon-based coumarins, which were confirmed by various spectrophotometers. Their hypoglycemic and free radical-housing effects were analyzed. The pharmacokinetic profile was checked in silico using pre-ADMET, known as a free online program. The hypoglycemic influence was tested against two types of the blood glucose-controlling enzymes. In addition, the new compounds’ potency index was measured. The free radical-housing potential was analyzed by testing these coumarins’ ability to scavenge DDPT and hydroxyl harmful radicals. Pharmacokinetic studies demonstrated that the synthesized albocarbon-based coumarins penetrate the gastrointestinal mucosa very well, and the majority of these compounds penetrate the blood-brain barrier only slightly. These findings suggest the good oral bioavailability along with low neurological toxicity profiles. The investigation of the hypoglycemic influence of these new compounds revealed that they had a less potent enzyme inhibition capacity compared to the standard, with LY5 being the most powerful one. Besides, the assessment of the free radical-housing potential of these synthesized albocarbon-based coumarins also indicated that all of them were less active than the reference. Among them, LY0 was the strongest free radical-housing compound from these recognitions, along with the safety and good pharmacokinetic parameters in accordance with the computer-based study. The researchers believed that these new albocarbon-based coumarins can be applied for the creation of new successful drugs with hypoglycemic and free radical-housing effects which can help in the modulation of much serious pathology.

Phytochemical Analysis and Antimicrobial Evaluation of Quince Seeds’ Extracts

Eman Tareq Mohammed; Raghad Riyadh Khalil; Yasser Fakri Mustafa

Volume 5, Issue 6 , November and December 2022, , Pages 968-979

https://doi.org/10.26655/JMCHEMSCI.2022.6.10

Abstract

Microbial infection and microbial resistance to the classical antibiotics have been immense challenges which portend the health of societies. This has directed researchers to straight ... Read More

A Comparative Study on the Effects of Propofol and Thiopental on the Apgar score of Neonates Undergoing Cesarean Section under General Anesthesia: A Systematic Review Study

Seyed Ebrahim Sadeghi; Mehrdad Malekshoar; Majid Vatankhah; Pourya Adibi; Elham Rahmanian; Mohammad Sadegh Sanie Jahromi; Maryam Nemati

Volume 5, Issue 6 , November and December 2022, , Pages 1008-1017

https://doi.org/10.26655/JMCHEMSCI.2022.6.14

Abstract

Introduction: Apgar score of neonates at birth is one of the determinants of postnatal mortality and one of the effective factors in Apgar score of cesarean section neonates that is ... Read More Introduction: Apgar score of neonates at birth is one of the determinants of postnatal mortality and one of the effective factors in Apgar score of cesarean section neonates that is the type of drug used for maternal anesthesia. Owing to the disagreement on the benefits and possible side effects of anesthetics, the present study was an attempt to evaluate and compare the effects of propofol and thiopental on the Apgar score of neonates undergoing cesarean section under the general anesthesia.Methods: The present study is a systematic review. Persian articles were searched in databases such as SID, Iranmedex, Magiran, and English articles were searched in databases such as Science Direct, PubMed, ProQuest, Cochrane Library, Embase, Scopus, and Google Scholar search engine without any time limitation. To access the full text of articles, the keywords of propofol, thiopental, general anesthesia, neonatal Apgar score, cesarean section, and their combination, the Boolean search methods, and conjunctions of “And” and “Or” were used. The information of reviewed articles included the first author, year of publication, the country of study, the sample size, and the outcome of the study.Results: A total of 27 articles were included to the study. In 22 studies, no statistically significant difference was found between thiopental and propofol effects on neonatal Apgar score at minutes 1 and 5. Also, in 4 studies, Apgar scores at minutes 1 and 5 were reported higher in the propofol group than the thiopental group. Furthermore, in one study, Apgar score at minute 1 was reported higher in the propofol group than the thiopental group. In three studies, Apgar score of neonates at the minute 1 in thiopental group was reported higher than the propofol group.Conclusion: It seems that neonates whose mothers underwent the general anesthesia with propofol for cesarean section have better Apgar scores than those who received thiopental. One of the effects of propofol is its shorter duration of action, and if the patient has a problem with difficult intubation, the effect of the drug ends sooner and the patient’s breathe returns as soon as possible. Likewise in this regard, compared to thiopental, which has a longer effect, Propofol is a more effective drug in cesarean section women under the general anesthesia.

Stress in University Teachers in the Framework of the Post-Pandemic Face-To-Face Academic Resumption

Elmer Benito Rivera Mansilla; Roxana Yolanda Castillo-Acobo; Elena Guillermina Martinez Puma; Yuselino Maquera Maquera; Jose Luis Arias Gonzales; Mario Mario Jose Vasquez-Pauca

Volume 5, Issue 6 , November and December 2022, , Pages 1040-1047

https://doi.org/10.26655/JMCHEMSCI.2022.6.17

Abstract

Teachers in America returned to work in September 2020 to a climate of fear and uncertainty due to the country’s first-ever government lockdown due to the Covid-19 pandemic. Since ... Read More Teachers in America returned to work in September 2020 to a climate of fear and uncertainty due to the country’s first-ever government lockdown due to the Covid-19 pandemic. Since the outbreak of the epidemic, teachers around the world have been building up psychological symptoms due to various factors which have accompanied the pandemic, these factors have resulted in a significant amount of stress, depression, and anxiety, among the other factors in teachers and this study is done to determine that how these factors affect teachers especially after the pandemic. They had to use online teaching throughout the lockdown, and now that schools are reopening, they have exhibited a lot of anxiety about the new and the unprecedented teaching environment. According to the findings of the study, females had the highest stress response with a mean of 7.11 and a standard deviation of 4.414, while males had lower stress level with a mean of 4.99 and a standard deviation of 2.32. The results of t-test also revealed that there was a significant stress in teachers at 5 percent level of significance (p-value = 0.000, df = 1549, and t-test= 2.28). On work stability, many respondents chose NO with a mean of 8.79 and a standard deviation of 5.309 implying that after Covid-19, the work stability of teachers had been affected and adapting to the new normal was difficult and had not only for students, but also for the teachers. Anxiety was another variable that was taken into consideration in this study and further, females had the highest response with a mean of 7.01 and a standard deviation of 4.53, on the other hand, males had a lower response of 4.53, the study proved the significance of the test that teachers are affected by anxiety during this period at 5% level of significance and p-value of 2.28. Finally, depression as a variable was further determined to be significance (p-value = 0.000, df = 1549, and t-test = 2.28) by the study. Therefore, the study concluded that, having school-aged children, being a victim of Covid-19 or having a relative affected by the virus increases stress, depression, and anxiety levels in teachers especially in female teachers. Teachers who have children are more likely to be stressed out because they have to cope with a hefty workload and at the same time, the burden of caring for their families. These professionals had to deal with the twin whammy of returning to school for themselves and for their children. Family life may have contributed to the elevated anxiety levels during the pandemic, as raising a family during crisis times can include the additional challenges, such as managing finances, child care, and home education obligations.

Evaluation of In vitro Antioxidant and Antidiabetic Properties of Cydonia Oblonga Seeds' Extracts

Raghad Riyadh Khalil; Eman Tareq Mohammed; Yasser Fakri Mustafa

Volume 5, Issue 6 , November and December 2022, , Pages 1048-1058

https://doi.org/10.26655/JMCHEMSCI.2022.6.18

Abstract

There is an unequivocal relationship between oxidative stress and diabetes development, progression, or both. In recent years, some novel bioactive compounds derived from plants have ... Read More

Investigating the Effect of Oral Clonidine on Surgeon Satisfaction from Surgical Field in Septorhinoplasty

Mojtaba Ghaedi; Lohrasb Taheri; Mojtaba Sohrabpour; Navid Kalani; Mohammad Sadegh Sanie Jahromi

Volume 5, Issue 6 , November and December 2022, , Pages 1085-1093

https://doi.org/10.26655/JMCHEMSCI.2022.6.21

Abstract

Introduction: Haemorrhage during septorhinoplasty surgery is challenging for the surgeons since it can reduce the visibility of the surgical site. Thus, the present study aimed to investigate ... Read More

Relationship between Psychological Distress and Physical Activity among Medical Students: A Cross-Sectional Study

Abdelkader Jalil El Hangouche; Jawhar Laamech; Youssra Amekran; Saad Chakkor; Said Bakkali; Nora Taiek; Narjisse Damoun

Volume 5, Issue 6 , November and December 2022, , Pages 1132-1141

https://doi.org/10.26655/JMCHEMSCI.2022.6.25

Abstract

Medical studies are known to be a source of psychological distress and radical changes in medical students’ behaviors and attitudes. We carried out this study to assess the prevalence ... Read More

Volume 6 (2023)

Volume 5 (2022)

Volume 4 (2021)

Volume 3 (2020)

Volume 2 (2019)

Volume 1 (2018)

Main Subjects = Pharmaceutical sciences &amp; Medicinal

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Main Subjects = Pharmaceutical sciences & Medicinal