Journal of Medicinal and Chemical Sciences

Role of Oxidative Stress in Molar Pregnancy

Luma Abd Almunim Baker; Shaymaa Z. Jalal Aldin; Abduqader Salim Ahmed

Volume 6, Issue 6 , June 2023, , Pages 1383-1393

https://doi.org/10.26655/JMCHEMSCI.2023.6.18

Abstract

A molar pregnancy is the result of an abnormally fertilized egg or placental tissue expansion. The goal of this research was to investigate the potential linkage between some biochemical ... Read More

Cilostazol Protects Against Sepsis-Induced Kidney Impairment in a Mice Model

Abdulla K K Raheem; Ahmed R. Abu-Raghif; Qassim A Zigam

Volume 6, Issue 5 , May 2023, , Pages 1193-1203

https://doi.org/10.26655/JMCHEMSCI.2023.5.25

Abstract

Sepsis is a type of systemic inflammatory disease caused by polymicrobial infection. To investigate the potential reno-protective benefits of cilostazol during sepsis-induced renal ... Read More

Anti-Atherosclerotic Effects of Pioglitazon by Interference with Inflammatory and Stress Pathway in Male Rabbits

Hajar Nazar Hashem; Fadhil A. Rizij

Volume 6, Issue 4 , April 2023, , Pages 746-754

https://doi.org/10.26655/JMCHEMSCI.2023.4.5

Abstract

Atherosclerosis is the leading cause of death worldwide. It is now widely accepted that it is a chronic inflammatory process. Minor inflammation, increased oxidative stress, and lipid ... Read More

Evaluation of Anti-atherosclerotic Effects of Melatonin Interference with Inflammatory and Oxidative Stress Pathway in Male Rabbits

Hajar Nazar Hashem; Fadhil A. Rizij

Volume 6, Issue 3 , March 2023, , Pages 559-568

https://doi.org/10.26655/JMCHEMSCI.2023.3.13

Abstract

Atherosclerosis is the primary cause of death worldwide. It is now commonly acknowledged that it is a persistent inflammatory process. Minor inflammation, increased oxidative stress, ... Read More Atherosclerosis is the primary cause of death worldwide. It is now commonly acknowledged that it is a persistent inflammatory process. Minor inflammation, increased oxidative stress, and lipid peroxidation all play the essential roles in the atherosclerosis progression. Melatonin (N-acetyl-5-methoxytryptamine) is a neuroendocrine hormone discovered in the bovine pineal gland. The antioxidant action of melatonin is manifested to its direct effects via M1,2 receptors. It not only increases antioxidant enzymes, but also suppresses mesenchymal cell apoptosis. Melatonin is anti-inflammatory and anti-oxidant. In contrast to well-known Instead of following an enzymatic pathway of reduction after oxidation, as do endogenous antioxidants such carotene and vitamins E and C, melatonin binds permanently to free radicals, which the kidneys eliminate. In comparison to the induced untreated group, melatonin has a significant impact on lipid parameters (P>0.001). Melatonin significantly reduced the elevation in ICAM and a mild effect on the aorta thickness compared with induced untreated groups (P<0.05). The drug restores aortic GSH and SOD level (P<0.001). The aim of this research is to evaluate whether melatonin can protect rabbits against atherosclerosis and their role in inflammatory and oxidative pathway. Twenty-four domestic male rabbits from the surrounding area were divided into three groups: Group One, normal Control group (n = 8). Group Two (n = 8): Rabbits were fed a 1% cholesterol diet (induced untreated group). Group Three (n = 8): 1% cholesterol diet + oral melatonin 10 mg/kg once per day before breakfast. Animals fed with an atherogenic diet had lower levels of GSH, SOD, and higher levels of total cholesterol, triglyceride, high-density lipoprotein cholesterol, low-density cholesterol, very low-density cholesterol, a therogenic index, iCAM, and intimal thickness of the aorta, as compared with controls (P<0.001). In comparison with the induced untreated group, melatonin has a significant impact on lipid parameters (P>0.001). Melatonin significantly reduced the ICAM elevation and a mild effect on aorta thickness compared with induced untreated groups (p<0.05). The drug restore aortic GSH and SOD level (P<0.001). The findings of the current study suggest that melatonin reduce the evolution of atherosclerosis in by meddling with inflammatory and oxidative processes and affecting lipid parameters, it was possible to treat hypercholesterolemic rabbits.

Energy Level and Oxidative Stress Status in Cardiovascular Disease

Hawraa Gatea Karkoush; Perry Habib Saifullah

Volume 6, Issue 2 , February 2023, , Pages 449-457

https://doi.org/10.26655/JMCHEMSCI.2023.2.25

Abstract

The mitochondrial metabolism is the primary source of energy upon which the heart draws to fulfill its function of pumping blood throughout the body to supply the organs with oxygen. ... Read More

Study the Effect of Pregnancy on Oxidative Stress Status in Pregnant Women with Gingivitis

Wisam R. N. Al-Muhsen; Hasan Abd Ali Khudhair; Nisreen Ahmed Hamzah

Volume 5, 7 (Special Issue) , November and December 2022, , Pages 1253-1264

https://doi.org/10.26655/JMCHEMSCI.2022.7.15

Abstract

Background: Gingivitis is an inflammation limited to marginal gingival tissues, which can be referred to as the mildest form of periodontal diseases, initial signs of inflammation which ... Read More Background: Gingivitis is an inflammation limited to marginal gingival tissues, which can be referred to as the mildest form of periodontal diseases, initial signs of inflammation which include: redness, bleeding, swelling, exudation, and to a lesser extent pain, which indicate the presence of gingivitis. Current research was proposed to detect the correlation between pregnancy status and oxidative stress (OS) levels among gingivitis pregnant women and to elucidate the role of pregnancy status in the pathogenicity of gingivitis.Methods: The current study was conducted in the Dental Center at Thi-Qar province (Iraq), and it included three study groups: 35 pregnant women with gingivitis, 35 non-pregnant women with gingivitis, and 30 non-pregnant women without gingivitis (the healthy control), with an age balance between the three study groups. Serological and salivary levels of malondialdehyde (MDA), total anti-oxidant capacity (TAC), protein carbonyl (Pc), protein, nitric oxide (NO), and ceruloplasmin (Crp) were biochemically determined.Results: The results of the tests showed that the concentrations of MDA, Pc, the total proteins (TP), NO, and Crp were significantly higher among pregnant and non-pregnant women with gingivitis compared with healthy controls in both serum and saliva, whereas the inverse findings were reported for TCA biomarker. The same results profiles were reported in comparison between pregnant women with gingivitis and non-pregnant women with gingivitis for serum biomarkers. For saliva biomarkers, the results revealed significant elevated levels of MDA, Pc, and NO among pregnant gingivitis women in comparison with non-pregnant gingivitis, whereas the other biomarkers revealed non-significant differences.Conclusions: The pregnancy status had an effect on the OS level which lead to a higher level of OS in both serum and saliva and the correlation between the pregnancy status and serum and/or saliva OS levels was positive which indicated the possible utility of its present lead to gingivitis development.

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Keywords = Oxidative stress

Role of Oxidative Stress in Molar Pregnancy

Abstract

Cilostazol Protects Against Sepsis-Induced Kidney Impairment in a Mice Model

Abstract

Anti-Atherosclerotic Effects of Pioglitazon by Interference with Inflammatory and Stress Pathway in Male Rabbits

Abstract

Evaluation of Anti-atherosclerotic Effects of Melatonin Interference with Inflammatory and Oxidative Stress Pathway in Male Rabbits

Abstract

Energy Level and Oxidative Stress Status in Cardiovascular Disease

Abstract

Study the Effect of Pregnancy on Oxidative Stress Status in Pregnant Women with Gingivitis

Abstract