Journal of Medicinal and Chemical Sciences

Development, Characterization, and Influence of Proanthocyanidin Loaded PLGA Nanoparticles on Push out Bond Strength of Glass Fibre Posts Bonded with Resin Cement to Root Dentin: In Vitro Study

Tarini Mullick; Sushruta S Hakkimane; Kishore Ginjupalli; Swathi Pai; Bharath Raja Guru; Krishnaraj Somayaji

Volume 7, Issue 1 , January 2024, , Pages 189-202

https://doi.org/10.26655/JMCHEMSCI.2024.1.18

Abstract

Partial or an incomplete penetration of bonding agent into the demineralized dentin can leave the denuded collagen fibres susceptible to degradation by photolytic enzymes. It is well ... Read More Partial or an incomplete penetration of bonding agent into the demineralized dentin can leave the denuded collagen fibres susceptible to degradation by photolytic enzymes. It is well known that the demineralized dentin and its collagen network is susceptible to degradation with time which can significantly affect the bond strength between root canal and sealer materials. The current study attempts assess the protective effect of proanthocyanidin (PA) loaded PLGA nanoparticles in minimizing the deterioration of demineralized dentin over a period. This is realized by determining/evaluating the push out bond strength between a glass fibre post cemented to root canal using resin luting cement. Ninety human mandibular premolars with single root canals were randomly divided into nine groups (n=10) after endodontic treatment and post space preparation. The root canal dentin of the control group was left unconditioned and the experimental groups i.e. proanthocyanidin and PA loaded PLGA nanoparticles (PA-NP) were conditioned respectively with the test solutions. The glass fibre posts (GFP) were cemented into the root canal with dual cure resin cement (RC). The push out bond strength (POBS) was measured at 30, 60, and 90 days. The mode of failure was evaluated with the help of stereomicroscope. The POBS were statistically analysed and evaluated with the help of paired t-test, ANOVA test and post hoc Bonferroni test at a confidence interval of 95% (α = 0.05). Unloaded NP's average particle size was found to be 237 16 nm, and its zeta potential was -54±4 mV. There was a statistically significant difference between the mean POBS at all time intervals among the groups tested. PA-NP showed a statistically significant higher bond strength compared to control at all time intervals, while it showed significantly better POBS compared to PA at 180 days. All the experimental groups showed higher POBS at all intervals of time compared to control group. Application of natural cross-linkers such as PA improves POBS of GFP bonded to root canal dentin. PA loaded PLGA nanoparticles (PA-NP) as a conditioning liquid prior to root canal cementation not only improved POBS significantly, but also reduced the time dependent reduction in the bond strength.

The Effect of Nanoparticles and Plant Growth Regulators on Germination of Miaze Seeds: A Comparative Study

Alyaa Muhsin Yousif; Sundus Hameed Ahmed; Rasha Saad Nuaman; Hadeel Radawi H Al-Newani; Isam Hussain T. Al-Karkhi

Volume 6, Issue 6 , June 2023, , Pages 1246-1253

https://doi.org/10.26655/JMCHEMSCI.2023.6.5

Abstract

Nowadays, nanoparticles (NPs) are used for agricultural purposes, such as developing germination of the seeds and enhancing nutrients in the soil. They are also applied in the synthesis ... Read More

Preparation, Characterization, and Ninhydrin Removal by Al2O3 and V2O5 Nanoparticles

Zainab J. Abdul-Zahra; Rashed T. Rasheed

Volume 6, Issue 2 , February 2023, , Pages 376-391

https://doi.org/10.26655/JMCHEMSCI.2023.2.18

Abstract

Two nanoparticles, aluminum dioxide (Al2O3) and vanadium pentoxide (V2O5) were prepared by hydrothermal autoclave and reflex methods, respectively. Every nanoparticle was heated at ... Read More

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Keywords = nanoparticles

Development, Characterization, and Influence of Proanthocyanidin Loaded PLGA Nanoparticles on Push out Bond Strength of Glass Fibre Posts Bonded with Resin Cement to Root Dentin: In Vitro Study

Abstract

The Effect of Nanoparticles and Plant Growth Regulators on Germination of Miaze Seeds: A Comparative Study

Abstract

Preparation, Characterization, and Ninhydrin Removal by Al2O3 and V2O5 Nanoparticles

Abstract