Journal of Medicinal and Chemical Sciences

Mortality and Prevalence of COVID-19 in Variable Cancer Subtypes with Radiological Correlation at the King Hussein Cancer Center

Mousa El Khaldi; Mira Al Jabi; Dana Alkhulaifat; Mais Zmaily; Maysa Al-Hussaini; Mariam Kharroubi; Tala Ghatasheh; Samar Taqatqeh; Abdallah Nofal

Volume 7, Issue 2 , February 2024, , Pages 352-362

https://doi.org/10.26655/JMCHEMSCI.2024.2.7

Abstract

Purpose: Radiographic abnormalities on first CT scans may correspond with increased risk of severe COVID-19 infections in cancer patients. Therefore, the purpose of this study is to ... Read More

Clinical Changes in Patterns of Moral Courage and Moral Distress Among Operating Room Nurses During COVID-19

Mahboobeh Khosravani; Ashkan Karimi; Sahar Khaki; Hamed Parnikh; Azam Moslemi; Zahra Mostafapour; Azadeh Amiri

Volume 7, Issue 1 , January 2024, , Pages 91-103

https://doi.org/10.26655/JMCHEMSCI.2024.1.9

Abstract

Healthcare personnel involved in COVID-19 care have been negatively affected by the associated excess stress. This study aimed to investigate the relationship between moral distress ... Read More Healthcare personnel involved in COVID-19 care have been negatively affected by the associated excess stress. This study aimed to investigate the relationship between moral distress and moral courage among operating room nurses due the hidden conditions of the effects of COVID during the outbreak of the coronavirus disease (COVID-19) crisis. This descriptive-correlation study was conducted on all operating room nurses working in educational and medical centers in Shiraz, Iran, 2022. The samples (n=141) were selected using a convenience sampling method. The required data were collected by questionnaires of demographic form, the Professional Sekerka Moral Courage and the Moral Distress Scale. The gathered data were analyzed in SPSS software through descriptive and analytical statistics. The mean scores of moral courage and moral distress only nurses who as Circuler Nurse were obtained at 61.67±7.79 was 47.4±18.9, respectively. It was revealed that there was a statistically significant relationship between the dimensions of moral courage and the dimensions of errors and inappropriate competencies and responsibilities of moral distress (P>0.05). The moral courage and moral distress of the nurses showed significant differences in terms of the type of employment, length of working experience, specialized field of surgery, and working ward, age, specialized field of surgery during the COVID-19 crisis. Moral agency and multiple values showed a statistically significant and direct relationship with total moral distress (R=0.20, P=0.01). Concerning the results of study, there can be stated that nurses were inclined to perform moral behaviors and an increase in their sense of responsibility during the COVID-19 crisis would lead to courageous behaviors and ultimately, a reduction in moral distress. Therefore, it is necessary that managers pay serious attention to the employment of training programs and improving the psychological knowledge of involved nurses and sharing nurses’ experiences of moral distress.

The Impact of Obesity and Diabetes on COVID-19 Severity

Asma Alanazi; Raseel Alsubaie; Wed Alwabel; Aram Alzahrani; Wasan Alenezi; Bushra Almutawa; Nada Al Eisa

Volume 7, Issue 1 , January 2024, , Pages 104-115

https://doi.org/10.26655/JMCHEMSCI.2024.1.10

Abstract

The seven human coronavirus, sever acute respiratory syndrome coronavirus 2 (SARS-CoV-2) had started a worldwide health pandemic that raised concern regarding its severe outcomes in ... Read More

Sorbitol Dehydrogenase and Other Liver Enzymes Before and After Five Days Remdesivir Therapy in Covid-19 Patients

Puspa Wardhani; Kustiah Kustiah; M. Robiul Fuadi; Yulia Nadar Indrasari; Dwita Riadini; Bambang Pujo Semedi

Volume 6, Issue 10 , October 2023, , Pages 2470-2479

https://doi.org/10.26655/JMCHEMSCI.2023.10.21

Abstract

The antiviral remdesivir has the potential to cause drug-induced liver injury in Covid-19 patients as seen in increased alanine aminotransferase (ALT) and aspartate aminotransferase ... Read More

Clinical and Laboratory Characteristics of COVID-19 Patients with Fecal SARS-CoV-2 Detection at a Tertiary Hospital in Indonesia

Andrew Adhytia Lieputra; Rebriarina Hapsari; Cecilia Oktaria Permatadewi; Irfan Kesumayadi; Iva Puspitasari; Purnomo Hadi; Nur Farhanah; Hendro Wahyono; Hery Djagat Purnomo

Volume 6, Issue 9 , September 2023, , Pages 1935-1942

https://doi.org/10.26655/JMCHEMSCI.2023.9.2

Abstract

Transmission prevention is important to prevent the spread of COVID-19. Although most cases are transmitted through droplets and aerosols, several studies have shown the possibility ... Read More

Survival Analysis of Delta versus Omicron Variants in COVID-19 Intensive Care Unit (ICU)

Somayeh Mehrpour; Mojdeh Bahadorzadeh; Hassan Safdari; Mansoureh Shakeri; Reihane Tabaraii

Volume 6, Issue 9 , September 2023, , Pages 2038-2045

https://doi.org/10.26655/JMCHEMSCI.2023.9.12

Abstract

Objective: COVID-19 has presented numerous epidemiological and clinical pictures from its beginning and much effort has been paid to detect the behavior of disease and its new types. ... Read More Objective: COVID-19 has presented numerous epidemiological and clinical pictures from its beginning and much effort has been paid to detect the behavior of disease and its new types. Therefore, in this study, we aimed to compare the in-hospital survival time of Delta and Omicron variant patients admitted to the intensive care unit. Methods: This was a secondary data analysis of the QCOVICU data registry of 200 COVID-19 patients admitted to the ICU of Shahid Beheshti-Amir Al-Momenin Hospital of Qom City, in 2021. Likewise, time to event data, demographics, and baseline laboratory data was collected. Time of transfer to ICU, survivals, and possible predictors of hazards of death was compared within the variants of Omicron and delta.Results: Two hundred patients (62.98±19.94 years old, 94 females/106 males; 100 Delta and 100 Omicron variant) participated in this study. Fifty percent of the population had died. Cross-tabulation showed comparable death rates among variants of delta and omicron (50.5% vs. 51%; p=0.999). There was a statistically significant higher time to ICU admission in Delta variant victims than in Omicron variant victims. The mean survival time of delta variant patients was 21.52 days (95% CI: 17.96 – 25.09) which was statistically higher than the mean survival of omicron patients (17.15 days, 95% CI: 13.65-20.64, p=0.018). The mean survival time of delta variant patients was ‎statistically higher than omicron patients (21.52 vs. 17.15 days, ‎p=0.018). Gender, age (years), and lymphocyte count were significant predictors of mortality based on the Cox regression analysis (P>0.05). There was a 5.9 times higher risk of mortality in females compared with males’ gender after adjusting for other variables and a 5.6% increase in death risk with a 1-year increase in age, and a 31.8% decrease in death risk with a 1% lymphocyte percentage increase.Conclusion: Critically patients with Delta variant are getting ICU admitted later and withstand more days at ICU than Omicron patients. It seems that Omicron variant causes sudden deterioration of the patient's condition.

Safety and Efficacy of Popular Iranian Herbal Cold Remedy for COVID-19: A Randomized Clinical Trial in Mild to Moderate COVID-19 Cases

Samaneh Abiri; Alireza Hashemi Shiri; Mohammad Sadegh Sanie Jahromi; Esmaeil Rayatdoost; Hamid Afkhami; Ruhollah Ravanshad; Seyed Ehsan Hosseini; Navid Kalani; Parasta Heidari; Rahim Raoufi

Volume 6, Issue 8 , August 2023, , Pages 1799-1809

https://doi.org/10.26655/JMCHEMSCI.2023.8.8

Abstract

Background: In traditional Persian medicine, an herbal cold remedy containing Sugarcane, Black Myrobalan, and mastic is mentioned and it was being widely provided by grocery stores. ... Read More Background: In traditional Persian medicine, an herbal cold remedy containing Sugarcane, Black Myrobalan, and mastic is mentioned and it was being widely provided by grocery stores. With the advent of the COVID-19 pandemic, the increased desire for this traditional remedy has led to a debate in society. Huge parts of the Iranian population have started using this remedy for the treatment of COVID-19; while no study has evaluated its efficiency and possible side effects. Thus, we aimed to evaluate the effects of Sugarcane, Black Myrobalan, and Mastic‏ ‏herbal medications for COVID-19 patients.Methods: This was a double-blinded randomized clinical trial study conducted over three months from May 2020 to July 2020 in SARS-COV2 PCR positive patients admitted in the COVID-19 ward of Peymaniyeh Hospital in Jahrom, Iran. Patients with severe COVID-19 infection were not recruited. The intervention group received the routine COVID-19 treatment protocol and the herbal supplement received the combination of black myrobalan and mastic and sugarcane, twice a day (3 g of herbal supplement). Study groups were compared in terms of demographic variables, vital signs, and clinical and laboratory variables for safety and efficiency assessment.Results: Seventy-two patients with COVID-19, divided into intervention (n=37) and control (n = 35) groups were studied. Intervention and control groups had not any significant difference in terms of baseline characteristics. The time-to-event analysis revealed a statistically significant difference in 4 symptoms of cough, fever, dyspnea, and myalgia (P<0.05). There was no significant difference in averaged O2 vital signs between the two groups (P>0.05). The Control group in comparison to the intervention group had a significantly lower decrease in C-reactive protein during 7 days (P<0.05). Patients in the herbal supplement group were hospitalized for 4.12 days and patients in the control group were hospitalized for 8.37 days (P=0.001). ICU admission and death only happened in 3 (8.6%) patients of the control group.Conclusion: This study showed that the proposed herbal remedy could be applied as supplementation to conventional management of COVID-19 patients with mild disease, while more research is needed for clinical application of this remedy.

Study of Effects and Complications for People Infected with COVID-19

Noor Hassoon Al-Qaraghuli; Israa Mahdi Zahid

Volume 6, Issue 5 , May 2023, , Pages 1137-1144

https://doi.org/10.26655/JMCHEMSCI.2023.5.19

Abstract

In December 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was identified in Wuhan, China from a cluster of severe pneumonia cases. The virus and the disease it ... Read More

Mortality Rate of COVID‐19 Patients in Intensive Care Unit: A Multicentre Retrospective Observational Study

Bastian Lubis; Arie Zainul Fatoni; Ahmad Feza Fadhlurrahman; Taufiq Agus Siswagama; Rudy Vitraludyono; Mayang Indah Lestari; Haizah Nurdin; Septian Adi Permana; Ade Susanti; Agus Prima; Vincent Viandy; Bram Kilapong; Nurita Dian Kestriani Saragi Sitio; Erwin Pradian; Ricky Aditya Ardiwinangun; Retnaningsih .; Danu Susilowati; Johan Arifin; Adhrie Sugiarto; Dita Aditianingsih

Volume 6, Issue 4 , April 2023, , Pages 764-770

https://doi.org/10.26655/JMCHEMSCI.2023.4.7

Abstract

The case of Coronavirus Disease 2019 (COVID-19) is growing rapidly worldwide. More than 6 million people in Indonesia were confirmed to be infected as of March 2022. This disease caused ... Read More

Study of Diabetic Imbalance During Acute Phase and Recovery in Patients with COVID-19 in Baghdad/Iraq

Ali Muhsin Hasan; Ahmed Saadi Hassan; Amal Hasan Atiyah

Volume 6, Issue 3 , March 2023, , Pages 515-521

https://doi.org/10.26655/JMCHEMSCI.2023.3.8

Abstract

This study aims to investigate traces of COVID-19 on diabetic profile during infection and after recovery to manifest the effects of disease upon pancreas due to uncensored elevation ... Read More

COVID-19 Vaccine Hesitancy among Iraqi Dentists

Madiha Fouad Jameel Al-azzawi; Maha Waleed Alghazali; Marwah M. Hareeja; Ishraq K. Abbas; Abdulkareem Hussain Alwan

Volume 6, Issue 2 , February 2023, , Pages 424-433

https://doi.org/10.26655/JMCHEMSCI.2023.2.22

Abstract

Since it was first detected in Iraq in February 2020, the COVID-19 epidemic has spread significantly among healthcare professionals. Due to the nature of dental practices, oral health ... Read More

Hematological Profile and Liver Biomarkers of COVID-19 Non Survivors in Iraq

Muna Hasson Saoudi; Ihab Abbas Taher

Volume 5, Issue 7 , November and December 2022, , Pages 1357-1363

https://doi.org/10.26655/JMCHEMSCI.2022.7.24

Abstract

Mortality of coronavirus disease (COVID-19) was elevated all over the world since 2019 due to its mainly spread through the respiratory route and mass contact. Many risk profiles on ... Read More

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Keywords = COVID

Mortality and Prevalence of COVID-19 in Variable Cancer Subtypes with Radiological Correlation at the King Hussein Cancer Center

Abstract

Clinical Changes in Patterns of Moral Courage and Moral Distress Among Operating Room Nurses During COVID-19

Abstract

The Impact of Obesity and Diabetes on COVID-19 Severity

Abstract

Sorbitol Dehydrogenase and Other Liver Enzymes Before and After Five Days Remdesivir Therapy in Covid-19 Patients

Abstract

Clinical and Laboratory Characteristics of COVID-19 Patients with Fecal SARS-CoV-2 Detection at a Tertiary Hospital in Indonesia

Abstract

Survival Analysis of Delta versus Omicron Variants in COVID-19 Intensive Care Unit (ICU)

Abstract

Safety and Efficacy of Popular Iranian Herbal Cold Remedy for COVID-19: A Randomized Clinical Trial in Mild to Moderate COVID-19 Cases

Abstract

Study of Effects and Complications for People Infected with COVID-19

Abstract

Mortality Rate of COVID‐19 Patients in Intensive Care Unit: A Multicentre Retrospective Observational Study

Abstract

Study of Diabetic Imbalance During Acute Phase and Recovery in Patients with COVID-19 in Baghdad/Iraq

Abstract

COVID-19 Vaccine Hesitancy among Iraqi Dentists

Abstract

Hematological Profile and Liver Biomarkers of COVID-19 Non Survivors in Iraq

Abstract