Journal of Medicinal and Chemical Sciences

Evaluating the Effectiveness of Ketamine in reducing Postoperative Nausea and Vomiting in Adults after General Anaesthesia: A Prospective Randomized Controlled Trial

Yachendra V.S.G; Girimurugan .N; Ameerunnisha Begum; Anand. S; Surya. R; Lakshmi. R

Volume 6, Issue 12 , December 2023, , Pages 2934-2940

https://doi.org/10.26655/JMCHEMSCI.2023.12.8

Abstract

Background: Postoperative Nausea and Vomiting (PONV) is defined as any nausea, retching or vomiting occurring during the first 24-48 hours after surgery with a reported incidence of ... Read More Background: Postoperative Nausea and Vomiting (PONV) is defined as any nausea, retching or vomiting occurring during the first 24-48 hours after surgery with a reported incidence of 30% in all post-surgical patients and up to 80% in high risk groups especially in laparoscopic surgeries under general anaesthesia. Many drugs have been tried and tested for abolishing PONV. We evaluated the efficacy of low dose ketamine in decreasing the incidence and severity of PONV following elective laparoscopic surgeries under general anaesthesia.Method: 40 patients belonging to American Society of Anaesthesiologists Physical status I who were scheduled for elective laparoscopic surgeries under general anaesthesia were recruited and randomized into two groups Group A and Group B. Standard protocol for general anaesthesia were followed for all patients. Patients in Group A received Intravenous ketamine of 0.2mg/kg and Patients in Group B received the saline control half an hour before extubation. The incidence and severity of PONV, number of rescue drug administration, and side effects were recorded for first 24 postoperative hours in different time periods.Results: Demographic profile were comparable among the groups. The incidence and severity of postoperative nausea were significantly higher in Group B when compared to Group A for the first 6 postoperative hours (p<0.05) and thereafter, it was comparable between the groups. The incidence of postoperative vomiting was significantly higher in Group B when compared to Group A for the first 2 postoperative hours (p<0.04), and then it was comparable between the groups. The number of rescue medications were significantly higher in Group B when compared with Group A. No complications were noted.Conclusion: Low dose intravenous ketamine (0.2 mg/kg) administered as a single bolus reduced the incidence and severity of postoperative nausea and vomiting in adults undergoing laparoscopic surgeries under general anaesthesia without any complications.

Modified Lung Ultrasound Score to Determine the Degree of Perioperative Atelectasis in Adults Undergoing Elective Laparoscopic Surgery Under General Anaesthesia- A Prospective Observational Study

Dhivya R; Arun Prasath D; Yachendra V.S.G; Surya R; Lakshmi Ramakrishnan

Volume 6, Issue 9 , September 2023, , Pages 2104-2110

https://doi.org/10.26655/JMCHEMSCI.2023.9.17

Abstract

Background: Lung ultrasound score (LUS) is a semiquantitative assessment tool that has been proposed to assess lung aeration changes in mechanically ventilated patients after therapeutic ... Read More

Increase of Neutrophil-Lymphocyte Ratio (NLR) during Urologic Laparoscopic Surgery with Intraoperative Complications in Dr. Sardjito Hospital

Hidayu Permata Hardi; Ahmad Zulfan Hendri; Sakti R. Brodjonegoro

Volume 4, Issue 5 , September and October 2021, , Pages 513-518

https://doi.org/10.26655/JMCHEMSCI.2021.5.13

Abstract

Laparoscopy is a minimally invasive surgery using advanced technology, so the resulting surgical wound is smaller than conventional surgery. Laparoscopy, especially in the field of ... Read More

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Keywords = Laparoscopy

Evaluating the Effectiveness of Ketamine in reducing Postoperative Nausea and Vomiting in Adults after General Anaesthesia: A Prospective Randomized Controlled Trial

Abstract

Modified Lung Ultrasound Score to Determine the Degree of Perioperative Atelectasis in Adults Undergoing Elective Laparoscopic Surgery Under General Anaesthesia- A Prospective Observational Study

Abstract

Increase of Neutrophil-Lymphocyte Ratio (NLR) during Urologic Laparoscopic Surgery with Intraoperative Complications in Dr. Sardjito Hospital

Abstract